HUMAN:TNFA

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	TNF ( synonyms: TNFA, TNFSF2 )
Protein Name(s)	Tumor necrosis factor Cachectin TNF-alpha Tumor necrosis factor ligand superfamily member 2 TNF-a Tumor necrosis factor, membrane form Tumor necrosis factor, soluble form
External Links
UniProt Identifier	TNFA_HUMAN
UniProt Accessions	P01375, O43647, Q9P1Q2, Q9UIV3,
EMBL	M16441, X02910, X01394, M10988, M26331, Z15026, Y14768, AF129756, BA000025, AB088112, AY066019, AY214167, BC028148, AF043342, AF098751,
PIR	A93585,
RefSeq	NP_000585.2,
PDB	1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 4TSV, 5TSW,
IntAct	P01375,
Ensembl	ENST00000376122, ENST00000383496, ENST00000412275, ENST00000420425, ENST00000443707, ENST00000448781, ENST00000449264,
Pfam	PF00229,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0000060	protein import into nucleus, translocation	PMID:16280327^[1]	IDA: Inferred from Direct Assay		P
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0000185	activation of MAPKKK activity	PMID:15310755^[2]	IDA: Inferred from Direct Assay		P
	GO:0000187	activation of MAPK activity	PMID:10748004^[3]	IDA: Inferred from Direct Assay		P
	GO:0001666	response to hypoxia	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0001775	cell activation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0001819	positive regulation of cytokine production	PMID:17922812^[4]	IDA: Inferred from Direct Assay		P
	GO:0001891	phagocytic cup	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	C
	GO:0001891	phagocytic cup	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P06804	C
	GO:0001932	regulation of protein phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0001934	positive regulation of protein phosphorylation	PMID:10748004^[3]	IDA: Inferred from Direct Assay		P
	GO:0002020	protease binding	PMID:12777399^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P78325	F
	GO:0002037	negative regulation of L-glutamate transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0002439	chronic inflammatory response to antigenic stimulus	PMID:14512626^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0002740	negative regulation of cytokine secretion involved in immune response	PMID:10443688^[7]	IDA: Inferred from Direct Assay		P
	GO:0002876	positive regulation of chronic inflammatory response to antigenic stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0003009	skeletal muscle contraction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0005125	cytokine activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0202	F
	GO:0005125	cytokine activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	F
	GO:0005125	cytokine activity	PMID:10748004^[3]	IDA: Inferred from Direct Assay		F
	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002959	F
	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006052	F
	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006053	F
	GO:0005164	tumor necrosis factor receptor binding	PMID:14512626^[6]	IDA: Inferred from Direct Assay		F
	GO:0005515	protein binding	PMID:2848815^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P19438	F
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005615	extracellular space	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0202	C
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	C
	GO:0005615	extracellular space	PMID:10443688^[7]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:12594207^[9]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:18355445^[10]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:3932069^[11]	IDA: Inferred from Direct Assay		C
	GO:0005622	intracellular	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	PMID:12887920^[12]	EXP: Inferred from Experiment		C
	GO:0005886	plasma membrane	PMID:2848815^[8]	EXP: Inferred from Experiment		C
	GO:0005886	plasma membrane	PMID:7758105^[13]	EXP: Inferred from Experiment		C
	GO:0005887	integral to plasma membrane	PMID:18355445^[10]	IDA: Inferred from Direct Assay		C
	GO:0006006	glucose metabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0006915	apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0006915	apoptosis	Reactome:REACT_578	TAS: Traceable Author Statement		P
	GO:0006916	anti-apoptosis	PMID:10748004^[3]	IDA: Inferred from Direct Assay		P
	GO:0006917	induction of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0006917	induction of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0006917	induction of apoptosis	PMID:18202225^[14]	IDA: Inferred from Direct Assay		P
	GO:0006919	activation of caspase activity	PMID:14512626^[6]	IDA: Inferred from Direct Assay		P
	GO:0006927	transformed cell apoptosis	PMID:3883195^[15]	IDA: Inferred from Direct Assay		P
	GO:0006952	defense response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0006954	inflammatory response	PMID:10748004^[3]	IDA: Inferred from Direct Assay		P
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002959	P
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006052	P
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006053	P
	GO:0006959	humoral immune response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0007165	signal transduction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0007254	JNK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0007275	multicellular organismal development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0008285	negative regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0008624	induction of apoptosis by extracellular signals	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0008624	induction of apoptosis by extracellular signals	PMID:10521396^[16]	IDA: Inferred from Direct Assay		P
	GO:0008624	induction of apoptosis by extracellular signals	Reactome:REACT_1059	TAS: Traceable Author Statement		P
	GO:0008624	induction of apoptosis by extracellular signals	Reactome:REACT_1619	TAS: Traceable Author Statement		P
	GO:0008625	induction of apoptosis via death domain receptors	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0008625	induction of apoptosis via death domain receptors	PMID:18676776^[17]	IDA: Inferred from Direct Assay		P
	GO:0009612	response to mechanical stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0009615	response to virus	PMID:10490959^[18]	IDA: Inferred from Direct Assay		P
	GO:0009651	response to salt stress	PMID:18355445^[10]	TAS: Traceable Author Statement		P
	GO:0009887	organ morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0009897	external side of plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	C
	GO:0009897	external side of plasma membrane	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P06804	C
	GO:0009986	cell surface	PMID:18355445^[10]	IDA: Inferred from Direct Assay		C
	GO:0010843	promoter binding	PMID:17350185^[19]	IDA: Inferred from Direct Assay		F
	GO:0010888	negative regulation of lipid storage	PMID:16464856^[20]	NAS: Non-traceable Author Statement		P
	GO:0010940	positive regulation of necrotic cell death	PMID:16507998^[21]	TAS: Traceable Author Statement		P
	GO:0014823	response to activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002959	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006052	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006053	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016021	integral to membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	C
	GO:0016563	transcription activator activity	PMID:17350185^[19]	IDA: Inferred from Direct Assay		F
	GO:0016564	transcription repressor activity	PMID:17350185^[19]	IDA: Inferred from Direct Assay		F
	GO:0019722	calcium-mediated signaling	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0030198	extracellular matrix organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0030316	osteoclast differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0030730	sequestering of triglyceride	PMID:19032770^[22]	IDA: Inferred from Direct Assay		P
	GO:0031334	positive regulation of protein complex assembly	PMID:12813029^[23]	IDA: Inferred from Direct Assay		P
	GO:0031622	positive regulation of fever generation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0031622	positive regulation of fever generation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P06804	P
	GO:0032582	negative regulation of gene-specific transcription	PMID:17350185^[19]	IDA: Inferred from Direct Assay		P
	GO:0032715	negative regulation of interleukin-6 production	PMID:10443688^[7]	IDA: Inferred from Direct Assay		P
	GO:0032722	positive regulation of chemokine production	PMID:10490959^[18]	IDA: Inferred from Direct Assay		P
	GO:0032729	positive regulation of interferon-gamma production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0032755	positive regulation of interleukin-6 production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0032800	receptor biosynthetic process	PMID:10443688^[7]	IDA: Inferred from Direct Assay		P
	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:17389591^[24]	IDA: Inferred from Direct Assay		P
	GO:0033209	tumor necrosis factor-mediated signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0033209	tumor necrosis factor-mediated signaling pathway	PMID:10748004^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0034116	positive regulation of heterotypic cell-cell adhesion	PMID:10604883^[25]	IDA: Inferred from Direct Assay		P
	GO:0042127	regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0042346	positive regulation of NF-kappaB import into nucleus	PMID:17922812^[4]	IDA: Inferred from Direct Assay		P
	GO:0042493	response to drug	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0042742	defense response to bacterium	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0042802	identical protein binding	PMID:14512626^[6]	IDA: Inferred from Direct Assay		F
	GO:0043066	negative regulation of apoptosis	PMID:10666185^[26]	IDA: Inferred from Direct Assay		P
	GO:0043122	regulation of I-kappaB kinase/NF-kappaB cascade	PMID:10748004^[3]	IDA: Inferred from Direct Assay		P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	PMID:15310755^[2]	IDA: Inferred from Direct Assay		P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	PMID:17922812^[4]	IDA: Inferred from Direct Assay		P
	GO:0043193	positive regulation of gene-specific transcription	PMID:14512626^[6]	IDA: Inferred from Direct Assay		P
	GO:0043193	positive regulation of gene-specific transcription	PMID:17350185^[19]	IDA: Inferred from Direct Assay		P
	GO:0043243	positive regulation of protein complex disassembly	PMID:12813029^[23]	IDA: Inferred from Direct Assay		P
	GO:0043406	positive regulation of MAP kinase activity	PMID:12813029^[23]	IDA: Inferred from Direct Assay		P
	GO:0043525	positive regulation of neuron apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0044130	negative regulation of growth of symbiont in host	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0045071	negative regulation of viral genome replication	PMID:10490959^[18]	IDA: Inferred from Direct Assay		P
	GO:0045080	positive regulation of chemokine biosynthetic process	PMID:10490959^[18]	IDA: Inferred from Direct Assay		P
	GO:0045121	membrane raft	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	C
	GO:0045121	membrane raft	PMID:17010968^[27]	IDA: Inferred from Direct Assay		C
	GO:0045123	cellular extravasation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0045429	positive regulation of nitric oxide biosynthetic process	PMID:8383325^[28]	IDA: Inferred from Direct Assay		P
	GO:0045599	negative regulation of fat cell differentiation	PMID:16464856^[20]	NAS: Non-traceable Author Statement		P
	GO:0045670	regulation of osteoclast differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0045672	positive regulation of osteoclast differentiation	PMID:17888176^[29]	IDA: Inferred from Direct Assay		P
	GO:0045840	positive regulation of mitosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:16895791^[30]	IDA: Inferred from Direct Assay		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:10748004^[3]	IDA: Inferred from Direct Assay		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:16803872^[31]	IGI: Inferred from Genetic Interaction	UniProtKB:Q8K120	P
	GO:0045994	positive regulation of translational initiation by iron	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0046325	negative regulation of glucose import	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0046325	negative regulation of glucose import	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0046330	positive regulation of JNK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0048566	embryonic digestive tract development	PMID:20875417^[32]	IEP: Inferred from Expression Pattern		P
	GO:0048661	positive regulation of smooth muscle cell proliferation	PMID:16518841^[33]	IDA: Inferred from Direct Assay		P
	GO:0050715	positive regulation of cytokine secretion	PMID:10443688^[7]	IDA: Inferred from Direct Assay		P
	GO:0050796	regulation of insulin secretion	PMID:8383325^[28]	IDA: Inferred from Direct Assay		P
	GO:0050806	positive regulation of synaptic transmission	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0050830	defense response to Gram-positive bacterium	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0050900	leukocyte migration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0050901	leukocyte tethering or rolling	PMID:10820279^[34]	IDA: Inferred from Direct Assay		P
	GO:0050995	negative regulation of lipid catabolic process	PMID:19032770^[22]	IDA: Inferred from Direct Assay		P
	GO:0051023	regulation of immunoglobulin secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	PMID:18373975^[35]	IDA: Inferred from Direct Assay		P
	GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	PMID:10748004^[3]	IDA: Inferred from Direct Assay		P
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:10383454^[36]	IDA: Inferred from Direct Assay		P
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:15790681^[37]	IDA: Inferred from Direct Assay		P
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:16280327^[1]	IDA: Inferred from Direct Assay		P
	GO:0051222	positive regulation of protein transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0051222	positive regulation of protein transport	PMID:15310755^[2]	IDA: Inferred from Direct Assay		P
	GO:0051384	response to glucocorticoid stimulus	PMID:10443688^[7]	IDA: Inferred from Direct Assay		P
	GO:0051533	positive regulation of NFAT protein import into nucleus	PMID:16803872^[31]	IDA: Inferred from Direct Assay		P
	GO:0051798	positive regulation of hair follicle development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0055037	recycling endosome	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	C
	GO:0055037	recycling endosome	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P06804	C
	GO:0060555	induction of necroptosis by extracellular signals	PMID:11101870^[38]	IDA: Inferred from Direct Assay		P
	GO:0060557	positive regulation of vitamin D biosynthetic process	PMID:1690216^[39]	IDA: Inferred from Direct Assay		P
	GO:0060559	positive regulation of calcidiol 1-monooxygenase activity	PMID:1690216^[39]	IDA: Inferred from Direct Assay		P
	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0060693	regulation of branching involved in salivary gland morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0061048	negative regulation of branching involved in lung morphogenesis	PMID:17350185^[19]	IDA: Inferred from Direct Assay		P
	GO:0070265	necrotic cell death	PMID:11101870^[38]	IDA: Inferred from Direct Assay		P
	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:18606301^[40]	NAS: Non-traceable Author Statement		P
	GO:0071316	cellular response to nicotine	PMID:18676776^[17]	IDA: Inferred from Direct Assay		P
	GO:0071803	positive regulation of podosome assembly	PMID:15220135^[41]	IDA: Inferred from Direct Assay		P
	GO:0000060	protein import into nucleus, translocation	PMID:16280327^[1]	IDA: Inferred from Direct Assay		P
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0000185	activation of MAPKKK activity	PMID:15310755^[2]	IDA: Inferred from Direct Assay		P
	GO:0000187	activation of MAPK activity	PMID:10748004^[3]	IDA: Inferred from Direct Assay		P
	GO:0001666	response to hypoxia	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0001775	cell activation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0001819	positive regulation of cytokine production	PMID:17922812^[4]	IDA: Inferred from Direct Assay		P
	GO:0001891	phagocytic cup	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	C
	GO:0001891	phagocytic cup	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P06804	C
	GO:0001932	regulation of protein phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0001934	positive regulation of protein phosphorylation	PMID:10748004^[3]	IDA: Inferred from Direct Assay		P
	GO:0002020	protease binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	F
	GO:0002020	protease binding	PMID:12777399^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P78325	F
	GO:0002037	negative regulation of L-glutamate transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0002439	chronic inflammatory response to antigenic stimulus	PMID:14512626^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0002740	negative regulation of cytokine secretion involved in immune response	PMID:10443688^[7]	IDA: Inferred from Direct Assay		P
	GO:0002876	positive regulation of chronic inflammatory response to antigenic stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0003009	skeletal muscle contraction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0005125	cytokine activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0202	F
	GO:0005125	cytokine activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	F
	GO:0005125	cytokine activity	PMID:10748004^[3]	IDA: Inferred from Direct Assay		F
	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002959	F
	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006052	F
	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006053	F
	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	F
	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	F
	GO:0005164	tumor necrosis factor receptor binding	PMID:14512626^[6]	IDA: Inferred from Direct Assay		F
	GO:0005515	protein binding	PMID:2848815^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P19438	F
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005615	extracellular space	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0202	C
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	C
	GO:0005615	extracellular space	PMID:10443688^[7]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:12594207^[9]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:18355445^[10]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:3932069^[11]	IDA: Inferred from Direct Assay		C
	GO:0005622	intracellular	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	Reactome:REACT_1856	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_2096	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_2175	TAS: Traceable Author Statement		C
	GO:0005887	integral to plasma membrane	PMID:18355445^[10]	IDA: Inferred from Direct Assay		C
	GO:0006006	glucose metabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0006915	apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0006915	apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0006915	apoptosis	Reactome:REACT_578	TAS: Traceable Author Statement		P
	GO:0006916	anti-apoptosis	PMID:10748004^[3]	IDA: Inferred from Direct Assay		P
	GO:0006917	induction of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0006917	induction of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0006917	induction of apoptosis	PMID:18202225^[14]	IDA: Inferred from Direct Assay		P
	GO:0006919	activation of caspase activity	PMID:14512626^[6]	IDA: Inferred from Direct Assay		P
	GO:0006927	transformed cell apoptosis	PMID:3883195^[15]	IDA: Inferred from Direct Assay		P
	GO:0006952	defense response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0006954	inflammatory response	PMID:10748004^[3]	IDA: Inferred from Direct Assay		P
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002959	P
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006052	P
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006053	P
	GO:0006959	humoral immune response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0007165	signal transduction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0007254	JNK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0007275	multicellular organismal development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0008285	negative regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0008624	induction of apoptosis by extracellular signals	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0008624	induction of apoptosis by extracellular signals	PMID:10521396^[16]	IDA: Inferred from Direct Assay		P
	GO:0008624	induction of apoptosis by extracellular signals	Reactome:REACT_1059	TAS: Traceable Author Statement		P
	GO:0008624	induction of apoptosis by extracellular signals	Reactome:REACT_1619	TAS: Traceable Author Statement		P
	GO:0008625	induction of apoptosis via death domain receptors	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0008625	induction of apoptosis via death domain receptors	PMID:18676776^[17]	IDA: Inferred from Direct Assay		P
	GO:0009612	response to mechanical stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0009615	response to virus	PMID:10490959^[18]	IDA: Inferred from Direct Assay		P
	GO:0009651	response to salt stress	PMID:18355445^[10]	TAS: Traceable Author Statement		P
	GO:0009887	organ morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0009897	external side of plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	C
	GO:0009897	external side of plasma membrane	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P06804	C
	GO:0009986	cell surface	PMID:18355445^[10]	IDA: Inferred from Direct Assay		C
	GO:0010888	negative regulation of lipid storage	PMID:16464856^[20]	NAS: Non-traceable Author Statement		P
	GO:0010940	positive regulation of necrotic cell death	PMID:16507998^[21]	TAS: Traceable Author Statement		P
	GO:0014823	response to activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002959	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006052	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006053	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016021	integral to membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	C
	GO:0019722	calcium-mediated signaling	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0030198	extracellular matrix organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0030730	sequestering of triglyceride	PMID:19032770^[22]	IDA: Inferred from Direct Assay		P
	GO:0031334	positive regulation of protein complex assembly	PMID:12813029^[23]	IDA: Inferred from Direct Assay		P
	GO:0031622	positive regulation of fever generation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0031622	positive regulation of fever generation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P06804	P
	GO:0032715	negative regulation of interleukin-6 production	PMID:10443688^[7]	IDA: Inferred from Direct Assay		P
	GO:0032722	positive regulation of chemokine production	PMID:10490959^[18]	IDA: Inferred from Direct Assay		P
	GO:0032729	positive regulation of interferon-gamma production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0032755	positive regulation of interleukin-6 production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0032800	receptor biosynthetic process	PMID:10443688^[7]	IDA: Inferred from Direct Assay		P
	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:17389591^[24]	IDA: Inferred from Direct Assay		P
	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:18440775^[42]	IDA: Inferred from Direct Assay		P
	GO:0033209	tumor necrosis factor-mediated signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0033209	tumor necrosis factor-mediated signaling pathway	PMID:10748004^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0034116	positive regulation of heterotypic cell-cell adhesion	PMID:10604883^[25]	IDA: Inferred from Direct Assay		P
	GO:0042127	regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0042346	positive regulation of NF-kappaB import into nucleus	PMID:17922812^[4]	IDA: Inferred from Direct Assay		P
	GO:0042493	response to drug	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0042742	defense response to bacterium	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0042802	identical protein binding	PMID:14512626^[6]	IDA: Inferred from Direct Assay		F
	GO:0043066	negative regulation of apoptosis	PMID:10666185^[26]	IDA: Inferred from Direct Assay		P
	GO:0043122	regulation of I-kappaB kinase/NF-kappaB cascade	PMID:10748004^[3]	IDA: Inferred from Direct Assay		P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	PMID:15310755^[2]	IDA: Inferred from Direct Assay		P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	PMID:17922812^[4]	IDA: Inferred from Direct Assay		P
	GO:0043243	positive regulation of protein complex disassembly	PMID:12813029^[23]	IDA: Inferred from Direct Assay		P
	GO:0043406	positive regulation of MAP kinase activity	PMID:12813029^[23]	IDA: Inferred from Direct Assay		P
	GO:0043406	positive regulation of MAP kinase activity	PMID:18440775^[42]	IDA: Inferred from Direct Assay		P
	GO:0043525	positive regulation of neuron apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0044130	negative regulation of growth of symbiont in host	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0044212	transcription regulatory region DNA binding	PMID:17350185^[19]	IDA: Inferred from Direct Assay		F
	GO:0045071	negative regulation of viral genome replication	PMID:10490959^[18]	IDA: Inferred from Direct Assay		P
	GO:0045080	positive regulation of chemokine biosynthetic process	PMID:10490959^[18]	IDA: Inferred from Direct Assay		P
	GO:0045121	membrane raft	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	C
	GO:0045121	membrane raft	PMID:17010968^[27]	IDA: Inferred from Direct Assay		C
	GO:0045123	cellular extravasation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0045429	positive regulation of nitric oxide biosynthetic process	PMID:8383325^[28]	IDA: Inferred from Direct Assay		P
	GO:0045599	negative regulation of fat cell differentiation	PMID:16464856^[20]	NAS: Non-traceable Author Statement		P
	GO:0045670	regulation of osteoclast differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0045672	positive regulation of osteoclast differentiation	PMID:17888176^[29]	IDA: Inferred from Direct Assay		P
	GO:0045840	positive regulation of mitosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:16895791^[30]	IDA: Inferred from Direct Assay		P
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:17350185^[19]	IDA: Inferred from Direct Assay		P
	GO:0045893	positive regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:10748004^[3]	IDA: Inferred from Direct Assay		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:14512626^[6]	IDA: Inferred from Direct Assay		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:17350185^[19]	IDA: Inferred from Direct Assay		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:16803872^[31]	IGI: Inferred from Genetic Interaction	UniProtKB:Q8K120	P
	GO:0045994	positive regulation of translational initiation by iron	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0046325	negative regulation of glucose import	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0046325	negative regulation of glucose import	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0046330	positive regulation of JNK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0048566	embryonic digestive tract development	PMID:20875417^[32]	IEP: Inferred from Expression Pattern		P
	GO:0048661	positive regulation of smooth muscle cell proliferation	PMID:16518841^[33]	IDA: Inferred from Direct Assay		P
	GO:0050708	regulation of protein secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0050715	positive regulation of cytokine secretion	PMID:10443688^[7]	IDA: Inferred from Direct Assay		P
	GO:0050796	regulation of insulin secretion	PMID:8383325^[28]	IDA: Inferred from Direct Assay		P
	GO:0050806	positive regulation of synaptic transmission	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0050830	defense response to Gram-positive bacterium	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0050900	leukocyte migration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0050901	leukocyte tethering or rolling	PMID:10820279^[34]	IDA: Inferred from Direct Assay		P
	GO:0050995	negative regulation of lipid catabolic process	PMID:19032770^[22]	IDA: Inferred from Direct Assay		P
	GO:0051023	regulation of immunoglobulin secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	PMID:18373975^[35]	IDA: Inferred from Direct Assay		P
	GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	PMID:10748004^[3]	IDA: Inferred from Direct Assay		P
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:10383454^[36]	IDA: Inferred from Direct Assay		P
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:15790681^[37]	IDA: Inferred from Direct Assay		P
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:16280327^[1]	IDA: Inferred from Direct Assay		P
	GO:0051222	positive regulation of protein transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0051222	positive regulation of protein transport	PMID:15310755^[2]	IDA: Inferred from Direct Assay		P
	GO:0051384	response to glucocorticoid stimulus	PMID:10443688^[7]	IDA: Inferred from Direct Assay		P
	GO:0051533	positive regulation of NFAT protein import into nucleus	PMID:16803872^[31]	IDA: Inferred from Direct Assay		P
	GO:0051798	positive regulation of hair follicle development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0055037	recycling endosome	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	C
	GO:0055037	recycling endosome	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P06804	C
	GO:0060555	induction of necroptosis by extracellular signals	PMID:11101870^[38]	IDA: Inferred from Direct Assay		P
	GO:0060557	positive regulation of vitamin D biosynthetic process	PMID:1690216^[39]	IDA: Inferred from Direct Assay		P
	GO:0060559	positive regulation of calcidiol 1-monooxygenase activity	PMID:1690216^[39]	IDA: Inferred from Direct Assay		P
	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0060693	regulation of branching involved in salivary gland morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025263	P
	GO:0061048	negative regulation of branching involved in lung morphogenesis	PMID:17350185^[19]	IDA: Inferred from Direct Assay		P
	GO:0070265	necrotic cell death	PMID:11101870^[38]	IDA: Inferred from Direct Assay		P
	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:18606301^[40]	NAS: Non-traceable Author Statement		P
	GO:0071316	cellular response to nicotine	PMID:18676776^[17]	IDA: Inferred from Direct Assay		P
	GO:0071803	positive regulation of podosome assembly	PMID:15220135^[41]	IDA: Inferred from Direct Assay		P
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Yeh PY et al. (2006) A pathway for tumor necrosis factor-alpha-induced Bcl10 nuclear translocation. Bcl10 is up-regulated by NF-kappaB and phosphorylated by Akt1 and then complexes with Bcl3 to enter the nucleus. J Biol Chem 281: 167-75 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Zhang H et al. (2004) AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation. J Biol Chem 279: 44955-65 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 ^3.15 ^3.16 ^3.17 Madge LA & Pober JS (2000) A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells. J Biol Chem 275: 15458-65 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Hohensinner PJ et al. (2007) Macrophage colony stimulating factor expression in human cardiac cells is upregulated by tumor necrosis factor-alpha via an NF-kappaB dependent mechanism. J Thromb Haemost 5: 2520-8 PubMed GONUTS page
↑ ^5.0 ^5.1 Fourie AM et al. (2003) Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23. J Biol Chem 278: 30469-77 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Steed PM et al. (2003) Inactivation of TNF signaling by rationally designed dominant-negative TNF variants. Science 301: 1895-8 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 Franchimont D et al. (1999) Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor. J Clin Endocrinol Metab 84: 2834-9 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Stauber GB et al. (1988) Human tumor necrosis factor-alpha receptor. Purification by immunoaffinity chromatography and initial characterization. J Biol Chem 263: 19098-104 PubMed GONUTS page
↑ ^9.0 ^9.1 Schröder NW et al. (2003) Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved. J Biol Chem 278: 15587-94 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 Hiraoka Y et al. (2008) Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases. Biochem Biophys Res Commun 370: 154-8 PubMed GONUTS page
↑ ^11.0 ^11.1 Marmenout A et al. (1985) Molecular cloning and expression of human tumor necrosis factor and comparison with mouse tumor necrosis factor. Eur J Biochem 152: 515-22 PubMed GONUTS page
↑ Micheau O & Tschopp J (2003) Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114: 181-90 PubMed GONUTS page
↑ Hsu H et al. (1995) The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell 81: 495-504 PubMed GONUTS page
↑ ^14.0 ^14.1 Rushworth SA & MacEwan DJ (2008) HO-1 underlies resistance of AML cells to TNF-induced apoptosis. Blood 111: 3793-801 PubMed GONUTS page
↑ ^15.0 ^15.1 Shirai T et al. (1985) Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor. Nature 313: 803-6 PubMed GONUTS page
↑ ^16.0 ^16.1 Lin Y et al. (1999) Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev 13: 2514-26 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Zhang J et al. (2009) Nicotine induces resistance to chemotherapy by modulating mitochondrial signaling in lung cancer. Am J Respir Cell Mol Biol 40: 135-46 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 Lane BR et al. (1999) TNF-alpha inhibits HIV-1 replication in peripheral blood monocytes and alveolar macrophages by inducing the production of RANTES and decreasing C-C chemokine receptor 5 (CCR5) expression. J Immunol 163: 3653-61 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 ^19.6 ^19.7 ^19.8 ^19.9 Zhu NL et al. (2007) TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells. Gene 393: 70-80 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Gustafson B & Smith U (2006) Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes. J Biol Chem 281: 9507-16 PubMed GONUTS page
↑ ^21.0 ^21.1 Temkin V et al. (2006) Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis. Mol Cell Biol 26: 2215-25 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 Persson J et al. (2008) Interleukin-1beta and tumour necrosis factor-alpha impede neutral lipid turnover in macrophage-derived foam cells. BMC Immunol 9: 70 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 Zhang R et al. (2003) AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3. J Clin Invest 111: 1933-43 PubMed GONUTS page
↑ ^24.0 ^24.1 Zhang H et al. (2007) RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation. J Biol Chem 282: 14788-96 PubMed GONUTS page
↑ ^25.0 ^25.1 Ouchi N et al. (1999) Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 100: 2473-6 PubMed GONUTS page
↑ ^26.0 ^26.1 Scheuerer B et al. (2000) The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages. Blood 95: 1158-66 PubMed GONUTS page
↑ ^27.0 ^27.1 Tellier E et al. (2006) The shedding activity of ADAM17 is sequestered in lipid rafts. Exp Cell Res 312: 3969-80 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 ^28.3 Corbett JA et al. (1993) Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc Natl Acad Sci U S A 90: 1731-5 PubMed GONUTS page
↑ ^29.0 ^29.1 Yago T et al. (2007) IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats. Arthritis Res Ther 9: R96 PubMed GONUTS page
↑ ^30.0 ^30.1 Afonso V et al. (2006) Tumor necrosis factor-alpha down-regulates human Cu/Zn superoxide dismutase 1 promoter via JNK/AP-1 signaling pathway. Free Radic Biol Med 41: 709-21 PubMed GONUTS page
↑ ^31.0 ^31.1 ^31.2 ^31.3 Yan Y et al. (2006) NFAT3 is specifically required for TNF-alpha-induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells. J Cell Sci 119: 2985-94 PubMed GONUTS page
↑ ^32.0 ^32.1 Maheshwari A et al. (2011) TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine. Gastroenterology 140: 242-53 PubMed GONUTS page
↑ ^33.0 ^33.1 Zhang HS & Wang SQ (2006) Ginsenoside Rg1 inhibits tumor necrosis factor-alpha (TNF-alpha)-induced human arterial smooth muscle cells (HASMCs) proliferation. J Cell Biochem 98: 1471-81 PubMed GONUTS page
↑ ^34.0 ^34.1 Luu NT et al. (2000) Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils. J Immunol 164: 5961-9 PubMed GONUTS page
↑ ^35.0 ^35.1 Schramme A et al. (2008) The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells. Biochem Biophys Res Commun 370: 311-6 PubMed GONUTS page
↑ ^36.0 ^36.1 Wesche H et al. (1999) IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem 274: 19403-10 PubMed GONUTS page
↑ ^37.0 ^37.1 Bettelli E et al. (2005) Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proc Natl Acad Sci U S A 102: 5138-43 PubMed GONUTS page
↑ ^38.0 ^38.1 ^38.2 ^38.3 Holler N et al. (2000) Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol 1: 489-95 PubMed GONUTS page
↑ ^39.0 ^39.1 ^39.2 ^39.3 Pryke AM et al. (1990) Tumor necrosis factor-alpha induces vitamin D-1-hydroxylase activity in normal human alveolar macrophages. J Cell Physiol 142: 652-6 PubMed GONUTS page
↑ ^40.0 ^40.1 Guerrini MM et al. (2008) Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations. Am J Hum Genet 83: 64-76 PubMed GONUTS page
↑ ^41.0 ^41.1 Johansson MW et al. (2004) Eosinophils adhere to vascular cell adhesion molecule-1 via podosomes. Am J Respir Cell Mol Biol 31: 413-22 PubMed GONUTS page
↑ ^42.0 ^42.1 Evans IM et al. (2008) Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase. Cell Signal 20: 1375-84 PubMed GONUTS page

[PMID:16280327-0] 1.0 ^1.1 ^1.2 ^1.3 Yeh PY et al. (2006) A pathway for tumor necrosis factor-alpha-induced Bcl10 nuclear translocation. Bcl10 is up-regulated by NF-kappaB and phosphorylated by Akt1 and then complexes with Bcl3 to enter the nucleus. J Biol Chem 281: 167-75 PubMed GONUTS page

[PMID:15310755-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Zhang H et al. (2004) AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation. J Biol Chem 279: 44955-65 PubMed GONUTS page

[PMID:10748004-2] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 ^3.15 ^3.16 ^3.17 Madge LA & Pober JS (2000) A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells. J Biol Chem 275: 15458-65 PubMed GONUTS page

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[PMID:12777399-4] 5.0 ^5.1 Fourie AM et al. (2003) Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23. J Biol Chem 278: 30469-77 PubMed GONUTS page

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[PMID:2848815-7] 8.0 ^8.1 ^8.2 Stauber GB et al. (1988) Human tumor necrosis factor-alpha receptor. Purification by immunoaffinity chromatography and initial characterization. J Biol Chem 263: 19098-104 PubMed GONUTS page

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[PMID:18355445-9] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 Hiraoka Y et al. (2008) Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases. Biochem Biophys Res Commun 370: 154-8 PubMed GONUTS page

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[PMID:12887920-11] Micheau O & Tschopp J (2003) Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114: 181-90 PubMed GONUTS page

[PMID:7758105-12] Hsu H et al. (1995) The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell 81: 495-504 PubMed GONUTS page

[PMID:18202225-13] 14.0 ^14.1 Rushworth SA & MacEwan DJ (2008) HO-1 underlies resistance of AML cells to TNF-induced apoptosis. Blood 111: 3793-801 PubMed GONUTS page

[PMID:3883195-14] 15.0 ^15.1 Shirai T et al. (1985) Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor. Nature 313: 803-6 PubMed GONUTS page

[PMID:10521396-15] 16.0 ^16.1 Lin Y et al. (1999) Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev 13: 2514-26 PubMed GONUTS page

[PMID:18676776-16] 17.0 ^17.1 ^17.2 ^17.3 Zhang J et al. (2009) Nicotine induces resistance to chemotherapy by modulating mitochondrial signaling in lung cancer. Am J Respir Cell Mol Biol 40: 135-46 PubMed GONUTS page

[PMID:10490959-17] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 Lane BR et al. (1999) TNF-alpha inhibits HIV-1 replication in peripheral blood monocytes and alveolar macrophages by inducing the production of RANTES and decreasing C-C chemokine receptor 5 (CCR5) expression. J Immunol 163: 3653-61 PubMed GONUTS page

[PMID:17350185-18] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 ^19.6 ^19.7 ^19.8 ^19.9 Zhu NL et al. (2007) TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells. Gene 393: 70-80 PubMed GONUTS page

[PMID:16464856-19] 20.0 ^20.1 ^20.2 ^20.3 Gustafson B & Smith U (2006) Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes. J Biol Chem 281: 9507-16 PubMed GONUTS page

[PMID:16507998-20] 21.0 ^21.1 Temkin V et al. (2006) Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis. Mol Cell Biol 26: 2215-25 PubMed GONUTS page

[PMID:19032770-21] 22.0 ^22.1 ^22.2 ^22.3 Persson J et al. (2008) Interleukin-1beta and tumour necrosis factor-alpha impede neutral lipid turnover in macrophage-derived foam cells. BMC Immunol 9: 70 PubMed GONUTS page

[PMID:12813029-22] 23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 Zhang R et al. (2003) AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3. J Clin Invest 111: 1933-43 PubMed GONUTS page

[PMID:17389591-23] 24.0 ^24.1 Zhang H et al. (2007) RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation. J Biol Chem 282: 14788-96 PubMed GONUTS page

[PMID:10604883-24] 25.0 ^25.1 Ouchi N et al. (1999) Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 100: 2473-6 PubMed GONUTS page

[PMID:10666185-25] 26.0 ^26.1 Scheuerer B et al. (2000) The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages. Blood 95: 1158-66 PubMed GONUTS page

[PMID:17010968-26] 27.0 ^27.1 Tellier E et al. (2006) The shedding activity of ADAM17 is sequestered in lipid rafts. Exp Cell Res 312: 3969-80 PubMed GONUTS page

[PMID:8383325-27] 28.0 ^28.1 ^28.2 ^28.3 Corbett JA et al. (1993) Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc Natl Acad Sci U S A 90: 1731-5 PubMed GONUTS page

[PMID:17888176-28] 29.0 ^29.1 Yago T et al. (2007) IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats. Arthritis Res Ther 9: R96 PubMed GONUTS page

[PMID:16895791-29] 30.0 ^30.1 Afonso V et al. (2006) Tumor necrosis factor-alpha down-regulates human Cu/Zn superoxide dismutase 1 promoter via JNK/AP-1 signaling pathway. Free Radic Biol Med 41: 709-21 PubMed GONUTS page

[PMID:16803872-30] 31.0 ^31.1 ^31.2 ^31.3 Yan Y et al. (2006) NFAT3 is specifically required for TNF-alpha-induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells. J Cell Sci 119: 2985-94 PubMed GONUTS page

[PMID:20875417-31] 32.0 ^32.1 Maheshwari A et al. (2011) TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine. Gastroenterology 140: 242-53 PubMed GONUTS page

[PMID:16518841-32] 33.0 ^33.1 Zhang HS & Wang SQ (2006) Ginsenoside Rg1 inhibits tumor necrosis factor-alpha (TNF-alpha)-induced human arterial smooth muscle cells (HASMCs) proliferation. J Cell Biochem 98: 1471-81 PubMed GONUTS page

[PMID:10820279-33] 34.0 ^34.1 Luu NT et al. (2000) Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils. J Immunol 164: 5961-9 PubMed GONUTS page

[PMID:18373975-34] 35.0 ^35.1 Schramme A et al. (2008) The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells. Biochem Biophys Res Commun 370: 311-6 PubMed GONUTS page

[PMID:10383454-35] 36.0 ^36.1 Wesche H et al. (1999) IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem 274: 19403-10 PubMed GONUTS page

[PMID:15790681-36] 37.0 ^37.1 Bettelli E et al. (2005) Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proc Natl Acad Sci U S A 102: 5138-43 PubMed GONUTS page

[PMID:11101870-37] 38.0 ^38.1 ^38.2 ^38.3 Holler N et al. (2000) Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol 1: 489-95 PubMed GONUTS page

[PMID:1690216-38] 39.0 ^39.1 ^39.2 ^39.3 Pryke AM et al. (1990) Tumor necrosis factor-alpha induces vitamin D-1-hydroxylase activity in normal human alveolar macrophages. J Cell Physiol 142: 652-6 PubMed GONUTS page

[PMID:18606301-39] 40.0 ^40.1 Guerrini MM et al. (2008) Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations. Am J Hum Genet 83: 64-76 PubMed GONUTS page

[PMID:15220135-40] 41.0 ^41.1 Johansson MW et al. (2004) Eosinophils adhere to vascular cell adhesion molecule-1 via podosomes. Am J Respir Cell Mol Biol 31: 413-22 PubMed GONUTS page

[PMID:18440775-41] 42.0 ^42.1 Evans IM et al. (2008) Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase. Cell Signal 20: 1375-84 PubMed GONUTS page

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HUMAN:TNFA

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