HUMAN:VEGFA

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	VEGFA ( synonyms: VEGF )
Protein Name(s)	Vascular endothelial growth factor A VEGF-A Vascular permeability factor VPF
External Links
UniProt Identifier	VEGFA_HUMAN
UniProt Accessions	P15692, B5BU86, O60720, O75875, Q074Z4, Q16889, Q5UB46, Q6P0P5, Q96KJ0, Q96L82, Q96NW5, Q9H1W8, Q9H1W9, Q9UH58, Q9UL23,
EMBL	M32977, M27281, M63978, M63971, M63972, M63973, M63974, M63975, M63976, M63977, S85192, S85224, S85199, S85201, S85219, S85222, X62568, AJ010438, AF022375, AF091352, AF430806, AB021221, AF214570, AY047581, AF486837, AY766116, DQ229900, AB451322, AB451451, AL136131, AL136131, AL136131, AL136131, CH471081, BC065522, AF437895, AF062645,
PIR	A41551,
RefSeq	NP_001020537.2, NP_001020538.2, NP_001020539.2, NP_001020540.2, NP_001020541.2, NP_001028928.1, NP_001165093.1, NP_001165094.1, NP_001165095.1, NP_001165096.1, NP_001165097.1, NP_001165098.1, NP_001165099.1, NP_001165100.1, NP_001165101.1, NP_001191313.1, NP_001191314.1, NP_003367.4,
PDB	1BJ1, 1CZ8, 1FLT, 1KAT, 1KMX, 1MJV, 1MKG, 1MKK, 1QTY, 1TZH, 1TZI, 1VGH, 1VPF, 1VPP, 2FJG, 2FJH, 2QR0, 2VGH, 2VPF, 3BDY,
IntAct	P15692,
Ensembl	ENST00000372055,
Pfam	PF00341,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0001525	angiogenesis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0037	P
	GO:0001525	angiogenesis	PMID:11427521^[1]	IDA: Inferred from Direct Assay		P
	GO:0001570	vasculogenesis	PMID:15015550^[2]	TAS: Traceable Author Statement		P
	GO:0001666	response to hypoxia	PMID:16490744^[3]	IDA: Inferred from Direct Assay		P
	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P15691	P
	GO:0001938	positive regulation of endothelial cell proliferation	PMID:10022831^[4]	IDA: Inferred from Direct Assay		P
	GO:0001938	positive regulation of endothelial cell proliferation	PMID:12714610^[5]	IDA: Inferred from Direct Assay		P
	GO:0001938	positive regulation of endothelial cell proliferation	PMID:18577655^[6]	IDA: Inferred from Direct Assay		P
	GO:0001938	positive regulation of endothelial cell proliferation	PMID:9202027^[7]	IDA: Inferred from Direct Assay		P
	GO:0001968	fibronectin binding	PMID:14570917^[8]	IDA: Inferred from Direct Assay		F
	GO:0002575	basophil chemotaxis	PMID:17082651^[9]	IDA: Inferred from Direct Assay		P
	GO:0002576	platelet degranulation	Reactome:REACT_318	TAS: Traceable Author Statement		P
	GO:0002687	positive regulation of leukocyte migration	PMID:1312256^[10]	TAS: Traceable Author Statement		P
	GO:0005125	cytokine activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P15691	F
	GO:0005161	platelet-derived growth factor receptor binding	PMID:17470632^[11]	IPI: Inferred from Physical Interaction	UniProtKB:P09619	F
	GO:0005161	platelet-derived growth factor receptor binding	PMID:17470632^[11]	IPI: Inferred from Physical Interaction	UniProtKB:P16234	F
	GO:0005172	vascular endothelial growth factor receptor binding	PMID:9529250^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O14786	F
	GO:0005515	protein binding	PMID:17222790^[13]	IPI: Inferred from Physical Interaction	UniProtKB:O14786	F
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005576	extracellular region	Reactome:REACT_12440	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_12494	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_12556	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_12588	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21351	TAS: Traceable Author Statement		C
	GO:0005578	proteinaceous extracellular matrix	PMID:14570917^[8]	NAS: Non-traceable Author Statement		C
	GO:0005615	extracellular space	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P15691	C
	GO:0005615	extracellular space	PMID:16490744^[3]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:9202027^[7]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:17082651^[9]	IDA: Inferred from Direct Assay		C
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0007399	nervous system development	PMID:15351965^[14]	TAS: Traceable Author Statement		P
	GO:0007596	blood coagulation	Reactome:REACT_604	TAS: Traceable Author Statement		P
	GO:0008083	growth factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000072	F
	GO:0008083	growth factor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0339	F
	GO:0008083	growth factor activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P15691	F
	GO:0008083	growth factor activity	PMID:9202027^[7]	IDA: Inferred from Direct Assay		F
	GO:0008201	heparin binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0358	F
	GO:0008201	heparin binding	PMID:14570917^[8]	IMP: Inferred from Mutant Phenotype		F
	GO:0008201	heparin binding	PMID:15001987^[15]	IDA: Inferred from Direct Assay		F
	GO:0008284	positive regulation of cell proliferation	PMID:17470632^[11]	IDA: Inferred from Direct Assay		P
	GO:0008284	positive regulation of cell proliferation	PMID:7929439^[16]	IDA: Inferred from Direct Assay		P
	GO:0008360	regulation of cell shape	PMID:10527820^[17]	IDA: Inferred from Direct Assay		P
	GO:0008360	regulation of cell shape	PMID:7929439^[16]	IDA: Inferred from Direct Assay		P
	GO:0009986	cell surface	PMID:17470632^[11]	IDA: Inferred from Direct Assay		C
	GO:0010595	positive regulation of endothelial cell migration	PMID:10022831^[4]	IDA: Inferred from Direct Assay		P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000072	C
	GO:0030141	stored secretory granule	PMID:17082651^[9]	IDA: Inferred from Direct Assay		C
	GO:0030154	cell differentiation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0221	P
	GO:0030168	platelet activation	Reactome:REACT_798	TAS: Traceable Author Statement		P
	GO:0030335	positive regulation of cell migration	PMID:17470632^[11]	IDA: Inferred from Direct Assay		P
	GO:0030335	positive regulation of cell migration	PMID:7929439^[16]	IDA: Inferred from Direct Assay		P
	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	PMID:1312256^[10]	IDA: Inferred from Direct Assay		P
	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	PMID:7929439^[16]	IDA: Inferred from Direct Assay		P
	GO:0031093	platelet alpha granule lumen	Reactome:REACT_21351	TAS: Traceable Author Statement		C
	GO:0042056	chemoattractant activity	PMID:17082651^[9]	IDA: Inferred from Direct Assay		F
	GO:0042056	chemoattractant activity	PMID:19275959^[18]	IDA: Inferred from Direct Assay		F
	GO:0042803	protein homodimerization activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P15691	F
	GO:0043066	negative regulation of apoptosis	PMID:10066377^[19]	IMP: Inferred from Mutant Phenotype		P
	GO:0043066	negative regulation of apoptosis	PMID:11461089^[20]	IMP: Inferred from Mutant Phenotype		P
	GO:0043117	positive regulation of vascular permeability	PMID:16109918^[21]	IDA: Inferred from Direct Assay		P
	GO:0043183	vascular endothelial growth factor receptor 1 binding	PMID:1312256^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P17948	F
	GO:0043184	vascular endothelial growth factor receptor 2 binding	PMID:10022831^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P35968	F
	GO:0043184	vascular endothelial growth factor receptor 2 binding	PMID:1417831^[22]	IPI: Inferred from Physical Interaction	UniProtKB:P35968	F
	GO:0043498	cell surface binding	PMID:17470632^[11]	IDA: Inferred from Direct Assay		F
	GO:0043536	positive regulation of blood vessel endothelial cell migration	PMID:9202027^[7]	IDA: Inferred from Direct Assay		P
	GO:0045766	positive regulation of angiogenesis	PMID:18275976^[23]	IMP: Inferred from Mutant Phenotype		P
	GO:0045766	positive regulation of angiogenesis	PMID:18577655^[6]	IDA: Inferred from Direct Assay		P
	GO:0046982	protein heterodimerization activity	PMID:8702615^[24]	IDA: Inferred from Direct Assay		F
	GO:0048008	platelet-derived growth factor receptor signaling pathway	PMID:17470632^[11]	IDA: Inferred from Direct Assay		P
	GO:0048010	vascular endothelial growth factor receptor signaling pathway	Reactome:REACT_12380	TAS: Traceable Author Statement		P
	GO:0048010	vascular endothelial growth factor receptor signaling pathway	Reactome:REACT_12529	TAS: Traceable Author Statement		P
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:10022831^[4]	IDA: Inferred from Direct Assay		P
	GO:0050840	extracellular matrix binding	PMID:14570917^[8]	IC: Inferred by Curator	GO:0001968	F
	GO:0050918	positive chemotaxis	PMID:17082651^[9]	IDA: Inferred from Direct Assay		P
	GO:0050918	positive chemotaxis	PMID:19275959^[18]	IDA: Inferred from Direct Assay		P
	GO:0050927	positive regulation of positive chemotaxis	PMID:12744932^[25]	IDA: Inferred from Direct Assay		P
	GO:0050927	positive regulation of positive chemotaxis	PMID:7929439^[16]	IDA: Inferred from Direct Assay		P
	GO:0050930	induction of positive chemotaxis	PMID:12744932^[25]	NAS: Non-traceable Author Statement		P
	GO:0050930	induction of positive chemotaxis	PMID:19275959^[18]	IDA: Inferred from Direct Assay		P
	GO:0051272	positive regulation of cellular component movement	PMID:10527820^[17]	IDA: Inferred from Direct Assay		P
	GO:0051272	positive regulation of cellular component movement	PMID:12744932^[25]	IDA: Inferred from Direct Assay		P
	GO:0051781	positive regulation of cell division	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0497	P
	GO:0060754	positive regulation of mast cell chemotaxis	PMID:19275959^[18]	IDA: Inferred from Direct Assay		P
	GO:0071456	cellular response to hypoxia	PMID:10575000^[26]	IDA: Inferred from Direct Assay		P
	GO:0001525	angiogenesis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0037	P
	GO:0001525	angiogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0001525	angiogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026637	P
	GO:0001525	angiogenesis	PMID:11427521^[1]	IDA: Inferred from Direct Assay		P
	GO:0001541	ovarian follicle development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0001568	blood vessel development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0001569	patterning of blood vessels	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0001570	vasculogenesis	PMID:15015550^[2]	TAS: Traceable Author Statement		P
	GO:0001666	response to hypoxia	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026637	P
	GO:0001666	response to hypoxia	PMID:16490744^[3]	IDA: Inferred from Direct Assay		P
	GO:0001701	in utero embryonic development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0001822	kidney development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P15691	P
	GO:0001938	positive regulation of endothelial cell proliferation	PMID:10022831^[4]	IDA: Inferred from Direct Assay		P
	GO:0001938	positive regulation of endothelial cell proliferation	PMID:12714610^[5]	IDA: Inferred from Direct Assay		P
	GO:0001938	positive regulation of endothelial cell proliferation	PMID:18577655^[6]	IDA: Inferred from Direct Assay		P
	GO:0001938	positive regulation of endothelial cell proliferation	PMID:9202027^[7]	IDA: Inferred from Direct Assay		P
	GO:0001944	vasculature development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0001968	fibronectin binding	PMID:14570917^[8]	IDA: Inferred from Direct Assay		F
	GO:0001974	blood vessel remodeling	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026637	P
	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0002575	basophil chemotaxis	PMID:17082651^[9]	IDA: Inferred from Direct Assay		P
	GO:0002576	platelet degranulation	Reactome:REACT_318	TAS: Traceable Author Statement		P
	GO:0002687	positive regulation of leukocyte migration	PMID:1312256^[10]	TAS: Traceable Author Statement		P
	GO:0003007	heart morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0005125	cytokine activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P15691	F
	GO:0005125	cytokine activity	PMID:18440775^[27]	IDA: Inferred from Direct Assay		F
	GO:0005161	platelet-derived growth factor receptor binding	PMID:17470632^[11]	IPI: Inferred from Physical Interaction	UniProtKB:P09619	F
	GO:0005161	platelet-derived growth factor receptor binding	PMID:17470632^[11]	IPI: Inferred from Physical Interaction	UniProtKB:P16234	F
	GO:0005172	vascular endothelial growth factor receptor binding	PMID:9529250^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O14786	F
	GO:0005515	protein binding	PMID:17222790^[13]	IPI: Inferred from Physical Interaction	UniProtKB:O14786	F
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005576	extracellular region	Reactome:REACT_12440	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_12494	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_12556	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_12588	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21351	TAS: Traceable Author Statement		C
	GO:0005578	proteinaceous extracellular matrix	PMID:14570917^[8]	NAS: Non-traceable Author Statement		C
	GO:0005604	basement membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026637	C
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	C
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026637	C
	GO:0005615	extracellular space	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P15691	C
	GO:0005615	extracellular space	PMID:16490744^[3]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:9202027^[7]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	C
	GO:0005737	cytoplasm	PMID:17082651^[9]	IDA: Inferred from Direct Assay		C
	GO:0006916	anti-apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0007399	nervous system development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026637	P
	GO:0007399	nervous system development	PMID:15351965^[14]	TAS: Traceable Author Statement		P
	GO:0007498	mesoderm development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0007595	lactation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0007596	blood coagulation	Reactome:REACT_604	TAS: Traceable Author Statement		P
	GO:0007610	behavior	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0008083	growth factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000072	F
	GO:0008083	growth factor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0339	F
	GO:0008083	growth factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026637	F
	GO:0008083	growth factor activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P15691	F
	GO:0008083	growth factor activity	PMID:9202027^[7]	IDA: Inferred from Direct Assay		F
	GO:0008201	heparin binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0358	F
	GO:0008201	heparin binding	PMID:14570917^[8]	IMP: Inferred from Mutant Phenotype		F
	GO:0008201	heparin binding	PMID:15001987^[15]	IDA: Inferred from Direct Assay		F
	GO:0008283	cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0008284	positive regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0008284	positive regulation of cell proliferation	PMID:17470632^[11]	IDA: Inferred from Direct Assay		P
	GO:0008284	positive regulation of cell proliferation	PMID:7929439^[16]	IDA: Inferred from Direct Assay		P
	GO:0008360	regulation of cell shape	PMID:10527820^[17]	IDA: Inferred from Direct Assay		P
	GO:0008360	regulation of cell shape	PMID:7929439^[16]	IDA: Inferred from Direct Assay		P
	GO:0009409	response to cold	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026637	P
	GO:0009967	positive regulation of signal transduction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026637	P
	GO:0009986	cell surface	PMID:17470632^[11]	IDA: Inferred from Direct Assay		C
	GO:0010595	positive regulation of endothelial cell migration	PMID:10022831^[4]	IDA: Inferred from Direct Assay		P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000072	C
	GO:0016477	cell migration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0030141	stored secretory granule	PMID:17082651^[9]	IDA: Inferred from Direct Assay		C
	GO:0030154	cell differentiation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0221	P
	GO:0030168	platelet activation	Reactome:REACT_798	TAS: Traceable Author Statement		P
	GO:0030324	lung development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0030335	positive regulation of cell migration	PMID:17470632^[11]	IDA: Inferred from Direct Assay		P
	GO:0030335	positive regulation of cell migration	PMID:7929439^[16]	IDA: Inferred from Direct Assay		P
	GO:0030855	epithelial cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	PMID:1312256^[10]	IDA: Inferred from Direct Assay		P
	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	PMID:7929439^[16]	IDA: Inferred from Direct Assay		P
	GO:0031077	post-embryonic camera-type eye development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0031093	platelet alpha granule lumen	Reactome:REACT_21351	TAS: Traceable Author Statement		C
	GO:0031988	membrane-bounded vesicle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026637	C
	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:18440775^[27]	IDA: Inferred from Direct Assay		P
	GO:0035767	endothelial cell chemotaxis	PMID:18440775^[27]	IDA: Inferred from Direct Assay		P
	GO:0040007	growth	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0042056	chemoattractant activity	PMID:17082651^[9]	IDA: Inferred from Direct Assay		F
	GO:0042056	chemoattractant activity	PMID:19275959^[18]	IDA: Inferred from Direct Assay		F
	GO:0042088	T-helper 1 type immune response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026637	P
	GO:0042462	eye photoreceptor cell development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0042803	protein homodimerization activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026637	F
	GO:0042803	protein homodimerization activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P15691	F
	GO:0043066	negative regulation of apoptosis	PMID:10066377^[19]	IMP: Inferred from Mutant Phenotype		P
	GO:0043066	negative regulation of apoptosis	PMID:11461089^[20]	IMP: Inferred from Mutant Phenotype		P
	GO:0043117	positive regulation of vascular permeability	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0043117	positive regulation of vascular permeability	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026637	P
	GO:0043117	positive regulation of vascular permeability	PMID:16109918^[21]	IDA: Inferred from Direct Assay		P
	GO:0043129	surfactant homeostasis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0043183	vascular endothelial growth factor receptor 1 binding	PMID:1312256^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P17948	F
	GO:0043184	vascular endothelial growth factor receptor 2 binding	PMID:10022831^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P35968	F
	GO:0043184	vascular endothelial growth factor receptor 2 binding	PMID:1417831^[22]	IPI: Inferred from Physical Interaction	UniProtKB:P35968	F
	GO:0043406	positive regulation of MAP kinase activity	PMID:18440775^[27]	IDA: Inferred from Direct Assay		P
	GO:0043498	cell surface binding	PMID:17470632^[11]	IDA: Inferred from Direct Assay		F
	GO:0043536	positive regulation of blood vessel endothelial cell migration	PMID:18440775^[27]	IDA: Inferred from Direct Assay		P
	GO:0043536	positive regulation of blood vessel endothelial cell migration	PMID:9202027^[7]	IDA: Inferred from Direct Assay		P
	GO:0045766	positive regulation of angiogenesis	PMID:18275976^[23]	IMP: Inferred from Mutant Phenotype		P
	GO:0045766	positive regulation of angiogenesis	PMID:18440775^[27]	IDA: Inferred from Direct Assay		P
	GO:0045766	positive regulation of angiogenesis	PMID:18577655^[6]	IDA: Inferred from Direct Assay		P
	GO:0045779	negative regulation of bone resorption	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026637	P
	GO:0045785	positive regulation of cell adhesion	PMID:19674970^[28]	IDA: Inferred from Direct Assay		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026637	P
	GO:0046982	protein heterodimerization activity	PMID:8702615^[24]	IDA: Inferred from Direct Assay		F
	GO:0048008	platelet-derived growth factor receptor signaling pathway	PMID:17470632^[11]	IDA: Inferred from Direct Assay		P
	GO:0048010	vascular endothelial growth factor receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0048010	vascular endothelial growth factor receptor signaling pathway	Reactome:REACT_12380	TAS: Traceable Author Statement		P
	GO:0048010	vascular endothelial growth factor receptor signaling pathway	Reactome:REACT_12529	TAS: Traceable Author Statement		P
	GO:0048255	mRNA stabilization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026637	P
	GO:0048286	lung alveolus development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026637	P
	GO:0048469	cell maturation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0048514	blood vessel morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0048593	camera-type eye morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026637	P
	GO:0048739	cardiac muscle fiber development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0048754	branching morphogenesis of a tube	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0048844	artery morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:10022831^[4]	IDA: Inferred from Direct Assay		P
	GO:0050840	extracellular matrix binding	PMID:14570917^[8]	IC: Inferred by Curator	GO:0001968	F
	GO:0050918	positive chemotaxis	PMID:17082651^[9]	IDA: Inferred from Direct Assay		P
	GO:0050918	positive chemotaxis	PMID:19275959^[18]	IDA: Inferred from Direct Assay		P
	GO:0050927	positive regulation of positive chemotaxis	PMID:12744932^[25]	IDA: Inferred from Direct Assay		P
	GO:0050927	positive regulation of positive chemotaxis	PMID:7929439^[16]	IDA: Inferred from Direct Assay		P
	GO:0050930	induction of positive chemotaxis	PMID:12744932^[25]	NAS: Non-traceable Author Statement		P
	GO:0050930	induction of positive chemotaxis	PMID:19275959^[18]	IDA: Inferred from Direct Assay		P
	GO:0051272	positive regulation of cellular component movement	PMID:10527820^[17]	IDA: Inferred from Direct Assay		P
	GO:0051272	positive regulation of cellular component movement	PMID:12744932^[25]	IDA: Inferred from Direct Assay		P
	GO:0051781	positive regulation of cell division	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0497	P
	GO:0060319	primitive erythrocyte differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0060749	mammary gland alveolus development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0060754	positive regulation of mast cell chemotaxis	PMID:19275959^[18]	IDA: Inferred from Direct Assay		P
	GO:0071445	cellular response to protein stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
	GO:0071456	cellular response to hypoxia	PMID:10575000^[26]	IDA: Inferred from Direct Assay		P
	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115883	P
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Murphy JF & Fitzgerald DJ (2001) Vascular endothelial growth factor induces cyclooxygenase-dependent proliferation of endothelial cells via the VEGF-2 receptor. FASEB J 15: 1667-9 PubMed GONUTS page
↑ ^2.0 ^2.1 Patan S (2004) Vasculogenesis and angiogenesis. Cancer Treat Res 117: 3-32 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Nakamura M et al. (2006) Hypoxic conditions stimulate the production of angiogenin and vascular endothelial growth factor by human renal proximal tubular epithelial cells in culture. Nephrol Dial Transplant 21: 1489-95 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Soldi R et al. (1999) Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2. EMBO J 18: 882-92 PubMed GONUTS page
↑ ^5.0 ^5.1 Oshima Y et al. (2003) Expression and localization of tenomodulin, a transmembrane type chondromodulin-I-related angiogenesis inhibitor, in mouse eyes. Invest Ophthalmol Vis Sci 44: 1814-23 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Browning AC et al. (2008) The effects of growth factors on the proliferation and in vitro angiogenesis of human macular inner choroidal endothelial cells. Br J Ophthalmol 92: 1003-8 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Pedram A et al. (1997) Vasoactive peptides modulate vascular endothelial cell growth factor production and endothelial cell proliferation and invasion. J Biol Chem 272: 17097-103 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Goerges AL & Nugent MA (2004) pH regulates vascular endothelial growth factor binding to fibronectin: a mechanism for control of extracellular matrix storage and release. J Biol Chem 279: 2307-15 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 ^9.8 ^9.9 de Paulis A et al. (2006) Expression and functions of the vascular endothelial growth factors and their receptors in human basophils. J Immunol 177: 7322-31 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 de Vries C et al. (1992) The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255: 989-91 PubMed GONUTS page
↑ ^11.00 ^11.01 ^11.02 ^11.03 ^11.04 ^11.05 ^11.06 ^11.07 ^11.08 ^11.09 ^11.10 ^11.11 ^11.12 ^11.13 Ball SG et al. (2007) Vascular endothelial growth factor can signal through platelet-derived growth factor receptors. J Cell Biol 177: 489-500 PubMed GONUTS page
↑ ^12.0 ^12.1 Soker S et al. (1998) Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92: 735-45 PubMed GONUTS page
↑ ^13.0 ^13.1 Pan Q et al. (2007) Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth. Cancer Cell 11: 53-67 PubMed GONUTS page
↑ ^14.0 ^14.1 Storkebaum E et al. (2004) VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection. Bioessays 26: 943-54 PubMed GONUTS page
↑ ^15.0 ^15.1 Héroult M et al. (2004) Heparin affin regulatory peptide binds to vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis. Oncogene 23: 1745-53 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 ^16.8 ^16.9 Waltenberger J et al. (1994) Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J Biol Chem 269: 26988-95 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Lash GE et al. (1999) The effects of angiogenic growth factors on extravillous trophoblast invasion and motility. Placenta 20: 661-7 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 Detoraki A et al. (2009) Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects. J Allergy Clin Immunol 123: 1142-9, 1149.e1-5 PubMed GONUTS page
↑ ^19.0 ^19.1 Gupta K et al. (1999) VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling. Exp Cell Res 247: 495-504 PubMed GONUTS page
↑ ^20.0 ^20.1 Pidgeon GP et al. (2001) Vascular endothelial growth factor (VEGF) upregulates BCL-2 and inhibits apoptosis in human and murine mammary adenocarcinoma cells. Br J Cancer 85: 273-8 PubMed GONUTS page
↑ ^21.0 ^21.1 Mould AW et al. (2005) Transgenic overexpression of vascular endothelial growth factor-B isoforms by endothelial cells potentiates postnatal vessel growth in vivo and in vitro. Circ Res 97: e60-70 PubMed GONUTS page
↑ ^22.0 ^22.1 Terman BI et al. (1992) Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem Biophys Res Commun 187: 1579-86 PubMed GONUTS page
↑ ^23.0 ^23.1 Kaneko K et al. (2008) Aquaporin 1 is required for hypoxia-inducible angiogenesis in human retinal vascular endothelial cells. Microvasc Res 75: 297-301 PubMed GONUTS page
↑ ^24.0 ^24.1 Olofsson B et al. (1996) Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform. J Biol Chem 271: 19310-7 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 ^25.4 ^25.5 Lash GE et al. (2003) Vascular endothelial growth factor is a chemoattractant for trophoblast cells. Placenta 24: 549-56 PubMed GONUTS page
↑ ^26.0 ^26.1 Yonekura H et al. (1999) Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis. J Biol Chem 274: 35172-8 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 ^27.3 ^27.4 ^27.5 Evans IM et al. (2008) Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase. Cell Signal 20: 1375-84 PubMed GONUTS page
↑ Song H et al. (2009) Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells. J Biol Chem 284: 29109-24 PubMed GONUTS page

[PMID:11427521-0] 1.0 ^1.1 Murphy JF & Fitzgerald DJ (2001) Vascular endothelial growth factor induces cyclooxygenase-dependent proliferation of endothelial cells via the VEGF-2 receptor. FASEB J 15: 1667-9 PubMed GONUTS page

[PMID:15015550-1] 2.0 ^2.1 Patan S (2004) Vasculogenesis and angiogenesis. Cancer Treat Res 117: 3-32 PubMed GONUTS page

[PMID:16490744-2] 3.0 ^3.1 ^3.2 ^3.3 Nakamura M et al. (2006) Hypoxic conditions stimulate the production of angiogenin and vascular endothelial growth factor by human renal proximal tubular epithelial cells in culture. Nephrol Dial Transplant 21: 1489-95 PubMed GONUTS page

[PMID:10022831-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Soldi R et al. (1999) Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2. EMBO J 18: 882-92 PubMed GONUTS page

[PMID:12714610-4] 5.0 ^5.1 Oshima Y et al. (2003) Expression and localization of tenomodulin, a transmembrane type chondromodulin-I-related angiogenesis inhibitor, in mouse eyes. Invest Ophthalmol Vis Sci 44: 1814-23 PubMed GONUTS page

[PMID:18577655-5] 6.0 ^6.1 ^6.2 ^6.3 Browning AC et al. (2008) The effects of growth factors on the proliferation and in vitro angiogenesis of human macular inner choroidal endothelial cells. Br J Ophthalmol 92: 1003-8 PubMed GONUTS page

[PMID:9202027-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Pedram A et al. (1997) Vasoactive peptides modulate vascular endothelial cell growth factor production and endothelial cell proliferation and invasion. J Biol Chem 272: 17097-103 PubMed GONUTS page

[PMID:14570917-7] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Goerges AL & Nugent MA (2004) pH regulates vascular endothelial growth factor binding to fibronectin: a mechanism for control of extracellular matrix storage and release. J Biol Chem 279: 2307-15 PubMed GONUTS page

[PMID:17082651-8] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 ^9.8 ^9.9 de Paulis A et al. (2006) Expression and functions of the vascular endothelial growth factors and their receptors in human basophils. J Immunol 177: 7322-31 PubMed GONUTS page

[PMID:1312256-9] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 de Vries C et al. (1992) The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255: 989-91 PubMed GONUTS page

[PMID:17470632-10] 11.00 ^11.01 ^11.02 ^11.03 ^11.04 ^11.05 ^11.06 ^11.07 ^11.08 ^11.09 ^11.10 ^11.11 ^11.12 ^11.13 Ball SG et al. (2007) Vascular endothelial growth factor can signal through platelet-derived growth factor receptors. J Cell Biol 177: 489-500 PubMed GONUTS page

[PMID:9529250-11] 12.0 ^12.1 Soker S et al. (1998) Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92: 735-45 PubMed GONUTS page

[PMID:17222790-12] 13.0 ^13.1 Pan Q et al. (2007) Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth. Cancer Cell 11: 53-67 PubMed GONUTS page

[PMID:15351965-13] 14.0 ^14.1 Storkebaum E et al. (2004) VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection. Bioessays 26: 943-54 PubMed GONUTS page

[PMID:15001987-14] 15.0 ^15.1 Héroult M et al. (2004) Heparin affin regulatory peptide binds to vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis. Oncogene 23: 1745-53 PubMed GONUTS page

[PMID:7929439-15] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 ^16.8 ^16.9 Waltenberger J et al. (1994) Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J Biol Chem 269: 26988-95 PubMed GONUTS page

[PMID:10527820-16] 17.0 ^17.1 ^17.2 ^17.3 Lash GE et al. (1999) The effects of angiogenic growth factors on extravillous trophoblast invasion and motility. Placenta 20: 661-7 PubMed GONUTS page

[PMID:19275959-17] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 Detoraki A et al. (2009) Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects. J Allergy Clin Immunol 123: 1142-9, 1149.e1-5 PubMed GONUTS page

[PMID:10066377-18] 19.0 ^19.1 Gupta K et al. (1999) VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling. Exp Cell Res 247: 495-504 PubMed GONUTS page

[PMID:11461089-19] 20.0 ^20.1 Pidgeon GP et al. (2001) Vascular endothelial growth factor (VEGF) upregulates BCL-2 and inhibits apoptosis in human and murine mammary adenocarcinoma cells. Br J Cancer 85: 273-8 PubMed GONUTS page

[PMID:16109918-20] 21.0 ^21.1 Mould AW et al. (2005) Transgenic overexpression of vascular endothelial growth factor-B isoforms by endothelial cells potentiates postnatal vessel growth in vivo and in vitro. Circ Res 97: e60-70 PubMed GONUTS page

[PMID:1417831-21] 22.0 ^22.1 Terman BI et al. (1992) Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem Biophys Res Commun 187: 1579-86 PubMed GONUTS page

[PMID:18275976-22] 23.0 ^23.1 Kaneko K et al. (2008) Aquaporin 1 is required for hypoxia-inducible angiogenesis in human retinal vascular endothelial cells. Microvasc Res 75: 297-301 PubMed GONUTS page

[PMID:8702615-23] 24.0 ^24.1 Olofsson B et al. (1996) Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform. J Biol Chem 271: 19310-7 PubMed GONUTS page

[PMID:12744932-24] 25.0 ^25.1 ^25.2 ^25.3 ^25.4 ^25.5 Lash GE et al. (2003) Vascular endothelial growth factor is a chemoattractant for trophoblast cells. Placenta 24: 549-56 PubMed GONUTS page

[PMID:10575000-25] 26.0 ^26.1 Yonekura H et al. (1999) Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis. J Biol Chem 274: 35172-8 PubMed GONUTS page

[PMID:18440775-26] 27.0 ^27.1 ^27.2 ^27.3 ^27.4 ^27.5 Evans IM et al. (2008) Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase. Cell Signal 20: 1375-84 PubMed GONUTS page

[PMID:19674970-27] Song H et al. (2009) Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells. J Biol Chem 284: 29109-24 PubMed GONUTS page

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HUMAN:VEGFA

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