HUMAN:WNT1

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	WNT1 ( synonyms: INT1 )
Protein Name(s)	Proto-oncogene Wnt-1 Proto-oncogene Int-1 homolog
External Links
UniProt Identifier	WNT1_HUMAN
UniProt Accessions	P04628, Q5U0N2,
EMBL	X03072, BT019429, CH471111, BC074798, BC074799,
PIR	A24674,
RefSeq	NP_005421.1,
Ensembl	ENST00000293549,
Pfam	PF00110,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0005578	proteinaceous extracellular matrix		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0005102	receptor binding		NAS: Non-traceable Author Statement		F	Source: UniProtKB
	GO:0004871	signal transducer activity		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0001708	cell fate specification		TAS: Traceable Author Statement		P	Source: UniProtKB
	GO:0016477	cell migration		TAS: Traceable Author Statement		P	Source: UniProtKB
	GO:0007163	establishment or maintenance of cell polarity		TAS: Traceable Author Statement		P	Source: UniProtKB
	GO:0009611	response to wounding		IEP: Inferred from Expression Pattern		P	Source: UniProtKB
	GO:0007223	Wnt receptor signaling pathway, calcium mod...		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0000578	embryonic axis specification	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0000578	embryonic axis specification	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04426	P
	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0005102	receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	F
	GO:0005102	receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009139	F
	GO:0005109	frizzled binding	PMID:19756656^[1]	IC: Inferred by Curator	GO:0060070	F
	GO:0005110	frizzled-2 binding	GO_REF:0000033		PANTHER:PTHR12027_AN89	F
	GO:0005125	cytokine activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	F
	GO:0005125	cytokine activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04426	F
	GO:0005515	protein binding	PMID:10347172^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q8N474	F
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	C
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009139	C
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0272	C
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0111	C
	GO:0005615	extracellular space	GO_REF:0000033		PANTHER:PTHR12027_AN0	C
	GO:0005737	cytoplasm	PMID:11793365^[3]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:19756656^[1]	IDA: Inferred from Direct Assay		C
	GO:0005769	early endosome	GO_REF:0000033		PANTHER:PTHR12027_AN89	C
	GO:0005770	late endosome	GO_REF:0000033		PANTHER:PTHR12027_AN89	C
	GO:0005886	plasma membrane	GO_REF:0000033		PANTHER:PTHR12027_AN0	C
	GO:0007223	Wnt receptor signaling pathway, calcium modulating pathway	GO_REF:0000033		PANTHER:PTHR12027_AN89	P
	GO:0007267	cell-cell signaling	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0007267	cell-cell signaling	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04426	P
	GO:0007275	multicellular organismal development	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	P
	GO:0007275	multicellular organismal development	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009139	P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0007520	myoblast fusion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0008284	positive regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0008284	positive regulation of cell proliferation	PMID:16501043^[4]	IDA: Inferred from Direct Assay		P
	GO:0008284	positive regulation of cell proliferation	PMID:19778454^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0009611	response to wounding	PMID:17982423^[6]	IEP: Inferred from Expression Pattern		P
	GO:0009798	axis specification	GO_REF:0000033		PANTHER:PTHR12027_AN0	P
	GO:0009880	embryonic pattern specification	GO_REF:0000033		PANTHER:PTHR12027_AN89	P
	GO:0009986	cell surface	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	C
	GO:0010592	positive regulation of lamellipodium assembly	PMID:19756656^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0010812	negative regulation of cell-substrate adhesion	PMID:16501043^[4]	IDA: Inferred from Direct Assay		P
	GO:0014902	myotube differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009139	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0879	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0016055	Wnt receptor signaling pathway	PMID:10644691^[7]	IDA: Inferred from Direct Assay		P
	GO:0019904	protein domain specific binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	F
	GO:0021527	spinal cord association neuron differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0021536	diencephalon development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0021536	diencephalon development	GO_REF:0000033		PANTHER:PTHR12027_AN145	P
	GO:0021551	central nervous system morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0021551	central nervous system morphogenesis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04426	P
	GO:0021587	cerebellum morphogenesis	GO_REF:0000033		PANTHER:PTHR12027_AN145	P
	GO:0021588	cerebellum formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0021588	cerebellum formation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04426	P
	GO:0021592	fourth ventricle development	GO_REF:0000033		PANTHER:PTHR12027_AN145	P
	GO:0021797	forebrain anterior/posterior pattern formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0021797	forebrain anterior/posterior pattern formation	GO_REF:0000033		PANTHER:PTHR12027_AN145	P
	GO:0022004	midbrain-hindbrain boundary maturation during brain development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0022004	midbrain-hindbrain boundary maturation during brain development	GO_REF:0000033		PANTHER:PTHR12027_AN145	P
	GO:0022037	metencephalon development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0022408	negative regulation of cell-cell adhesion	PMID:17072303^[8]	IMP: Inferred from Mutant Phenotype		P
	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0030579	ubiquitin-dependent SMAD protein catabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0030901	midbrain development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0030901	midbrain development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04426	P
	GO:0030901	midbrain development	GO_REF:0000033		PANTHER:PTHR12027_AN145	P
	GO:0030917	midbrain-hindbrain boundary development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0031100	organ regeneration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019641	P
	GO:0033077	T cell differentiation in thymus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0033077	T cell differentiation in thymus	GO_REF:0000033		PANTHER:PTHR12027_AN145	P
	GO:0035284	brain segmentation	GO_REF:0000033		PANTHER:PTHR12027_AN145	P
	GO:0042472	inner ear morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0042472	inner ear morphogenesis	GO_REF:0000033		PANTHER:PTHR12027_AN90	P
	GO:0042770	signal transduction in response to DNA damage	PMID:16501043^[4]	IDA: Inferred from Direct Assay		P
	GO:0043066	negative regulation of apoptosis	PMID:19756656^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0043066	negative regulation of apoptosis	PMID:19778454^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	PMID:12154096^[9]	IDA: Inferred from Direct Assay		P
	GO:0044212	transcription regulatory region DNA binding	PMID:19847889^[10]	IDA: Inferred from Direct Assay		F
	GO:0044336	canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis	PMID:12154096^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0045121	membrane raft	GO_REF:0000033		PANTHER:PTHR12027_AN89	C
	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04426	P
	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000033		PANTHER:PTHR12027_AN89	P
	GO:0045747	positive regulation of Notch signaling pathway	PMID:16501043^[4]	IDA: Inferred from Direct Assay		P
	GO:0045893	positive regulation of transcription, DNA-dependent	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04426	P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:10644691^[7]	IDA: Inferred from Direct Assay		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:19847889^[10]	IMP: Inferred from Mutant Phenotype		P
	GO:0048146	positive regulation of fibroblast proliferation	PMID:19734317^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0048332	mesoderm morphogenesis	GO_REF:0000033		PANTHER:PTHR12027_AN89	P
	GO:0048663	neuron fate commitment	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0048664	neuron fate determination	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0048664	neuron fate determination	GO_REF:0000033		PANTHER:PTHR12027_AN144	P
	GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04426	P
	GO:0060061	Spemann organizer formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0060061	Spemann organizer formation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04426	P
	GO:0060070	canonical Wnt receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0060070	canonical Wnt receptor signaling pathway	PMID:19756656^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0060070	canonical Wnt receptor signaling pathway	PMID:19778454^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0061054	dermatome development	PMID:10654605^[12]	IDA: Inferred from Direct Assay		P
	GO:0070365	hepatocyte differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019641	P
	GO:0070365	hepatocyte differentiation	GO_REF:0000033		PANTHER:PTHR12027_AN145	P
	GO:0071375	cellular response to peptide hormone stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019641	P
	GO:0071425	hemopoietic stem cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
	GO:0071425	hemopoietic stem cell proliferation	GO_REF:0000033		PANTHER:PTHR12027_AN90	P
	GO:0090344	negative regulation of cell aging	PMID:16501043^[4]	IDA: Inferred from Direct Assay		P
	GO:2000002	negative regulation of DNA damage checkpoint	PMID:16501043^[4]	IDA: Inferred from Direct Assay		P
	GO:2000059	negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023734	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Zhang L et al. (2009) The effect on cell growth by Wnt1 RNAi in human neuroblastoma SH-SY5Y cell line. Pediatr Surg Int 25: 1065-71 PubMed GONUTS page
↑ Bafico A et al. (1999) Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling. J Biol Chem 274: 16180-7 PubMed GONUTS page
↑ Wong SC et al. (2002) Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours. J Pathol 196: 145-53 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Ayyanan A et al. (2006) Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism. Proc Natl Acad Sci U S A 103: 3799-804 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Wei W et al. (2009) Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells. Mol Cancer 8: 76 PubMed GONUTS page
↑ McGowan SL et al. (2007) Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas. Mol Vis 13: 1984-2000 PubMed GONUTS page
↑ ^7.0 ^7.1 Strovel ET et al. (2000) Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription. J Biol Chem 275: 2399-403 PubMed GONUTS page
↑ Yook JI et al. (2006) A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat Cell Biol 8: 1398-406 PubMed GONUTS page
↑ ^9.0 ^9.1 Longo KA et al. (2002) Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors. J Biol Chem 277: 38239-44 PubMed GONUTS page
↑ ^10.0 ^10.1 Pizzatti L et al. (2010) SUZ12 is a candidate target of the non-canonical WNT pathway in the progression of chronic myeloid leukemia. Genes Chromosomes Cancer 49: 107-18 PubMed GONUTS page
↑ Salazar KD et al. (2009) Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts. Am J Physiol Lung Cell Mol Physiol 297: L1002-11 PubMed GONUTS page
↑ Lee CS et al. (2000) SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. Development 127: 109-18 PubMed GONUTS page

[PMID:19756656-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Zhang L et al. (2009) The effect on cell growth by Wnt1 RNAi in human neuroblastoma SH-SY5Y cell line. Pediatr Surg Int 25: 1065-71 PubMed GONUTS page

[PMID:10347172-1] Bafico A et al. (1999) Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling. J Biol Chem 274: 16180-7 PubMed GONUTS page

[PMID:11793365-2] Wong SC et al. (2002) Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours. J Pathol 196: 145-53 PubMed GONUTS page

[PMID:16501043-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Ayyanan A et al. (2006) Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism. Proc Natl Acad Sci U S A 103: 3799-804 PubMed GONUTS page

[PMID:19778454-4] 5.0 ^5.1 ^5.2 Wei W et al. (2009) Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells. Mol Cancer 8: 76 PubMed GONUTS page

[PMID:17982423-5] McGowan SL et al. (2007) Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas. Mol Vis 13: 1984-2000 PubMed GONUTS page

[PMID:10644691-6] 7.0 ^7.1 Strovel ET et al. (2000) Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription. J Biol Chem 275: 2399-403 PubMed GONUTS page

[PMID:17072303-7] Yook JI et al. (2006) A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat Cell Biol 8: 1398-406 PubMed GONUTS page

[PMID:12154096-8] 9.0 ^9.1 Longo KA et al. (2002) Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors. J Biol Chem 277: 38239-44 PubMed GONUTS page

[PMID:19847889-9] 10.0 ^10.1 Pizzatti L et al. (2010) SUZ12 is a candidate target of the non-canonical WNT pathway in the progression of chronic myeloid leukemia. Genes Chromosomes Cancer 49: 107-18 PubMed GONUTS page

[PMID:19734317-10] Salazar KD et al. (2009) Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts. Am J Physiol Lung Cell Mol Physiol 297: L1002-11 PubMed GONUTS page

[PMID:10654605-11] Lee CS et al. (2000) SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. Development 127: 109-18 PubMed GONUTS page

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HUMAN:WNT1

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