HUMAN:TTP

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	ZFP36 ( synonyms: G0S24, RNF162A, TIS11A, TTP )
Protein Name(s)	Tristetraprolin TTP G0/G1 switch regulatory protein 24 Growth factor-inducible nuclear protein NUP475 Protein TIS11A TIS11 Zinc finger protein 36 homolog Zfp-36
External Links
UniProt Identifier	TTP_HUMAN
UniProt Accessions	P26651, B2RA54,
EMBL	M92843, M92844, M63625, AK314042, AY771351, BC009693,
PIR	S34427,
RefSeq	NP_003398.1,
IntAct	P26651,
Ensembl	ENST00000248673,
Pfam	PF00642,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000057815	P
	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000057815	P
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000571	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003727	single-stranded RNA binding	PMID:9703499^[1]	TAS: Traceable Author Statement		F
	GO:0003729	mRNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000057815	F
	GO:0003729	mRNA binding	PMID:11782475^[2]	IDA: Inferred from Direct Assay		F
	GO:0005515	protein binding	PMID:15231747^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q96B26	F
	GO:0005515	protein binding	PMID:15231747^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q9HAU5	F
	GO:0005515	protein binding	PMID:16364915^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q8IU60-1	F
	GO:0005515	protein binding	PMID:16364915^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q96F86	F
	GO:0005515	protein binding	PMID:16364915^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NPI6	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000057815	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026661	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:10330172^[5]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000057815	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026661	C
	GO:0005737	cytoplasm	PMID:10330172^[5]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:9703499^[1]	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000057815	C
	GO:0005829	cytosol	PMID:10751406^[6]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	Reactome:REACT_24978	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_25171	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_25297	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_25366	TAS: Traceable Author Statement		C
	GO:0006402	mRNA catabolic process	PMID:10330172^[5]	IDA: Inferred from Direct Assay		P
	GO:0006402	mRNA catabolic process	PMID:10751406^[6]	IDA: Inferred from Direct Assay		P
	GO:0006402	mRNA catabolic process	PMID:11782475^[2]	IDA: Inferred from Direct Assay		P
	GO:0006402	mRNA catabolic process	PMID:9703499^[1]	TAS: Traceable Author Statement		P
	GO:0007243	intracellular protein kinase cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000057815	P
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000571	F
	GO:0016070	RNA metabolic process	Reactome:REACT_21257	TAS: Traceable Author Statement		P
	GO:0016071	mRNA metabolic process	Reactome:REACT_20605	TAS: Traceable Author Statement		P
	GO:0017091	AU-rich element binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000057815	F
	GO:0017091	AU-rich element binding	PMID:10330172^[5]	IDA: Inferred from Direct Assay		F
	GO:0043488	regulation of mRNA stability	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000057815	P
	GO:0045638	negative regulation of myeloid cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000057815	P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0050728	negative regulation of inflammatory response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000057815	P
	GO:0050779	RNA destabilization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000057815	P
	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	PMID:10330172^[5]	IDA: Inferred from Direct Assay		P
	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000057815	P
	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000057815	P
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000571	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003727	single-stranded RNA binding	PMID:9703499^[1]	TAS: Traceable Author Statement		F
	GO:0003729	mRNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000057815	F
	GO:0003729	mRNA binding	PMID:11782475^[2]	IDA: Inferred from Direct Assay		F
	GO:0005515	protein binding	PMID:15231747^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q96B26	F
	GO:0005515	protein binding	PMID:15231747^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q9HAU5	F
	GO:0005515	protein binding	PMID:16364915^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q8IU60-1	F
	GO:0005515	protein binding	PMID:16364915^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q96F86	F
	GO:0005515	protein binding	PMID:16364915^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NPI6	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000057815	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:10330172^[5]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000057815	C
	GO:0005737	cytoplasm	PMID:10330172^[5]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:9703499^[1]	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000057815	C
	GO:0005829	cytosol	PMID:10751406^[6]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	Reactome:REACT_24978	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_25171	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_25297	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_25366	TAS: Traceable Author Statement		C
	GO:0006402	mRNA catabolic process	PMID:10330172^[5]	IDA: Inferred from Direct Assay		P
	GO:0006402	mRNA catabolic process	PMID:10751406^[6]	IDA: Inferred from Direct Assay		P
	GO:0006402	mRNA catabolic process	PMID:11782475^[2]	IDA: Inferred from Direct Assay		P
	GO:0006402	mRNA catabolic process	PMID:9703499^[1]	TAS: Traceable Author Statement		P
	GO:0007243	intracellular protein kinase cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000057815	P
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000571	F
	GO:0016070	RNA metabolic process	Reactome:REACT_21257	TAS: Traceable Author Statement		P
	GO:0016071	mRNA metabolic process	Reactome:REACT_20605	TAS: Traceable Author Statement		P
	GO:0017091	AU-rich element binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000057815	F
	GO:0017091	AU-rich element binding	PMID:10330172^[5]	IDA: Inferred from Direct Assay		F
	GO:0043488	regulation of mRNA stability	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000057815	P
	GO:0045638	negative regulation of myeloid cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000057815	P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0050728	negative regulation of inflammatory response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000057815	P
	GO:0050779	RNA destabilization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000057815	P
	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	PMID:10330172^[5]	IDA: Inferred from Direct Assay		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Carballo E et al. (1998) Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin. Science 281: 1001-5 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Lai WS et al. (2002) Interactions of CCCH zinc finger proteins with mRNA: non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAs. J Biol Chem 277: 9606-13 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Lehner B & Sanderson CM (2004) A protein interaction framework for human mRNA degradation. Genome Res 14: 1315-23 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Fenger-Grøn M et al. (2005) Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. Mol Cell 20: 905-15 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Lai WS et al. (1999) Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA. Mol Cell Biol 19: 4311-23 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Lai WS et al. (2000) Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA. J Biol Chem 275: 17827-37 PubMed GONUTS page

[PMID:9703499-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Carballo E et al. (1998) Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin. Science 281: 1001-5 PubMed GONUTS page

[PMID:11782475-1] 2.0 ^2.1 ^2.2 ^2.3 Lai WS et al. (2002) Interactions of CCCH zinc finger proteins with mRNA: non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAs. J Biol Chem 277: 9606-13 PubMed GONUTS page

[PMID:15231747-2] 3.0 ^3.1 ^3.2 ^3.3 Lehner B & Sanderson CM (2004) A protein interaction framework for human mRNA degradation. Genome Res 14: 1315-23 PubMed GONUTS page

[PMID:16364915-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Fenger-Grøn M et al. (2005) Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. Mol Cell 20: 905-15 PubMed GONUTS page

[PMID:10330172-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Lai WS et al. (1999) Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA. Mol Cell Biol 19: 4311-23 PubMed GONUTS page

[PMID:10751406-5] 6.0 ^6.1 ^6.2 ^6.3 Lai WS et al. (2000) Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA. J Biol Chem 275: 17827-37 PubMed GONUTS page

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HUMAN:TTP

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