HUMAN:TRPV4

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	TRPV4 ( synonyms: VRL2, VROAC )
Protein Name(s)	Transient receptor potential cation channel subfamily V member 4 TrpV4 Osm-9-like TRP channel 4 OTRPC4 Transient receptor potential protein 12 TRP12 Vanilloid receptor-like channel 2 Vanilloid receptor-like protein 2 VRL-2 Vanilloid receptor-related osmotically-activated channel VR-OAC
External Links
UniProt Identifier	TRPV4_HUMAN
UniProt Accessions	Q9HBA0, B7ZKQ6, Q17R79, Q2Y122, Q2Y123, Q2Y124, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0,
EMBL	AF263523, AF258465, AB100308, AB032427, AB073669, AJ296305, DQ059644, DQ059645, DQ059646, CH471054, BC117426, BC143315, AF279673,
RefSeq	NP_001170899.1, NP_001170902.1, NP_001170904.1, NP_067638.3, NP_671737.1,
IntAct	Q9HBA0,
Ensembl	ENST00000261740,
Pfam	PF00023, PF00520,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004729	C
	GO:0071476	cellular hypotonic response	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EPK8	P
	GO:0003779	actin binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	F
	GO:0030426	growth cone	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	C
	GO:0008219	cell death	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0523	P
	GO:0006816	calcium ion transport	PMID:11025659^[1]	NAS: Non-traceable Author Statement		P
	GO:0055085	transmembrane transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005821	P
	GO:0007231	osmosensory signaling pathway	PMID:12724311^[2]	TAS: Traceable Author Statement		P
	GO:0005262	calcium channel activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	F
	GO:0005080	protein kinase C binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	F
	GO:0019901	protein kinase binding	PMID:12538589^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P07947	F
	GO:0006874	cellular calcium ion homeostasis	PMID:12724311^[2]	IDA: Inferred from Direct Assay		P
	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	P
	GO:0047484	regulation of response to osmotic stress	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	P
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0006816	calcium ion transport	PMID:18458941^[4]	IDA: Inferred from Direct Assay		P
	GO:0006884	cell volume homeostasis	PMID:12724311^[2]	TAS: Traceable Author Statement		P
	GO:0005929	cilium	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	C
	GO:0030054	cell junction	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0965	C
	GO:0030864	cortical actin cytoskeleton	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	C
	GO:0042538	hyperosmotic salinity response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	P
	GO:0007015	actin filament organization	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	P
	GO:0005516	calmodulin binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0112	F
	GO:0006970	response to osmotic stress	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	P
	GO:0008017	microtubule binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	F
	GO:0051015	actin filament binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	F
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0005034	osmosensor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	F
	GO:0006811	ion transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0406	P
	GO:0030103	vasopressin secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	P
	GO:0005912	adherens junction	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EPK8	C
	GO:0005912	adherens junction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	C
	GO:0005262	calcium channel activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0107	F
	GO:0006811	ion transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004729	P
	GO:0005515	protein binding	PMID:16293632^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9HBA0-4	F
	GO:0070588	calcium ion transmembrane transport	PMID:18458941^[4]	IDA: Inferred from Direct Assay		P
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0042802	identical protein binding	PMID:16293632^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9HBA0	F
	GO:0005216	ion channel activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004729	F
	GO:0005216	ion channel activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0407	F
	GO:0005515	protein binding	PMID:16293632^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9HBA0-1	F
	GO:0007231	osmosensory signaling pathway	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EPK8	P
	GO:0009612	response to mechanical stimulus	PMID:15753126^[6]	TAS: Traceable Author Statement		P
	GO:0070509	calcium ion import	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	P
	GO:0005515	protein binding	PMID:16293632^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9HBA0-1	F
	GO:0007204	elevation of cytosolic calcium ion concentration	PMID:18458941^[4]	IDA: Inferred from Direct Assay		P
	GO:0016021	integral to membrane	PMID:11025659^[1]	NAS: Non-traceable Author Statement		C
	GO:0042802	identical protein binding	PMID:16293632^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9HBA0-1	F
	GO:0006811	ion transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005821	P
	GO:0005216	ion channel activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005821	F
	GO:0043622	cortical microtubule organization	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	P
	GO:0030175	filopodium	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	C
	GO:0005912	adherens junction	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0009	C
	GO:0010977	negative regulation of neuron projection development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	P
	GO:0007043	cell-cell junction assembly	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	P
	GO:0005261	cation channel activity	PMID:12724311^[2]	IDA: Inferred from Direct Assay		F
	GO:0007043	cell-cell junction assembly	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EPK8	P
	GO:0030027	lamellipodium	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	C
	GO:0005516	calmodulin binding	PMID:12724311^[2]	IMP: Inferred from Mutant Phenotype		F
	GO:0042169	SH2 domain binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EPK8	F
	GO:0005515	protein binding	PMID:16293632^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9HBA0	F
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EPK8	C
	GO:0006816	calcium ion transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0109	P
	GO:0005262	calcium channel activity	PMID:18458941^[4]	IDA: Inferred from Direct Assay		F
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	C
	GO:0005881	cytoplasmic microtubule	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	C
	GO:0005925	focal adhesion	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	C
	GO:0046785	microtubule polymerization	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	P
	GO:0019901	protein kinase binding	PMID:12538589^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P12931	F
	GO:0019901	protein kinase binding	PMID:12538589^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P07948	F
	GO:0006810	transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P
	GO:0048487	beta-tubulin binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	F
	GO:0031117	positive regulation of microtubule depolymerization	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	P
	GO:0043014	alpha-tubulin binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	F
	GO:0070509	calcium ion import	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EPK8	P
	GO:0007231	osmosensory signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	P
	GO:0005886	plasma membrane	PMID:15753126^[6]	IDA: Inferred from Direct Assay		C
	GO:0032587	ruffle membrane	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005821	C
	GO:0070588	calcium ion transmembrane transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0107	P
	GO:0006971	hypotonic response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	P
	GO:0031513	cilium	PMID:18024594^[7]	IDA: Inferred from Direct Assay		C	Figure 2: They found that TRPV4 is expressed in cholangiocyte cilia	complete
	GO:0003779	actin binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	F
	GO:0005080	protein kinase C binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	F
	GO:0005216	ion channel activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004729	F
	GO:0005216	ion channel activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005821	F
	GO:0005216	ion channel activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0407	F
	GO:0005261	cation channel activity	PMID:12724311^[2]	IDA: Inferred from Direct Assay		F
	GO:0005262	calcium channel activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0107	F
	GO:0005262	calcium channel activity	PMID:18458941^[4]	IDA: Inferred from Direct Assay		F
	GO:0005515	protein binding	PMID:16293632^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9HBA0-1	F
	GO:0005515	protein binding	PMID:16293632^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9HBA0-4	F
	GO:0005516	calmodulin binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0112	F
	GO:0005516	calmodulin binding	PMID:12724311^[2]	IMP: Inferred from Mutant Phenotype		F
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EPK8	C
	GO:0005886	plasma membrane	PMID:15753126^[6]	IDA: Inferred from Direct Assay		C
	GO:0005912	adherens junction	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0009	C
	GO:0005912	adherens junction	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EPK8	C
	GO:0005925	focal adhesion	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	C
	GO:0006810	transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P
	GO:0006811	ion transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004729	P
	GO:0006811	ion transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005821	P
	GO:0006811	ion transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0406	P
	GO:0006816	calcium ion transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0109	P
	GO:0006816	calcium ion transport	PMID:11025659^[1]	NAS: Non-traceable Author Statement		P
	GO:0006816	calcium ion transport	PMID:18458941^[4]	IDA: Inferred from Direct Assay		P
	GO:0006874	cellular calcium ion homeostasis	PMID:12724311^[2]	IDA: Inferred from Direct Assay		P
	GO:0006884	cell volume homeostasis	PMID:12724311^[2]	TAS: Traceable Author Statement		P
	GO:0007015	actin filament organization	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	P
	GO:0007043	cell-cell junction assembly	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EPK8	P
	GO:0007204	elevation of cytosolic calcium ion concentration	PMID:18458941^[4]	IDA: Inferred from Direct Assay		P
	GO:0007231	osmosensory signaling pathway	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EPK8	P
	GO:0007231	osmosensory signaling pathway	PMID:12724311^[2]	TAS: Traceable Author Statement		P
	GO:0008017	microtubule binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	F
	GO:0008219	cell death	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0523	P
	GO:0009612	response to mechanical stimulus	PMID:15753126^[6]	TAS: Traceable Author Statement		P
	GO:0010977	negative regulation of neuron projection development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005821	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004729	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016021	integral to membrane	PMID:11025659^[1]	NAS: Non-traceable Author Statement		C
	GO:0019901	protein kinase binding	PMID:12538589^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P07947	F
	GO:0019901	protein kinase binding	PMID:12538589^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P07948	F
	GO:0019901	protein kinase binding	PMID:12538589^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P12931	F
	GO:0030027	lamellipodium	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	C
	GO:0030054	cell junction	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0965	C
	GO:0030175	filopodium	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	C
	GO:0030426	growth cone	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	C
	GO:0030864	cortical actin cytoskeleton	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	C
	GO:0031117	positive regulation of microtubule depolymerization	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	P
	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	P
	GO:0032587	ruffle membrane	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	C
	GO:0042169	SH2 domain binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EPK8	F
	GO:0043014	alpha-tubulin binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	F
	GO:0043622	cortical microtubule organization	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	P
	GO:0046785	microtubule polymerization	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	P
	GO:0048487	beta-tubulin binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	F
	GO:0051015	actin filament binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	F
	GO:0055085	transmembrane transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005821	P
	GO:0070509	calcium ion import	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EPK8	P
	GO:0070509	calcium ion import	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	P
	GO:0070588	calcium ion transmembrane transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0107	P
	GO:0070588	calcium ion transmembrane transport	PMID:18458941^[4]	IDA: Inferred from Direct Assay		P
	GO:0071476	cellular hypotonic response	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EPK8	P
colocalizes_with	GO:0005881	cytoplasmic microtubule	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9ERZ8	C
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Strotmann R et al. (2000) OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol 2: 695-702 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Strotmann R et al. (2003) Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site. J Biol Chem 278: 26541-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Xu H et al. (2003) Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. J Biol Chem 278: 11520-7 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Fernández-Fernández JM et al. (2008) Functional coupling of TRPV4 cationic channel and large conductance, calcium-dependent potassium channel in human bronchial epithelial cell lines. Pflugers Arch 457: 149-59 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Arniges M et al. (2006) Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking. J Biol Chem 281: 1580-6 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Andrade YN et al. (2005) TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity. J Cell Biol 168: 869-74 PubMed GONUTS page
↑ Gradilone SA et al. (2007) Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion. Proc Natl Acad Sci U S A 104: 19138-43 PubMed GONUTS page

[PMID:11025659-0] 1.0 ^1.1 ^1.2 ^1.3 Strotmann R et al. (2000) OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol 2: 695-702 PubMed GONUTS page

[PMID:12724311-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Strotmann R et al. (2003) Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site. J Biol Chem 278: 26541-9 PubMed GONUTS page

[PMID:12538589-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Xu H et al. (2003) Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. J Biol Chem 278: 11520-7 PubMed GONUTS page

[PMID:18458941-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Fernández-Fernández JM et al. (2008) Functional coupling of TRPV4 cationic channel and large conductance, calcium-dependent potassium channel in human bronchial epithelial cell lines. Pflugers Arch 457: 149-59 PubMed GONUTS page

[PMID:16293632-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Arniges M et al. (2006) Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking. J Biol Chem 281: 1580-6 PubMed GONUTS page

[PMID:15753126-5] 6.0 ^6.1 ^6.2 ^6.3 Andrade YN et al. (2005) TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity. J Cell Biol 168: 869-74 PubMed GONUTS page

[PMID:18024594-6] Gradilone SA et al. (2007) Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion. Proc Natl Acad Sci U S A 104: 19138-43 PubMed GONUTS page

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HUMAN:TRPV4

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