HUMAN:WNT3

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	WNT3 ( synonyms: INT4 )
Protein Name(s)	Proto-oncogene Wnt-3 Proto-oncogene Int-4 homolog
External Links
UniProt Identifier	WNT3_HUMAN
UniProt Accessions	P56703, Q2M237, Q9H1J9,
EMBL	AY009397, AB067628, BC112116, BC112118, BC114219,
PIR	A47536,
RefSeq	NP_110380.1,
IntAct	P56703,
Ensembl	ENST00000225512,
Pfam	PF00110,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0005578	proteinaceous extracellular matrix		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0005201	extracellular matrix structural constituent		NAS: Non-traceable Author Statement		F	Source: UniProtKB
	GO:0005109	frizzled binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0004871	signal transducer activity		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0060070	Wnt receptor signaling pathway through beta...		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0007223	Wnt receptor signaling pathway, calcium mod...		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0000902	cell morphogenesis	PMID:15588944^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0001707	mesoderm formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000127	P
	GO:0001707	mesoderm formation	GO_REF:0000033		PANTHER:PTHR12027_AN91	P
	GO:0005102	receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	F
	GO:0005102	receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009141	F
	GO:0005109	frizzled binding	PMID:10557084^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UP38	F
	GO:0005109	frizzled binding	PMID:18313787^[3]	IPI: Inferred from Physical Interaction	UniProtKB:O75084	F
	GO:0005110	frizzled-2 binding	GO_REF:0000033		PANTHER:PTHR12027_AN89	F
	GO:0005515	protein binding	PMID:21314951^[4]	IPI: Inferred from Physical Interaction	UniProtKB:O75084	F
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	C
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009141	C
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0272	C
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0111	C
	GO:0005615	extracellular space	GO_REF:0000033		PANTHER:PTHR12027_AN0	C
	GO:0005615	extracellular space	PMID:18313787^[3]	TAS: Traceable Author Statement		C
	GO:0005624	membrane fraction	PMID:15588944^[1]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005176	C
	GO:0005769	early endosome	GO_REF:0000033		PANTHER:PTHR12027_AN89	C
	GO:0005770	late endosome	GO_REF:0000033		PANTHER:PTHR12027_AN89	C
	GO:0005886	plasma membrane	GO_REF:0000033		PANTHER:PTHR12027_AN0	C
	GO:0007223	Wnt receptor signaling pathway, calcium modulating pathway	GO_REF:0000033		PANTHER:PTHR12027_AN89	P
	GO:0007275	multicellular organismal development	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	P
	GO:0007275	multicellular organismal development	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009141	P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0007411	axon guidance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000127	P
	GO:0008284	positive regulation of cell proliferation	GO_REF:0000033		PANTHER:PTHR12027_AN89	P
	GO:0009880	embryonic pattern specification	GO_REF:0000033		PANTHER:PTHR12027_AN89	P
	GO:0009948	anterior/posterior axis specification	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000127	P
	GO:0009950	dorsal/ventral axis specification	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000127	P
	GO:0009950	dorsal/ventral axis specification	GO_REF:0000033		PANTHER:PTHR12027_AN94	P
	GO:0009952	anterior/posterior pattern formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000127	P
	GO:0010628	positive regulation of gene expression	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000127	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009141	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0879	P
	GO:0019904	protein domain specific binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000127	F
	GO:0030182	neuron differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P56706	P
	GO:0030917	midbrain-hindbrain boundary development	GO_REF:0000033		PANTHER:PTHR12027_AN89	P
	GO:0031012	extracellular matrix	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000127	C
	GO:0035115	embryonic forelimb morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000127	P
	GO:0035115	embryonic forelimb morphogenesis	GO_REF:0000033		PANTHER:PTHR12027_AN94	P
	GO:0035116	embryonic hindlimb morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000127	P
	GO:0035116	embryonic hindlimb morphogenesis	GO_REF:0000033		PANTHER:PTHR12027_AN94	P
	GO:0042472	inner ear morphogenesis	GO_REF:0000033		PANTHER:PTHR12027_AN90	P
	GO:0044338	canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation	PMID:20039315^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0044339	canonical Wnt receptor signaling pathway involved in osteoblast differentiation	PMID:20039315^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0045121	membrane raft	GO_REF:0000033		PANTHER:PTHR12027_AN89	C
	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000033		PANTHER:PTHR12027_AN89	P
	GO:0048646	anatomical structure formation involved in morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000127	P
	GO:0048697	positive regulation of collateral sprouting in absence of injury	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000127	P
	GO:0048843	negative regulation of axon extension involved in axon guidance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000127	P
	GO:0060064	Spemann organizer formation at the anterior end of the primitive streak	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000127	P
	GO:0060064	Spemann organizer formation at the anterior end of the primitive streak	GO_REF:0000033		PANTHER:PTHR12027_AN94	P
	GO:0060070	canonical Wnt receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000127	P
	GO:0060070	canonical Wnt receptor signaling pathway	PMID:10557084^[2]	IDA: Inferred from Direct Assay		P
	GO:0060070	canonical Wnt receptor signaling pathway	PMID:15588944^[1]	IDA: Inferred from Direct Assay		P
	GO:0060070	canonical Wnt receptor signaling pathway	PMID:18044981^[6]	IDA: Inferred from Direct Assay		P
	GO:0060173	limb development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000127	P
	GO:0060174	limb bud formation	PMID:14872406^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:0060323	head morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000127	P
	GO:0060323	head morphogenesis	GO_REF:0000033		PANTHER:PTHR12027_AN94	P
	GO:0061180	mammary gland epithelium development	PMID:8168088^[8]	IEP: Inferred from Expression Pattern		P
	GO:0071300	cellular response to retinoic acid	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P56706	P
	GO:0071425	hemopoietic stem cell proliferation	GO_REF:0000033		PANTHER:PTHR12027_AN90	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Chiba H et al. (2004) Wnt3 modulates the characteristics and cobblestone area-supporting activity of human stromal cells. Exp Hematol 32: 1194-203 PubMed GONUTS page
↑ ^2.0 ^2.1 Gazit A et al. (1999) Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. Oncogene 18: 5959-66 PubMed GONUTS page
↑ ^3.0 ^3.1 Kim M et al. (2008) Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. J Hepatol 48: 780-91 PubMed GONUTS page
↑ Wei W et al. (2011) Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin. Mol Cancer 10: 16 PubMed GONUTS page
↑ ^5.0 ^5.1 Bhat RA et al. (2010) Wnt3-frizzled 1 chimera as a model to study canonical Wnt signaling. J Cell Biochem 109: 876-84 PubMed GONUTS page
↑ Björklund P et al. (2007) An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling. PLoS Med 4: e328 PubMed GONUTS page
↑ Niemann S et al. (2004) Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. Am J Hum Genet 74: 558-63 PubMed GONUTS page
↑ Huguet EL et al. (1994) Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Cancer Res 54: 2615-21 PubMed GONUTS page

[PMID:15588944-0] 1.0 ^1.1 ^1.2 Chiba H et al. (2004) Wnt3 modulates the characteristics and cobblestone area-supporting activity of human stromal cells. Exp Hematol 32: 1194-203 PubMed GONUTS page

[PMID:10557084-1] 2.0 ^2.1 Gazit A et al. (1999) Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. Oncogene 18: 5959-66 PubMed GONUTS page

[PMID:18313787-2] 3.0 ^3.1 Kim M et al. (2008) Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. J Hepatol 48: 780-91 PubMed GONUTS page

[PMID:21314951-3] Wei W et al. (2011) Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin. Mol Cancer 10: 16 PubMed GONUTS page

[PMID:20039315-4] 5.0 ^5.1 Bhat RA et al. (2010) Wnt3-frizzled 1 chimera as a model to study canonical Wnt signaling. J Cell Biochem 109: 876-84 PubMed GONUTS page

[PMID:18044981-5] Björklund P et al. (2007) An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling. PLoS Med 4: e328 PubMed GONUTS page

[PMID:14872406-6] Niemann S et al. (2004) Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. Am J Hum Genet 74: 558-63 PubMed GONUTS page

[PMID:8168088-7] Huguet EL et al. (1994) Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Cancer Res 54: 2615-21 PubMed GONUTS page

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HUMAN:WNT3

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