HUMAN:TFR1

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Species (Taxon ID)	Homo sapiens (Human). ([1])
Gene Name(s)	TFRC
Protein Name(s)	Transferrin receptor protein 1 TR TfR TfR1 Trfr T9 p90 Transferrin receptor protein 1, serum form sTfR
External Links
EMBL	X01060 M11507 AF187320 AB209254 DQ496099 CH471191 CH471191 BC001188
IPI	IPI00022462
PIR	A93343
RefSeq	NP_001121620.1 NP_003225.2
UniGene	Hs.529618
PDB	1CX8 1DE4 1SUV 2NSU 3KAS 3S9L 3S9M 3S9N
PDBsum	1CX8 1DE4 1SUV 2NSU 3KAS 3S9L 3S9M 3S9N
ProteinModelPortal	P02786
SMR	P02786
DIP	DIP-2736N
IntAct	P02786
MINT	MINT-4999032
STRING	P02786
MEROPS	M28.972
GlycoSuiteDB	P02786
PhosphoSite	P02786
PeptideAtlas	P02786
PRIDE	P02786
Ensembl	ENST00000360110 ENST00000392396
GeneID	7037
KEGG	hsa:7037
UCSC	uc003fvz.2
CTD	7037
GeneCards	GC03M193076
H-InvDB	HIX0003963
HGNC	HGNC:11763
HPA	CAB000153 HPA028598
MIM	190010
neXtProt	NX_P02786
eggNOG	prNOG10849
GeneTree	ENSGT00550000074421
HOGENOM	HBG403144
HOVERGEN	HBG023177
InParanoid	P02786
OMA	IGYLGYC
OrthoDB	EOG41C6VQ
PhylomeDB	P02786
Pathway_Interaction_DB	hnf3bpathway hif1_tfpathway
Reactome	REACT_11123 REACT_15518
NextBio	27493
ArrayExpress	P02786
Bgee	P02786
CleanEx	HS_TFRC
Genevestigator	P02786
GermOnline	ENSG00000072274
GO	GO:0005905 GO:0005887 GO:0042470 GO:0008233 GO:0004998 GO:0006879 GO:0044419 GO:0006508 GO:0033572 GO:0055085
InterPro	IPR007484 IPR003137 IPR007365
Gene3D	G3DSA:1.20.930.40
Pfam	PF02225 PF04389 PF04253
SUPFAM	SSF47672

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0001666	response to hypoxia	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000002407	P	Seeded From UniProt
	GO:0004872	receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0675	F	Seeded From UniProt
	GO:0004998	transferrin receptor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000002407	F	Seeded From UniProt
	GO:0004998	transferrin receptor activity	PMID:10192390^[1]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0004998	transferrin receptor activity	PMID:1871153^[2]	NAS: Non-traceable Author Statement		F	Seeded From UniProt
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C	Seeded From UniProt
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C	Seeded From UniProt
	GO:0005576	extracellular region	PMID:1871153^[2]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005739	mitochondrion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000002407	C	Seeded From UniProt
	GO:0005768	endosome	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023486	C	Seeded From UniProt
	GO:0005768	endosome	PMID:14612438^[3]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005768	endosome	PMID:8394993^[4]	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C	Seeded From UniProt
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023486	C	Seeded From UniProt
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000002407	C	Seeded From UniProt
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C	Seeded From UniProt
	GO:0005886	plasma membrane	Reactome:REACT_24927	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005886	plasma membrane	Reactome:REACT_24945	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005886	plasma membrane	Reactome:REACT_24977	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005886	plasma membrane	Reactome:REACT_25277	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005886	plasma membrane	Reactome:REACT_25389	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005887	integral to plasma membrane	PMID:6090955^[5]	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005905	coated pit	PMID:12857860^[6]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007484	P	Seeded From UniProt
	GO:0006879	cellular iron ion homeostasis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023486	P	Seeded From UniProt
	GO:0006879	cellular iron ion homeostasis	PMID:10192390^[1]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006879	cellular iron ion homeostasis	PMID:1871153^[2]	NAS: Non-traceable Author Statement		P	Seeded From UniProt
	GO:0006879	cellular iron ion homeostasis	Reactome:REACT_25060	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006897	endocytosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0254	P	Seeded From UniProt
	GO:0006953	acute-phase response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000002407	P	Seeded From UniProt
	GO:0007568	aging	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000002407	P	Seeded From UniProt
	GO:0007584	response to nutrient	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000002407	P	Seeded From UniProt
	GO:0008233	peptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007484	F	Seeded From UniProt
	GO:0009986	cell surface	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000002407	C	Seeded From UniProt
	GO:0010033	response to organic substance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000002407	P	Seeded From UniProt
	GO:0010035	response to inorganic substance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000002407	P	Seeded From UniProt
	GO:0010039	response to iron ion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000002407	P	Seeded From UniProt
	GO:0010042	response to manganese ion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000002407	P	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded From UniProt
	GO:0016020	membrane	PMID:1871153^[2]	NAS: Non-traceable Author Statement		C	Seeded From UniProt
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded From UniProt
	GO:0016023	cytoplasmic membrane-bounded vesicle	PMID:15229288^[7]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0030316	osteoclast differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023486	P	Seeded From UniProt
	GO:0030544	Hsp70 protein binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000002407	F	Seeded From UniProt
	GO:0032526	response to retinoic acid	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000002407	P	Seeded From UniProt
	GO:0033572	transferrin transport	Reactome:REACT_25283	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0042470	melanosome	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0161	C	Seeded From UniProt
	GO:0044419	interspecies interaction between organisms	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0945	P	Seeded From UniProt
	GO:0045780	positive regulation of bone resorption	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023486	P	Seeded From UniProt
	GO:0046688	response to copper ion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000002407	P	Seeded From UniProt
	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023486	C	Seeded From UniProt
	GO:0051087	chaperone binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000002407	F	Seeded From UniProt
	GO:0055038	recycling endosome membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000002407	C	Seeded From UniProt
	GO:0055085	transmembrane transport	Reactome:REACT_15518	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0070062	extracellular vesicular exosome	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023486	C	Seeded From UniProt
	GO:0070062	extracellular vesicular exosome	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000002407	C	Seeded From UniProt
	GO:0048471	perinuclear region of cytoplasm	PMID:20202662^[8]	IDA: Inferred from Direct Assay		C	Fig. 2C	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Levy JE et al. (1999) Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat Genet 21: 396-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Baynes RD et al. (1991) Characterization of transferrin receptor released by K562 erythroleukemia cells. Proc Soc Exp Biol Med 197: 416-23 PubMed GONUTS page
↑ Kim BE et al. (2004) Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane. J Biol Chem 279: 4523-30 PubMed GONUTS page
↑ Liao JF & Perkins JP (1993) Differential effects of antimycin A on endocytosis and exocytosis of transferrin also are observed for internalization and externalization of beta-adrenergic receptors. Mol Pharmacol 44: 364-70 PubMed GONUTS page
↑ Schneider C et al. (1984) Primary structure of human transferrin receptor deduced from the mRNA sequence. Nature 311: 675-8 PubMed GONUTS page
↑ Aschenbrenner L et al. (2003) Myo6 facilitates the translocation of endocytic vesicles from cell peripheries. Mol Biol Cell 14: 2728-43 PubMed GONUTS page
↑ Coumailleau F et al. (2004) Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment. Mol Biol Cell 15: 4444-56 PubMed GONUTS page
↑ Bhattacharyya S et al. (2010) Ebola virus uses clathrin-mediated endocytosis as an entry pathway. Virology 401: 18-28 PubMed GONUTS page

[PMID:10192390-0] 1.0 ^1.1 Levy JE et al. (1999) Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat Genet 21: 396-9 PubMed GONUTS page

[PMID:1871153-1] 2.0 ^2.1 ^2.2 ^2.3 Baynes RD et al. (1991) Characterization of transferrin receptor released by K562 erythroleukemia cells. Proc Soc Exp Biol Med 197: 416-23 PubMed GONUTS page

[PMID:14612438-2] Kim BE et al. (2004) Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane. J Biol Chem 279: 4523-30 PubMed GONUTS page

[PMID:8394993-3] Liao JF & Perkins JP (1993) Differential effects of antimycin A on endocytosis and exocytosis of transferrin also are observed for internalization and externalization of beta-adrenergic receptors. Mol Pharmacol 44: 364-70 PubMed GONUTS page

[PMID:6090955-4] Schneider C et al. (1984) Primary structure of human transferrin receptor deduced from the mRNA sequence. Nature 311: 675-8 PubMed GONUTS page

[PMID:12857860-5] Aschenbrenner L et al. (2003) Myo6 facilitates the translocation of endocytic vesicles from cell peripheries. Mol Biol Cell 14: 2728-43 PubMed GONUTS page

[PMID:15229288-6] Coumailleau F et al. (2004) Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment. Mol Biol Cell 15: 4444-56 PubMed GONUTS page

[PMID:20202662-7] Bhattacharyya S et al. (2010) Ebola virus uses clathrin-mediated endocytosis as an entry pathway. Virology 401: 18-28 PubMed GONUTS page

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HUMAN:TFR1

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