GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
HUMAN:UBE3A
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | UBE3A (synonyms: E6AP, EPVE6AP, HPVE6A) | |
| Protein Name(s) | Ubiquitin-protein ligase E3A
E6AP ubiquitin-protein ligase Human papillomavirus E6-associated protein Oncogenic protein-associated protein E6-AP Renal carcinoma antigen NY-REN-54 | |
| External Links | ||
| EMBL | X98021 X98027 X98022 X98023 X98024 X98025 X98026 X98028 X98029 X98030 X98031 X98032 X98033 AC100774 AK292514 AC124997 CH471151 L07557 AF016708 AF016703 AF016704 AF016705 AF016706 AF016707 U84404 AJ001107 AJ001108 AJ001109 AJ001110 AJ001111 AJ001112 | |
| IPI | IPI00011609 IPI00219197 IPI00219198 | |
| RefSeq | NP_000453.2 NP_570853.1 NP_570854.1 | |
| UniGene | Hs.598862 | |
| PDB | 1C4Z 1D5F 1EQX 2KR1 | |
| PDBsum | 1C4Z 1D5F 1EQX 2KR1 | |
| ProteinModelPortal | Q05086 | |
| SMR | Q05086 | |
| DIP | DIP-6002N | |
| IntAct | Q05086 | |
| MINT | MINT-147444 | |
| STRING | Q05086 | |
| PhosphoSite | Q05086 | |
| PRIDE | Q05086 | |
| Ensembl | ENST00000397954 | |
| GeneID | 7337 | |
| KEGG | hsa:7337 | |
| CTD | 7337 | |
| GeneCards | GC15M003706 | |
| HGNC | HGNC:12496 | |
| HPA | HPA039410 | |
| MIM | 105830 601623 | |
| neXtProt | NX_Q05086 | |
| Orphanet | 72 98794 | |
| PharmGKB | PA37144 | |
| eggNOG | prNOG11307 | |
| HOVERGEN | HBG059326 | |
| InParanoid | Q05086 | |
| OMA | NEFNSRN | |
| Pathway_Interaction_DB | ar_pathway telomerasepathway | |
| Reactome | REACT_6900 | |
| NextBio | 28722 | |
| ArrayExpress | Q05086 | |
| Bgee | Q05086 | |
| Genevestigator | Q05086 | |
| GermOnline | ENSG00000114062 | |
| GO | GO:0005634 GO:0000502 GO:0005515 GO:0004842 GO:0007420 GO:0044419 GO:0070936 GO:0042787 | |
| InterPro | IPR000569 IPR017134 | |
| KO | K10587 | |
| Pfam | PF00632 | |
| PIRSF | PIRSF037201 | |
| SMART | SM00119 | |
| SUPFAM | SSF56204 | |
| PROSITE | PS50237 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000502 |
proteasome complex |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0001541 |
ovarian follicle development |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000082326 |
P |
Seeded From UniProt |
|||
| GO:0003713 |
transcription coactivator activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000082326 |
F |
Seeded From UniProt |
|||
| GO:0004842 |
ubiquitin-protein ligase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005622 |
intracellular |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000082326 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
Seeded From UniProt |
|||
| GO:0005829 |
cytosol |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000082326 |
C |
Seeded From UniProt |
|||
| GO:0006464 |
protein modification process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006508 |
proteolysis |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0006511 |
ubiquitin-dependent protein catabolic process |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000082326 |
P |
Seeded From UniProt |
|||
| GO:0006511 |
ubiquitin-dependent protein catabolic process |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0007420 |
brain development |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0014068 |
positive regulation of phosphatidylinositol 3-kinase cascade |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000082326 |
P |
Seeded From UniProt |
|||
| GO:0016567 |
protein ubiquitination |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000082326 |
P |
Seeded From UniProt |
|||
| GO:0016874 |
ligase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016881 |
acid-amino acid ligase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0030521 |
androgen receptor signaling pathway |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000082326 |
P |
Seeded From UniProt |
|||
| GO:0035037 |
sperm entry |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000082326 |
P |
Seeded From UniProt |
|||
| GO:0042787 |
protein ubiquitination involved in ubiquitin-dependent protein catabolic process |
PANTHER:PTHR11254_AN0 |
P |
Seeded From UniProt |
||||
| GO:0044419 |
interspecies interaction between organisms |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000082326 |
P |
Seeded From UniProt |
|||
| GO:0060736 |
prostate gland growth |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000082326 |
P |
Seeded From UniProt |
|||
| GO:0070936 |
protein K48-linked ubiquitination |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0031398 |
regulation of protein ubiquitination |
IDA: Inferred from Direct Assay |
P |
Figures 4-10: Ubiquitin ligase E6AP binds to HCV (Hepatitis C Virus) core protein to mediate and promote ubiquitination and degradation of the core protein. |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Wu-Baer F et al. (2003) The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin. J Biol Chem 278: 34743-6 PubMed GONUTS page
- ↑ 2.0 2.1 Ro HS et al. (2006) Surface plasmon resonance imaging protein arrays for analysis of triple protein interactions of HPV, E6, E6AP, and p53. Proteomics 6: 2108-11 PubMed GONUTS page
- ↑ 3.0 3.1 Scheffner M et al. (1993) The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 75: 495-505 PubMed GONUTS page
- ↑ Kishino T et al. (1997) UBE3A/E6-AP mutations cause Angelman syndrome. Nat Genet 15: 70-3 PubMed GONUTS page
- ↑ Shirakura M et al. (2007) E6AP ubiquitin ligase mediates ubiquitylation and degradation of hepatitis C virus core protein. J Virol 81: 1174-85 PubMed GONUTS page
