HUMAN:TYY1

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Species (Taxon ID)	Homo sapiens (Human). ([1])
Gene Name(s)	YY1 (synonyms: INO80S)
Protein Name(s)	Transcriptional repressor protein YY1 Delta transcription factor INO80 complex subunit S NF-E1 Yin and yang 1 YY-1
External Links
EMBL	M77698 M76541 Z14077 BC037308 BC065366
IPI	IPI00014513
PIR	A40350
RefSeq	NP_003394.1
UniGene	Hs.388927
PDB	1UBD 1ZNM
PDBsum	1UBD 1ZNM
ProteinModelPortal	P25490
SMR	P25490
DIP	DIP-150N DIP-28144N
IntAct	P25490
STRING	P25490
PhosphoSite	P25490
PeptideAtlas	P25490
PRIDE	P25490
Ensembl	ENST00000262238
GeneID	7528
KEGG	hsa:7528
UCSC	uc001ygy.1
CTD	7528
GeneCards	GC14P080888
H-InvDB	HIX0026638
HGNC	HGNC:12856
HPA	CAB009392 HPA001119
MIM	600013
neXtProt	NX_P25490
PharmGKB	PA37445
eggNOG	prNOG19754
GeneTree	ENSGT00560000076847
HOGENOM	HBG713851
HOVERGEN	HBG006823
InParanoid	P25490
OMA	PLVTDDP
OrthoDB	EOG4D26QN
PhylomeDB	P25490
Pathway_Interaction_DB	hdac_classi_pathway
NextBio	29449
PMAP-CutDB	P25490
ArrayExpress	P25490
Bgee	P25490
CleanEx	HS_YY1
Genevestigator	P25490
GermOnline	ENSG00000100811
GO	GO:0031011 GO:0016363 GO:0005886 GO:0000400 GO:0005515 GO:0003723 GO:0003700 GO:0003713 GO:0003714 GO:0044212 GO:0008270 GO:0030154 GO:0034644 GO:0000724 GO:0000122 GO:0010225 GO:0007283
InterPro	IPR017114 IPR007087 IPR015880 IPR013087
Gene3D	G3DSA:3.30.160.60
KO	K09201
Pfam	PF00096
PIRSF	PIRSF037113
SMART	SM00355
PROSITE	PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000021692	P	Seeded From UniProt
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:9857059^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0000400	four-way junction DNA binding	PMID:18026119^[2]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0000724	double-strand break repair via homologous recombination	PMID:18026119^[2]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013087	F	Seeded From UniProt
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F	Seeded From UniProt
	GO:0003677	DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000021692	F	Seeded From UniProt
	GO:0003677	DNA binding	PMID:21729784^[3]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000021692	F	Seeded From UniProt
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:1946405^[4]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0003713	transcription coactivator activity	PMID:1946405^[4]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0003714	transcription corepressor activity	PMID:1655281^[5]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0003723	RNA binding	PMID:21729784^[3]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0005515	protein binding	PMID:10369680^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q8CCI5	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:18026119^[2]	IPI: Inferred from Physical Interaction	UniProtKB:O96019	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:18026119^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P78527	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:18026119^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9ULG1	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:18026119^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y230	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:18026119^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y265	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:19879840^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P49407	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:9016636^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q8IY57	F	Seeded From UniProt
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007087	C	Seeded From UniProt
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015880	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000021692	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005743	C	Seeded From UniProt
	GO:0005634	nucleus	PMID:18026119^[2]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005634	nucleus	PMID:18029348^[9]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005667	transcription factor complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000021692	C	Seeded From UniProt
	GO:0005667	transcription factor complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005743	C	Seeded From UniProt
	GO:0005886	plasma membrane	PMID:18029348^[9]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0006281	DNA repair	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0234	P	Seeded From UniProt
	GO:0006310	DNA recombination	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0233	P	Seeded From UniProt
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P	Seeded From UniProt
	GO:0006351	transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000021692	P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000021692	P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005743	P	Seeded From UniProt
	GO:0006357	regulation of transcription from RNA polymerase II promoter	PMID:1655281^[5]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006974	response to DNA damage stimulus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0227	P	Seeded From UniProt
	GO:0006974	response to DNA damage stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000021692	P	Seeded From UniProt
	GO:0006974	response to DNA damage stimulus	PMID:18026119^[2]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0007283	spermatogenesis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0744	P	Seeded From UniProt
	GO:0007283	spermatogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000021692	P	Seeded From UniProt
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007087	F	Seeded From UniProt
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015880	F	Seeded From UniProt
	GO:0008270	zinc ion binding	PMID:1655281^[5]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0009952	anterior/posterior pattern specification	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000021692	P	Seeded From UniProt
	GO:0010225	response to UV-C	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000021692	P	Seeded From UniProt
	GO:0010225	response to UV-C	PMID:18026119^[2]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0016363	nuclear matrix	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0181	C	Seeded From UniProt
	GO:0030154	cell differentiation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0221	P	Seeded From UniProt
	GO:0031011	Ino80 complex	PMID:18026119^[2]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0031011	Ino80 complex	PMID:21303910^[10]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0031519	PcG protein complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000021692	C	Seeded From UniProt
	GO:0034644	cellular response to UV	PMID:18026119^[2]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0044212	transcription regulatory region DNA binding	PMID:9857059^[1]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F	Seeded From UniProt
	GO:0048593	camera-type eye morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000021692	P	Seeded From UniProt
	GO:0051276	chromosome organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000021692	P	Seeded From UniProt
	GO:0032688	negative regulation of interferon-beta production	PMID:22065573^[11]	IMP: Inferred from Mutant Phenotype		P	Fig. 2DE, Fig. 5BC, and Fig. 6	complete
	GO:0005634	nucleus	PMID:22065573^[11]	IMP: Inferred from Mutant Phenotype		C	Fig. 5A and Fig. 6C	complete
	GO:0010629	negative regulation of gene expression	PMID:22065573^[11]	IMP: Inferred from Mutant Phenotype		P	Fig. 5CD	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Du K et al. (1998) Transcriptional up-regulation of the delayed early gene HRS/SRp40 during liver regeneration. Interactions among YY1, GA-binding proteins, and mitogenic signals. J Biol Chem 273: 35208-15 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 Wu S et al. (2007) A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair. Nat Struct Mol Biol 14: 1165-72 PubMed GONUTS page
↑ ^3.0 ^3.1 Jeon Y & Lee JT (2011) YY1 tethers Xist RNA to the inactive X nucleation center. Cell 146: 119-33 PubMed GONUTS page
↑ ^4.0 ^4.1 Park K & Atchison ML (1991) Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site. Proc Natl Acad Sci U S A 88: 9804-8 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Shi Y et al. (1991) Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein. Cell 67: 377-88 PubMed GONUTS page
↑ García E et al. (1999) RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1. EMBO J 18: 3404-18 PubMed GONUTS page
↑ Yue R et al. (2009) Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression. Cell 139: 535-46 PubMed GONUTS page
↑ Kalenik JL et al. (1997) Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1. Nucleic Acids Res 25: 843-9 PubMed GONUTS page
↑ ^9.0 ^9.1 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
↑ Chen L et al. (2011) Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. J Biol Chem 286: 11283-9 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Siednienko J et al. (2011) Nuclear factor κB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1. J Biol Chem 286: 44750-63 PubMed GONUTS page

[PMID:9857059-0] 1.0 ^1.1 Du K et al. (1998) Transcriptional up-regulation of the delayed early gene HRS/SRp40 during liver regeneration. Interactions among YY1, GA-binding proteins, and mitogenic signals. J Biol Chem 273: 35208-15 PubMed GONUTS page

[PMID:18026119-1] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 Wu S et al. (2007) A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair. Nat Struct Mol Biol 14: 1165-72 PubMed GONUTS page

[PMID:21729784-2] 3.0 ^3.1 Jeon Y & Lee JT (2011) YY1 tethers Xist RNA to the inactive X nucleation center. Cell 146: 119-33 PubMed GONUTS page

[PMID:1946405-3] 4.0 ^4.1 Park K & Atchison ML (1991) Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site. Proc Natl Acad Sci U S A 88: 9804-8 PubMed GONUTS page

[PMID:1655281-4] 5.0 ^5.1 ^5.2 Shi Y et al. (1991) Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein. Cell 67: 377-88 PubMed GONUTS page

[PMID:10369680-5] García E et al. (1999) RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1. EMBO J 18: 3404-18 PubMed GONUTS page

[PMID:19879840-6] Yue R et al. (2009) Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression. Cell 139: 535-46 PubMed GONUTS page

[PMID:9016636-7] Kalenik JL et al. (1997) Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1. Nucleic Acids Res 25: 843-9 PubMed GONUTS page

[PMID:18029348-8] 9.0 ^9.1 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page

[PMID:21303910-9] Chen L et al. (2011) Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. J Biol Chem 286: 11283-9 PubMed GONUTS page

[PMID:22065573-10] 11.0 ^11.1 ^11.2 Siednienko J et al. (2011) Nuclear factor κB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1. J Biol Chem 286: 44750-63 PubMed GONUTS page

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HUMAN:TYY1

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