HUMAN:TAL1

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	TAL1 ( synonyms: BHLHA17, SCL, TCL5 )
Protein Name(s)	T-cell acute lymphocytic leukemia protein 1 TAL-1 Class A basic helix-loop-helix protein 17 bHLHa17 Stem cell protein T-cell leukemia/lymphoma protein 5
External Links
UniProt Identifier	TAL1_HUMAN
UniProt Accessions	P17542, D3DQ24,
EMBL	M61108, M61103, M61104, M61105, M63572, M63589, M63576, M63584, AL135960, CH471059, CH471059, CH471059, X58621, X58622, M29038, X51990,
PIR	A36358, I38253,
RefSeq	NP_003180.1,
IntAct	P17542,
Ensembl	ENST00000294339, ENST00000371884,
Pfam	PF00010,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005634	nucleus		IDA: Inferred from Direct Assay		C	Source: BHF-UCL
	GO:0042826	histone deacetylase binding		IPI: Inferred from Physical Interaction		F	Source: BHF-UCL
	GO:0010843	promoter binding		ISS: Inferred from Sequence or Structural Similarity		F	Source: BHF-UCL
	GO:0003700	sequence-specific DNA binding transcription factor activity		IDA: Inferred from Direct Assay		F	Source: BHF-UCL
	GO:0016563	transcription activator activity		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0045165	cell fate commitment		ISS: Inferred from Sequence or Structural Similarity		P	Source: BHF-UCL
	GO:0008283	cell proliferation		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0035162	embryonic hemopoiesis		ISS: Inferred from Sequence or Structural Similarity		P	Source: UniProtKB
	GO:0030218	erythrocyte differentiation		ISS: Inferred from Sequence or Structural Similarity		P	Source: BHF-UCL
	GO:0045648	positive regulation of erythrocyte differentiation		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0051781	positive regulation of cell division	PMID:20855495^[1]	IMP: Inferred from Mutant Phenotype		P	Fig 1a (bottom). " TAL1 knockdown lengthend the doubling time of cells...".	complete
	GO:0010551	regulation of gene-specific transcription from RNA polymerase II promoter		ISS: Inferred from Sequence or Structural Similarity		P	Source: BHF-UCL
	GO:0045931	positive regulation of mitotic cell cycle	PMID:20855495^[1]	IMP: Inferred from Mutant Phenotype		P	Tal-1 knockdown induced a partial blockage of the G2/M to G1 transition (Fig 1 b) and diminished uptake of BrdU in HSB2 cells indicated slow progression in S phase (Fig 1 c).	complete
	GO:0051091	positive regulation of transcription factor activity	PMID:20855495^[1]	IMP: Inferred from Mutant Phenotype		P	NKX3.1 messenger RNA (mRNA) and NKX3.1 protein levels were three- to fourfold decreased when TAL1 expression was decreased in Jurkat and HSB2 cells using shTAL1 constructs (Fig. 2, b and c.	complete
	GO:0070888	E-box binding	PMID:20855495^[1]	IDA: Inferred from Direct Assay		F	using oligonucleotides that cover all E-boxes and GATA binding sites present in the −875/−570 human NKX3.1 promoter region, we found that TAL1 and GATA-3 can bind an E-box located at −738 and/or two GATA binding sites at −748 and −697 (Fig. 3 c)	complete
	GO:0010843	promoter binding	PMID:20855495^[1]	IDA: Inferred from Direct Assay		F	Chromatin immunoprecipitation (ChIP) showed that TAL1 and GATA-3, the only member of the GATA family expressed in T cells, were specifically bound in vivo to the −875/−570 region of the human NKX3.1 gene promoter (Fig. 3 b).	complete
	GO:0031334	positive regulation of protein complex assembly	PMID:20855495^[1]	IDA: Inferred from Direct Assay		P	Expression of TAL1 led to its recruitment by GATA-3 (Fig. 4 a, top right) and to the formation of a transcriptional complex containing LMO1/2 and Ldb1 proteins on the NKX3.1 promoter (Fig. 4 a, bottom).	complete
	GO:0000790	nuclear chromatin	PMID:20855495^[1]	IDA: Inferred from Direct Assay		C
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003677	DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000030489	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:19497860^[2]	IDA: Inferred from Direct Assay		F
	GO:0005515	protein binding	PMID:17474147^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P46108	F
	GO:0005515	protein binding	PMID:19497860^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q16576	F
	GO:0005515	protein binding	PMID:20028976^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P62256	F
	GO:0005515	protein binding	PMID:7568177^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P25801	F
	GO:0005515	protein binding	PMID:9824680^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P15884	F
	GO:0005515	protein binding	PMID:9824680^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P15923	F
	GO:0005515	protein binding	PMID:9824680^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y295	F
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011598	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000030489	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:19497860^[2]	IDA: Inferred from Direct Assay		C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006351	transcription, DNA-dependent	PMID:19497860^[2]	IDA: Inferred from Direct Assay		P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001092	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011598	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006357	regulation of transcription from RNA polymerase II promoter	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22091	P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0008283	cell proliferation	PMID:2303035^[7]	TAS: Traceable Author Statement		P
	GO:0019899	enzyme binding	PMID:19497860^[2]	IPI: Inferred from Physical Interaction	UniProtKB:O60341	F
	GO:0030097	hemopoiesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000030489	P
	GO:0030097	hemopoiesis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22091	P
	GO:0030154	cell differentiation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0221	P
	GO:0030218	erythrocyte differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000030489	P
	GO:0030218	erythrocyte differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22091	P
	GO:0030218	erythrocyte differentiation	PMID:7678994^[8]	IEP: Inferred from Expression Pattern		P
	GO:0030219	megakaryocyte differentiation	PMID:7678994^[8]	IEP: Inferred from Expression Pattern		P
	GO:0030221	basophil differentiation	PMID:7678994^[8]	IEP: Inferred from Expression Pattern		P
	GO:0031334	positive regulation of protein complex assembly	PMID:20855495^[1]	IDA: Inferred from Direct Assay		P
	GO:0035162	embryonic hemopoiesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000030489	P
	GO:0035162	embryonic hemopoiesis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22091	P
	GO:0042826	histone deacetylase binding	PMID:19497860^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q13547	F
	GO:0042826	histone deacetylase binding	PMID:19497860^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q92769	F
	GO:0043234	protein complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000030489	C
	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22091	F
	GO:0045165	cell fate commitment	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000030489	P
	GO:0045165	cell fate commitment	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22091	P
	GO:0045648	positive regulation of erythrocyte differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000030489	P
	GO:0045648	positive regulation of erythrocyte differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22091	P
	GO:0045648	positive regulation of erythrocyte differentiation	PMID:20028976^[4]	IDA: Inferred from Direct Assay		P
	GO:0045799	positive regulation of chromatin assembly or disassembly	PMID:20855495^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:20028976^[4]	IDA: Inferred from Direct Assay		P
	GO:0045931	positive regulation of mitotic cell cycle	PMID:20855495^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:20855495^[1]	IDA: Inferred from Direct Assay		P
	GO:0051781	positive regulation of cell division	PMID:20855495^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0070888	E-box binding	PMID:20855495^[1]	IDA: Inferred from Direct Assay		F
colocalizes_with	GO:0000118	histone deacetylase complex	PMID:19497860^[2]	IDA: Inferred from Direct Assay		C
colocalizes_with	GO:0033193	Lsd1/2 complex	PMID:19497860^[2]	IDA: Inferred from Direct Assay		C
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 Kusy S et al. (2010) NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia. J Exp Med 207: 2141-56 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Hu X et al. (2009) LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis. Proc Natl Acad Sci U S A 106: 10141-6 PubMed GONUTS page
↑ Wu C et al. (2007) Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. Proteomics 7: 1775-85 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Lausen J et al. (2010) Targets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1. J Biol Chem 285: 5338-46 PubMed GONUTS page
↑ Osada H et al. (1995) Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1. Proc Natl Acad Sci U S A 92: 9585-9 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Zhao XF & Aplan PD (1998) SCL binds the human homologue of DRG in vivo. Biochim Biophys Acta 1448: 109-14 PubMed GONUTS page
↑ Chen Q et al. (1990) The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. EMBO J 9: 415-24 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Mouthon MA et al. (1993) Expression of tal-1 and GATA-binding proteins during human hematopoiesis. Blood 81: 647-55 PubMed GONUTS page

[PMID:20855495-0] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 Kusy S et al. (2010) NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia. J Exp Med 207: 2141-56 PubMed GONUTS page

[PMID:19497860-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Hu X et al. (2009) LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis. Proc Natl Acad Sci U S A 106: 10141-6 PubMed GONUTS page

[PMID:17474147-2] Wu C et al. (2007) Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. Proteomics 7: 1775-85 PubMed GONUTS page

[PMID:20028976-3] 4.0 ^4.1 ^4.2 Lausen J et al. (2010) Targets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1. J Biol Chem 285: 5338-46 PubMed GONUTS page

[PMID:7568177-4] Osada H et al. (1995) Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1. Proc Natl Acad Sci U S A 92: 9585-9 PubMed GONUTS page

[PMID:9824680-5] 6.0 ^6.1 ^6.2 Zhao XF & Aplan PD (1998) SCL binds the human homologue of DRG in vivo. Biochim Biophys Acta 1448: 109-14 PubMed GONUTS page

[PMID:2303035-6] Chen Q et al. (1990) The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. EMBO J 9: 415-24 PubMed GONUTS page

[PMID:7678994-7] 8.0 ^8.1 ^8.2 Mouthon MA et al. (1993) Expression of tal-1 and GATA-binding proteins during human hematopoiesis. Blood 81: 647-55 PubMed GONUTS page

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HUMAN:TAL1

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