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HUMAN:TP53B

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Contents

Species (Taxon ID) Homo sapiens (Human). (taxon:9606)
Gene Name(s) TP53BP1
Protein Name(s)
  • Tumor suppressor p53-binding protein 1
  • 53BP1
  • p53-binding protein 1
  • p53BP1
External Links
UniProt Identifier TP53B_HUMAN
UniProt Accessions Q12888, Q2M1Z7, Q4LE46, Q5FWZ3, Q7Z3U4,
EMBL AF078776, AB210025, BX537418, AY904026, BC112161, U09477,
PIR I38604,
RefSeq NP_001135451.1, NP_001135452.1, NP_005648.1,
PDB 1GZH, 1KZY, 1XNI, 2G3R, 2IG0, 3LGF, 3LGL, 3LH0,
IntAct Q12888,
Ensembl ENST00000263801, ENST00000382044, ENST00000404183,
Pfam PF09038,

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000724

double-strand break repair via homologous recombination

Reactome:REACT_1874

TAS: Traceable Author Statement

P

GO:0000775

chromosome, centromeric region

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0137

C

GO:0000776

kinetochore

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0995

C

GO:0000777

condensed chromosome kinetochore

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0149

C

GO:0003677

DNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

GO:0005515

protein binding

PMID:12607005[1]

IPI: Inferred from Physical Interaction

UniProtKB:P16104

F

GO:0005515

protein binding

PMID:16901786[2]

IPI: Inferred from Physical Interaction

UniProtKB:Q96RU2

F

GO:0005515

protein binding

PMID:17525332[3]

IPI: Inferred from Physical Interaction

UniProtKB:P38398

F

GO:0005515

protein binding

PMID:20347427[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q2TAK8

F

GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001357

C

GO:0005634

nucleus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

GO:0005634

nucleus

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0191

C

GO:0005634

nucleus

PMID:18029348[5]

IDA: Inferred from Direct Assay

C

GO:0005654

nucleoplasm

PMID:12556884[6]

EXP: Inferred from Experiment

C

GO:0005654

nucleoplasm

PMID:9748285[7]

IDA: Inferred from Direct Assay

C

GO:0005654

nucleoplasm

Reactome:REACT_1259

TAS: Traceable Author Statement

C

GO:0005694

chromosome

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0158

C

GO:0005737

cytoplasm

PMID:9748285[7]

IDA: Inferred from Direct Assay

C

GO:0006281

DNA repair

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0234

P

GO:0006281

DNA repair

Reactome:REACT_216

TAS: Traceable Author Statement

P

GO:0006302

double-strand break repair

Reactome:REACT_2054

TAS: Traceable Author Statement

P

GO:0006351

transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0805

P

GO:0006974

response to DNA damage stimulus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0227

P

GO:0016563

transcription activator activity

PMID:9748285[7]

NAS: Non-traceable Author Statement

F

GO:0045893

positive regulation of transcription, DNA-dependent

PMID:9748285[7]

NAS: Non-traceable Author Statement

P

GO:0000781

chromosome, telomeric region

PMID:15149599[8]

IDA: Inferred from Direct Assay

C

GO:0000724

double-strand break repair via homologous recombination

Reactome:REACT_1874

TAS: Traceable Author Statement

P

GO:0000775

chromosome, centromeric region

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0137

C

GO:0000776

kinetochore

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0995

C

GO:0000776

kinetochore

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000106278

C

GO:0000777

condensed chromosome kinetochore

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0149

C

GO:0001102

RNA polymerase II activating transcription factor binding

PMID:17805299[9]

IPI: Inferred from Physical Interaction

UniProtKB:P04637

F

GO:0001104

RNA polymerase II transcription cofactor activity

PMID:17805299[9]

IMP: Inferred from Mutant Phenotype

F

GO:0002039

p53 binding

PMID:17805299[9]

IPI: Inferred from Physical Interaction

UniProtKB:P04637

F

GO:0003677

DNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

GO:0003684

damaged DNA binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000106278

F

GO:0005515

protein binding

PMID:12607005[1]

IPI: Inferred from Physical Interaction

UniProtKB:P16104

F

GO:0005515

protein binding

PMID:16901786[2]

IPI: Inferred from Physical Interaction

UniProtKB:Q96RU2

F

GO:0005515

protein binding

PMID:17525332[3]

IPI: Inferred from Physical Interaction

UniProtKB:P38398

F

GO:0005515

protein binding

PMID:20347427[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q2TAK8

F

GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001357

C

GO:0005634

nucleus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

GO:0005634

nucleus

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0191

C

GO:0005634

nucleus

PMID:18029348[5]

IDA: Inferred from Direct Assay

C

GO:0005654

nucleoplasm

PMID:9748285[7]

IDA: Inferred from Direct Assay

C

GO:0005654

nucleoplasm

Reactome:REACT_1259

TAS: Traceable Author Statement

C

GO:0005654

nucleoplasm

Reactome:REACT_1508

TAS: Traceable Author Statement

C

GO:0005657

replication fork

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000106278

C

GO:0005694

chromosome

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0158

C

GO:0005737

cytoplasm

PMID:9748285[7]

IDA: Inferred from Direct Assay

C

GO:0006281

DNA repair

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0234

P

GO:0006281

DNA repair

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000106278

P

GO:0006281

DNA repair

Reactome:REACT_216

TAS: Traceable Author Statement

P

GO:0006302

double-strand break repair

Reactome:REACT_2054

TAS: Traceable Author Statement

P

GO:0006351

transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0805

P

GO:0006974

response to DNA damage stimulus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0227

P

GO:0042162

telomeric DNA binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000106278

F

GO:0045893

positive regulation of transcription, DNA-dependent

PMID:9748285[7]

NAS: Non-traceable Author Statement

P

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:17805299[9]

IMP: Inferred from Mutant Phenotype

P

GO:0051091

positive regulation of sequence-specific DNA binding transcription factor activity

PMID:17805299[9]

IC: Inferred by Curator

GO:0045944

P

colocalizes_with

GO:0000781

chromosome, telomeric region

PMID:15149599[8]

IDA: Inferred from Direct Assay

C


edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Stewart GS et al. (2003) MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature 421: 961-6 PubMed GONUTS page
  2. ↑ 2.0 2.1 Zhang D et al. (2006) A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell 126: 529-42 PubMed GONUTS page
  3. ↑ 3.0 3.1 Matsuoka S et al. (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316: 1160-6 PubMed GONUTS page
  4. ↑ 4.0 4.1 Huen MS et al. (2010) Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1. Mol Cell 37: 854-64 PubMed GONUTS page
  5. ↑ 5.0 5.1 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
  6. ↑ Bakkenist CJ & Kastan MB (2003) DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421: 499-506 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Iwabuchi K et al. (1998) Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2. J Biol Chem 273: 26061-8 PubMed GONUTS page
  8. ↑ 8.0 8.1 Herbig U et al. (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell 14: 501-13 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 9.3 9.4 Huang J et al. (2007) p53 is regulated by the lysine demethylase LSD1. Nature 449: 105-8 PubMed GONUTS page
Retrieved from "http://gowiki.tamu.edu/wiki/index.php/HUMAN:TP53B"
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