HUMAN:VDR

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Species (Taxon ID)	Homo sapiens (Human). ([1])
Gene Name(s)	VDR (synonyms: NR1I1)
Protein Name(s)	Vitamin D3 receptor VDR 1,25-dihydroxyvitamin D3 receptor Nuclear receptor subfamily 1 group I member 1
External Links
EMBL	J03258 X67482 AF026260 AB002168 AY342401 AK312267 CH471111 BC060832 M65208 AY827087
IPI	IPI00005716
PIR	A28200
RefSeq	NP_000367.1 NP_001017535.1 NP_001017536.1
UniGene	Hs.524368
PDB	1DB1 1IE8 1IE9 1KB2 1KB4 1KB6 1S0Z 1S19 1TXI 1YNW 2HAM 2HAR 2HAS 2HB7 2HB8 3A2I 3A2J 3A3Z 3A40 3A78 3AUQ 3AUR 3B0T 3CS4 3CS6 3M7R 3OGT 3P8X
PDBsum	1DB1 1IE8 1IE9 1KB2 1KB4 1KB6 1S0Z 1S19 1TXI 1YNW 2HAM 2HAR 2HAS 2HB7 2HB8 3A2I 3A2J 3A3Z 3A40 3A78 3AUQ 3AUR 3B0T 3CS4 3CS6 3M7R 3OGT 3P8X
ProteinModelPortal	P11473
SMR	P11473
DisProt	DP00184
IntAct	P11473
MINT	MINT-236408
STRING	P11473
PhosphoSite	P11473
PRIDE	P11473
Ensembl	ENST00000229022 ENST00000395324
GeneID	7421
KEGG	hsa:7421
UCSC	uc001rqm.1
CTD	7421
GeneCards	GC12M045266
H-InvDB	HIX0010581
HGNC	HGNC:12679
HPA	CAB004617
MIM	277440 601769 607948
neXtProt	NX_P11473
Orphanet	93160 437
PharmGKB	PA37301
eggNOG	prNOG11938
HOGENOM	HBG713785
HOVERGEN	HBG108655
InParanoid	P11473
OMA	KDSLRPK
OrthoDB	EOG4J6RR1
PhylomeDB	P11473
Pathway_Interaction_DB	smad2_3nuclearpathway retinoic_acid_pathway rxr_vdr_pathway
Reactome	REACT_71
DrugBank	DB00146 DB02300 DB00136 DB01070 DB00153 DB00910
NextBio	29054
ArrayExpress	P11473
Bgee	P11473
CleanEx	HS_VDR
Genevestigator	P11473
GermOnline	ENSG00000111424
GO	GO:0005654 GO:0046965 GO:0003700 GO:0003707 GO:0008434 GO:0008270 GO:0046697 GO:0008285 GO:0000122 GO:0010980 GO:0060558 GO:0034339
InterPro	IPR008946 IPR000536 IPR001723 IPR000324 IPR001628 IPR013088
Gene3D	G3DSA:1.10.565.10 G3DSA:3.30.50.10
KO	K08539
Pfam	PF00104 PF00105
PRINTS	PR00398 PR00047 PR00350
SMART	SM00430 SM00399
SUPFAM	SSF48508
PROSITE	PS00031 PS51030

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:17426122^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0000902	cell morphogenesis	PMID:17223341^[2]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0001501	skeletal system development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023119	P	Seeded From UniProt
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000324	F	Seeded From UniProt
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001723	F	Seeded From UniProt
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F	Seeded From UniProt
	GO:0003677	DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023119	F	Seeded From UniProt
	GO:0003677	DNA binding	PMID:11891224^[3]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0003677	DNA binding	PMID:2849209^[4]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000536	F	Seeded From UniProt
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001628	F	Seeded From UniProt
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008946	F	Seeded From UniProt
	GO:0003707	steroid hormone receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000536	F	Seeded From UniProt
	GO:0003707	steroid hormone receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001723	F	Seeded From UniProt
	GO:0003707	steroid hormone receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008946	F	Seeded From UniProt
	GO:0004872	receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0675	F	Seeded From UniProt
	GO:0004879	ligand-dependent nuclear receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000324	F	Seeded From UniProt
	GO:0004879	ligand-dependent nuclear receptor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023119	F	Seeded From UniProt
	GO:0005499	vitamin D binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000011601	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:10409738^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q15545	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:10744685^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q15544	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:10866662^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9JLI4	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:16252006^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UIG0	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:17254542^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q15648	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:17426122^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P19793	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:20227041^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P04637	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:20413580^[11]	IPI: Inferred from Physical Interaction	UniProtKB:O75528	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:21119599^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P26045	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:9653119^[13]	IPI: Inferred from Physical Interaction	UniProtKB:Q15648	F	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000324	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000536	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001628	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001723	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008946	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C	Seeded From UniProt
	GO:0005634	nucleus	PMID:15589699^[14]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005634	nucleus	PMID:17082781^[15]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005654	nucleoplasm	Reactome:REACT_19207	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005720	nuclear heterochromatin	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000011601	C	Seeded From UniProt
	GO:0005792	microsome	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000011601	C	Seeded From UniProt
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000011601	C	Seeded From UniProt
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000324	P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000536	P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001628	P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001723	P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008946	P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013088	P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023119	P	Seeded From UniProt
	GO:0006816	calcium ion transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023119	P	Seeded From UniProt
	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023119	P	Seeded From UniProt
	GO:0007165	signal transduction	PMID:2849209^[4]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007275	multicellular organismal development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023119	P	Seeded From UniProt
	GO:0007568	aging	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000011601	P	Seeded From UniProt
	GO:0007595	lactation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023119	P	Seeded From UniProt
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001628	F	Seeded From UniProt
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013088	F	Seeded From UniProt
	GO:0008285	negative regulation of cell proliferation	PMID:16549446^[16]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0008434	vitamin D3 receptor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000011601	F	Seeded From UniProt
	GO:0008434	vitamin D3 receptor activity	PMID:16549446^[16]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0008434	vitamin D3 receptor activity	PMID:17082781^[15]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0008624	induction of apoptosis by extracellular signals	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000011601	P	Seeded From UniProt
	GO:0009887	organ morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023119	P	Seeded From UniProt
	GO:0010467	gene expression	Reactome:REACT_71	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0010628	positive regulation of gene expression	PMID:17223341^[2]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0010839	negative regulation of keratinocyte proliferation	PMID:17223341^[2]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0010980	positive regulation of vitamin D 24-hydroxylase activity	PMID:16549446^[16]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0030315	T-tubule	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000011601	C	Seeded From UniProt
	GO:0030522	intracellular receptor mediated signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023119	P	Seeded From UniProt
	GO:0032355	response to estradiol stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000011601	P	Seeded From UniProt
	GO:0034339	regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	Reactome:REACT_15525	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000536	P	Seeded From UniProt
	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008946	P	Seeded From UniProt
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001628	F	Seeded From UniProt
	GO:0043565	sequence-specific DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000011601	F	Seeded From UniProt
	GO:0045618	positive regulation of keratinocyte differentiation	PMID:17082781^[15]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:11891224^[3]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:17082781^[15]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:17254542^[9]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0046697	decidualization	PMID:16720713^[17]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F	Seeded From UniProt
	GO:0046965	retinoid X receptor binding	PMID:17426122^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P19793	F	Seeded From UniProt
	GO:0050892	intestinal absorption	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023119	P	Seeded From UniProt
	GO:0051592	response to calcium ion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000011601	P	Seeded From UniProt
	GO:0051929	positive regulation of calcium ion transport via voltage-gated calcium channel activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000011601	P	Seeded From UniProt
	GO:0060058	positive regulation of apoptosis involved in mammary gland involution	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023119	P	Seeded From UniProt
	GO:0060558	regulation of calcidiol 1-monooxygenase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023119	P	Seeded From UniProt
	GO:0060558	regulation of calcidiol 1-monooxygenase activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P48281	P	Seeded From UniProt
	GO:0060745	mammary gland branching involved in pregnancy	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023119	P	Seeded From UniProt
	GO:0070561	vitamin D receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000011601	P	Seeded From UniProt
	GO:0070561	vitamin D receptor signaling pathway	PMID:16549446^[16]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:17426122^[1]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0070644	vitamin D response element binding	PMID:17426122^[1]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0046649	lymphocyte activation	PMID:1850412^[18]	IEP: Inferred from Expression Pattern		P	FIG. 7. Western blot analysis of 1,25-(OH)2Ds receptor in activated human lymphocytes.	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Turunen MM et al. (2007) Selective use of multiple vitamin D response elements underlies the 1 alpha,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene. Nucleic Acids Res 35: 2734-47 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Oda Y et al. (2007) Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiation. J Steroid Biochem Mol Biol 103: 776-80 PubMed GONUTS page
↑ ^3.0 ^3.1 Gonzalez MM & Carlberg C (2002) Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors. J Biol Chem 277: 18501-9 PubMed GONUTS page
↑ ^4.0 ^4.1 Hughes MR et al. (1988) Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets. Science 242: 1702-5 PubMed GONUTS page
↑ Lavigne AC et al. (1999) Human TAF(II)55 interacts with the vitamin D(3) and thyroid hormone receptors and with derivatives of the retinoid X receptor that have altered transactivation properties. Mol Cell Biol 19: 5486-94 PubMed GONUTS page
↑ Mengus G et al. (2000) The human transcription factor IID subunit human TATA-binding protein-associated factor 28 interacts in a ligand-reversible manner with the vitamin D(3) and thyroid hormone receptors. J Biol Chem 275: 10064-71 PubMed GONUTS page
↑ Mahajan MA & Samuels HH (2000) A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein. Mol Cell Biol 20: 5048-63 PubMed GONUTS page
↑ Fujiki R et al. (2005) Ligand-induced transrepression by VDR through association of WSTF with acetylated histones. EMBO J 24: 3881-94 PubMed GONUTS page
↑ ^9.0 ^9.1 Zella LA et al. (2007) The vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifs. Arch Biochem Biophys 460: 206-12 PubMed GONUTS page
↑ Stambolsky P et al. (2010) Modulation of the vitamin D3 response by cancer-associated mutant p53. Cancer Cell 17: 273-85 PubMed GONUTS page
↑ Li CW et al. (2010) Human ADA3 regulates RARalpha transcriptional activity through direct contact between LxxLL motifs and the receptor coactivator pocket. Nucleic Acids Res 38: 5291-303 PubMed GONUTS page
↑ Zhi HY et al. (2011) PTPH1 cooperates with vitamin D receptor to stimulate breast cancer growth through their mutual stabilization. Oncogene 30: 1706-15 PubMed GONUTS page
↑ Yuan CX et al. (1998) The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc Natl Acad Sci U S A 95: 7939-44 PubMed GONUTS page
↑ Eyles DW et al. (2005) Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat 29: 21-30 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Hawker NP et al. (2007) Regulation of human epidermal keratinocyte differentiation by the vitamin D receptor and its coactivators DRIP205, SRC2, and SRC3. J Invest Dermatol 127: 874-80 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Kemmis CM et al. (2006) Human mammary epithelial cells express CYP27B1 and are growth inhibited by 25-hydroxyvitamin D-3, the major circulating form of vitamin D-3. J Nutr 136: 887-92 PubMed GONUTS page
↑ Viganò P et al. (2006) Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system. J Mol Endocrinol 36: 415-24 PubMed GONUTS page
↑ Yu XP et al. (1991) Vitamin D receptor expression in human lymphocytes. Signal requirements and characterization by western blots and DNA sequencing. J Biol Chem 266: 7588-95 PubMed GONUTS page

[PMID:17426122-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Turunen MM et al. (2007) Selective use of multiple vitamin D response elements underlies the 1 alpha,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene. Nucleic Acids Res 35: 2734-47 PubMed GONUTS page

[PMID:17223341-1] 2.0 ^2.1 ^2.2 Oda Y et al. (2007) Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiation. J Steroid Biochem Mol Biol 103: 776-80 PubMed GONUTS page

[PMID:11891224-2] 3.0 ^3.1 Gonzalez MM & Carlberg C (2002) Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors. J Biol Chem 277: 18501-9 PubMed GONUTS page

[PMID:2849209-3] 4.0 ^4.1 Hughes MR et al. (1988) Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets. Science 242: 1702-5 PubMed GONUTS page

[PMID:10409738-4] Lavigne AC et al. (1999) Human TAF(II)55 interacts with the vitamin D(3) and thyroid hormone receptors and with derivatives of the retinoid X receptor that have altered transactivation properties. Mol Cell Biol 19: 5486-94 PubMed GONUTS page

[PMID:10744685-5] Mengus G et al. (2000) The human transcription factor IID subunit human TATA-binding protein-associated factor 28 interacts in a ligand-reversible manner with the vitamin D(3) and thyroid hormone receptors. J Biol Chem 275: 10064-71 PubMed GONUTS page

[PMID:10866662-6] Mahajan MA & Samuels HH (2000) A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein. Mol Cell Biol 20: 5048-63 PubMed GONUTS page

[PMID:16252006-7] Fujiki R et al. (2005) Ligand-induced transrepression by VDR through association of WSTF with acetylated histones. EMBO J 24: 3881-94 PubMed GONUTS page

[PMID:17254542-8] 9.0 ^9.1 Zella LA et al. (2007) The vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifs. Arch Biochem Biophys 460: 206-12 PubMed GONUTS page

[PMID:20227041-9] Stambolsky P et al. (2010) Modulation of the vitamin D3 response by cancer-associated mutant p53. Cancer Cell 17: 273-85 PubMed GONUTS page

[PMID:20413580-10] Li CW et al. (2010) Human ADA3 regulates RARalpha transcriptional activity through direct contact between LxxLL motifs and the receptor coactivator pocket. Nucleic Acids Res 38: 5291-303 PubMed GONUTS page

[PMID:21119599-11] Zhi HY et al. (2011) PTPH1 cooperates with vitamin D receptor to stimulate breast cancer growth through their mutual stabilization. Oncogene 30: 1706-15 PubMed GONUTS page

[PMID:9653119-12] Yuan CX et al. (1998) The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc Natl Acad Sci U S A 95: 7939-44 PubMed GONUTS page

[PMID:15589699-13] Eyles DW et al. (2005) Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat 29: 21-30 PubMed GONUTS page

[PMID:17082781-14] 15.0 ^15.1 ^15.2 ^15.3 Hawker NP et al. (2007) Regulation of human epidermal keratinocyte differentiation by the vitamin D receptor and its coactivators DRIP205, SRC2, and SRC3. J Invest Dermatol 127: 874-80 PubMed GONUTS page

[PMID:16549446-15] 16.0 ^16.1 ^16.2 ^16.3 Kemmis CM et al. (2006) Human mammary epithelial cells express CYP27B1 and are growth inhibited by 25-hydroxyvitamin D-3, the major circulating form of vitamin D-3. J Nutr 136: 887-92 PubMed GONUTS page

[PMID:16720713-16] Viganò P et al. (2006) Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system. J Mol Endocrinol 36: 415-24 PubMed GONUTS page

[PMID:1850412-17] Yu XP et al. (1991) Vitamin D receptor expression in human lymphocytes. Signal requirements and characterization by western blots and DNA sequencing. J Biol Chem 266: 7588-95 PubMed GONUTS page

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HUMAN:VDR

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