HUMAN:TRAF6

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	TRAF6 ( synonyms: RNF85 )
Protein Name(s)	TNF receptor-associated factor 6 E3 ubiquitin-protein ligase TRAF6 Interleukin-1 signal transducer RING finger protein 85
External Links
UniProt Identifier	TRAF6_HUMAN
UniProt Accessions	Q9Y4K3, A6NKI7, A8KAB3, D3DR16, Q8NEH5,
EMBL	U78798, AY228337, AK292978, AC009656, AC061999, CH471064, CH471064, CH471064, BC031052,
PIR	S71821,
RefSeq	NP_004611.1, NP_665802.1,
PDB	1LB4, 1LB5, 1LB6, 2ECI, 2JMD, 3HCS, 3HCT, 3HCU,
IntAct	Q9Y4K3,
Ensembl	ENST00000313105, ENST00000348124,
Pfam	PF00917, PF00097,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0005938	cell cortex		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0005829	cytosol		EXP: Inferred from Experiment		C	Source: Reactome
	GO:0010008	endosome membrane		EXP: Inferred from Experiment		C	Source: Reactome
	GO:0005634	nucleus		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0005886	plasma membrane		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0042826	histone deacetylase binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0031435	mitogen-activated protein kinase kinase kin...		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0043422	protein kinase B binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0047485	protein N-terminus binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0016564	transcription repressor activity		IMP: Inferred from Mutant Phenotype		F	Source: UniProtKB
	GO:0004842	ubiquitin-protein ligase activity		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0008270	zinc ion binding		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0007250	activation of NF-kappaB-inducing kinase act...		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0006916	anti-apoptosis		EXP: Inferred from Experiment		P	Source: Reactome
	GO:0006915	apoptosis		EXP: Inferred from Experiment		P	Source: Reactome
	GO:0008624	induction of apoptosis by extracellular sig...		EXP: Inferred from Experiment		P	Source: Reactome
	GO:0031293	membrane protein intracellular domain prote...		EXP: Inferred from Experiment		P	Source: Reactome
	GO:0000122	negative regulation of transcription from R...		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0001503	ossification		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0043123	positive regulation of I-kappaB kinase/NF-k...		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0032743	positive regulation of interleukin-2 produc...		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0043507	positive regulation of JUN kinase activity		NAS: Non-traceable Author Statement		P	Source: UniProtKB
	GO:0051092	positive regulation of NF-kappaB transcript...		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0045672	positive regulation of osteoclast different...		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0002726	positive regulation of T cell cytokine prod...		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0051865	protein autoubiquitination		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0070534	protein K63-linked ubiquitination		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0000209	protein polyubiquitination		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0070555	response to interleukin-1		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0050852	T cell receptor signaling pathway		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:18093978^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0000187	activation of MAPK activity	Reactome:REACT_21399	TAS: Traceable Author Statement		P
	GO:0000209	protein polyubiquitination	PMID:15125833^[2]	IDA: Inferred from Direct Assay		P
	GO:0000209	protein polyubiquitination	PMID:19675569^[3]	IDA: Inferred from Direct Assay		P
	GO:0001503	ossification	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0892	P
	GO:0002218	activation of innate immune response	Reactome:REACT_75913	TAS: Traceable Author Statement		P
	GO:0002224	toll-like receptor signaling pathway	Reactome:REACT_8006	TAS: Traceable Author Statement		P
	GO:0002726	positive regulation of T cell cytokine production	PMID:15125833^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Reactome:REACT_27215	TAS: Traceable Author Statement		P
	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Reactome:REACT_6788	TAS: Traceable Author Statement		P
	GO:0002756	MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6782	TAS: Traceable Author Statement		P
	GO:0002756	MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809	TAS: Traceable Author Statement		P
	GO:0002756	MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6976	TAS: Traceable Author Statement		P
	GO:0004842	ubiquitin-protein ligase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013323	F
	GO:0004842	ubiquitin-protein ligase activity	PMID:15125833^[2]	IDA: Inferred from Direct Assay		F
	GO:0004842	ubiquitin-protein ligase activity	PMID:17135271^[4]	IDA: Inferred from Direct Assay		F
	GO:0004842	ubiquitin-protein ligase activity	PMID:19713527^[5]	IDA: Inferred from Direct Assay		F
	GO:0004842	ubiquitin-protein ligase activity	Reactome:REACT_12595	TAS: Traceable Author Statement		F
	GO:0004842	ubiquitin-protein ligase activity	Reactome:REACT_22430	TAS: Traceable Author Statement		F
	GO:0004842	ubiquitin-protein ligase activity	Reactome:REACT_25090	EXP: Inferred from Experiment		F
	GO:0005515	protein binding	PMID:10075662^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y6Q6	F
	GO:0005515	protein binding	PMID:10094049^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q15750	F
	GO:0005515	protein binding	PMID:10383454^[8]	IPI: Inferred from Physical Interaction	UniProtKB:O43187	F
	GO:0005515	protein binding	PMID:10383454^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y616	F
	GO:0005515	protein binding	PMID:10465784^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q9QZH6	F
	GO:0005515	protein binding	PMID:10514511^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P07174	F
	GO:0005515	protein binding	PMID:10920205^[11]	IPI: Inferred from Physical Interaction	UniProtKB:Q86VP1	F
	GO:0005515	protein binding	PMID:11244088^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P37198	F
	GO:0005515	protein binding	PMID:11397809^[13]	IPI: Inferred from Physical Interaction	UniProtKB:P51617	F
	GO:0005515	protein binding	PMID:11463333^[14]	IPI: Inferred from Physical Interaction	UniProtKB:P21580	F
	GO:0005515	protein binding	PMID:11463333^[14]	IPI: Inferred from Physical Interaction	UniProtKB:P21580	F
	GO:0005515	protein binding	PMID:11463333^[14]	IPI: Inferred from Physical Interaction	UniProtKB:Q6GQQ9	F
	GO:0005515	protein binding	PMID:11463333^[14]	IPI: Inferred from Physical Interaction	UniProtKB:Q6GQQ9	F
	GO:0005515	protein binding	PMID:11463333^[14]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UGI0	F
	GO:0005515	protein binding	PMID:11463333^[14]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UGI0	F
	GO:0005515	protein binding	PMID:11518704^[15]	IPI: Inferred from Physical Interaction	UniProtKB:P51617	F
	GO:0005515	protein binding	PMID:11751921^[16]	IPI: Inferred from Physical Interaction	UniProtKB:Q8TD23	F
	GO:0005515	protein binding	PMID:11751921^[16]	IPI: Inferred from Physical Interaction	UniProtKB:Q8TD23	F
	GO:0005515	protein binding	PMID:12140561^[17]	IPI: Inferred from Physical Interaction	UniProtKB:P25942	F
	GO:0005515	protein binding	PMID:12270937^[18]	IPI: Inferred from Physical Interaction	UniProtKB:Q9HAV5	F
	GO:0005515	protein binding	PMID:12721283^[19]	IPI: Inferred from Physical Interaction	UniProtKB:Q86XR7	F
	GO:0005515	protein binding	PMID:12874243^[20]	IPI: Inferred from Physical Interaction	UniProtKB:Q8N2H9-1	F
	GO:0005515	protein binding	PMID:12874243^[20]	IPI: Inferred from Physical Interaction	UniProtKB:Q8N2H9-2	F
	GO:0005515	protein binding	PMID:12925853^[21]	IPI: Inferred from Physical Interaction	UniProtKB:Q6IA17	F
	GO:0005515	protein binding	PMID:14982987^[22]	IPI: Inferred from Physical Interaction	UniProtKB:Q8IUC6	F
	GO:0005515	protein binding	PMID:15125833^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UDY8	F
	GO:0005515	protein binding	PMID:15280356^[23]	IPI: Inferred from Physical Interaction	UniProtKB:Q9HAV5	F
	GO:0005515	protein binding	PMID:15998638^[24]	IPI: Inferred from Physical Interaction	UniProtKB:Q01220	F
	GO:0005515	protein binding	PMID:16221674^[25]	IPI: Inferred from Physical Interaction	UniProtKB:O14545	F
	GO:0005515	protein binding	PMID:16286016^[26]	IPI: Inferred from Physical Interaction	UniProtKB:Q01638	F
	GO:0005515	protein binding	PMID:16286467^[27]	IPI: Inferred from Physical Interaction	UniProtKB:P14778	F
	GO:0005515	protein binding	PMID:16286467^[27]	IPI: Inferred from Physical Interaction	UniProtKB:Q99558	F
	GO:0005515	protein binding	PMID:16378096^[28]	IPI: Inferred from Physical Interaction	UniProtKB:P32121	F
	GO:0005515	protein binding	PMID:16378096^[28]	IPI: Inferred from Physical Interaction	UniProtKB:P49407	F
	GO:0005515	protein binding	PMID:16378096^[28]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y4K3	F
	GO:0005515	protein binding	PMID:17353931^[29]	IPI: Inferred from Physical Interaction	UniProtKB:O15067	F
	GO:0005515	protein binding	PMID:17353931^[29]	IPI: Inferred from Physical Interaction	UniProtKB:O60573	F
	GO:0005515	protein binding	PMID:17353931^[29]	IPI: Inferred from Physical Interaction	UniProtKB:P11586	F
	GO:0005515	protein binding	PMID:17353931^[29]	IPI: Inferred from Physical Interaction	UniProtKB:P17812	F
	GO:0005515	protein binding	PMID:17353931^[29]	IPI: Inferred from Physical Interaction	UniProtKB:P21796	F
	GO:0005515	protein binding	PMID:17353931^[29]	IPI: Inferred from Physical Interaction	UniProtKB:P22234	F
	GO:0005515	protein binding	PMID:17353931^[29]	IPI: Inferred from Physical Interaction	UniProtKB:P26639	F
	GO:0005515	protein binding	PMID:17353931^[29]	IPI: Inferred from Physical Interaction	UniProtKB:P26640	F
	GO:0005515	protein binding	PMID:17353931^[29]	IPI: Inferred from Physical Interaction	UniProtKB:P33993	F
	GO:0005515	protein binding	PMID:17353931^[29]	IPI: Inferred from Physical Interaction	UniProtKB:P49321	F
	GO:0005515	protein binding	PMID:17353931^[29]	IPI: Inferred from Physical Interaction	UniProtKB:P55072	F
	GO:0005515	protein binding	PMID:17353931^[29]	IPI: Inferred from Physical Interaction	UniProtKB:P58107	F
	GO:0005515	protein binding	PMID:17353931^[29]	IPI: Inferred from Physical Interaction	UniProtKB:Q14697	F
	GO:0005515	protein binding	PMID:17353931^[29]	IPI: Inferred from Physical Interaction	UniProtKB:Q76L83	F
	GO:0005515	protein binding	PMID:17353931^[29]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UDY2	F
	GO:0005515	protein binding	PMID:17449468^[30]	IPI: Inferred from Physical Interaction	UniProtKB:Q9BYM8	F
	GO:0005515	protein binding	PMID:18093978^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P10242	F
	GO:0005515	protein binding	PMID:18093978^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P46060	F
	GO:0005515	protein binding	PMID:19549727^[31]	IPI: Inferred from Physical Interaction	UniProtKB:P51668	F
	GO:0005515	protein binding	PMID:19549727^[31]	IPI: Inferred from Physical Interaction	UniProtKB:P51965	F
	GO:0005515	protein binding	PMID:19549727^[31]	IPI: Inferred from Physical Interaction	UniProtKB:P61077	F
	GO:0005515	protein binding	PMID:19549727^[31]	IPI: Inferred from Physical Interaction	UniProtKB:P61088	F
	GO:0005515	protein binding	PMID:19549727^[31]	IPI: Inferred from Physical Interaction	UniProtKB:P62837	F
	GO:0005515	protein binding	PMID:19879840^[32]	IPI: Inferred from Physical Interaction	UniProtKB:P49407	F
	GO:0005515	protein binding	PMID:20079715^[33]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y6R0	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:18029348^[34]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:18093978^[1]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	PMID:16378096^[28]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:18029348^[34]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:18093978^[1]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	Reactome:REACT_12448	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_12518	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_12553	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_12581	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_12595	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_13439	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_13446	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_13488	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_13502	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_13512	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_13584	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_13586	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_13710	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_13726	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_13753	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_13754	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_13785	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_21338	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_21367	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_22171	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_22176	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_22209	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_22311	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_22322	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_22324	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_22416	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_22430	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_24935	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_24943	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_24952	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_24960	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_24986	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_25079	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_25119	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_25150	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_25183	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_25262	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_25305	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_25308	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_25327	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_27141	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6789	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6856	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6935	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6962	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6973	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_75924	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	PMID:18093978^[1]	IDA: Inferred from Direct Assay		C
	GO:0005886	plasma membrane	Reactome:REACT_24943	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_24952	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_24985	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_25022	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_25119	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_25142	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_25183	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_25200	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_25261	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_25288	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_25318	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_25362	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_25375	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_27141	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_27177	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_6736	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_6856	TAS: Traceable Author Statement		C
	GO:0005938	cell cortex	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0138	C
	GO:0006915	apoptosis	Reactome:REACT_13643	TAS: Traceable Author Statement		P
	GO:0006916	anti-apoptosis	Reactome:REACT_13537	TAS: Traceable Author Statement		P
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012227	P
	GO:0007249	I-kappaB kinase/NF-kappaB cascade	Reactome:REACT_25351	TAS: Traceable Author Statement		P
	GO:0007250	activation of NF-kappaB-inducing kinase activity	PMID:15125833^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0007254	JNK cascade	Reactome:REACT_21368	TAS: Traceable Author Statement		P
	GO:0008063	Toll signaling pathway	Reactome:REACT_6894	TAS: Traceable Author Statement		P
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001293	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001841	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012227	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013323	F
	GO:0008624	induction of apoptosis by extracellular signals	Reactome:REACT_13720	TAS: Traceable Author Statement		P
	GO:0009898	internal side of plasma membrane	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P70196	C
	GO:0010008	endosome membrane	Reactome:REACT_21364	TAS: Traceable Author Statement		C
	GO:0010008	endosome membrane	Reactome:REACT_21381	TAS: Traceable Author Statement		C
	GO:0010008	endosome membrane	Reactome:REACT_22324	TAS: Traceable Author Statement		C
	GO:0010008	endosome membrane	Reactome:REACT_24960	TAS: Traceable Author Statement		C
	GO:0010008	endosome membrane	Reactome:REACT_24976	TAS: Traceable Author Statement		C
	GO:0010008	endosome membrane	Reactome:REACT_24996	TAS: Traceable Author Statement		C
	GO:0010008	endosome membrane	Reactome:REACT_25001	TAS: Traceable Author Statement		C
	GO:0010008	endosome membrane	Reactome:REACT_25023	TAS: Traceable Author Statement		C
	GO:0010008	endosome membrane	Reactome:REACT_25072	TAS: Traceable Author Statement		C
	GO:0010008	endosome membrane	Reactome:REACT_25090	TAS: Traceable Author Statement		C
	GO:0010008	endosome membrane	Reactome:REACT_25111	TAS: Traceable Author Statement		C
	GO:0010008	endosome membrane	Reactome:REACT_25150	TAS: Traceable Author Statement		C
	GO:0010008	endosome membrane	Reactome:REACT_25241	TAS: Traceable Author Statement		C
	GO:0010008	endosome membrane	Reactome:REACT_25251	TAS: Traceable Author Statement		C
	GO:0010008	endosome membrane	Reactome:REACT_25312	TAS: Traceable Author Statement		C
	GO:0010008	endosome membrane	Reactome:REACT_25322	TAS: Traceable Author Statement		C
	GO:0010008	endosome membrane	Reactome:REACT_6730	TAS: Traceable Author Statement		C
	GO:0010008	endosome membrane	Reactome:REACT_6789	TAS: Traceable Author Statement		C
	GO:0010008	endosome membrane	Reactome:REACT_6921	TAS: Traceable Author Statement		C
	GO:0016567	protein ubiquitination	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013323	P
	GO:0016567	protein ubiquitination	Reactome:REACT_25090	EXP: Inferred from Experiment		P
	GO:0016874	ligase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0436	F
	GO:0019901	protein kinase binding	PMID:19713527^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P31749	F
	GO:0019901	protein kinase binding	PMID:19713527^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P31751	F
	GO:0031293	membrane protein intracellular domain proteolysis	Reactome:REACT_13443	TAS: Traceable Author Statement		P
	GO:0031435	mitogen-activated protein kinase kinase kinase binding	PMID:10094049^[7]	IPI: Inferred from Physical Interaction	UniProtKB:O43318	F
	GO:0031965	nuclear membrane	PMID:18029348^[34]	IDA: Inferred from Direct Assay		C
	GO:0032147	activation of protein kinase activity	PMID:17135271^[4]	IDA: Inferred from Direct Assay		P
	GO:0032743	positive regulation of interleukin-2 production	PMID:15125833^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0034130	toll-like receptor 1 signaling pathway	Reactome:REACT_8005	TAS: Traceable Author Statement		P
	GO:0034134	toll-like receptor 2 signaling pathway	Reactome:REACT_7980	TAS: Traceable Author Statement		P
	GO:0034138	toll-like receptor 3 signaling pathway	Reactome:REACT_6783	TAS: Traceable Author Statement		P
	GO:0034142	toll-like receptor 4 signaling pathway	Reactome:REACT_6890	TAS: Traceable Author Statement		P
	GO:0035631	CD40 receptor complex	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P70196	C
	GO:0042826	histone deacetylase binding	PMID:18093978^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q13547	F
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012227	P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	PMID:12761501^[35]	IEP: Inferred from Expression Pattern		P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	PMID:17135271^[4]	IDA: Inferred from Direct Assay		P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Reactome:REACT_24918	TAS: Traceable Author Statement		P
	GO:0043422	protein kinase B binding	PMID:19713527^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y243	F
	GO:0043507	positive regulation of JUN kinase activity	PMID:11751921^[16]	IDA: Inferred from Direct Assay		P
	GO:0043507	positive regulation of JUN kinase activity	PMID:17135271^[4]	NAS: Non-traceable Author Statement		P
	GO:0045087	innate immune response	Reactome:REACT_6802	TAS: Traceable Author Statement		P
	GO:0045672	positive regulation of osteoclast differentiation	PMID:17135271^[4]	IDA: Inferred from Direct Assay		P
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:18093978^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:11751921^[16]	IDA: Inferred from Direct Assay		P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0047485	protein N-terminus binding	PMID:14530355^[36]	IPI: Inferred from Physical Interaction	UniProtKB:Q8IUC6	F
	GO:0048011	nerve growth factor receptor signaling pathway	Reactome:REACT_11061	TAS: Traceable Author Statement		P
	GO:0048011	nerve growth factor receptor signaling pathway	Reactome:REACT_13776	TAS: Traceable Author Statement		P
	GO:0048471	perinuclear region of cytoplasm	PMID:11751921^[16]	IDA: Inferred from Direct Assay		C
	GO:0050852	T cell receptor signaling pathway	PMID:15125833^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0050852	T cell receptor signaling pathway	Reactome:REACT_12526	TAS: Traceable Author Statement		P
	GO:0050870	positive regulation of T cell activation	PMID:15125833^[2]	IC: Inferred by Curator	GO:0001819	P
	GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	PMID:12296995^[37]	IMP: Inferred from Mutant Phenotype		P
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:11751921^[16]	IDA: Inferred from Direct Assay		P
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:12296995^[37]	IMP: Inferred from Mutant Phenotype		P
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:16378096^[28]	IDA: Inferred from Direct Assay		P
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Reactome:REACT_21281	TAS: Traceable Author Statement		P
	GO:0051403	stress-activated MAPK cascade	Reactome:REACT_21308	TAS: Traceable Author Statement		P
	GO:0051865	protein autoubiquitination	PMID:16378096^[28]	TAS: Traceable Author Statement		P
	GO:0051865	protein autoubiquitination	PMID:17135271^[4]	IDA: Inferred from Direct Assay		P
	GO:0051865	protein autoubiquitination	PMID:18093978^[1]	IDA: Inferred from Direct Assay		P
	GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	Reactome:REACT_75776	TAS: Traceable Author Statement		P
	GO:0070534	protein K63-linked ubiquitination	PMID:17135271^[4]	IGI: Inferred from Genetic Interaction	UniProtKB:P0CG47	P
	GO:0070534	protein K63-linked ubiquitination	PMID:19675569^[3]	IGI: Inferred from Genetic Interaction	UniProtKB:P0CG47	P
	GO:0070534	protein K63-linked ubiquitination	PMID:19713527^[5]	IDA: Inferred from Direct Assay		P
	GO:0070555	response to interleukin-1	PMID:17135271^[4]	IDA: Inferred from Direct Assay		P
	GO:2000679	positive regulation of transcription regulatory region DNA binding	PMID:11751921^[16]	IDA: Inferred from Direct Assay		P
NOT	GO:0005730	nucleolus	PMID:18029348^[34]	IDA: Inferred from Direct Assay		C
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Pham LV et al. (2008) Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification. J Biol Chem 283: 5081-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Sun L et al. (2004) The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol Cell 14: 289-301 PubMed GONUTS page
↑ ^3.0 ^3.1 Xia ZP et al. (2009) Direct activation of protein kinases by unanchored polyubiquitin chains. Nature 461: 114-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Lamothe B et al. (2007) Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation. J Biol Chem 282: 4102-12 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Yang WL et al. (2009) The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science 325: 1134-8 PubMed GONUTS page
↑ Darnay BG et al. (1999) Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif. J Biol Chem 274: 7724-31 PubMed GONUTS page
↑ ^7.0 ^7.1 Ninomiya-Tsuji J et al. (1999) The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature 398: 252-6 PubMed GONUTS page
↑ ^8.0 ^8.1 Wesche H et al. (1999) IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem 274: 19403-10 PubMed GONUTS page
↑ Kopp E et al. (1999) ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes Dev 13: 2059-71 PubMed GONUTS page
↑ Ye X et al. (1999) TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. J Biol Chem 274: 30202-8 PubMed GONUTS page
↑ Ling L & Goeddel DV (2000) T6BP, a TRAF6-interacting protein involved in IL-1 signaling. Proc Natl Acad Sci U S A 97: 9567-72 PubMed GONUTS page
↑ Wooten MW et al. (2001) The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor. J Biol Chem 276: 7709-12 PubMed GONUTS page
↑ Jensen LE & Whitehead AS (2001) IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability. J Biol Chem 276: 29037-44 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Evans PC et al. (2001) Isolation and characterization of two novel A20-like proteins. Biochem J 357: 617-23 PubMed GONUTS page
↑ Qian Y et al. (2001) IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B. J Biol Chem 276: 41661-7 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 Shin JN et al. (2002) A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6. J Biol Chem 277: 8346-53 PubMed GONUTS page
↑ Ye H et al. (2002) Distinct molecular mechanism for initiating TRAF6 signalling. Nature 418: 443-7 PubMed GONUTS page
↑ Sinha SK et al. (2002) Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor. J Biol Chem 277: 44953-61 PubMed GONUTS page
↑ Bin LH et al. (2003) TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. J Biol Chem 278: 24526-32 PubMed GONUTS page
↑ ^20.0 ^20.1 Jensen LE & Whitehead AS (2003) Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein. J Immunol 171: 1500-6 PubMed GONUTS page
↑ Wald D et al. (2003) SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol 4: 920-7 PubMed GONUTS page
↑ Jiang Z et al. (2004) Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. Proc Natl Acad Sci U S A 101: 3533-8 PubMed GONUTS page
↑ Sinha SK & Chaudhary PM (2004) Induction of apoptosis by X-linked ectodermal dysplasia receptor via a caspase 8-dependent mechanism. J Biol Chem 279: 41873-81 PubMed GONUTS page
↑ Maloney G et al. (2005) Vaccinia virus protein A52R activates p38 mitogen-activated protein kinase and potentiates lipopolysaccharide-induced interleukin-10. J Biol Chem 280: 30838-44 PubMed GONUTS page
↑ Mashima R et al. (2005) FLN29, a novel interferon- and LPS-inducible gene acting as a negative regulator of toll-like receptor signaling. J Biol Chem 280: 41289-97 PubMed GONUTS page
↑ Schmitz J et al. (2005) IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 23: 479-90 PubMed GONUTS page
↑ ^27.0 ^27.1 Li Q & Engelhardt JF (2006) Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase. J Biol Chem 281: 1495-505 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 ^28.3 ^28.4 ^28.5 Wang Y et al. (2006) Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol 7: 139-47 PubMed GONUTS page
↑ ^29.00 ^29.01 ^29.02 ^29.03 ^29.04 ^29.05 ^29.06 ^29.07 ^29.08 ^29.09 ^29.10 ^29.11 ^29.12 ^29.13 ^29.14 Ewing RM et al. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol 3: 89 PubMed GONUTS page
↑ Tian Y et al. (2007) RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. J Biol Chem 282: 16776-82 PubMed GONUTS page
↑ ^31.0 ^31.1 ^31.2 ^31.3 ^31.4 Markson G et al. (2009) Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. Genome Res 19: 1905-11 PubMed GONUTS page
↑ Yue R et al. (2009) Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression. Cell 139: 535-46 PubMed GONUTS page
↑ Zhou L et al. (2010) NUMBL interacts with TRAF6 and promotes the degradation of TRAF6. Biochem Biophys Res Commun 392: 409-14 PubMed GONUTS page
↑ ^34.0 ^34.1 ^34.2 ^34.3 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
↑ Matsuda A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22: 3307-18 PubMed GONUTS page
↑ Sato S et al. (2003) Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. J Immunol 171: 4304-10 PubMed GONUTS page
↑ ^37.0 ^37.1 Lee SW et al. (2002) TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB. J Biochem Mol Biol 35: 371-6 PubMed GONUTS page

[PMID:18093978-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Pham LV et al. (2008) Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification. J Biol Chem 283: 5081-9 PubMed GONUTS page

[PMID:15125833-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Sun L et al. (2004) The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol Cell 14: 289-301 PubMed GONUTS page

[PMID:19675569-2] 3.0 ^3.1 Xia ZP et al. (2009) Direct activation of protein kinases by unanchored polyubiquitin chains. Nature 461: 114-9 PubMed GONUTS page

[PMID:17135271-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Lamothe B et al. (2007) Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation. J Biol Chem 282: 4102-12 PubMed GONUTS page

[PMID:19713527-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Yang WL et al. (2009) The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science 325: 1134-8 PubMed GONUTS page

[PMID:10075662-5] Darnay BG et al. (1999) Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif. J Biol Chem 274: 7724-31 PubMed GONUTS page

[PMID:10094049-6] 7.0 ^7.1 Ninomiya-Tsuji J et al. (1999) The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature 398: 252-6 PubMed GONUTS page

[PMID:10383454-7] 8.0 ^8.1 Wesche H et al. (1999) IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem 274: 19403-10 PubMed GONUTS page

[PMID:10465784-8] Kopp E et al. (1999) ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes Dev 13: 2059-71 PubMed GONUTS page

[PMID:10514511-9] Ye X et al. (1999) TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. J Biol Chem 274: 30202-8 PubMed GONUTS page

[PMID:10920205-10] Ling L & Goeddel DV (2000) T6BP, a TRAF6-interacting protein involved in IL-1 signaling. Proc Natl Acad Sci U S A 97: 9567-72 PubMed GONUTS page

[PMID:11244088-11] Wooten MW et al. (2001) The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor. J Biol Chem 276: 7709-12 PubMed GONUTS page

[PMID:11397809-12] Jensen LE & Whitehead AS (2001) IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability. J Biol Chem 276: 29037-44 PubMed GONUTS page

[PMID:11463333-13] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Evans PC et al. (2001) Isolation and characterization of two novel A20-like proteins. Biochem J 357: 617-23 PubMed GONUTS page

[PMID:11518704-14] Qian Y et al. (2001) IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B. J Biol Chem 276: 41661-7 PubMed GONUTS page

[PMID:11751921-15] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 Shin JN et al. (2002) A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6. J Biol Chem 277: 8346-53 PubMed GONUTS page

[PMID:12140561-16] Ye H et al. (2002) Distinct molecular mechanism for initiating TRAF6 signalling. Nature 418: 443-7 PubMed GONUTS page

[PMID:12270937-17] Sinha SK et al. (2002) Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor. J Biol Chem 277: 44953-61 PubMed GONUTS page

[PMID:12721283-18] Bin LH et al. (2003) TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. J Biol Chem 278: 24526-32 PubMed GONUTS page

[PMID:12874243-19] 20.0 ^20.1 Jensen LE & Whitehead AS (2003) Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein. J Immunol 171: 1500-6 PubMed GONUTS page

[PMID:12925853-20] Wald D et al. (2003) SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol 4: 920-7 PubMed GONUTS page

[PMID:14982987-21] Jiang Z et al. (2004) Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. Proc Natl Acad Sci U S A 101: 3533-8 PubMed GONUTS page

[PMID:15280356-22] Sinha SK & Chaudhary PM (2004) Induction of apoptosis by X-linked ectodermal dysplasia receptor via a caspase 8-dependent mechanism. J Biol Chem 279: 41873-81 PubMed GONUTS page

[PMID:15998638-23] Maloney G et al. (2005) Vaccinia virus protein A52R activates p38 mitogen-activated protein kinase and potentiates lipopolysaccharide-induced interleukin-10. J Biol Chem 280: 30838-44 PubMed GONUTS page

[PMID:16221674-24] Mashima R et al. (2005) FLN29, a novel interferon- and LPS-inducible gene acting as a negative regulator of toll-like receptor signaling. J Biol Chem 280: 41289-97 PubMed GONUTS page

[PMID:16286016-25] Schmitz J et al. (2005) IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 23: 479-90 PubMed GONUTS page

[PMID:16286467-26] 27.0 ^27.1 Li Q & Engelhardt JF (2006) Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase. J Biol Chem 281: 1495-505 PubMed GONUTS page

[PMID:16378096-27] 28.0 ^28.1 ^28.2 ^28.3 ^28.4 ^28.5 Wang Y et al. (2006) Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol 7: 139-47 PubMed GONUTS page

[PMID:17353931-28] 29.00 ^29.01 ^29.02 ^29.03 ^29.04 ^29.05 ^29.06 ^29.07 ^29.08 ^29.09 ^29.10 ^29.11 ^29.12 ^29.13 ^29.14 Ewing RM et al. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol 3: 89 PubMed GONUTS page

[PMID:17449468-29] Tian Y et al. (2007) RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. J Biol Chem 282: 16776-82 PubMed GONUTS page

[PMID:19549727-30] 31.0 ^31.1 ^31.2 ^31.3 ^31.4 Markson G et al. (2009) Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. Genome Res 19: 1905-11 PubMed GONUTS page

[PMID:19879840-31] Yue R et al. (2009) Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression. Cell 139: 535-46 PubMed GONUTS page

[PMID:20079715-32] Zhou L et al. (2010) NUMBL interacts with TRAF6 and promotes the degradation of TRAF6. Biochem Biophys Res Commun 392: 409-14 PubMed GONUTS page

[PMID:18029348-33] 34.0 ^34.1 ^34.2 ^34.3 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page

[PMID:12761501-34] Matsuda A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22: 3307-18 PubMed GONUTS page

[PMID:14530355-35] Sato S et al. (2003) Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. J Immunol 171: 4304-10 PubMed GONUTS page

[PMID:12296995-36] 37.0 ^37.1 Lee SW et al. (2002) TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB. J Biochem Mol Biol 35: 371-6 PubMed GONUTS page

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