HUMAN:UBR5

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	UBR5 ( synonyms: EDD, EDD1, HYD, KIAA0896 )
Protein Name(s)	E3 ubiquitin-protein ligase UBR5 E3 ubiquitin-protein ligase, HECT domain-containing 1 Hyperplastic discs protein homolog hHYD Progestin-induced protein
External Links
UniProt Identifier	UBR5_HUMAN
UniProt Accessions	O95071, B2RP24, O94970, Q9NPL3,
EMBL	AF006010, U95000, AB020703, BC137234,
RefSeq	NP_056986.2,
PDB	1I2T, 2QHO,
IntAct	O95071,
Ensembl	ENST00000220959,
Pfam	PF00632, PF00658, PF02207,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005634	nucleus		IDA: Inferred from Direct Assay		C	Source: HGNC
	GO:0005625	soluble fraction		TAS: Traceable Author Statement		C	Source: ProtInc
	GO:0005515	protein binding		IPI: Inferred from Physical Interaction		F	Source: IntAct
	GO:0003723	RNA binding		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0004842	ubiquitin-protein ligase activity		TAS: Traceable Author Statement		F	Source: ProtInc
	GO:0008270	zinc ion binding		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0008283	cell proliferation		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0050847	progesterone receptor signaling pathway		IDA: Inferred from Direct Assay		P	Source: HGNC
	GO:0006974	response to DNA damage stimulus		IDA: Inferred from Direct Assay		P	Source: HGNC
	GO:0006511	ubiquitin-dependent protein catabolic process		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0005515	protein binding	PMID:21118991^[1]	IPI: Inferred from Physical Interaction	UniProtKB:p49841	F	Fig 1A, 1B – Co-immunoprecipitation between GSK-3 and EDD Fig 1E – Pulldown GSK-3β bound EDD	complete
	GO:0000209	protein polyubiquitination	PMID:21118991^[1]	IDA: Inferred from Direct Assay		P	Fig. 5B EDD was silenced in HEK293T cells expressing HA-ubiquitin causing reduced ubiqutination of endogenous β-catenin, indicating a specific ubiquitination of β-catenin by EDD	complete
	GO:0005634	nucleus	PMID:21118991^[1]	IDA: Inferred from Direct Assay		C	Fig 2A, B shows EDD in nucleus. Nucleus marked by DAPI in B.	complete
	GO:0000209	protein polyubiquitination	PMID:21118991^[1]	IDA: Inferred from Direct Assay		P
	GO:0003723	RNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002004	F
	GO:0004842	ubiquitin-protein ligase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003126	F
	GO:0004842	ubiquitin-protein ligase activity	PMID:10030672^[2]	TAS: Traceable Author Statement		F
	GO:0005515	protein binding	PMID:12011095^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P06401	F
	GO:0005515	protein binding	PMID:12011095^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P52294	F
	GO:0005515	protein binding	PMID:12011095^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q99828	F
	GO:0005515	protein binding	PMID:17353931^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q96EZ8	F
	GO:0005515	protein binding	PMID:17353931^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y5V3	F
	GO:0005515	protein binding	PMID:21118991^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P49841	F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000569	C
	GO:0005625	soluble fraction	PMID:10030672^[2]	TAS: Traceable Author Statement		C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:12011095^[3]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:21118991^[1]	IDA: Inferred from Direct Assay		C
	GO:0006464	protein modification process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000569	P
	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:10030672^[2]	TAS: Traceable Author Statement		P
	GO:0006974	response to DNA damage stimulus	PMID:12011095^[3]	IDA: Inferred from Direct Assay		P
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003126	F
	GO:0008283	cell proliferation	PMID:10030672^[2]	TAS: Traceable Author Statement		P
	GO:0016567	protein ubiquitination	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003126	P
	GO:0016567	protein ubiquitination	PMID:10030672^[2]	TAS: Traceable Author Statement		P
	GO:0016874	ligase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0436	F
	GO:0016881	acid-amino acid ligase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000569	F
	GO:0033160	positive regulation of protein import into nucleus, translocation	PMID:21118991^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0034450	ubiquitin-ubiquitin ligase activity	PMID:21118991^[1]	IDA: Inferred from Direct Assay		F
	GO:0035413	positive regulation of catenin import into nucleus	PMID:21118991^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	GO_REF:0000033		PANTHER:PTHR11254_AN0	P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0050847	progesterone receptor signaling pathway	PMID:12011095^[3]	IDA: Inferred from Direct Assay		P
	GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	PMID:21118991^[1]	IMP: Inferred from Mutant Phenotype		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Hay-Koren A et al. (2011) The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin. Mol Biol Cell 22: 399-411 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Callaghan MJ et al. (1998) Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs. Oncogene 17: 3479-91 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Henderson MJ et al. (2002) EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response. J Biol Chem 277: 26468-78 PubMed GONUTS page
↑ ^4.0 ^4.1 Ewing RM et al. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol 3: 89 PubMed GONUTS page

[PMID:21118991-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Hay-Koren A et al. (2011) The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin. Mol Biol Cell 22: 399-411 PubMed GONUTS page

[PMID:10030672-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Callaghan MJ et al. (1998) Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs. Oncogene 17: 3479-91 PubMed GONUTS page

[PMID:12011095-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Henderson MJ et al. (2002) EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response. J Biol Chem 277: 26468-78 PubMed GONUTS page

[PMID:17353931-3] 4.0 ^4.1 Ewing RM et al. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol 3: 89 PubMed GONUTS page

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HUMAN:UBR5

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