HUMAN:WNT4

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	WNT4
Protein Name(s)	Protein Wnt-4
External Links
UniProt Identifier	WNT4_HUMAN
UniProt Accessions	P56705, Q5TZQ0, Q96T81, Q9BXF5, Q9H1J8, Q9UJM2,
EMBL	AY009398, AF316543, AY358947, BT020125, AL445253, AL031281, AL031281, AL445253, BC057781, AF335591, AY033057,
RefSeq	NP_110388.2,
Ensembl	ENST00000290167,
Pfam	PF00110,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0005578	proteinaceous extracellular matrix		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0005201	extracellular matrix structural constituent		NAS: Non-traceable Author Statement		F	Source: UniProtKB
	GO:0004871	signal transducer activity		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0007267	cell-cell signaling		NAS: Non-traceable Author Statement		P	Source: UniProtKB
	GO:0007223	Wnt receptor signaling pathway, calcium mod...		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0001656	metanephros development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0001656	metanephros development	GO_REF:0000033		PANTHER:PTHR12027_AN532	P
	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000033		PANTHER:PTHR12027_AN532	P
	GO:0001664	G-protein-coupled receptor binding	GO_REF:0000033		PANTHER:PTHR12027_AN0	F
	GO:0001822	kidney development	PMID:15312687^[1]	IEP: Inferred from Expression Pattern		P
	GO:0001823	mesonephros development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0001837	epithelial to mesenchymal transition	PMID:12841867^[2]	IEP: Inferred from Expression Pattern		P
	GO:0001838	embryonic epithelial tube formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0001889	liver development	PMID:15312687^[1]	IEP: Inferred from Expression Pattern		P
	GO:0003714	transcription corepressor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	F
	GO:0003714	transcription corepressor activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22724	F
	GO:0005102	receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	F
	GO:0005102	receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009142	F
	GO:0005109	frizzled binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	F
	GO:0005201	extracellular matrix structural constituent	GO_REF:0000029	NAS: Non-traceable Author Statement		F
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	C
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009142	C
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0272	C
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0111	C
	GO:0005615	extracellular space	PMID:16959810^[3]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000018064	C
	GO:0005737	cytoplasm	PMID:16959810^[3]	IDA: Inferred from Direct Assay		C
	GO:0005794	Golgi apparatus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000018064	C
	GO:0005794	Golgi apparatus	GO_REF:0000033		PANTHER:PTHR12027_AN532	C
	GO:0005886	plasma membrane	GO_REF:0000033		PANTHER:PTHR12027_AN0	C
	GO:0006702	androgen biosynthetic process	PMID:16959810^[3]	IDA: Inferred from Direct Assay		P
	GO:0007267	cell-cell signaling	GO_REF:0000029	NAS: Non-traceable Author Statement		P
	GO:0007275	multicellular organismal development	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	P
	GO:0007275	multicellular organismal development	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009142	P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0007276	gamete generation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0007492	endoderm development	GO_REF:0000033		PANTHER:PTHR12027_AN384	P
	GO:0007548	sex differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0008584	male gonad development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0008584	male gonad development	PMID:11283799^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0008584	male gonad development	PMID:17848411^[5]	IEP: Inferred from Expression Pattern		P
	GO:0008585	female gonad development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0008585	female gonad development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22724	P
	GO:0008585	female gonad development	GO_REF:0000033		PANTHER:PTHR12027_AN532	P
	GO:0009798	axis specification	GO_REF:0000033		PANTHER:PTHR12027_AN0	P
	GO:0009952	anterior/posterior pattern formation	GO_REF:0000033		PANTHER:PTHR12027_AN0	P
	GO:0009986	cell surface	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	C
	GO:0009986	cell surface	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22724	C
	GO:0010629	negative regulation of gene expression	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0010629	negative regulation of gene expression	PMID:15317892^[6]	IDA: Inferred from Direct Assay		P
	GO:0010894	negative regulation of steroid biosynthetic process	PMID:15317892^[6]	IDA: Inferred from Direct Assay		P
	GO:0010894	negative regulation of steroid biosynthetic process	PMID:16959810^[3]	IDA: Inferred from Direct Assay		P
	GO:0010894	negative regulation of steroid biosynthetic process	PMID:18182450^[7]	IDA: Inferred from Direct Assay		P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009142	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0879	P
	GO:0018345	protein palmitoylation	PMID:15317892^[6]	IDA: Inferred from Direct Assay		P
	GO:0022407	regulation of cell-cell adhesion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0030154	cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0030237	female sex determination	PMID:11283799^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0030325	adrenal gland development	PMID:12844346^[8]	IEP: Inferred from Expression Pattern		P
	GO:0030501	positive regulation of bone mineralization	PMID:17720811^[9]	IDA: Inferred from Direct Assay		P
	GO:0031012	extracellular matrix	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	C
	GO:0032349	positive regulation of aldosterone biosynthetic process	PMID:16981135^[10]	IDA: Inferred from Direct Assay		P
	GO:0032355	response to estradiol stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000018064	P
	GO:0032967	positive regulation of collagen biosynthetic process	PMID:17720811^[9]	IDA: Inferred from Direct Assay		P
	GO:0033077	T cell differentiation in thymus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0033077	T cell differentiation in thymus	GO_REF:0000033		PANTHER:PTHR12027_AN535	P
	GO:0033080	immature T cell proliferation in thymus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0035239	tube morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0035567	non-canonical Wnt receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	GO_REF:0000033		PANTHER:PTHR12027_AN532	P
	GO:0042445	hormone metabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0045165	cell fate commitment	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0045596	negative regulation of cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0045669	positive regulation of osteoblast differentiation	PMID:17720811^[9]	IDA: Inferred from Direct Assay		P
	GO:0045836	positive regulation of meiosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0045892	negative regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0045892	negative regulation of transcription, DNA-dependent	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22724	P
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:12949260^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0045893	positive regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:11283799^[4]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22724	P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:16959810^[3]	IDA: Inferred from Direct Assay		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:16981135^[10]	IDA: Inferred from Direct Assay		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:18182450^[7]	IDA: Inferred from Direct Assay		P
	GO:0048599	oocyte development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0048599	oocyte development	GO_REF:0000033		PANTHER:PTHR12027_AN532	P
	GO:0048754	branching morphogenesis of a tube	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0048856	anatomical structure development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0051145	smooth muscle cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0051145	smooth muscle cell differentiation	GO_REF:0000033		PANTHER:PTHR12027_AN532	P
	GO:0060070	canonical Wnt receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0060070	canonical Wnt receptor signaling pathway	PMID:15317892^[6]	IDA: Inferred from Direct Assay		P
	GO:0060126	somatotropin secreting cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0060126	somatotropin secreting cell differentiation	GO_REF:0000033		PANTHER:PTHR12027_AN532	P
	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation	GO_REF:0000033		PANTHER:PTHR12027_AN532	P
	GO:0060231	mesenchymal to epithelial transition	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0060748	tertiary branching involved in mammary gland duct morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0060748	tertiary branching involved in mammary gland duct morphogenesis	GO_REF:0000033		PANTHER:PTHR12027_AN532	P
	GO:0061054	dermatome development	PMID:10654605^[12]	IDA: Inferred from Direct Assay		P
	GO:0061180	mammary gland epithelium development	PMID:8168088^[13]	IEP: Inferred from Expression Pattern		P
	GO:0061205	paramesonephric duct development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0061205	paramesonephric duct development	PMID:18182450^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:0061369	negative regulation of testicular blood vessel morphogenesis	PMID:12949260^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0071392	cellular response to estradiol stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000018064	P
	GO:0071464	cellular response to hydrostatic pressure	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000018064	P
	GO:0071560	cellular response to transforming growth factor beta stimulus	PMID:15040835^[14]	IEP: Inferred from Expression Pattern		P
	GO:0072033	renal vesicle formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0072033	renal vesicle formation	GO_REF:0000033		PANTHER:PTHR12027_AN532	P
	GO:0072034	renal vesicle induction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0072162	metanephric mesenchymal cell differentiation	PMID:16368682^[15]	NAS: Non-traceable Author Statement		P
	GO:0072164	mesonephric tubule development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0072164	mesonephric tubule development	GO_REF:0000033		PANTHER:PTHR12027_AN532	P
	GO:0072273	metanephric nephron morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0090002	establishment of protein localization in plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:0090002	establishment of protein localization in plasma membrane	PMID:17976063^[16]	IDA: Inferred from Direct Assay		P
	GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	PMID:17976063^[16]	IDA: Inferred from Direct Assay		P
	GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	PMID:16959810^[3]	IDA: Inferred from Direct Assay		P
	GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	PMID:18182450^[7]	IDA: Inferred from Direct Assay		P
	GO:2000019	negative regulation of male gonad development	PMID:11283799^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:2000066	positive regulation of cortisol biosynthetic process	PMID:16981135^[10]	IDA: Inferred from Direct Assay		P
	GO:2000225	negative regulation of testosterone biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000036580	P
	GO:2000225	negative regulation of testosterone biosynthetic process	PMID:12949260^[11]	IMP: Inferred from Mutant Phenotype		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Peltoketo H et al. (2004) Characterization and expression of the human WNT4; lack of associated germline mutations in high--to moderate--risk breast and ovarian cancer. Cancer Lett 213: 83-90 PubMed GONUTS page
↑ Taki M et al. (2003) Down-regulation of Wnt-4 and up-regulation of Wnt-5a expression by epithelial-mesenchymal transition in human squamous carcinoma cells. Cancer Sci 94: 593-7 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Biason-Lauber A et al. (2007) WNT4 deficiency--a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report. Hum Reprod 22: 224-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Jordan BK et al. (2001) Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans. Am J Hum Genet 68: 1102-9 PubMed GONUTS page
↑ O'Shaughnessy PJ et al. (2007) Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester. J Clin Endocrinol Metab 92: 4792-801 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Biason-Lauber A et al. (2004) A WNT4 mutation associated with Müllerian-duct regression and virilization in a 46,XX woman. N Engl J Med 351: 792-8 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Philibert P et al. (2008) Identification and functional analysis of a new WNT4 gene mutation among 28 adolescent girls with primary amenorrhea and müllerian duct abnormalities: a French collaborative study. J Clin Endocrinol Metab 93: 895-900 PubMed GONUTS page
↑ Suwa T et al. (2003) Zonal expression of dickkopf-3 and components of the Wnt signalling pathways in the human adrenal cortex. J Endocrinol 178: 149-58 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Chang J et al. (2007) Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK. J Biol Chem 282: 30938-48 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Chen M & Hornsby PJ (2006) Adenovirus-delivered DKK3/WNT4 and steroidogenesis in primary cultures of adrenocortical cells. Horm Metab Res 38: 549-55 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Jordan BK et al. (2003) Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy. Proc Natl Acad Sci U S A 100: 10866-71 PubMed GONUTS page
↑ Lee CS et al. (2000) SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. Development 127: 109-18 PubMed GONUTS page
↑ Huguet EL et al. (1994) Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Cancer Res 54: 2615-21 PubMed GONUTS page
↑ Zhou S et al. (2004) Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells. J Bone Miner Res 19: 463-70 PubMed GONUTS page
↑ Torban E et al. (2006) PAX2 activates WNT4 expression during mammalian kidney development. J Biol Chem 281: 12705-12 PubMed GONUTS page
↑ ^16.0 ^16.1 Kelly JM et al. (2007) Effects of grade of oocyte-cumulus complex and the interactions between grades on the production of blastocysts in the cow, ewe and lamb. Reprod Domest Anim 42: 577-82 PubMed GONUTS page

[PMID:15312687-0] 1.0 ^1.1 Peltoketo H et al. (2004) Characterization and expression of the human WNT4; lack of associated germline mutations in high--to moderate--risk breast and ovarian cancer. Cancer Lett 213: 83-90 PubMed GONUTS page

[PMID:12841867-1] Taki M et al. (2003) Down-regulation of Wnt-4 and up-regulation of Wnt-5a expression by epithelial-mesenchymal transition in human squamous carcinoma cells. Cancer Sci 94: 593-7 PubMed GONUTS page

[PMID:16959810-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Biason-Lauber A et al. (2007) WNT4 deficiency--a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report. Hum Reprod 22: 224-9 PubMed GONUTS page

[PMID:11283799-3] 4.0 ^4.1 ^4.2 ^4.3 Jordan BK et al. (2001) Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans. Am J Hum Genet 68: 1102-9 PubMed GONUTS page

[PMID:17848411-4] O'Shaughnessy PJ et al. (2007) Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester. J Clin Endocrinol Metab 92: 4792-801 PubMed GONUTS page

[PMID:15317892-5] 6.0 ^6.1 ^6.2 ^6.3 Biason-Lauber A et al. (2004) A WNT4 mutation associated with Müllerian-duct regression and virilization in a 46,XX woman. N Engl J Med 351: 792-8 PubMed GONUTS page

[PMID:18182450-6] 7.0 ^7.1 ^7.2 ^7.3 Philibert P et al. (2008) Identification and functional analysis of a new WNT4 gene mutation among 28 adolescent girls with primary amenorrhea and müllerian duct abnormalities: a French collaborative study. J Clin Endocrinol Metab 93: 895-900 PubMed GONUTS page

[PMID:12844346-7] Suwa T et al. (2003) Zonal expression of dickkopf-3 and components of the Wnt signalling pathways in the human adrenal cortex. J Endocrinol 178: 149-58 PubMed GONUTS page

[PMID:17720811-8] 9.0 ^9.1 ^9.2 Chang J et al. (2007) Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK. J Biol Chem 282: 30938-48 PubMed GONUTS page

[PMID:16981135-9] 10.0 ^10.1 ^10.2 Chen M & Hornsby PJ (2006) Adenovirus-delivered DKK3/WNT4 and steroidogenesis in primary cultures of adrenocortical cells. Horm Metab Res 38: 549-55 PubMed GONUTS page

[PMID:12949260-10] 11.0 ^11.1 ^11.2 Jordan BK et al. (2003) Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy. Proc Natl Acad Sci U S A 100: 10866-71 PubMed GONUTS page

[PMID:10654605-11] Lee CS et al. (2000) SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. Development 127: 109-18 PubMed GONUTS page

[PMID:8168088-12] Huguet EL et al. (1994) Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Cancer Res 54: 2615-21 PubMed GONUTS page

[PMID:15040835-13] Zhou S et al. (2004) Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells. J Bone Miner Res 19: 463-70 PubMed GONUTS page

[PMID:16368682-14] Torban E et al. (2006) PAX2 activates WNT4 expression during mammalian kidney development. J Biol Chem 281: 12705-12 PubMed GONUTS page

[PMID:17976063-15] 16.0 ^16.1 Kelly JM et al. (2007) Effects of grade of oocyte-cumulus complex and the interactions between grades on the production of blastocysts in the cow, ewe and lamb. Reprod Domest Anim 42: 577-82 PubMed GONUTS page

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HUMAN:WNT4

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