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HUMAN:TY3H

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TH (synonyms: TYH)
Protein Name(s) Tyrosine 3-monooxygenase

Tyrosine 3-hydroxylase TH

External Links
UniProt P07101
EMBL M17589
X05290
Y00414
DQ677336
DQ677337
AC132217
M24791
M24787
M24789
CH471158
BC104967
BC143611
BC143614
M24791
M24787
M20911
CCDS CCDS31338.1
CCDS7730.1
CCDS7731.1
PIR A30002
RefSeq NP_000351.2
NP_954986.2
NP_954987.2
UniGene Hs.435609
PDB 2XSN
4J6S
PDBsum 2XSN
4J6S
ProteinModelPortal P07101
SMR P07101
BioGrid 112912
IntAct P07101
MINT MINT-198913
STRING 9606.ENSP00000370571
BindingDB P07101
ChEMBL CHEMBL1969
DrugBank DB00120
DB00135
DB00765
DB00360
GuidetoPHARMACOLOGY 1243
PhosphoSite P07101
DMDM 239938945
PaxDb P07101
PRIDE P07101
Ensembl ENST00000333684
ENST00000352909
ENST00000381175
ENST00000381178
GeneID 7054
KEGG hsa:7054
UCSC uc001lvp.3
uc001lvq.3
uc001lvr.3
uc010qxj.2
CTD 7054
GeneCards GC11M002185
GeneReviews TH
H-InvDB HIX0035928
HGNC HGNC:11782
HPA CAB002522
MIM 191290
605407
neXtProt NX_P07101
Orphanet 101150
PharmGKB PA351
eggNOG COG3186
GeneTree ENSGT00390000010268
HOGENOM HOG000233373
HOVERGEN HBG006841
InParanoid P07101
KO K00501
OMA YATHACG
PhylomeDB P07101
TreeFam TF313327
Reactome REACT_15551
UniPathway UPA00747
GeneWiki Tyrosine_hydroxylase
GenomeRNAi 7054
NextBio 27583
PRO PR:P07101
Proteomes UP000005640
Bgee P07101
CleanEx HS_TH
ExpressionAtlas P07101
Genevestigator P07101
GO GO:0005737
GO:0009898
GO:0031410
GO:0005829
GO:0030425
GO:0033162
GO:0005739
GO:0043005
GO:0005634
GO:0043204
GO:0005790
GO:0008021
GO:0043195
GO:0016597
GO:0035240
GO:0019899
GO:0008199
GO:0008198
GO:0019825
GO:0034617
GO:0004511
GO:0009653
GO:0042423
GO:0034641
GO:0035690
GO:0071333
GO:0071363
GO:0071287
GO:0071316
GO:0021987
GO:0042745
GO:0042416
GO:0006585
GO:0042755
GO:0048596
GO:0042418
GO:0042462
GO:0006631
GO:0016137
GO:0007507
GO:0003007
GO:0033076
GO:0007612
GO:0007626
GO:0007617
GO:0007613
GO:0010259
GO:0042136
GO:0042421
GO:0009887
GO:0018963
GO:0052314
GO:0043473
GO:0008016
GO:0014823
GO:0001975
GO:0051412
GO:0051602
GO:0032355
GO:0045471
GO:0045472
GO:0009635
GO:0001666
GO:0035902
GO:0009416
GO:0032496
GO:0031667
GO:0043434
GO:0046684
GO:0009651
GO:0009414
GO:0010043
GO:0007605
GO:0044281
GO:0035176
GO:0006665
GO:0001963
GO:0015842
GO:0042214
GO:0007601
Gene3D 1.10.800.10
InterPro IPR001273
IPR018301
IPR019774
IPR005962
IPR019773
IPR021164
PANTHER PTHR11473
Pfam PF00351
PF12549
PIRSF PIRSF000336
PRINTS PR00372
SUPFAM SSF56534
TIGRFAMs TIGR01269
PROSITE PS00367
PS51410

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0042421

norepinephrine biosynthetic process

PMID:14216443[1]

ECO:0000314

P

Source: BHF-UCL

complete

enables

GO:0004511

tyrosine 3-monooxygenase activity

PMID:19703902[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

PMID:19703902[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P20711

F

Seeded From UniProt

complete

involved_in

GO:0048596

embryonic camera-type eye morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P24529

P

Seeded From UniProt

complete

involved_in

GO:0045471

response to ethanol

PMID:18343820[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0043204

perikaryon

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P24529

C

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

PMID:17135716[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042462

eye photoreceptor cell development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P24529

P

Seeded From UniProt

complete

involved_in

GO:0042421

norepinephrine biosynthetic process

PMID:12457228[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042418

epinephrine biosynthetic process

PMID:12457228[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042416

dopamine biosynthetic process

PMID:12457228[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0033162

melanosome membrane

PMID:12631248[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

PMID:12457228[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0009898

cytoplasmic side of plasma membrane

PMID:12457228[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0009887

animal organ morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P24529

P

Seeded From UniProt

complete

involved_in

GO:0008016

regulation of heart contraction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P24529

P

Seeded From UniProt

complete

involved_in

GO:0007626

locomotory behavior

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P24529

P

Seeded From UniProt

complete

involved_in

GO:0007613

memory

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P24529

P

Seeded From UniProt

complete

involved_in

GO:0007612

learning

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P24529

P

Seeded From UniProt

complete

involved_in

GO:0007601

visual perception

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P24529

P

Seeded From UniProt

complete

involved_in

GO:0007507

heart development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P24529

P

Seeded From UniProt

complete

involved_in

GO:0006585

dopamine biosynthetic process from tyrosine

PMID:10907721[7]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005790

smooth endoplasmic reticulum

PMID:12457228[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P24529

C

Seeded From UniProt

complete

enables

GO:0004511

tyrosine 3-monooxygenase activity

PMID:2896667[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004511

tyrosine 3-monooxygenase activity

PMID:11943812[9]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004511

tyrosine 3-monooxygenase activity

PMID:12631248[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0003007

heart morphogenesis

PMID:12113410[10]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001963

synaptic transmission, dopaminergic

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P24529

P

Seeded From UniProt

complete

involved_in

GO:0001666

response to hypoxia

PMID:17520326[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:10907721[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004511

tyrosine 3-monooxygenase activity

PMID:16338639[12]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045471

response to ethanol

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000158541
RGD:3853
UniProtKB:P07101

P

Seeded From UniProt

complete

part_of

GO:0043204

perikaryon

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98735
PANTHER:PTN000158532
RGD:3853

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98735
PANTHER:PTN000158532
RGD:3853
WB:WBGene00000296

C

Seeded From UniProt

complete

involved_in

GO:0007507

heart development

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98735
PANTHER:PTN000158541
RGD:3853

P

Seeded From UniProt

complete

involved_in

GO:0006585

dopamine biosynthetic process from tyrosine

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98735
PANTHER:PTN001690342
RGD:3853

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98735
PANTHER:PTN000158532
RGD:3853
UniProtKB:P07101
UniProtKB:Q9PU40

C

Seeded From UniProt

complete

enables

GO:0004511

tyrosine 3-monooxygenase activity

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000158532
RGD:3853
UniProtKB:P07101
UniProtKB:Q9PU40
WB:WBGene00000296
ZFIN:ZDB-GENE-990621-5

F

Seeded From UniProt

complete

involved_in

GO:0001666

response to hypoxia

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000158541
RGD:3853
UniProtKB:P07101

P

Seeded From UniProt

complete

involved_in

GO:0071363

cellular response to growth factor stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0071333

cellular response to glucose stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0071316

cellular response to nicotine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0071312

cellular response to alkaloid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0071287

cellular response to manganese ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0070848

response to growth factor

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0052314

phytoalexin metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0051602

response to electrical stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0051412

response to corticosterone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0050890

cognition

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0048545

response to steroid hormone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0046684

response to pyrethroid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0045472

response to ether

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0045471

response to ethanol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0043434

response to peptide hormone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

part_of

GO:0043204

perikaryon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

C

Seeded From UniProt

complete

part_of

GO:0043195

terminal bouton

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

C

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

C

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

C

Seeded From UniProt

complete

involved_in

GO:0042745

circadian sleep/wake cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0042423

catecholamine biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0042214

terpene metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0035902

response to immobilization stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0035900

response to isolation stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0035690

cellular response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

enables

GO:0035240

dopamine binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

F

Seeded From UniProt

complete

involved_in

GO:0035176

social behavior

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0035094

response to nicotine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

enables

GO:0034617

tetrahydrobiopterin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

F

Seeded From UniProt

complete

involved_in

GO:0033076

isoquinoline alkaloid metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0032496

response to lipopolysaccharide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0032355

response to estradiol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0031667

response to nutrient levels

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

part_of

GO:0030659

cytoplasmic vesicle membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

C

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

C

Seeded From UniProt

complete

involved_in

GO:0021987

cerebral cortex development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

F

Seeded From UniProt

complete

enables

GO:0019825

oxygen binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

F

Seeded From UniProt

complete

involved_in

GO:0018963

phthalate metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0017085

response to insecticide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

enables

GO:0016597

amino acid binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

F

Seeded From UniProt

complete

involved_in

GO:0016137

glycoside metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0015842

aminergic neurotransmitter loading into synaptic vesicle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0014823

response to activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0014070

response to organic cyclic compound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0010259

multicellular organism aging

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0010043

response to zinc ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0010038

response to metal ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0009651

response to salt stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0009635

response to herbicide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0009416

response to light stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0009414

response to water deprivation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

enables

GO:0008199

ferric iron binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

F

Seeded From UniProt

complete

enables

GO:0008198

ferrous iron binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

F

Seeded From UniProt

complete

part_of

GO:0008021

synaptic vesicle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

C

Seeded From UniProt

complete

involved_in

GO:0007605

sensory perception of sound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0007507

heart development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0006665

sphingolipid metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0006631

fatty acid metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0006585

dopamine biosynthetic process from tyrosine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

C

Seeded From UniProt

complete

enables

GO:0004511

tyrosine 3-monooxygenase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

F

Seeded From UniProt

complete

enables

GO:0004497

monooxygenase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

F

Seeded From UniProt

complete

involved_in

GO:0001975

response to amphetamine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0001666

response to hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04177
ensembl:ENSRNOP00000027682

P

Seeded From UniProt

complete

involved_in

GO:0048596

embryonic camera-type eye morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24529
ensembl:ENSMUSP00000000219

P

Seeded From UniProt

complete

part_of

GO:0043204

perikaryon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24529
ensembl:ENSMUSP00000000219

C

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24529
ensembl:ENSMUSP00000000219

C

Seeded From UniProt

complete

involved_in

GO:0042755

eating behavior

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24529
ensembl:ENSMUSP00000000219

P

Seeded From UniProt

complete

involved_in

GO:0042462

eye photoreceptor cell development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24529
ensembl:ENSMUSP00000000219

P

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24529
ensembl:ENSMUSP00000000219

C

Seeded From UniProt

complete

involved_in

GO:0009887

animal organ morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24529
ensembl:ENSMUSP00000000219

P

Seeded From UniProt

complete

involved_in

GO:0008016

regulation of heart contraction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24529
ensembl:ENSMUSP00000000219

P

Seeded From UniProt

complete

involved_in

GO:0007626

locomotory behavior

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24529
ensembl:ENSMUSP00000000219

P

Seeded From UniProt

complete

involved_in

GO:0007617

mating behavior

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24529
ensembl:ENSMUSP00000000219

P

Seeded From UniProt

complete

involved_in

GO:0007613

memory

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24529
ensembl:ENSMUSP00000000219

P

Seeded From UniProt

complete

involved_in

GO:0007612

learning

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24529
ensembl:ENSMUSP00000000219

P

Seeded From UniProt

complete

involved_in

GO:0007601

visual perception

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24529
ensembl:ENSMUSP00000000219

P

Seeded From UniProt

complete

involved_in

GO:0007507

heart development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24529
ensembl:ENSMUSP00000000219

P

Seeded From UniProt

complete

involved_in

GO:0006585

dopamine biosynthetic process from tyrosine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24529
ensembl:ENSMUSP00000000219

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24529
ensembl:ENSMUSP00000000219

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24529
ensembl:ENSMUSP00000000219

C

Seeded From UniProt

complete

involved_in

GO:0001963

synaptic transmission, dopaminergic

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24529
ensembl:ENSMUSP00000000219

P

Seeded From UniProt

complete

enables

GO:0004497

monooxygenase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001273
InterPro:IPR018301
InterPro:IPR036951

F

Seeded From UniProt

complete

enables

GO:0004511

tyrosine 3-monooxygenase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005962
InterPro:IPR021164

F

Seeded From UniProt

complete

enables

GO:0005506

iron ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001273
InterPro:IPR018301
InterPro:IPR036951

F

Seeded From UniProt

complete

involved_in

GO:0009072

aromatic amino acid family metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001273
InterPro:IPR018301
InterPro:IPR036951

P

Seeded From UniProt

complete

enables

GO:0016714

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019773
InterPro:IPR019774

F

Seeded From UniProt

complete

involved_in

GO:0042423

catecholamine biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005962

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001273
InterPro:IPR005962
InterPro:IPR018301
InterPro:IPR019773
InterPro:IPR019774
InterPro:IPR021164
InterPro:IPR036951

P

Seeded From UniProt

complete

enables

GO:0004511

tyrosine 3-monooxygenase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.14.16.2

F

Seeded From UniProt

complete

involved_in

GO:0009653

anatomical structure morphogenesis

PMID:7715703[14]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043473

pigmentation

PMID:12631248[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042423

catecholamine biosynthetic process

Reactome:R-HSA-209905

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-209823

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0042136

neurotransmitter biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0530

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

enables

GO:0004497

monooxygenase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0503

F

Seeded From UniProt

complete

involved_in

GO:0042423

catecholamine biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0127

P

Seeded From UniProt

complete

involved_in

GO:0042416

dopamine biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00747

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. NAGATSU, T et al. (1964) TYROSINE HYDROXYLASE. THE INITIAL STEP IN NOREPINEPHRINE BIOSYNTHESIS. J. Biol. Chem. 239 2910-7 PubMed GONUTS page
  2. 2.0 2.1 Ishikawa, S et al. (2009) Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1. J. Biol. Chem. 284 28832-44 PubMed GONUTS page
  3. He, DY & Ron, D (2008) Glial cell line-derived neurotrophic factor reverses ethanol-mediated increases in tyrosine hydroxylase immunoreactivity via altering the activity of heat shock protein 90. J. Biol. Chem. 283 12811-8 PubMed GONUTS page
  4. Kontostavlaki, DP et al. (2006) Co-expression of tyrosine hydroxylase and GTP cyclohydrolase I in arginine vasopressin-synthesizing neurons of the human supraoptic nucleus demonstrated by laser microdissection and real-time PCR. Neuroendocrinology 84 386-95 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 Reguzzoni, M et al. (2002) Ultrastructural localization of tyrosine hydroxylase in human peripheral blood mononuclear cells: effect of stimulation with phytohaemagglutinin. Cell Tissue Res. 310 297-304 PubMed GONUTS page
  6. 6.0 6.1 6.2 Marles, LK et al. (2003) Tyrosine hydroxylase isoenzyme I is present in human melanosomes: a possible novel function in pigmentation. Exp. Dermatol. 12 61-70 PubMed GONUTS page
  7. 7.0 7.1 Nagatsu, I et al. (1999) Specific localization of the guanosine triphosphate (GTP) cyclohydrolase I-immunoreactivity in the human brain. J Neural Transm (Vienna) 106 607-17 PubMed GONUTS page
  8. Ginns, EI et al. (1988) Expression of human tyrosine hydroxylase cDNA in invertebrate cells using a baculovirus vector. J. Biol. Chem. 263 7406-10 PubMed GONUTS page
  9. Perez, RG et al. (2002) A role for alpha-synuclein in the regulation of dopamine biosynthesis. J. Neurosci. 22 3090-9 PubMed GONUTS page
  10. Linhart, A et al. (2002) Association between tyrosine hydroxylase polymorphisms and left ventricular structure in young normotensive men. Br. J. Biomed. Sci. 59 90-4 PubMed GONUTS page
  11. Rostrup, M et al. (2008) Oxygen dependence of tyrosine hydroxylase. Amino Acids 34 455-64 PubMed GONUTS page
  12. Duan, CL et al. (2005) The assays of activities and function of TH, AADC, and GCH1 and their potential use in ex vivo gene therapy of PD. Brain Res. Brain Res. Protoc. 16 37-43 PubMed GONUTS page
  13. 13.0 13.1 13.2 13.3 13.4 13.5 13.6 13.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  14. Zhou, QY et al. (1995) Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Nature 374 640-3 PubMed GONUTS page