HUMAN:WNT3A

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	WNT3A
Protein Name(s)	Protein Wnt-3a
External Links
UniProt Identifier	WNT3A_HUMAN
UniProt Accessions	P56704, Q3SY80, Q969P2,
EMBL	AB060284, AK056278, AL136379, BC103922,
RefSeq	NP_149122.1,
Ensembl	ENST00000284523, ENST00000366753,
Pfam	PF00110,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005578	proteinaceous extracellular matrix		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0005201	extracellular matrix structural constituent		NAS: Non-traceable Author Statement		F	Source: UniProtKB
	GO:0004871	signal transducer activity		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0003136	canonical Wnt receptor signaling pathway in...		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0007223	Wnt receptor signaling pathway, calcium mod...		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	PMID:20723538^[1]	IDA: Inferred from Direct Assay		P	Figure 1A: Wnt3a increased the total beta-catenin level in HEK293A cells indicating that Wnt3a activates the canonical pathway in the particular cells.	complete
	GO:0035413	positive regulation of catenin protein nuclear translocation	PMID:20723538^[1]	IDA: Inferred from Direct Assay		P	Figure 1B: induction of beta-catenin protein level upon Wnt3a/sFRP2 showed increased beta-catenin nuclear translocation	complete
	GO:0017025	TATA-binding protein binding	PMID:20723538^[1]	IDA: Inferred from Direct Assay		F	Figure 1(B): Wnt3a binds to TATA binding protein.	complete

	GO:0001934	positive regulation of protein phosphorylation	PMID:20723538^[1]	IDA: Inferred from Direct Assay		P	Figure 1(D): Treatment with Wnt3a lead to induced phosphorylation of LRP6. In addition, treatment with both the Wnt3a and sFRP2 enhanced the LRP6 phosphorylation in HEK293A cells.	complete
	GO:0045941	positive regulation of transcription	PMID:20723538^[1]	IDA: Inferred from Direct Assay		P	Figure 3:When Wnt3a plus sFRP2 were used for treatment of Wnt11 showed enhanced mRNA expression.	complete
	GO:0001649	osteoblast differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0001701	in utero embryonic development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0001756	somitogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0001756	somitogenesis	GO_REF:0000033		PANTHER:PTHR12027_AN119	P
	GO:0001934	positive regulation of protein phosphorylation	PMID:20137080^[2]	IDA: Inferred from Direct Assay		P
	GO:0001934	positive regulation of protein phosphorylation	PMID:20412773^[3]	IDA: Inferred from Direct Assay		P
	GO:0001947	heart looping	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0002092	positive regulation of receptor internalization	PMID:16890161^[4]	IDA: Inferred from Direct Assay		P
	GO:0003136	negative regulation of heart induction by canonical Wnt receptor signaling pathway	PMID:19736317^[5]	IDA: Inferred from Direct Assay		P
	GO:0003713	transcription coactivator activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	F
	GO:0003713	transcription coactivator activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P27467	F
	GO:0005102	receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	F
	GO:0005102	receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009141	F
	GO:0005109	frizzled binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	F
	GO:0005110	frizzled-2 binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	F
	GO:0005110	frizzled-2 binding	GO_REF:0000033		PANTHER:PTHR12027_AN89	F
	GO:0005201	extracellular matrix structural constituent	GO_REF:0000029	NAS: Non-traceable Author Statement		F
	GO:0005515	protein binding	PMID:19072540^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q8N474	F
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	C
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009141	C
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000029	NAS: Non-traceable Author Statement		C
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0272	C
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0111	C
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	C
	GO:0005615	extracellular space	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P27467	C
	GO:0005615	extracellular space	GO_REF:0000033		PANTHER:PTHR12027_AN0	C
	GO:0005769	early endosome	GO_REF:0000033		PANTHER:PTHR12027_AN89	C
	GO:0005770	late endosome	GO_REF:0000033		PANTHER:PTHR12027_AN89	C
	GO:0005886	plasma membrane	GO_REF:0000033		PANTHER:PTHR12027_AN0	C
	GO:0007223	Wnt receptor signaling pathway, calcium modulating pathway	GO_REF:0000033		PANTHER:PTHR12027_AN89	P
	GO:0007267	cell-cell signaling	GO_REF:0000029	NAS: Non-traceable Author Statement		P
	GO:0007275	multicellular organismal development	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	P
	GO:0007275	multicellular organismal development	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009141	P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0007368	determination of left/right symmetry	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0007368	determination of left/right symmetry	GO_REF:0000033		PANTHER:PTHR12027_AN119	P
	GO:0007409	axonogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0007409	axonogenesis	GO_REF:0000033		PANTHER:PTHR12027_AN119	P
	GO:0007411	axon guidance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0007498	mesoderm development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0008284	positive regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0008284	positive regulation of cell proliferation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P27467	P
	GO:0008284	positive regulation of cell proliferation	GO_REF:0000033		PANTHER:PTHR12027_AN89	P
	GO:0009653	anatomical structure morphogenesis	GO_REF:0000029	NAS: Non-traceable Author Statement		P
	GO:0009798	axis specification	GO_REF:0000033		PANTHER:PTHR12027_AN0	P
	GO:0009880	embryonic pattern specification	GO_REF:0000033		PANTHER:PTHR12027_AN89	P
	GO:0009952	anterior/posterior pattern formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0009986	cell surface	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	C
	GO:0009986	cell surface	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P27467	C
	GO:0010387	signalosome assembly	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0010387	signalosome assembly	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P27467	P
	GO:0010977	negative regulation of neuron projection development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P27467	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009141	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0879	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0019904	protein domain specific binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	F
	GO:0021527	spinal cord association neuron differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0021766	hippocampus development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0021766	hippocampus development	GO_REF:0000033		PANTHER:PTHR12027_AN119	P
	GO:0021846	cell proliferation in forebrain	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0021846	cell proliferation in forebrain	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P27467	P
	GO:0021874	Wnt receptor signaling pathway involved in forebrain neuroblast division	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0021874	Wnt receptor signaling pathway involved in forebrain neuroblast division	GO_REF:0000033		PANTHER:PTHR12027_AN119	P
	GO:0021904	dorsal/ventral neural tube patterning	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0021904	dorsal/ventral neural tube patterning	GO_REF:0000033		PANTHER:PTHR12027_AN119	P
	GO:0030097	hemopoiesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0030168	platelet activation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0030182	neuron differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P56706	P
	GO:0030198	extracellular matrix organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0030198	extracellular matrix organization	GO_REF:0000033		PANTHER:PTHR12027_AN119	P
	GO:0030879	mammary gland development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0030879	mammary gland development	GO_REF:0000033		PANTHER:PTHR12027_AN119	P
	GO:0030890	positive regulation of B cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0030903	notochord development	GO_REF:0000033		PANTHER:PTHR12027_AN119	P
	GO:0030917	midbrain-hindbrain boundary development	GO_REF:0000033		PANTHER:PTHR12027_AN89	P
	GO:0032092	positive regulation of protein binding	PMID:16890161^[4]	IDA: Inferred from Direct Assay		P
	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:20723538^[1]	IDA: Inferred from Direct Assay		P
	GO:0034613	cellular protein localization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0035121	tail morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0035121	tail morphogenesis	GO_REF:0000033		PANTHER:PTHR12027_AN119	P
	GO:0035413	positive regulation of catenin import into nucleus	PMID:20137080^[2]	IDA: Inferred from Direct Assay		P
	GO:0035413	positive regulation of catenin import into nucleus	PMID:20723538^[1]	IDA: Inferred from Direct Assay		P
	GO:0042472	inner ear morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0042472	inner ear morphogenesis	GO_REF:0000033		PANTHER:PTHR12027_AN90	P
	GO:0043280	positive regulation of caspase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0045121	membrane raft	GO_REF:0000033		PANTHER:PTHR12027_AN89	C
	GO:0045595	regulation of cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000033		PANTHER:PTHR12027_AN89	P
	GO:0045893	positive regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0045893	positive regulation of transcription, DNA-dependent	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P27467	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:20723538^[1]	IDA: Inferred from Direct Assay		P
	GO:0048018	receptor agonist activity	PMID:20723538^[1]	IDA: Inferred from Direct Assay		F
	GO:0048103	somatic stem cell division	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0048343	paraxial mesodermal cell fate commitment	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0048343	paraxial mesodermal cell fate commitment	GO_REF:0000033		PANTHER:PTHR12027_AN119	P
	GO:0048697	positive regulation of collateral sprouting in absence of injury	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0048843	negative regulation of axon extension involved in axon guidance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0050768	negative regulation of neurogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0050768	negative regulation of neurogenesis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P27467	P
	GO:0050770	regulation of axonogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0060021	palate development	PMID:18413325^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:0060026	convergent extension	GO_REF:0000033		PANTHER:PTHR12027_AN119	P
	GO:0060070	canonical Wnt receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0060070	canonical Wnt receptor signaling pathway	PMID:19101069^[8]	IDA: Inferred from Direct Assay		P
	GO:0060070	canonical Wnt receptor signaling pathway	PMID:20137080^[2]	IDA: Inferred from Direct Assay		P
	GO:0060070	canonical Wnt receptor signaling pathway	PMID:20723538^[1]	IDA: Inferred from Direct Assay		P
	GO:0061054	dermatome development	PMID:10654605^[9]	IDA: Inferred from Direct Assay		P
	GO:0061098	positive regulation of protein tyrosine kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0070507	regulation of microtubule cytoskeleton organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0070527	platelet aggregation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0071300	cellular response to retinoic acid	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P56706	P
	GO:0071425	hemopoietic stem cell proliferation	GO_REF:0000033		PANTHER:PTHR12027_AN90	P
	GO:0090245	axis elongation involved in somitogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	PMID:17976063^[10]	IDA: Inferred from Direct Assay		P
	GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	PMID:18941195^[11]	IDA: Inferred from Direct Assay		P
	GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
	GO:2000081	positive regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000010044	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 von Marschall Z & Fisher LW (2010) Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling. Biochem Biophys Res Commun 400: 299-304 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Gnad T et al. (2010) Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled. Mol Cancer 9: 31 PubMed GONUTS page
↑ Varelas X et al. (2010) The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell 18: 579-91 PubMed GONUTS page
↑ ^4.0 ^4.1 Yamamoto H et al. (2006) Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. Dev Cell 11: 213-23 PubMed GONUTS page
↑ Stefanovic S et al. (2009) Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate. J Cell Biol 186: 665-73 PubMed GONUTS page
↑ Moore WJ et al. (2009) Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J Med Chem 52: 105-16 PubMed GONUTS page
↑ Chiquet BT et al. (2008) Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate. Hum Mol Genet 17: 2212-8 PubMed GONUTS page
↑ Nygren MK et al. (2009) beta-catenin is involved in N-cadherin-dependent adhesion, but not in canonical Wnt signaling in E2A-PBX1-positive B acute lymphoblastic leukemia cells. Exp Hematol 37: 225-33 PubMed GONUTS page
↑ Lee CS et al. (2000) SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. Development 127: 109-18 PubMed GONUTS page
↑ Kelly JM et al. (2007) Effects of grade of oocyte-cumulus complex and the interactions between grades on the production of blastocysts in the cow, ewe and lamb. Reprod Domest Anim 42: 577-82 PubMed GONUTS page
↑ Yokota T et al. (2008) Soluble frizzled-related protein 1 is estrogen inducible in bone marrow stromal cells and suppresses the earliest events in lymphopoiesis. J Immunol 181: 6061-72 PubMed GONUTS page

[PMID:20723538-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 von Marschall Z & Fisher LW (2010) Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling. Biochem Biophys Res Commun 400: 299-304 PubMed GONUTS page

[PMID:20137080-1] 2.0 ^2.1 ^2.2 Gnad T et al. (2010) Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled. Mol Cancer 9: 31 PubMed GONUTS page

[PMID:20412773-2] Varelas X et al. (2010) The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell 18: 579-91 PubMed GONUTS page

[PMID:16890161-3] 4.0 ^4.1 Yamamoto H et al. (2006) Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. Dev Cell 11: 213-23 PubMed GONUTS page

[PMID:19736317-4] Stefanovic S et al. (2009) Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate. J Cell Biol 186: 665-73 PubMed GONUTS page

[PMID:19072540-5] Moore WJ et al. (2009) Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J Med Chem 52: 105-16 PubMed GONUTS page

[PMID:18413325-6] Chiquet BT et al. (2008) Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate. Hum Mol Genet 17: 2212-8 PubMed GONUTS page

[PMID:19101069-7] Nygren MK et al. (2009) beta-catenin is involved in N-cadherin-dependent adhesion, but not in canonical Wnt signaling in E2A-PBX1-positive B acute lymphoblastic leukemia cells. Exp Hematol 37: 225-33 PubMed GONUTS page

[PMID:10654605-8] Lee CS et al. (2000) SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. Development 127: 109-18 PubMed GONUTS page

[PMID:17976063-9] Kelly JM et al. (2007) Effects of grade of oocyte-cumulus complex and the interactions between grades on the production of blastocysts in the cow, ewe and lamb. Reprod Domest Anim 42: 577-82 PubMed GONUTS page

[PMID:18941195-10] Yokota T et al. (2008) Soluble frizzled-related protein 1 is estrogen inducible in bone marrow stromal cells and suppresses the earliest events in lymphopoiesis. J Immunol 181: 6061-72 PubMed GONUTS page

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HUMAN:WNT3A

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