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HUMAN:TADBP
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | TARDBP (synonyms: TDP43) | |
| Protein Name(s) | TAR DNA-binding protein 43
TDP-43 | |
| External Links | ||
| EMBL | U23731 EF434181 EF434182 EF434183 AK312416 CR533534 AK222754 AL050265 AL109811 CH471130 BC071657 BC095435 | |
| IPI | IPI00025815 IPI00844544 IPI00971018 | |
| PIR | I38977 | |
| RefSeq | NP_031401.1 | |
| UniGene | Hs.300624 Hs.635053 | |
| PDB | 1WF0 2CQG | |
| PDBsum | 1WF0 2CQG | |
| ProteinModelPortal | Q13148 | |
| SMR | Q13148 | |
| IntAct | Q13148 | |
| STRING | Q13148 | |
| PhosphoSite | Q13148 | |
| PRIDE | Q13148 | |
| Ensembl | ENST00000240185 | |
| GeneID | 23435 | |
| KEGG | hsa:23435 | |
| UCSC | uc001art.1 | |
| CTD | 23435 | |
| GeneCards | GC01P010224 | |
| H-InvDB | HIX0000120 HIX0030280 | |
| HGNC | HGNC:11571 | |
| HPA | CAB003703 HPA017284 | |
| MIM | 605078 612069 | |
| neXtProt | NX_Q13148 | |
| Orphanet | 803 98929 | |
| HOVERGEN | HBG058671 | |
| InParanoid | Q13148 | |
| OMA | KHNSSRQ | |
| OrthoDB | EOG447FTT | |
| PhylomeDB | Q13148 | |
| NextBio | 45695 | |
| ArrayExpress | Q13148 | |
| Bgee | Q13148 | |
| CleanEx | HS_TARDBP | |
| Genevestigator | Q13148 | |
| GermOnline | ENSG00000120948 | |
| GO | GO:0005634 GO:0003690 GO:0003730 GO:0000166 GO:0005515 GO:0003700 GO:0070935 GO:0008219 GO:0006397 GO:0043922 GO:0008380 GO:0006366 | |
| InterPro | IPR012677 IPR000504 | |
| Gene3D | G3DSA:3.30.70.330 | |
| Pfam | PF00076 | |
| SMART | SM00360 | |
| PROSITE | PS50102 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003676 |
nucleic acid binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003690 |
double-stranded DNA binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0003723 |
RNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003723 |
RNA binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0003730 |
mRNA 3'-UTR binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0006351 |
transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0006366 |
transcription from RNA polymerase II promoter |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0006397 |
mRNA processing |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0008219 |
cell death |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0008380 |
RNA splicing |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0008380 |
RNA splicing |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0043922 |
negative regulation by host of viral transcription |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0070935 |
3'-UTR-mediated mRNA stabilization |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0005730 |
nucleolus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Ou SH et al. (1995) Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. J Virol 69: 3584-96 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Buratti E et al. (2001) Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping. EMBO J 20: 1774-84 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Strong MJ et al. (2007) TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein. Mol Cell Neurosci 35: 320-7 PubMed GONUTS page
- ↑ Elden AC et al. (2010) Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS. Nature 466: 1069-75 PubMed GONUTS page
- ↑ Simpson JC et al. (2000) Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. EMBO Rep 1: 287-92 PubMed GONUTS page
- ↑ 6.0 6.1 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
