HUMAN:WNT16

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	WNT16
Protein Name(s)	Protein Wnt-16
External Links
UniProt Identifier	WNT16_HUMAN
UniProt Accessions	Q9UBV4, Q2M3G1, Q9Y5C0,
EMBL	AF169963, AF152584, AC006364, BC104919, BC104945,
RefSeq	NP_057171.2, NP_476509.1,
Ensembl	ENST00000222462,
Pfam	PF00110,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0005578	proteinaceous extracellular matrix		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0005201	extracellular matrix structural constituent		NAS: Non-traceable Author Statement		F	Source: UniProtKB
	GO:0004871	signal transducer activity		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0007267	cell-cell signaling		NAS: Non-traceable Author Statement		P	Source: UniProtKB
	GO:0007275	multicellular organismal development		NAS: Non-traceable Author Statement		P	Source: UniProtKB
	GO:0007223	Wnt receptor signaling pathway, calcium mod...		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0003408	optic cup formation involved in camera-type eye development	PMID:16258938^[1]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q3L248	P
	GO:0005102	receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	F
	GO:0005102	receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013304	F
	GO:0005109	frizzled binding	GO_REF:0000033		PANTHER:PTHR12027_AN170	F
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	C
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013304	C
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0272	C
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0111	C
	GO:0005615	extracellular space	PMID:10500199^[2]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:17200136^[3]	IDA: Inferred from Direct Assay		C
	GO:0005886	plasma membrane	GO_REF:0000033		PANTHER:PTHR12027_AN0	C
	GO:0007275	multicellular organismal development	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	P
	GO:0007275	multicellular organismal development	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013304	P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0007409	axonogenesis	GO_REF:0000033		PANTHER:PTHR12027_AN170	P
	GO:0009798	axis specification	GO_REF:0000033		PANTHER:PTHR12027_AN0	P
	GO:0009952	anterior/posterior pattern formation	GO_REF:0000033		PANTHER:PTHR12027_AN0	P
	GO:0010628	positive regulation of gene expression	PMID:16007226^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0014068	positive regulation of phosphatidylinositol 3-kinase cascade	PMID:19951988^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013304	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0879	P
	GO:0030216	keratinocyte differentiation	PMID:17200136^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0043616	keratinocyte proliferation	PMID:17200136^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0046330	positive regulation of JNK cascade	PMID:17200136^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0060070	canonical Wnt receptor signaling pathway	GO_REF:0000033		PANTHER:PTHR12027_AN0	P
	GO:0060317	cardiac epithelial to mesenchymal transition	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000031681	P
	GO:0060548	negative regulation of cell death	PMID:17200136^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0090399	replicative senescence	PMID:19951988^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0090403	oxidative stress-induced premature senescence	PMID:19951988^[5]	IMP: Inferred from Mutant Phenotype		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Fokina VM & Frolova EI (2006) Expression patterns of Wnt genes during development of an anterior part of the chicken eye. Dev Dyn 235: 496-505 PubMed GONUTS page
↑ McWhirter JR et al. (1999) Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia. Proc Natl Acad Sci U S A 96: 11464-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Teh MT et al. (2007) Role for WNT16B in human epidermal keratinocyte proliferation and differentiation. J Cell Sci 120: 330-9 PubMed GONUTS page
↑ Mazieres J et al. (2005) Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis. Oncogene 24: 5396-400 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Binet R et al. (2009) WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway. Cancer Res 69: 9183-91 PubMed GONUTS page

[PMID:16258938-0] Fokina VM & Frolova EI (2006) Expression patterns of Wnt genes during development of an anterior part of the chicken eye. Dev Dyn 235: 496-505 PubMed GONUTS page

[PMID:10500199-1] McWhirter JR et al. (1999) Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia. Proc Natl Acad Sci U S A 96: 11464-9 PubMed GONUTS page

[PMID:17200136-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Teh MT et al. (2007) Role for WNT16B in human epidermal keratinocyte proliferation and differentiation. J Cell Sci 120: 330-9 PubMed GONUTS page

[PMID:16007226-3] Mazieres J et al. (2005) Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis. Oncogene 24: 5396-400 PubMed GONUTS page

[PMID:19951988-4] 5.0 ^5.1 ^5.2 Binet R et al. (2009) WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway. Cancer Res 69: 9183-91 PubMed GONUTS page

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HUMAN:WNT16

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