HUMAN:TPPP

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	TPPP ( synonyms: TPPP1 )
Protein Name(s)	Tubulin polymerization-promoting protein TPPP 25 kDa brain-specific protein TPPP/p25 p24 p25-alpha
External Links
UniProt Identifier	TPPP_HUMAN
UniProt Accessions	O94811,
EMBL	AB017016, BT020035, BC040496,
RefSeq	NP_008961.1,
Ensembl	ENST00000360578,
Pfam	PF05517,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0015631	tubulin binding	PMID:17105200^[1]	IDA: Inferred from Direct Assay		F
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000022057	C
	GO:0005856	cytoskeleton	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0206	C
	GO:0008017	microtubule binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q27957	F
	GO:0005737	cytoplasm	PMID:18028908^[2]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000022057	C
	GO:0046785	microtubule polymerization	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q27957	P
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0015631	tubulin binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q27957	F
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005515	protein binding	PMID:15590652^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P37840	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005856	cytoskeleton	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0090	C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0001578	microtubule bundle formation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q27957	P
	GO:0032273	positive regulation of protein polymerization	PMID:15590652^[3]	IDA: Inferred from Direct Assay		P
	GO:0005625	soluble fraction	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q27957	C
	GO:0005874	microtubule	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000022057	C
	GO:0005634	nucleus	PMID:18028908^[2]	IDA: Inferred from Direct Assay		C
	GO:0046785	microtubule polymerization	PMID:18028908^[2]	IDA: Inferred from Direct Assay		P
	GO:0001578	microtubule bundle formation	PMID:17105200^[1]	IDA: Inferred from Direct Assay		P
	GO:0005515	protein binding	PMID:18028908^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P53667	F
	GO:0031334	positive regulation of protein complex assembly	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q27957	P
	GO:0048471	perinuclear region of cytoplasm	PMID:15590652^[3]	IDA: Inferred from Direct Assay		C
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011992	F
	GO:0005874	microtubule	PMID:18028908^[2]	IDA: Inferred from Direct Assay		C
	GO:0048714	regulation of oligodendrocyte differentiation	PMID:19606501^[4]	IDA: Inferred from Direct Assay		P	Fig. 5A. More oligodendrocytes were differentiated when TPPP/p25 was increases	complete
	GO:0001578	microtubule bundle formation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q27957	P
	GO:0001578	microtubule bundle formation	PMID:17105200^[1]	IDA: Inferred from Direct Assay		P
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011992	F
	GO:0005515	protein binding	PMID:15590652^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P37840	F
	GO:0005515	protein binding	PMID:18028908^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P53667	F
	GO:0005625	soluble fraction	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q27957	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000022057	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:18028908^[2]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000022057	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	PMID:18028908^[2]	IDA: Inferred from Direct Assay		C
	GO:0005856	cytoskeleton	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0206	C
	GO:0005856	cytoskeleton	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0090	C
	GO:0005874	microtubule	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000022057	C
	GO:0008017	microtubule binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q27957	F
	GO:0015631	tubulin binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q27957	F
	GO:0015631	tubulin binding	PMID:17105200^[1]	IDA: Inferred from Direct Assay		F
	GO:0031334	positive regulation of protein complex assembly	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q27957	P
	GO:0032273	positive regulation of protein polymerization	PMID:15590652^[3]	IDA: Inferred from Direct Assay		P
	GO:0046785	microtubule polymerization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000022057	P
	GO:0046785	microtubule polymerization	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q27957	P
	GO:0046785	microtubule polymerization	PMID:18028908^[2]	IDA: Inferred from Direct Assay		P
	GO:0048471	perinuclear region of cytoplasm	PMID:15590652^[3]	IDA: Inferred from Direct Assay		C
colocalizes_with	GO:0005874	microtubule	PMID:18028908^[2]	IDA: Inferred from Direct Assay		C
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Vincze O et al. (2006) Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. Biochemistry 45: 13818-26 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Acevedo K et al. (2007) The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules. Exp Cell Res 313: 4091-106 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Lindersson E et al. (2005) p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. J Biol Chem 280: 5703-15 PubMed GONUTS page
↑ Lehotzky A et al. (2010) Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation. Glia 58: 157-68 PubMed GONUTS page

[PMID:17105200-0] 1.0 ^1.1 ^1.2 ^1.3 Vincze O et al. (2006) Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. Biochemistry 45: 13818-26 PubMed GONUTS page

[PMID:18028908-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Acevedo K et al. (2007) The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules. Exp Cell Res 313: 4091-106 PubMed GONUTS page

[PMID:15590652-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Lindersson E et al. (2005) p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. J Biol Chem 280: 5703-15 PubMed GONUTS page

[PMID:19606501-3] Lehotzky A et al. (2010) Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation. Glia 58: 157-68 PubMed GONUTS page

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HUMAN:TPPP

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