HUMAN:UB2E1

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	UBE2E1 ( synonyms: UBCH6 )
Protein Name(s)	Ubiquitin-conjugating enzyme E2 E1 UbcH6 Ubiquitin carrier protein E1 Ubiquitin-protein ligase E1
External Links
UniProt Identifier	UB2E1_HUMAN
UniProt Accessions	P51965, B2RBX4,
EMBL	X92963, AK314854, CH471055, BC009139,
RefSeq	NP_003332.1, NP_872607.1,
PDB	1XR9, 3BZH,
IntAct	P51965,
Ensembl	ENST00000306627,
Pfam	PF00179,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005829	cytosol		EXP: Inferred from Experiment		C	Source: Reactome
	GO:0005654	nucleoplasm		EXP: Inferred from Experiment		C	Source: Reactome
	GO:0000151	ubiquitin ligase complex		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0005524	ATP binding		IEA: Inferred from Electronic Annotation		F	Source: UniProtKB-KW
	GO:0042296	ISG15 ligase activity		IDA: Inferred from Direct Assay		F	Source: HGNC
	GO:0005515	protein binding		IPI: Inferred from Physical Interaction		F	Source: IntAct
	GO:0004842	ubiquitin-protein ligase activity		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0031145	anaphase-promoting complex-dependent protea...		EXP: Inferred from Experiment		P	Source: Reactome
	GO:0033523	histone H2B ubiquitination		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0010390	histone monoubiquitination		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0032020	ISG15-protein conjugation		IDA: Inferred from Direct Assay		P	Source: HGNC
	GO:0051436	negative regulation of ubiquitin-protein li...		EXP: Inferred from Experiment		P	Source: Reactome
	GO:0051437	positive regulation of ubiquitin-protein li...		EXP: Inferred from Experiment		P	Source: Reactome
	GO:0070936	protein K48-linked ubiquitination		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0000209	protein polyubiquitination		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	PMID:18439907^[1]	IMP: Inferred from Mutant Phenotype		P	Figure 4	complete
	GO:0000075	cell cycle checkpoint	Reactome:REACT_1538	TAS: Traceable Author Statement		P
	GO:0000151	ubiquitin ligase complex	PMID:16307923^[2]	IDA: Inferred from Direct Assay		C
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0000209	protein polyubiquitination	PMID:16522193^[3]	IDA: Inferred from Direct Assay		P
	GO:0000278	mitotic cell cycle	Reactome:REACT_152	TAS: Traceable Author Statement		P
	GO:0004842	ubiquitin-protein ligase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:6.3.2.19	F
	GO:0004842	ubiquitin-protein ligase activity	PMID:16307923^[2]	IDA: Inferred from Direct Assay		F
	GO:0004842	ubiquitin-protein ligase activity	PMID:16522193^[3]	IDA: Inferred from Direct Assay		F
	GO:0004842	ubiquitin-protein ligase activity	PMID:20061386^[4]	IDA: Inferred from Direct Assay		F
	GO:0004842	ubiquitin-protein ligase activity	PMID:8576257^[5]	TAS: Traceable Author Statement		F
	GO:0005515	protein binding	PMID:14667819^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q99942	F
	GO:0005515	protein binding	PMID:19549727^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P98170	F
	GO:0005515	protein binding	PMID:19549727^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y3C5	F
	GO:0005515	protein binding	PMID:19549727^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y4K3	F
	GO:0005515	protein binding	PMID:19690564^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q6ZNA4	F
	GO:0005515	protein binding	PMID:19690564^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q8ND25	F
	GO:0005515	protein binding	PMID:19690564^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q96BH1	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:18845142^[9]	IDA: Inferred from Direct Assay		C
	GO:0005654	nucleoplasm	Reactome:REACT_6715	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_6721	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_6791	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_6845	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_6859	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_6942	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_9051	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_1951	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6723	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6733	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6735	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6741	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6748	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6749	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6766	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6777	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6824	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6826	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6830	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6893	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6914	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6937	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6974	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_7992	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_7995	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_8025	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_9035	TAS: Traceable Author Statement		C
	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:8576257^[5]	TAS: Traceable Author Statement		P
	GO:0007094	mitotic cell cycle spindle assembly checkpoint	Reactome:REACT_2137	TAS: Traceable Author Statement		P
	GO:0010390	histone monoubiquitination	PMID:16307923^[2]	IDA: Inferred from Direct Assay		P
	GO:0016567	protein ubiquitination	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:6.3.2.19	P
	GO:0016567	protein ubiquitination	PMID:8576257^[5]	TAS: Traceable Author Statement		P
	GO:0016567	protein ubiquitination	PMID:9990509^[10]	IDA: Inferred from Direct Assay		P
	GO:0016874	ligase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0436	F
	GO:0016881	acid-amino acid ligase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000608	F
	GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Reactome:REACT_6761	TAS: Traceable Author Statement		P
	GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Reactome:REACT_6820	TAS: Traceable Author Statement		P
	GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Reactome:REACT_6828	TAS: Traceable Author Statement		P
	GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Reactome:REACT_6850	TAS: Traceable Author Statement		P
	GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Reactome:REACT_6871	TAS: Traceable Author Statement		P
	GO:0032020	ISG15-protein conjugation	PMID:16428300^[11]	IDA: Inferred from Direct Assay		P
	GO:0033523	histone H2B ubiquitination	PMID:16307923^[2]	IDA: Inferred from Direct Assay		P
	GO:0042296	ISG15 ligase activity	PMID:16428300^[11]	IDA: Inferred from Direct Assay		F
	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Reactome:REACT_1041	TAS: Traceable Author Statement		P
	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Reactome:REACT_6785	TAS: Traceable Author Statement		P
	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Reactome:REACT_6904	TAS: Traceable Author Statement		P
	GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Reactome:REACT_6837	TAS: Traceable Author Statement		P
	GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Reactome:REACT_6867	TAS: Traceable Author Statement		P
	GO:0070936	protein K48-linked ubiquitination	PMID:20061386^[4]	IDA: Inferred from Direct Assay		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Hong S et al. (2008) UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1. Biochem Biophys Res Commun 371: 256-60 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Zhu B et al. (2005) Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol Cell 20: 601-11 PubMed GONUTS page
↑ ^3.0 ^3.1 Nishito Y et al. (2006) MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis. Biochem J 396: 411-7 PubMed GONUTS page
↑ ^4.0 ^4.1 David Y et al. (2010) The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. J Biol Chem 285: 8595-604 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Nuber U et al. (1996) Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5. J Biol Chem 271: 2795-800 PubMed GONUTS page
↑ Lehner B et al. (2004) Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. Genomics 83: 153-67 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Markson G et al. (2009) Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. Genome Res 19: 1905-11 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 van Wijk SJ et al. (2009) A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. Mol Syst Biol 5: 295 PubMed GONUTS page
↑ Espinosa A et al. (2008) The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide. Exp Cell Res 314: 3605-13 PubMed GONUTS page
↑ Anan T et al. (1998) Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. Genes Cells 3: 751-63 PubMed GONUTS page
↑ ^11.0 ^11.1 Takeuchi T et al. (2005) Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme. J Biochem 138: 711-9 PubMed GONUTS page

[PMID:18439907-0] Hong S et al. (2008) UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1. Biochem Biophys Res Commun 371: 256-60 PubMed GONUTS page

[PMID:16307923-1] 2.0 ^2.1 ^2.2 ^2.3 Zhu B et al. (2005) Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol Cell 20: 601-11 PubMed GONUTS page

[PMID:16522193-2] 3.0 ^3.1 Nishito Y et al. (2006) MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis. Biochem J 396: 411-7 PubMed GONUTS page

[PMID:20061386-3] 4.0 ^4.1 David Y et al. (2010) The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. J Biol Chem 285: 8595-604 PubMed GONUTS page

[PMID:8576257-4] 5.0 ^5.1 ^5.2 Nuber U et al. (1996) Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5. J Biol Chem 271: 2795-800 PubMed GONUTS page

[PMID:14667819-5] Lehner B et al. (2004) Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. Genomics 83: 153-67 PubMed GONUTS page

[PMID:19549727-6] 7.0 ^7.1 ^7.2 Markson G et al. (2009) Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. Genome Res 19: 1905-11 PubMed GONUTS page

[PMID:19690564-7] 8.0 ^8.1 ^8.2 van Wijk SJ et al. (2009) A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. Mol Syst Biol 5: 295 PubMed GONUTS page

[PMID:18845142-8] Espinosa A et al. (2008) The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide. Exp Cell Res 314: 3605-13 PubMed GONUTS page

[PMID:9990509-9] Anan T et al. (1998) Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. Genes Cells 3: 751-63 PubMed GONUTS page

[PMID:16428300-10] 11.0 ^11.1 Takeuchi T et al. (2005) Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme. J Biochem 138: 711-9 PubMed GONUTS page

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HUMAN:UB2E1

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