HUMAN:UROM

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	UMOD
Protein Name(s)	Uromodulin Tamm-Horsfall urinary glycoprotein THP Uromodulin, secreted form
External Links
UniProt Identifier	UROM_HUMAN
UniProt Accessions	P07911, B3KP48, B3KRN9, Q540J6, Q6ZS84, Q8IYG0,
EMBL	M15881, M17778, AY162970, AY162963, AY162964, AY162965, AY162967, AY162968, AY162969, AK127643, AK055722, AK091961, AC106796, BC035975,
PIR	A30452,
RefSeq	NP_001008390.1, NP_003352.2,
IntAct	P07911,
Ensembl	ENST00000302509, ENST00000396138,
Pfam	PF07645, PF00100,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0000922	spindle pole	PMID:20172860^[1]	IDA: Inferred from Direct Assay		C
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001881	F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018097	F
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000021027	C
	GO:0005794	Golgi apparatus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000021027	C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0006968	cellular defense response	PMID:2409603^[2]	TAS: Traceable Author Statement		P
	GO:0007588	excretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033263	P
	GO:0008285	negative regulation of cell proliferation	PMID:2409603^[2]	TAS: Traceable Author Statement		P
	GO:0010033	response to organic substance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000021027	P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016323	basolateral plasma membrane	PMID:7028707^[3]	IDA: Inferred from Direct Assay		C
	GO:0016324	apical plasma membrane	PMID:18025791^[4]	IDA: Inferred from Direct Assay		C
	GO:0016324	apical plasma membrane	PMID:7028707^[3]	IDA: Inferred from Direct Assay		C
	GO:0019898	extrinsic to membrane	PMID:7873609^[5]	TAS: Traceable Author Statement		C
	GO:0031225	anchored to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0336	C
	GO:0031225	anchored to membrane	PMID:91065873^[6]	IDA: Inferred from Direct Assay		C
	GO:0031410	cytoplasmic vesicle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000021027	C
	GO:0045121	membrane raft	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000021027	C
	GO:0045177	apical part of cell	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000021027	C
	GO:0048878	chemical homeostasis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033263	P
	GO:0072372	primary cilium	PMID:20172860^[1]	IDA: Inferred from Direct Assay		C
	GO:0000922	spindle pole	PMID:20172860^[1]	IDA: Inferred from Direct Assay		C
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001881	F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018097	F
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000021027	C
	GO:0005794	Golgi apparatus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000021027	C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005929	cilium	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0969	C
	GO:0006968	cellular defense response	PMID:2409603^[2]	TAS: Traceable Author Statement		P
	GO:0007588	excretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033263	P
	GO:0008285	negative regulation of cell proliferation	PMID:2409603^[2]	TAS: Traceable Author Statement		P
	GO:0010033	response to organic substance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000021027	P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016323	basolateral plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0026	C
	GO:0016323	basolateral plasma membrane	PMID:7028707^[3]	IDA: Inferred from Direct Assay		C
	GO:0016324	apical plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0015	C
	GO:0016324	apical plasma membrane	PMID:18025791^[4]	IDA: Inferred from Direct Assay		C
	GO:0016324	apical plasma membrane	PMID:7028707^[3]	IDA: Inferred from Direct Assay		C
	GO:0019898	extrinsic to membrane	PMID:7873609^[5]	TAS: Traceable Author Statement		C
	GO:0031225	anchored to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0336	C
	GO:0031225	anchored to membrane	PMID:91065873^[6]	IDA: Inferred from Direct Assay		C
	GO:0031410	cytoplasmic vesicle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000021027	C
	GO:0042995	cell projection	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0966	C
	GO:0045121	membrane raft	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000021027	C
	GO:0045177	apical part of cell	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000021027	C
	GO:0048878	chemical homeostasis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033263	P
	GO:0060170	cilium membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0305	C
	GO:0072218	metanephric ascending thin limb development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033263	P
	GO:0072221	metanephric distal convoluted tubule development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033263	P
	GO:0072233	metanephric thick ascending limb development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033263	P
	GO:0072372	primary cilium	PMID:20172860^[1]	IDA: Inferred from Direct Assay		C
	GO:2000021	regulation of ion homeostasis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033263	P
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Zaucke F et al. (2010) Uromodulin is expressed in renal primary cilia and UMOD mutations result in decreased ciliary uromodulin expression. Hum Mol Genet 19: 1985-97 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Muchmore AV & Decker JM (1985) Uromodulin: a unique 85-kilodalton immunosuppressive glycoprotein isolated from urine of pregnant women. Science 229: 479-81 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Sikri KL et al. (1981) Localization of Tamm-Horsfall glycoprotein in the human kidney using immuno-fluorescence and immuno-electron microscopical techniques. J Anat 132: 597-605 PubMed GONUTS page
↑ ^4.0 ^4.1 Trzpis M et al. (2007) Spatial and temporal expression patterns of the epithelial cell adhesion molecule (EpCAM/EGP-2) in developing and adult kidneys. Nephron Exp Nephrol 107: e119-31 PubMed GONUTS page
↑ ^5.0 ^5.1 Prasadan K et al. (1995) Nucleotide sequence and peptide motifs of mouse uromodulin (Tamm-Horsfall protein)--the most abundant protein in mammalian urine. Biochim Biophys Acta 1260: 328-32 PubMed GONUTS page
↑ ^6.0 ^6.1 Error. Invalid PMID ID number

[PMID:20172860-0] 1.0 ^1.1 ^1.2 ^1.3 Zaucke F et al. (2010) Uromodulin is expressed in renal primary cilia and UMOD mutations result in decreased ciliary uromodulin expression. Hum Mol Genet 19: 1985-97 PubMed GONUTS page

[PMID:2409603-1] 2.0 ^2.1 ^2.2 ^2.3 Muchmore AV & Decker JM (1985) Uromodulin: a unique 85-kilodalton immunosuppressive glycoprotein isolated from urine of pregnant women. Science 229: 479-81 PubMed GONUTS page

[PMID:7028707-2] 3.0 ^3.1 ^3.2 ^3.3 Sikri KL et al. (1981) Localization of Tamm-Horsfall glycoprotein in the human kidney using immuno-fluorescence and immuno-electron microscopical techniques. J Anat 132: 597-605 PubMed GONUTS page

[PMID:18025791-3] 4.0 ^4.1 Trzpis M et al. (2007) Spatial and temporal expression patterns of the epithelial cell adhesion molecule (EpCAM/EGP-2) in developing and adult kidneys. Nephron Exp Nephrol 107: e119-31 PubMed GONUTS page

[PMID:7873609-4] 5.0 ^5.1 Prasadan K et al. (1995) Nucleotide sequence and peptide motifs of mouse uromodulin (Tamm-Horsfall protein)--the most abundant protein in mammalian urine. Biochim Biophys Acta 1260: 328-32 PubMed GONUTS page

[PMID:91065873-5] 6.0 ^6.1 Error. Invalid PMID ID number

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HUMAN:UROM

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