HUMAN:TMPS3

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	TMPRSS3 ( synonyms: ECHOS1, TADG12 )
Protein Name(s)	Transmembrane protease serine 3 Serine protease TADG-12 Tumor-associated differentially-expressed gene 12 protein
External Links
UniProt Identifier	TMPS3_HUMAN
UniProt Accessions	P57727, D3DSJ6, Q6ZMC3,
EMBL	AF201380, AB038157, AB038158, AB038159, AB038160, AK172842, AY358458, CH471079, CH471079, BC074846, BC074847,
RefSeq	NP_076927.1, NP_115781.1,
IntAct	P57727,
Ensembl	ENST00000291532, ENST00000380399,
Pfam	PF00057, PF00530, PF00089,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009003	F
	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001254	F
	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001314	F
	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018114	F
	GO:0004252	serine-type endopeptidase activity	PMID:11068177^[1]	NAS: Non-traceable Author Statement		F
	GO:0004252	serine-type endopeptidase activity	PMID:11137999^[2]	NAS: Non-traceable Author Statement		F
	GO:0005044	scavenger receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001190	F
	GO:0005044	scavenger receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017448	F
	GO:0005783	endoplasmic reticulum	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0256	C
	GO:0005783	endoplasmic reticulum	PMID:16780588^[3]	IDA: Inferred from Direct Assay		C
	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0097	C
	GO:0005789	endoplasmic reticulum membrane	PMID:12393794^[4]	IDA: Inferred from Direct Assay		C
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001254	P
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001314	P
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018114	P
	GO:0006508	proteolysis	PMID:11068177^[1]	NAS: Non-traceable Author Statement		P
	GO:0006883	cellular sodium ion homeostasis	PMID:12393794^[4]	IDA: Inferred from Direct Assay		P
	GO:0008233	peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0645	F
	GO:0008236	serine-type peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0720	F
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001190	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017448	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016021	integral to membrane	PMID:11068177^[1]	NAS: Non-traceable Author Statement		C
	GO:0016021	integral to membrane	PMID:11137999^[2]	NAS: Non-traceable Author Statement		C
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0017080	sodium channel regulator activity	PMID:12393794^[4]	IDA: Inferred from Direct Assay		F
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009003	F
	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001254	F
	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001314	F
	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018114	F
	GO:0004252	serine-type endopeptidase activity	PMID:11068177^[1]	NAS: Non-traceable Author Statement		F
	GO:0004252	serine-type endopeptidase activity	PMID:11137999^[2]	NAS: Non-traceable Author Statement		F
	GO:0005044	scavenger receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001190	F
	GO:0005044	scavenger receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017448	F
	GO:0005783	endoplasmic reticulum	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0256	C
	GO:0005783	endoplasmic reticulum	PMID:16780588^[3]	IDA: Inferred from Direct Assay		C
	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0097	C
	GO:0005789	endoplasmic reticulum membrane	PMID:12393794^[4]	IDA: Inferred from Direct Assay		C
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001254	P
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001314	P
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018114	P
	GO:0006508	proteolysis	PMID:11068177^[1]	NAS: Non-traceable Author Statement		P
	GO:0006883	cellular sodium ion homeostasis	PMID:12393794^[4]	IDA: Inferred from Direct Assay		P
	GO:0007605	sensory perception of sound	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001540	P
	GO:0008233	peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0645	F
	GO:0008236	serine-type peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0720	F
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001190	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017448	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016021	integral to membrane	PMID:11068177^[1]	NAS: Non-traceable Author Statement		C
	GO:0016021	integral to membrane	PMID:11137999^[2]	NAS: Non-traceable Author Statement		C
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0017080	sodium channel regulator activity	PMID:12393794^[4]	IDA: Inferred from Direct Assay		F
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Underwood LJ et al. (2000) Ovarian tumor cells express a novel multi-domain cell surface serine protease. Biochim Biophys Acta 1502: 337-50 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Scott HS et al. (2001) Insertion of beta-satellite repeats identifies a transmembrane protease causing both congenital and childhood onset autosomal recessive deafness. Nat Genet 27: 59-63 PubMed GONUTS page
↑ ^3.0 ^3.1 Hu YH et al. (2006) Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. BMC Genomics 7: 155 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Guipponi M et al. (2002) The transmembrane serine protease (TMPRSS3) mutated in deafness DFNB8/10 activates the epithelial sodium channel (ENaC) in vitro. Hum Mol Genet 11: 2829-36 PubMed GONUTS page

[PMID:11068177-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Underwood LJ et al. (2000) Ovarian tumor cells express a novel multi-domain cell surface serine protease. Biochim Biophys Acta 1502: 337-50 PubMed GONUTS page

[PMID:11137999-1] 2.0 ^2.1 ^2.2 ^2.3 Scott HS et al. (2001) Insertion of beta-satellite repeats identifies a transmembrane protease causing both congenital and childhood onset autosomal recessive deafness. Nat Genet 27: 59-63 PubMed GONUTS page

[PMID:16780588-2] 3.0 ^3.1 Hu YH et al. (2006) Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. BMC Genomics 7: 155 PubMed GONUTS page

[PMID:12393794-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Guipponi M et al. (2002) The transmembrane serine protease (TMPRSS3) mutated in deafness DFNB8/10 activates the epithelial sodium channel (ENaC) in vitro. Hum Mol Genet 11: 2829-36 PubMed GONUTS page

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HUMAN:TMPS3

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