HUMAN:VHL

From GONUTS

Jump to: navigation, search

Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	VHL
Protein Name(s)	Von Hippel-Lindau disease tumor suppressor Protein G7 pVHL
External Links
UniProt Identifier	VHL_HUMAN
UniProt Accessions	P40337, B2RE45, Q13599, Q6PDA9,
EMBL	AF010238, L15409, AK315799, AC034193, CH471055, BC058831, U54612, X96489,
PIR	I38926,
RefSeq	NP_000542.1, NP_937799.1,
PDB	1LM8, 1LQB, 1VCB,
IntAct	P40337,
Ensembl	ENST00000256474,
Pfam	PF01847,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013727	P
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:7660122^[1]	TAS: Traceable Author Statement		P
	GO:0000902	cell morphogenesis	PMID:12169691^[2]	NAS: Non-traceable Author Statement		P
	GO:0001525	angiogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000039418	P
	GO:0001666	response to hypoxia	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013727	P
	GO:0005515	protein binding	PMID:11739384^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q8TEY7	F
	GO:0005515	protein binding	PMID:12032852^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q8WU17	F
	GO:0005515	protein binding	PMID:12032852^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q8WU17	F
	GO:0005515	protein binding	PMID:12032852^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q92905	F
	GO:0005515	protein binding	PMID:12169691^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q6IE81	F
	GO:0005515	protein binding	PMID:15721254^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q16665	F
	GO:0005515	protein binding	PMID:16234850^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P22557	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:O15067	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:O43294	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:O75716	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:O95267	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:O95340	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P04080	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P07741	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P08134	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P10599	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P12268	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P13693	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P19105	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P20618	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P22061	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P23284	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P23508	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P24941	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P26441	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P26639	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P35244	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P37802	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P46781	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P49720	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P50748	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P51149	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P62807	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P62877	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q12996	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q13526	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q13617	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q15185	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q15369	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q15370	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q15843	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q16658	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q7Z443	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q8N4S0	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q92839	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q99700	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9H0U4	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9P031	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UNM6	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UQN3	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y376	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y3A3	F
	GO:0005515	protein binding	PMID:17986458^[8]	IPI: Inferred from Physical Interaction	UniProtKB:O75912	F
	GO:0005515	protein binding	PMID:17986458^[8]	IPI: Inferred from Physical Interaction	UniProtKB:O75912	F
	GO:0005515	protein binding	PMID:20802534^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UM11	F
	GO:0005515	protein binding	PMID:20802534^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UM11	F
	GO:0005515	protein binding	PMID:20802534^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UM11	F
	GO:0005515	protein binding	PMID:20871634^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P63244	F
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002714	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013727	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:7604013^[11]	TAS: Traceable Author Statement		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005739	mitochondrion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013727	C
	GO:0005739	mitochondrion	PMID:12169691^[2]	NAS: Non-traceable Author Statement		C
	GO:0005783	endoplasmic reticulum	PMID:12169691^[2]	NAS: Non-traceable Author Statement		C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013727	C
	GO:0005829	cytosol	PMID:7604013^[11]	TAS: Traceable Author Statement		C
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013727	P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:15824735^[12]	IMP: Inferred from Mutant Phenotype		P
	GO:0006508	proteolysis	PMID:10353251^[13]	TAS: Traceable Author Statement		P
	GO:0006916	anti-apoptosis	PMID:12169691^[2]	NAS: Non-traceable Author Statement		P
	GO:0006950	response to stress	PMID:12169691^[2]	NAS: Non-traceable Author Statement		P
	GO:0008134	transcription factor binding	PMID:7660122^[1]	TAS: Traceable Author Statement		F
	GO:0008285	negative regulation of cell proliferation	PMID:7660130^[14]	TAS: Traceable Author Statement		P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C
	GO:0016567	protein ubiquitination	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002714	P
	GO:0016567	protein ubiquitination	PMID:12169691^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0030163	protein catabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000039418	P
	GO:0030182	neuron differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013727	P
	GO:0030198	extracellular matrix organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000039418	P
	GO:0030891	VCB complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013727	C
	GO:0042069	regulation of catecholamine metabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013727	P
	GO:0043534	blood vessel endothelial cell migration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000039418	P
	GO:0045471	response to ethanol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013727	P
	GO:0045597	positive regulation of cell differentiation	PMID:12169691^[2]	NAS: Non-traceable Author Statement		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:17973242^[15]	IMP: Inferred from Mutant Phenotype		P
	GO:0050821	protein stabilization	PMID:12169691^[2]	NAS: Non-traceable Author Statement		P
	GO:0051291	protein heterooligomerization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013727	P
	GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	PMID 11641274	IMP: Inferred from Mutant Phenotype		P	Figure 3	complete
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013727	P
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:7660122^[1]	TAS: Traceable Author Statement		P
	GO:0000902	cell morphogenesis	PMID:12169691^[2]	NAS: Non-traceable Author Statement		P
	GO:0001525	angiogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000039418	P
	GO:0001666	response to hypoxia	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013727	P
	GO:0005515	protein binding	PMID:11739384^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q8TEY7	F
	GO:0005515	protein binding	PMID:12032852^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q8WU17	F
	GO:0005515	protein binding	PMID:12032852^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q8WU17	F
	GO:0005515	protein binding	PMID:12032852^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q92905	F
	GO:0005515	protein binding	PMID:12169691^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q6IE81	F
	GO:0005515	protein binding	PMID:15721254^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q16665	F
	GO:0005515	protein binding	PMID:16234850^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P22557	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:O15067	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:O43294	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:O75716	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:O95267	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:O95340	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P04080	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P07741	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P08134	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P10599	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P12268	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P13693	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P19105	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P20618	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P22061	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P23284	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P23508	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P24941	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P26441	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P26639	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P35244	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P37802	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P46781	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P49720	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P50748	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P51149	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P62807	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P62877	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q12996	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q13526	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q13617	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q15185	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q15369	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q15370	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q15843	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q16658	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q7Z443	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q8N4S0	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q92839	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q99700	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9H0U4	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9P031	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UNM6	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UQN3	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y376	F
	GO:0005515	protein binding	PMID:17353931^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y3A3	F
	GO:0005515	protein binding	PMID:17986458^[8]	IPI: Inferred from Physical Interaction	UniProtKB:O75912	F
	GO:0005515	protein binding	PMID:17986458^[8]	IPI: Inferred from Physical Interaction	UniProtKB:O75912	F
	GO:0005515	protein binding	PMID:20802534^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UM11	F
	GO:0005515	protein binding	PMID:20802534^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UM11	F
	GO:0005515	protein binding	PMID:20802534^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UM11	F
	GO:0005515	protein binding	PMID:20871634^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P63244	F
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002714	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013727	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:7604013^[11]	TAS: Traceable Author Statement		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005739	mitochondrion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013727	C
	GO:0005739	mitochondrion	PMID:12169691^[2]	NAS: Non-traceable Author Statement		C
	GO:0005783	endoplasmic reticulum	PMID:12169691^[2]	NAS: Non-traceable Author Statement		C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013727	C
	GO:0005829	cytosol	PMID:7604013^[11]	TAS: Traceable Author Statement		C
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013727	P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:15824735^[12]	IMP: Inferred from Mutant Phenotype		P
	GO:0006508	proteolysis	PMID:10353251^[13]	TAS: Traceable Author Statement		P
	GO:0006916	anti-apoptosis	PMID:12169691^[2]	NAS: Non-traceable Author Statement		P
	GO:0006950	response to stress	PMID:12169691^[2]	NAS: Non-traceable Author Statement		P
	GO:0008134	transcription factor binding	PMID:7660122^[1]	TAS: Traceable Author Statement		F
	GO:0008285	negative regulation of cell proliferation	PMID:7660130^[14]	TAS: Traceable Author Statement		P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C
	GO:0016567	protein ubiquitination	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002714	P
	GO:0016567	protein ubiquitination	PMID:12169691^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0030163	protein catabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000039418	P
	GO:0030182	neuron differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013727	P
	GO:0030198	extracellular matrix organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000039418	P
	GO:0030891	VCB complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013727	C
	GO:0042069	regulation of catecholamine metabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013727	P
	GO:0043534	blood vessel endothelial cell migration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000039418	P
	GO:0045471	response to ethanol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013727	P
	GO:0045597	positive regulation of cell differentiation	PMID:12169691^[2]	NAS: Non-traceable Author Statement		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:17973242^[15]	IMP: Inferred from Mutant Phenotype		P
	GO:0050821	protein stabilization	PMID:12169691^[2]	NAS: Non-traceable Author Statement		P
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Duan DR et al. (1995) Inhibition of transcription elongation by the VHL tumor suppressor protein. Science 269: 1402-6 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 ^2.17 Zhou MI et al. (2002) The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1. J Biol Chem 277: 39887-98 PubMed GONUTS page
↑ ^3.0 ^3.1 Li Z et al. (2002) Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. J Biol Chem 277: 4656-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Gemmill RM et al. (2002) The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway. Oncogene 21: 3507-16 PubMed GONUTS page
↑ ^5.0 ^5.1 Baek JH et al. (2005) OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha. Mol Cell 17: 503-12 PubMed GONUTS page
↑ ^6.0 ^6.1 Abu-Farha M et al. (2005) Erythroid-specific 5-aminolevulinate synthase protein is stabilized by low oxygen and proteasomal inhibition. Biochem Cell Biol 83: 620-30 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 ^7.14 ^7.15 ^7.16 ^7.17 ^7.18 ^7.19 ^7.20 ^7.21 ^7.22 ^7.23 ^7.24 ^7.25 ^7.26 ^7.27 ^7.28 ^7.29 ^7.30 ^7.31 ^7.32 ^7.33 ^7.34 ^7.35 ^7.36 ^7.37 ^7.38 ^7.39 ^7.40 ^7.41 ^7.42 ^7.43 ^7.44 ^7.45 ^7.46 ^7.47 ^7.48 ^7.49 ^7.50 ^7.51 ^7.52 ^7.53 ^7.54 ^7.55 ^7.56 ^7.57 ^7.58 ^7.59 ^7.60 ^7.61 ^7.62 ^7.63 ^7.64 ^7.65 ^7.66 ^7.67 ^7.68 ^7.69 ^7.70 ^7.71 ^7.72 ^7.73 ^7.74 ^7.75 ^7.76 ^7.77 ^7.78 ^7.79 ^7.80 ^7.81 ^7.82 ^7.83 ^7.84 ^7.85 ^7.86 ^7.87 ^7.88 ^7.89 Ewing RM et al. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol 3: 89 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Bex C et al. (2007) A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor protein. Nucleic Acids Res 35: e142 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Liu W et al. (2011) Hypoxia and cell cycle regulation of the von Hippel-Lindau tumor suppressor. Oncogene 30: 21-31 PubMed GONUTS page
↑ ^10.0 ^10.1 He X et al. (2011) Regulation of receptor for activated C kinase 1 protein by the von Hippel-Lindau tumor suppressor in IGF-I-induced renal carcinoma cell invasiveness. Oncogene 30: 535-47 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Duan DR et al. (1995) Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations. Proc Natl Acad Sci U S A 92: 6459-63 PubMed GONUTS page
↑ ^12.0 ^12.1 Maina EN et al. (2005) Identification of novel VHL target genes and relationship to hypoxic response pathways. Oncogene 24: 4549-58 PubMed GONUTS page
↑ ^13.0 ^13.1 Maxwell PH et al. (1999) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399: 271-5 PubMed GONUTS page
↑ ^14.0 ^14.1 Kibel A et al. (1995) Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C. Science 269: 1444-6 PubMed GONUTS page
↑ ^15.0 ^15.1 Ivanova AV et al. (2008) Loss of PL6 protein expression in renal clear cell carcinomas and other VHL-deficient tumours. J Pathol 214: 46-57 PubMed GONUTS page

[PMID:7660122-0] 1.0 ^1.1 ^1.2 ^1.3 Duan DR et al. (1995) Inhibition of transcription elongation by the VHL tumor suppressor protein. Science 269: 1402-6 PubMed GONUTS page

[PMID:12169691-1] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 ^2.17 Zhou MI et al. (2002) The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1. J Biol Chem 277: 39887-98 PubMed GONUTS page

[PMID:11739384-2] 3.0 ^3.1 Li Z et al. (2002) Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. J Biol Chem 277: 4656-62 PubMed GONUTS page

[PMID:12032852-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Gemmill RM et al. (2002) The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway. Oncogene 21: 3507-16 PubMed GONUTS page

[PMID:15721254-4] 5.0 ^5.1 Baek JH et al. (2005) OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha. Mol Cell 17: 503-12 PubMed GONUTS page

[PMID:16234850-5] 6.0 ^6.1 Abu-Farha M et al. (2005) Erythroid-specific 5-aminolevulinate synthase protein is stabilized by low oxygen and proteasomal inhibition. Biochem Cell Biol 83: 620-30 PubMed GONUTS page

[PMID:17353931-6] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 ^7.14 ^7.15 ^7.16 ^7.17 ^7.18 ^7.19 ^7.20 ^7.21 ^7.22 ^7.23 ^7.24 ^7.25 ^7.26 ^7.27 ^7.28 ^7.29 ^7.30 ^7.31 ^7.32 ^7.33 ^7.34 ^7.35 ^7.36 ^7.37 ^7.38 ^7.39 ^7.40 ^7.41 ^7.42 ^7.43 ^7.44 ^7.45 ^7.46 ^7.47 ^7.48 ^7.49 ^7.50 ^7.51 ^7.52 ^7.53 ^7.54 ^7.55 ^7.56 ^7.57 ^7.58 ^7.59 ^7.60 ^7.61 ^7.62 ^7.63 ^7.64 ^7.65 ^7.66 ^7.67 ^7.68 ^7.69 ^7.70 ^7.71 ^7.72 ^7.73 ^7.74 ^7.75 ^7.76 ^7.77 ^7.78 ^7.79 ^7.80 ^7.81 ^7.82 ^7.83 ^7.84 ^7.85 ^7.86 ^7.87 ^7.88 ^7.89 Ewing RM et al. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol 3: 89 PubMed GONUTS page

[PMID:17986458-7] 8.0 ^8.1 ^8.2 ^8.3 Bex C et al. (2007) A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor protein. Nucleic Acids Res 35: e142 PubMed GONUTS page

[PMID:20802534-8] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Liu W et al. (2011) Hypoxia and cell cycle regulation of the von Hippel-Lindau tumor suppressor. Oncogene 30: 21-31 PubMed GONUTS page

[PMID:20871634-9] 10.0 ^10.1 He X et al. (2011) Regulation of receptor for activated C kinase 1 protein by the von Hippel-Lindau tumor suppressor in IGF-I-induced renal carcinoma cell invasiveness. Oncogene 30: 535-47 PubMed GONUTS page

[PMID:7604013-10] 11.0 ^11.1 ^11.2 ^11.3 Duan DR et al. (1995) Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations. Proc Natl Acad Sci U S A 92: 6459-63 PubMed GONUTS page

[PMID:15824735-11] 12.0 ^12.1 Maina EN et al. (2005) Identification of novel VHL target genes and relationship to hypoxic response pathways. Oncogene 24: 4549-58 PubMed GONUTS page

[PMID:10353251-12] 13.0 ^13.1 Maxwell PH et al. (1999) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399: 271-5 PubMed GONUTS page

[PMID:7660130-13] 14.0 ^14.1 Kibel A et al. (1995) Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C. Science 269: 1444-6 PubMed GONUTS page

[PMID:17973242-14] 15.0 ^15.1 Ivanova AV et al. (2008) Loss of PL6 protein expression in renal clear cell carcinomas and other VHL-deficient tumours. J Pathol 214: 46-57 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

HUMAN:VHL

Contents

Annotations

Notes

References

a

b

c

e

m

n

p

p cont.

r

t

v

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox