HUMAN:TNAP3

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	TNFAIP3 ( synonyms: OTUD7C )
Protein Name(s)	Tumor necrosis factor alpha-induced protein 3 TNF alpha-induced protein 3 OTU domain-containing protein 7C Putative DNA-binding protein A20 Zinc finger protein A20
External Links
UniProt Identifier	TNAP3_HUMAN
UniProt Accessions	P21580, B2R767, E1P588, Q2HIX9, Q5VXQ7, Q9NSR6,
EMBL	M59465, AK312862, AY248754, AL357060, CH471051, CH471051, BC113871, BC114480, AL157444,
PIR	A35797,
RefSeq	NP_006281.1,
PDB	2EQE, 2EQF, 2EQG, 2VFJ, 3DKB, 3OJ3, 3OJ4,
IntAct	P21580,
Ensembl	ENST00000237289,
Pfam	PF02338, PF01754,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0032480	negative regulation of type I interferon production	Reactome:REACT_25271	TAS: Traceable Author Statement		P
	GO:0070936	protein K48-linked ubiquitination	PMID:15258597^[1]	IDA: Inferred from Direct Assay		P
	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB cascade	PMID:11463333^[2]	IDA: Inferred from Direct Assay		P
	GO:0002634	regulation of germinal center formation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q60769	P
	GO:0002237	response to molecule of bacterial origin	PMID:19912257^[3]	IDA: Inferred from Direct Assay		P
	GO:0005813	centrosome	PMID:18029348^[4]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005515	protein binding	PMID:15474016^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q86VP1	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002653	F
	GO:0006915	apoptosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0053	P
	GO:0051259	protein oligomerization	PMID:15474016^[5]	NAS: Non-traceable Author Statement		P
	GO:0004221	ubiquitin thiolesterase activity	PMID:15258597^[1]	IMP: Inferred from Mutant Phenotype		F
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0004843	ubiquitin-specific protease activity	PMID:20392859^[6]	TAS: Traceable Author Statement		F
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0090291	negative regulation of osteoclast proliferation	PMID:21127049^[7]	NAS: Non-traceable Author Statement		P
	GO:0071222	cellular response to lipopolysaccharide	PMID:21127049^[7]	IDA: Inferred from Direct Assay		P
	GO:0045732	positive regulation of protein catabolic process	PMID:21127049^[7]	IDA: Inferred from Direct Assay		P
	GO:0008152	metabolic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0511	P
	GO:2000349	negative regulation of CD40 signaling pathway	PMID:12885753^[8]	IMP: Inferred from Mutant Phenotype		P
	GO:0005515	protein binding	PMID:15474016^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y6K9	F
	GO:0005634	nucleus	PMID:11463333^[2]	IDA: Inferred from Direct Assay		C
	GO:0003824	catalytic activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0511	F
	GO:0005515	protein binding	PMID:11463333^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y4K3	F
	GO:0016874	ligase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0436	F
	GO:0061043	regulation of vascular wound healing	PMID:16816117^[9]	NAS: Non-traceable Author Statement		P
	GO:0016579	protein deubiquitination	PMID:20392859^[6]	TAS: Traceable Author Statement		P
	GO:0031397	negative regulation of protein ubiquitination	PMID:20392859^[6]	IDA: Inferred from Direct Assay		P
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0072573	tolerance induction to lipopolysaccharide	PMID:21220427^[10]	IMP: Inferred from Mutant Phenotype		P
	GO:2000352	negative regulation of endothelial cell apoptosis	PMID:12885753^[8]	IDA: Inferred from Direct Assay		P
	GO:0032088	negative regulation of NF-kappaB transcription factor activity	PMID:18223652^[11]	IDA: Inferred from Direct Assay		P
	GO:0043130	ubiquitin binding	PMID:19285159^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P0CG48	F
	GO:0050869	negative regulation of B cell activation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q60769	P
	GO:0071222	cellular response to lipopolysaccharide	PMID:19912257^[3]	IDA: Inferred from Direct Assay		P
	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q60769	P
	GO:0005515	protein binding	PMID:15474016^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q8NFZ5	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB cascade	PMID:21127049^[7]	IDA: Inferred from Direct Assay		P
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002653	F
	GO:0050691	regulation of defense response to virus by host	PMID:15142865^[13]	NAS: Non-traceable Author Statement		P
	GO:0001922	B-1 B cell homeostasis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q60769	P
	GO:0006916	anti-apoptosis	PMID:12167698^[14]	IDA: Inferred from Direct Assay		P
	GO:0070536	protein K63-linked deubiquitination	PMID:15258597^[1]	IDA: Inferred from Direct Assay		P
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000019997	C
	GO:0006916	anti-apoptosis	GO_REF:0000029	NAS: Non-traceable Author Statement		P
	GO:0008233	peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0645	F
	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway	PMID:15474016^[5]	IDA: Inferred from Direct Assay		P
	GO:0005829	cytosol	PMID:20304918^[15]	EXP: Inferred from Experiment		C
	GO:0043621	protein self-association	PMID:15474016^[5]	IDA: Inferred from Direct Assay		F
	GO:0005515	protein binding	PMID:20392859^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q92985	F
	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway	PMID:15142865^[13]	NAS: Non-traceable Author Statement		P
	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB cascade	PMID:15258597^[1]	IDA: Inferred from Direct Assay		P
	GO:0005737	cytoplasm	PMID:18029348^[4]	IDA: Inferred from Direct Assay		C
	GO:0045779	negative regulation of bone resorption	PMID:21127049^[7]	NAS: Non-traceable Author Statement		P
	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	PMID:15142865^[13]	NAS: Non-traceable Author Statement		P
	GO:0002020	protease binding	PMID:18223652^[11]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UDY8	F
	GO:0043027	caspase inhibitor activity	PMID:12167698^[14]	NAS: Non-traceable Author Statement		F
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0032715	negative regulation of interleukin-6 production	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q60769	P
	GO:0050728	negative regulation of inflammatory response	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q60769	P
	GO:0071222	cellular response to lipopolysaccharide	PMID:21220427^[10]	IDA: Inferred from Direct Assay		P
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0004842	ubiquitin-protein ligase activity	PMID:15258597^[1]	IDA: Inferred from Direct Assay		F
	GO:0043621	protein self-association	PMID:8797804^[16]	IDA: Inferred from Direct Assay		F
	GO:0008234	cysteine-type peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0788	F
	GO:0005515	protein binding	PMID:11463333^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y4K3	F
	GO:0004843	ubiquitin-specific protease activity	PMID:15258597^[1]	IDA: Inferred from Direct Assay		F
	GO:0005515	protein binding	PMID:15474016^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q15025	F
	GO:0032703	negative regulation of interleukin-2 production	PMID:18223652^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0043154	negative regulation of caspase activity	PMID:12167698^[14]	IDA: Inferred from Direct Assay		P
	GO:0048662	negative regulation of smooth muscle cell proliferation	PMID:16816117^[9]	IDA: Inferred from Direct Assay		P
	GO:0005515	protein binding	PMID:15142865^[13]	IPI: Inferred from Physical Interaction	UniProtKB:Q8IUC6	F
	GO:0005515	protein binding	PMID:15169888^[17]	IPI: Inferred from Physical Interaction	UniProtKB:Q8NFZ5	F
	GO:0001922	B-1 B cell homeostasis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q60769	P
	GO:0002020	protease binding	PMID:18223652^[11]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UDY8	F
	GO:0002218	activation of innate immune response	Reactome:REACT_75913	TAS: Traceable Author Statement		P
	GO:0002237	response to molecule of bacterial origin	PMID:19912257^[3]	IDA: Inferred from Direct Assay		P
	GO:0002634	regulation of germinal center formation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q60769	P
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002653	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003824	catalytic activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0511	F
	GO:0004221	ubiquitin thiolesterase activity	PMID:15258597^[1]	IMP: Inferred from Mutant Phenotype		F
	GO:0004842	ubiquitin-protein ligase activity	PMID:15258597^[1]	IDA: Inferred from Direct Assay		F
	GO:0004843	ubiquitin-specific protease activity	PMID:15258597^[1]	IDA: Inferred from Direct Assay		F
	GO:0004843	ubiquitin-specific protease activity	PMID:20392859^[6]	TAS: Traceable Author Statement		F
	GO:0005515	protein binding	PMID:11463333^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y4K3	F
	GO:0005515	protein binding	PMID:11463333^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y4K3	F
	GO:0005515	protein binding	PMID:15142865^[13]	IPI: Inferred from Physical Interaction	UniProtKB:Q8IUC6	F
	GO:0005515	protein binding	PMID:15169888^[17]	IPI: Inferred from Physical Interaction	UniProtKB:Q8NFZ5	F
	GO:0005515	protein binding	PMID:15474016^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q15025	F
	GO:0005515	protein binding	PMID:15474016^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q86VP1	F
	GO:0005515	protein binding	PMID:15474016^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q8NFZ5	F
	GO:0005515	protein binding	PMID:15474016^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y6K9	F
	GO:0005515	protein binding	PMID:20392859^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q92985	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:11463333^[2]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000019997	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	PMID:18029348^[4]	IDA: Inferred from Direct Assay		C
	GO:0005813	centrosome	PMID:18029348^[4]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	Reactome:REACT_25179	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_75888	TAS: Traceable Author Statement		C
	GO:0006915	apoptosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0053	P
	GO:0006916	anti-apoptosis	GO_REF:0000029	NAS: Non-traceable Author Statement		P
	GO:0006916	anti-apoptosis	PMID:12167698^[14]	IDA: Inferred from Direct Assay		P
	GO:0008152	metabolic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0511	P
	GO:0008233	peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0645	F
	GO:0008234	cysteine-type peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0788	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002653	F
	GO:0016579	protein deubiquitination	PMID:20392859^[6]	TAS: Traceable Author Statement		P
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0016874	ligase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0436	F
	GO:0031397	negative regulation of protein ubiquitination	PMID:20392859^[6]	IDA: Inferred from Direct Assay		P
	GO:0032088	negative regulation of NF-kappaB transcription factor activity	PMID:18223652^[11]	IDA: Inferred from Direct Assay		P
	GO:0032480	negative regulation of type I interferon production	Reactome:REACT_25271	TAS: Traceable Author Statement		P
	GO:0032703	negative regulation of interleukin-2 production	PMID:18223652^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0032715	negative regulation of interleukin-6 production	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q60769	P
	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q60769	P
	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway	PMID:15142865^[13]	NAS: Non-traceable Author Statement		P
	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway	PMID:15474016^[5]	IDA: Inferred from Direct Assay		P
	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	PMID:15142865^[13]	NAS: Non-traceable Author Statement		P
	GO:0043027	caspase inhibitor activity	PMID:12167698^[14]	NAS: Non-traceable Author Statement		F
	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB cascade	PMID:11463333^[2]	IDA: Inferred from Direct Assay		P
	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB cascade	PMID:15258597^[1]	IDA: Inferred from Direct Assay		P
	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB cascade	PMID:21127049^[7]	IDA: Inferred from Direct Assay		P
	GO:0043130	ubiquitin binding	PMID:19285159^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P0CG48	F
	GO:0043154	negative regulation of caspase activity	PMID:12167698^[14]	IDA: Inferred from Direct Assay		P
	GO:0043154	negative regulation of caspase activity	PMID:12167698^[14]	NAS: Non-traceable Author Statement		P
	GO:0043621	protein self-association	PMID:15474016^[5]	IDA: Inferred from Direct Assay		F
	GO:0043621	protein self-association	PMID:8797804^[16]	IDA: Inferred from Direct Assay		F
	GO:0045087	innate immune response	Reactome:REACT_6802	TAS: Traceable Author Statement		P
	GO:0045732	positive regulation of protein catabolic process	PMID:21127049^[7]	IDA: Inferred from Direct Assay		P
	GO:0045779	negative regulation of bone resorption	PMID:21127049^[7]	NAS: Non-traceable Author Statement		P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0048662	negative regulation of smooth muscle cell proliferation	PMID:16816117^[9]	IDA: Inferred from Direct Assay		P
	GO:0050691	regulation of defense response to virus by host	PMID:15142865^[13]	NAS: Non-traceable Author Statement		P
	GO:0050728	negative regulation of inflammatory response	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q60769	P
	GO:0050869	negative regulation of B cell activation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q60769	P
	GO:0051259	protein oligomerization	PMID:15474016^[5]	NAS: Non-traceable Author Statement		P
	GO:0061043	regulation of vascular wound healing	PMID:16816117^[9]	NAS: Non-traceable Author Statement		P
	GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	Reactome:REACT_75776	TAS: Traceable Author Statement		P
	GO:0070536	protein K63-linked deubiquitination	PMID:15258597^[1]	IDA: Inferred from Direct Assay		P
	GO:0070936	protein K48-linked ubiquitination	PMID:15258597^[1]	IDA: Inferred from Direct Assay		P
	GO:0071222	cellular response to lipopolysaccharide	PMID:19912257^[3]	IDA: Inferred from Direct Assay		P
	GO:0071222	cellular response to lipopolysaccharide	PMID:21127049^[7]	IDA: Inferred from Direct Assay		P
	GO:0071222	cellular response to lipopolysaccharide	PMID:21220427^[10]	IDA: Inferred from Direct Assay		P
	GO:0072573	tolerance induction to lipopolysaccharide	PMID:21220427^[10]	IMP: Inferred from Mutant Phenotype		P
	GO:0090291	negative regulation of osteoclast proliferation	PMID:21127049^[7]	NAS: Non-traceable Author Statement		P
	GO:2000349	negative regulation of CD40 signaling pathway	PMID:12885753^[8]	IMP: Inferred from Mutant Phenotype		P
	GO:2000352	negative regulation of endothelial cell apoptosis	PMID:12885753^[8]	IDA: Inferred from Direct Assay		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Wertz IE et al. (2004) De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 430: 694-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Evans PC et al. (2001) Isolation and characterization of two novel A20-like proteins. Biochem J 357: 617-23 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Oshima N et al. (2010) A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation. Clin Exp Immunol 159: 185-98 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 ^5.13 Wang YY et al. (2004) A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter. FEBS Lett 576: 86-90 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Ning S & Pagano JS (2010) The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7. J Virol 84: 6130-8 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Mabilleau G et al. (2011) Role of the A20-TRAF6 axis in lipopolysaccharide-mediated osteoclastogenesis. J Biol Chem 286: 3242-9 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Longo CR et al. (2003) A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis. Circulation 108: 1113-8 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Patel VI et al. (2006) A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression of neointimal hyperplasia. FASEB J 20: 1418-30 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Xiong Y et al. (2011) Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression. J Biol Chem 286: 7905-16 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Coornaert B et al. (2008) T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Nat Immunol 9: 263-71 PubMed GONUTS page
↑ ^12.0 ^12.1 Fenner BJ et al. (2009) Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays. Biochim Biophys Acta 1794: 1010-6 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Gon Y et al. (2004) A20 inhibits toll-like receptor 2- and 4-mediated interleukin-8 synthesis in airway epithelial cells. Am J Respir Cell Mol Biol 31: 330-6 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 He KL & Ting AT (2002) A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells. Mol Cell Biol 22: 6034-45 PubMed GONUTS page
↑ Parvatiyar K et al. (2010) TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases. J Biol Chem 285: 14999-5009 PubMed GONUTS page
↑ ^16.0 ^16.1 De Valck D et al. (1996) A20, an inhibitor of cell death, self-associates by its zinc finger domain. FEBS Lett 384: 61-4 PubMed GONUTS page
↑ ^17.0 ^17.1 Lang V et al. (2004) ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability. Mol Cell Biol 24: 5235-48 PubMed GONUTS page

[PMID:15258597-0] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Wertz IE et al. (2004) De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 430: 694-9 PubMed GONUTS page

[PMID:11463333-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Evans PC et al. (2001) Isolation and characterization of two novel A20-like proteins. Biochem J 357: 617-23 PubMed GONUTS page

[PMID:19912257-2] 3.0 ^3.1 ^3.2 ^3.3 Oshima N et al. (2010) A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation. Clin Exp Immunol 159: 185-98 PubMed GONUTS page

[PMID:18029348-3] 4.0 ^4.1 ^4.2 ^4.3 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page

[PMID:15474016-4] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 ^5.13 Wang YY et al. (2004) A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter. FEBS Lett 576: 86-90 PubMed GONUTS page

[PMID:20392859-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Ning S & Pagano JS (2010) The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7. J Virol 84: 6130-8 PubMed GONUTS page

[PMID:21127049-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Mabilleau G et al. (2011) Role of the A20-TRAF6 axis in lipopolysaccharide-mediated osteoclastogenesis. J Biol Chem 286: 3242-9 PubMed GONUTS page

[PMID:12885753-7] 8.0 ^8.1 ^8.2 ^8.3 Longo CR et al. (2003) A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis. Circulation 108: 1113-8 PubMed GONUTS page

[PMID:16816117-8] 9.0 ^9.1 ^9.2 ^9.3 Patel VI et al. (2006) A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression of neointimal hyperplasia. FASEB J 20: 1418-30 PubMed GONUTS page

[PMID:21220427-9] 10.0 ^10.1 ^10.2 ^10.3 Xiong Y et al. (2011) Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression. J Biol Chem 286: 7905-16 PubMed GONUTS page

[PMID:18223652-10] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Coornaert B et al. (2008) T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Nat Immunol 9: 263-71 PubMed GONUTS page

[PMID:19285159-11] 12.0 ^12.1 Fenner BJ et al. (2009) Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays. Biochim Biophys Acta 1794: 1010-6 PubMed GONUTS page

[PMID:15142865-12] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Gon Y et al. (2004) A20 inhibits toll-like receptor 2- and 4-mediated interleukin-8 synthesis in airway epithelial cells. Am J Respir Cell Mol Biol 31: 330-6 PubMed GONUTS page

[PMID:12167698-13] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 He KL & Ting AT (2002) A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells. Mol Cell Biol 22: 6034-45 PubMed GONUTS page

[PMID:20304918-14] Parvatiyar K et al. (2010) TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases. J Biol Chem 285: 14999-5009 PubMed GONUTS page

[PMID:8797804-15] 16.0 ^16.1 De Valck D et al. (1996) A20, an inhibitor of cell death, self-associates by its zinc finger domain. FEBS Lett 384: 61-4 PubMed GONUTS page

[PMID:15169888-16] 17.0 ^17.1 Lang V et al. (2004) ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability. Mol Cell Biol 24: 5235-48 PubMed GONUTS page

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HUMAN:TNAP3

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