HUMAN:WN10B

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	WNT10B ( synonyms: WNT12 )
Protein Name(s)	Protein Wnt-10b Protein Wnt-12
External Links
UniProt Identifier	WN10B_HUMAN
UniProt Accessions	O00744, B2R7A5, O00747, Q4VAJ5, Q8WZ97,
EMBL	U81787, AB070724, AK312906, CH471111, BC096353, BC096354, BC096356, X97057, AF028700,
RefSeq	NP_003385.2,
Ensembl	ENST00000301061,
Pfam	PF00110,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0005615	extracellular space		NAS: Non-traceable Author Statement		C	Source: UniProtKB
	GO:0005578	proteinaceous extracellular matrix		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0004871	signal transducer activity		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0002062	chondrocyte differentiation		IEP: Inferred from Expression Pattern		P	Source: UniProtKB
	GO:0007165	signal transduction		NAS: Non-traceable Author Statement		P	Source: ProtInc
	GO:0007223	Wnt receptor signaling pathway, calcium mod...		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0000086	G2/M transition of mitotic cell cycle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0001664	G-protein-coupled receptor binding	GO_REF:0000033		PANTHER:PTHR12027_AN0	F
	GO:0002062	chondrocyte differentiation	PMID:15135146^[1]	IEP: Inferred from Expression Pattern		P
	GO:0005102	receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	F
	GO:0005102	receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013302	F
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	C
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013302	C
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0272	C
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0111	C
	GO:0005615	extracellular space	GO_REF:0000033		PANTHER:PTHR12027_AN0	C
	GO:0005615	extracellular space	PMID:15135146^[1]	NAS: Non-traceable Author Statement		C
	GO:0005886	plasma membrane	GO_REF:0000033		PANTHER:PTHR12027_AN0	C
	GO:0006629	lipid metabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0007050	cell cycle arrest	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0007224	smoothened signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0007224	smoothened signaling pathway	GO_REF:0000033		PANTHER:PTHR12027_AN4	P
	GO:0007275	multicellular organismal development	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	P
	GO:0007275	multicellular organismal development	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013302	P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0008284	positive regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0008284	positive regulation of cell proliferation	GO_REF:0000033		PANTHER:PTHR12027_AN4	P
	GO:0008585	female gonad development	GO_REF:0000033		PANTHER:PTHR12027_AN1	P
	GO:0009798	axis specification	GO_REF:0000033		PANTHER:PTHR12027_AN0	P
	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0014835	myoblast cell differentiation involved in skeletal muscle regeneration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0014835	myoblast cell differentiation involved in skeletal muscle regeneration	GO_REF:0000033		PANTHER:PTHR12027_AN4	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013302	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0879	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0016055	Wnt receptor signaling pathway	PMID:15135146^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0030182	neuron differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P56706	P
	GO:0030501	positive regulation of bone mineralization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0030501	positive regulation of bone mineralization	GO_REF:0000033		PANTHER:PTHR12027_AN4	P
	GO:0030858	positive regulation of epithelial cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0030858	positive regulation of epithelial cell differentiation	GO_REF:0000033		PANTHER:PTHR12027_AN4	P
	GO:0030917	midbrain-hindbrain boundary development	GO_REF:0000033		PANTHER:PTHR12027_AN4	P
	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0043065	positive regulation of apoptosis	PMID:17761539^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0043403	skeletal muscle tissue regeneration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0043586	tongue development	GO_REF:0000033		PANTHER:PTHR12027_AN4	P
	GO:0045598	regulation of fat cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0045599	negative regulation of fat cell differentiation	PMID:10937998^[3]	IDA: Inferred from Direct Assay		P
	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000033		PANTHER:PTHR12027_AN4	P
	GO:0045778	positive regulation of ossification	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0048641	regulation of skeletal muscle tissue development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0048641	regulation of skeletal muscle tissue development	GO_REF:0000033		PANTHER:PTHR12027_AN4	P
	GO:0048741	skeletal muscle fiber development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0048741	skeletal muscle fiber development	GO_REF:0000033		PANTHER:PTHR12027_AN4	P
	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000033		PANTHER:PTHR12027_AN4	P
	GO:0050821	protein stabilization	PMID:10937998^[3]	IDA: Inferred from Direct Assay		P
	GO:0050909	sensory perception of taste	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0051246	regulation of protein metabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0051885	positive regulation of anagen	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0051885	positive regulation of anagen	GO_REF:0000033		PANTHER:PTHR12027_AN4	P
	GO:0060070	canonical Wnt receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0060070	canonical Wnt receptor signaling pathway	PMID:17761539^[2]	IDA: Inferred from Direct Assay		P
	GO:0060346	bone trabecula formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0060346	bone trabecula formation	GO_REF:0000033		PANTHER:PTHR12027_AN4	P
	GO:0061196	fungiform papilla development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0071300	cellular response to retinoic acid	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P56706	P
	GO:0071310	cellular response to organic substance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0071320	cellular response to cAMP	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0071374	cellular response to parathyroid hormone stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0071425	hemopoietic stem cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
	GO:0071425	hemopoietic stem cell proliferation	PMID:9787155^[4]	IDA: Inferred from Direct Assay		P
	GO:0071464	cellular response to hydrostatic pressure	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019505	P
	GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023732	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Yates KE (2004) Demineralized bone alters expression of Wnt network components during chondroinduction of post-natal fibroblasts. Osteoarthritis Cartilage 12: 497-505 PubMed GONUTS page
↑ ^2.0 ^2.1 Yoshikawa H et al. (2007) WNT10B functional dualism: beta-catenin/Tcf-dependent growth promotion or independent suppression with deregulated expression in cancer. Mol Biol Cell 18: 4292-303 PubMed GONUTS page
↑ ^3.0 ^3.1 Ross SE et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science 289: 950-3 PubMed GONUTS page
↑ Van Den Berg DJ et al. (1998) Role of members of the Wnt gene family in human hematopoiesis. Blood 92: 3189-202 PubMed GONUTS page

[PMID:15135146-0] 1.0 ^1.1 ^1.2 Yates KE (2004) Demineralized bone alters expression of Wnt network components during chondroinduction of post-natal fibroblasts. Osteoarthritis Cartilage 12: 497-505 PubMed GONUTS page

[PMID:17761539-1] 2.0 ^2.1 Yoshikawa H et al. (2007) WNT10B functional dualism: beta-catenin/Tcf-dependent growth promotion or independent suppression with deregulated expression in cancer. Mol Biol Cell 18: 4292-303 PubMed GONUTS page

[PMID:10937998-2] 3.0 ^3.1 Ross SE et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science 289: 950-3 PubMed GONUTS page

[PMID:9787155-3] Van Den Berg DJ et al. (1998) Role of members of the Wnt gene family in human hematopoiesis. Blood 92: 3189-202 PubMed GONUTS page

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HUMAN:WN10B

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