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HUMAN:UIMC1
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | UIMC1 (synonyms: RAP80, RXRIP110) | |
| Protein Name(s) | BRCA1-A complex subunit RAP80
Receptor-associated protein 80 Retinoid X receptor-interacting protein 110 Ubiquitin interaction motif-containing protein 1 | |
| External Links | ||
| EMBL | AF349313 AF113538 AF284749 AF284753 AK023044 AK304794 BX537376 AC027318 BC006078 BC032561 | |
| IPI | IPI00328521 IPI00396071 IPI00552059 IPI00872390 IPI00910121 | |
| RefSeq | NP_001186226.1 NP_001186227.1 NP_057374.3 | |
| UniGene | Hs.232721 | |
| ProteinModelPortal | Q96RL1 | |
| SMR | Q96RL1 | |
| DIP | DIP-29936N | |
| IntAct | Q96RL1 | |
| MINT | MINT-1197441 | |
| STRING | Q96RL1 | |
| PhosphoSite | Q96RL1 | |
| PRIDE | Q96RL1 | |
| Ensembl | ENST00000377227 | |
| GeneID | 51720 | |
| KEGG | hsa:51720 | |
| UCSC | uc003mfc.1 uc010jkh.1 | |
| CTD | 51720 | |
| GeneCards | GC05M171254 | |
| H-InvDB | HIX0005450 | |
| HGNC | HGNC:30298 | |
| HPA | HPA037503 HPA037504 | |
| MIM | 609433 | |
| neXtProt | NX_Q96RL1 | |
| PharmGKB | PA162408624 | |
| eggNOG | prNOG08946 | |
| HOVERGEN | HBG056783 | |
| OrthoDB | EOG4TXBRC | |
| PhylomeDB | Q96RL1 | |
| NextBio | 55772 | |
| ArrayExpress | Q96RL1 | |
| Bgee | Q96RL1 | |
| CleanEx | HS_UIMC1 | |
| Genevestigator | Q96RL1 | |
| GermOnline | ENSG00000087206 | |
| GO | GO:0070531 GO:0042393 GO:0070530 GO:0006302 GO:0031572 GO:0070537 GO:0045892 GO:0045739 GO:0010212 GO:0006351 | |
| InterPro | IPR003903 | |
| SMART | SM00726 | |
| PROSITE | PS50330 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0006281 |
DNA repair |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006302 |
double-strand break repair |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0006302 |
double-strand break repair |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0006302 |
double-strand break repair |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0006302 |
double-strand break repair |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0006302 |
double-strand break repair |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0006351 |
transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006974 |
response to DNA damage stimulus |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0010212 |
response to ionizing radiation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0010212 |
response to ionizing radiation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0010212 |
response to ionizing radiation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0010212 |
response to ionizing radiation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0010212 |
response to ionizing radiation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0016568 |
chromatin modification |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0031572 |
G2/M transition DNA damage checkpoint |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0031572 |
G2/M transition DNA damage checkpoint |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0031572 |
G2/M transition DNA damage checkpoint |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0031572 |
G2/M transition DNA damage checkpoint |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0031572 |
G2/M transition DNA damage checkpoint |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0042393 |
histone binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0042393 |
histone binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0045739 |
positive regulation of DNA repair |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0045739 |
positive regulation of DNA repair |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0045739 |
positive regulation of DNA repair |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0045739 |
positive regulation of DNA repair |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0045739 |
positive regulation of DNA repair |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0046965 |
retinoid X receptor binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000097095 |
F |
Seeded From UniProt |
|||
| GO:0070530 |
K63-linked polyubiquitin binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0070530 |
K63-linked polyubiquitin binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0070530 |
K63-linked polyubiquitin binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0070531 |
BRCA1-A complex |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0070531 |
BRCA1-A complex |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0070531 |
BRCA1-A complex |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0070531 |
BRCA1-A complex |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0070531 |
BRCA1-A complex |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0070531 |
BRCA1-A complex |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0070537 |
histone H2A K63-linked deubiquitination |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Yan Z et al. (2002) RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor. J Biol Chem 277: 32379-88 PubMed GONUTS page
- ↑ Kim YS et al. (2004) Tsp57: a novel gene induced during a specific stage of spermatogenesis. Biol Reprod 70: 106-13 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Wang B et al. (2007) Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science 316: 1194-8 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Liu Z et al. (2007) CCDC98 targets BRCA1 to DNA damage sites. Nat Struct Mol Biol 14: 716-20 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Feng L et al. (2009) MERIT40 facilitates BRCA1 localization and DNA damage repair. Genes Dev 23: 719-28 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Wang B et al. (2009) NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Genes Dev 23: 729-39 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 Sobhian B et al. (2007) RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Science 316: 1198-202 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 Kim H et al. (2007) Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Science 316: 1202-5 PubMed GONUTS page
- ↑ Shao G et al. (2009) MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks. Genes Dev 23: 740-54 PubMed GONUTS page
- ↑ Shao G et al. (2009) The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks. Proc Natl Acad Sci U S A 106: 3166-71 PubMed GONUTS page
