HUMAN:STAT3

From GONUTS

Jump to: navigation, search

Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	STAT3 ( synonyms: APRF )
Protein Name(s)	Signal transducer and activator of transcription 3 Acute-phase response factor
External Links
UniProt Identifier	STAT3_HUMAN
UniProt Accessions	P40763, O14916, Q9BW54,
EMBL	L29277, AJ012463, AY572796, BC000627, BC014482, AF029311,
PIR	A54444,
RefSeq	NP_003141.2, NP_644805.1, NP_998827.1,
IntAct	P40763,
Ensembl	ENST00000264657,
Pfam	PF00017, PF01017, PF02864, PF02865,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0005737	cytoplasm		TAS: Traceable Author Statement		C	Source: ProtInc
	GO:0005634	nucleus		IDA: Inferred from Direct Assay		C	Source: HGNC
	GO:0005509	calcium ion binding		IEA		F	Source: InterPro
	GO:0005062	hematopoietin/interferon-class (D200-domain...		TAS: Traceable Author Statement		F	Source: ProtInc
	GO:0019901	protein kinase binding		ISS: Inferred from Sequence or Structural Similarity		F	Source: UniProtKB
	GO:0003700	transcription factor activity		TAS: Traceable Author Statement		F	Source: ProtInc
	GO:0008134	transcription factor binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0006928	cell motion		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0032870	cellular response to hormone stimulus		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0070102	interleukin-6-mediated signaling pathway		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0044419	interspecies interaction between organisms		IEA		P	Source: UniProtKB-KW
	GO:0060397	JAK-STAT cascade involved in growth hormone...		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0000122	negative regulation of transcription from R...		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0007399	nervous system development		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0032355	response to estradiol stimulus		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:8675499^[1]	TAS: Traceable Author Statement		P
	GO:0001659	temperature homeostasis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000120152	P
	GO:0001659	temperature homeostasis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P42227	P
	GO:0001754	eye photoreceptor cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000120152	P
	GO:0001754	eye photoreceptor cell differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P42227	P
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003677	DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000120152	F
	GO:0003677	DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026760	F
	GO:0003677	DNA binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P42227	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001217	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008967	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012345	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013799	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013800	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013801	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015988	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:7512451^[2]	TAS: Traceable Author Statement		F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:8675499^[1]	TAS: Traceable Author Statement		F
	GO:0003706	ligand-regulated transcription factor activity	PMID:17324931^[3]	IDA: Inferred from Direct Assay		F
	GO:0004715	non-membrane spanning protein tyrosine kinase activity	Reactome:REACT_27203	TAS: Traceable Author Statement		F
	GO:0004871	signal transducer activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001217	F
	GO:0004871	signal transducer activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012345	F
	GO:0004871	signal transducer activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013799	F
	GO:0004871	signal transducer activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013800	F
	GO:0004871	signal transducer activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013801	F
	GO:0004871	signal transducer activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015988	F
	GO:0004871	signal transducer activity	PMID:7512451^[2]	TAS: Traceable Author Statement		F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011992	F
	GO:0005515	protein binding	PMID:11585385^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q07666	F
	GO:0005515	protein binding	PMID:15764709^[5]	IPI: Inferred from Physical Interaction	UniProtKB:O43318	F
	GO:0005515	protein binding	PMID:16306601^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P20749	F
	GO:0005515	protein binding	PMID:16331268^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UER7	F
	GO:0005515	protein binding	PMID:16531398^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q96EY1-1	F
	GO:0005515	protein binding	PMID:17923090^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P52630	F
	GO:0005515	protein binding	PMID:18234692^[10]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y2Y0	F
	GO:0005515	protein binding	PMID:18503751^[11]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y5S9	F
	GO:0005515	protein binding	PMID:19345327^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q04206	F
	GO:0005515	protein binding	PMID:20871632^[13]	IPI: Inferred from Physical Interaction	UniProtKB:P45984	F
	GO:0005515	protein binding	PMID:20871632^[13]	IPI: Inferred from Physical Interaction	UniProtKB:P45984-1	F
	GO:0005515	protein binding	PMID:20929579^[14]	IPI: Inferred from Physical Interaction	UniProtKB:O00570	F
	GO:0005515	protein binding	PMID:9989503^[15]	IPI: Inferred from Physical Interaction	UniProtKB:Q13287	F
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001217	C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012345	C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013800	C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013801	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000120152	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026760	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P42227	C
	GO:0005634	nucleus	PMID:12444102^[16]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:17324931^[3]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:18029348^[17]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:18234692^[10]	IDA: Inferred from Direct Assay		C
	GO:0005654	nucleoplasm	Reactome:REACT_27303	TAS: Traceable Author Statement		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000120152	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026760	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P42227	C
	GO:0005737	cytoplasm	PMID:18029348^[17]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:18234692^[10]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:7512451^[2]	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000120152	C
	GO:0005829	cytosol	Reactome:REACT_12057	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_16982	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_27182	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_27203	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_27225	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_27262	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_27303	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_27311	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000120152	C
	GO:0005886	plasma membrane	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P42227	C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006351	transcription, DNA-dependent	PMID:7512451^[2]	TAS: Traceable Author Statement		P
	GO:0006351	transcription, DNA-dependent	PMID:8675499^[1]	TAS: Traceable Author Statement		P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001217	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008967	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012345	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013799	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013800	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013801	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015988	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:15664994^[18]	IDA: Inferred from Direct Assay		P
	GO:0006357	regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000120152	P
	GO:0006357	regulation of transcription from RNA polymerase II promoter	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P42227	P
	GO:0006357	regulation of transcription from RNA polymerase II promoter	PMID:7512451^[2]	TAS: Traceable Author Statement		P
	GO:0006366	transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000120152	P
	GO:0006606	protein import into nucleus	PMID:18234692^[10]	IDA: Inferred from Direct Assay		P
	GO:0006928	cellular component movement	PMID:9670957^[19]	TAS: Traceable Author Statement		P
	GO:0006953	acute-phase response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026760	P
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001217	P
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012345	P
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013799	P
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013800	P
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013801	P
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015988	P
	GO:0007165	signal transduction	PMID:10205054^[20]	TAS: Traceable Author Statement		P
	GO:0007165	signal transduction	PMID:7512451^[2]	TAS: Traceable Author Statement		P
	GO:0007259	JAK-STAT cascade	PMID:15664994^[18]	TAS: Traceable Author Statement		P
	GO:0007259	JAK-STAT cascade	PMID:9670957^[19]	TAS: Traceable Author Statement		P
	GO:0007399	nervous system development	PMID:10205054^[20]	TAS: Traceable Author Statement		P
	GO:0008134	transcription factor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026760	F
	GO:0008134	transcription factor binding	PMID:15664994^[18]	IPI: Inferred from Physical Interaction	UniProtKB:P49715	F
	GO:0010033	response to organic substance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026760	P
	GO:0014070	response to organic cyclic compound	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026760	P
	GO:0019221	cytokine-mediated signaling pathway	PMID:15664994^[18]	NAS: Non-traceable Author Statement		P
	GO:0019901	protein kinase binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000120152	F
	GO:0019901	protein kinase binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P42227	F
	GO:0019953	sexual reproduction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000120152	P
	GO:0019953	sexual reproduction	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P42227	P
	GO:0031730	CCR5 chemokine receptor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026760	F
	GO:0032355	response to estradiol stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026760	P
	GO:0032355	response to estradiol stimulus	PMID:12552091^[21]	IDA: Inferred from Direct Assay		P
	GO:0032870	cellular response to hormone stimulus	PMID:12552091^[21]	IDA: Inferred from Direct Assay		P
	GO:0034097	response to cytokine stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026760	P
	GO:0035259	glucocorticoid receptor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026760	F
	GO:0040014	regulation of multicellular organism growth	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000120152	P
	GO:0042493	response to drug	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026760	P
	GO:0042593	glucose homeostasis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000120152	P
	GO:0042593	glucose homeostasis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P42227	P
	GO:0042755	eating behavior	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000120152	P
	GO:0042755	eating behavior	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P42227	P
	GO:0043434	response to peptide hormone stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026760	P
	GO:0043565	sequence-specific DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000120152	F
	GO:0043565	sequence-specific DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026760	F
	GO:0044212	transcription regulatory region DNA binding	PMID:17324931^[3]	IDA: Inferred from Direct Assay		F
	GO:0044419	interspecies interaction between organisms	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0945	P
	GO:0045471	response to ethanol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026760	P
	GO:0045893	positive regulation of transcription, DNA-dependent	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P42227	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000120152	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:17324931^[3]	IDA: Inferred from Direct Assay		P
	GO:0046983	protein dimerization activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000120152	F
	GO:0046983	protein dimerization activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P42227	F
	GO:0048011	nerve growth factor receptor signaling pathway	Reactome:REACT_11061	TAS: Traceable Author Statement		P
	GO:0060396	growth hormone receptor signaling pathway	PMID:10925297^[22]	IDA: Inferred from Direct Assay		P
	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000120152	P
	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P42227	P
	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway	PMID:12552091^[21]	IDA: Inferred from Direct Assay		P
	GO:0070102	interleukin-6-mediated signaling pathway	PMID:12552091^[21]	IDA: Inferred from Direct Assay		P
	GO:0070102	interleukin-6-mediated signaling pathway	PMID:17324931^[3]	IDA: Inferred from Direct Assay		P
NOT	GO:0005730	nucleolus	PMID:18029348^[17]	IDA: Inferred from Direct Assay		C
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Caldenhoven E et al. (1996) STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription. J Biol Chem 271: 13221-7 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Akira S et al. (1994) Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 77: 63-71 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Theiss AL et al. (2007) Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells. J Biol Chem 282: 12804-12 PubMed GONUTS page
↑ Sanchez-Margalet V & Martin-Romero C (2001) Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway. Cell Immunol 211: 30-6 PubMed GONUTS page
↑ Kojima H et al. (2005) STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation. Proc Natl Acad Sci U S A 102: 4524-9 PubMed GONUTS page
↑ Jamaluddin M et al. (2005) Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter. J Virol 79: 15302-13 PubMed GONUTS page
↑ Muromoto R et al. (2006) Physical and functional interactions between Daxx and STAT3. Oncogene 25: 2131-6 PubMed GONUTS page
↑ Lu B et al. (2006) Tid1 isoforms are mitochondrial DnaJ-like chaperones with unique carboxyl termini that determine cytosolic fate. J Biol Chem 281: 13150-8 PubMed GONUTS page
↑ Tang X et al. (2007) Acetylation-dependent signal transduction for type I interferon receptor. Cell 131: 93-105 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Muromoto R et al. (2008) BART is essential for nuclear retention of STAT3. Int Immunol 20: 395-403 PubMed GONUTS page
↑ Ohbayashi N et al. (2008) An RNA biding protein, Y14 interacts with and modulates STAT3 activation. Biochem Biophys Res Commun 372: 475-9 PubMed GONUTS page
↑ Lee H et al. (2009) Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. Cancer Cell 15: 283-93 PubMed GONUTS page
↑ ^13.0 ^13.1 Nitta RT et al. (2011) The role of the c-Jun N-terminal kinase 2-α-isoform in non-small cell lung carcinoma tumorigenesis. Oncogene 30: 234-44 PubMed GONUTS page
↑ Mathews LA et al. (2010) Epigenetic regulation of CpG promoter methylation in invasive prostate cancer cells. Mol Cancer 9: 267 PubMed GONUTS page
↑ Zhu M et al. (1999) Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling. Cell 96: 121-30 PubMed GONUTS page
↑ Scoles DR et al. (2002) Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling. Hum Mol Genet 11: 3179-89 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Numata A et al. (2005) Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway. J Biol Chem 280: 12621-9 PubMed GONUTS page
↑ ^19.0 ^19.1 Mellado M et al. (1998) The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor. J Immunol 161: 805-13 PubMed GONUTS page
↑ ^20.0 ^20.1 Nakashima K et al. (1999) Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. Science 284: 479-82 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Leung KC et al. (2003) Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2. Proc Natl Acad Sci U S A 100: 1016-21 PubMed GONUTS page
↑ Ryu H et al. (2000) Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin. J Immunol 165: 2116-23 PubMed GONUTS page

[PMID:8675499-0] 1.0 ^1.1 ^1.2 Caldenhoven E et al. (1996) STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription. J Biol Chem 271: 13221-7 PubMed GONUTS page

[PMID:7512451-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Akira S et al. (1994) Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 77: 63-71 PubMed GONUTS page

[PMID:17324931-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Theiss AL et al. (2007) Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells. J Biol Chem 282: 12804-12 PubMed GONUTS page

[PMID:11585385-3] Sanchez-Margalet V & Martin-Romero C (2001) Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway. Cell Immunol 211: 30-6 PubMed GONUTS page

[PMID:15764709-4] Kojima H et al. (2005) STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation. Proc Natl Acad Sci U S A 102: 4524-9 PubMed GONUTS page

[PMID:16306601-5] Jamaluddin M et al. (2005) Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter. J Virol 79: 15302-13 PubMed GONUTS page

[PMID:16331268-6] Muromoto R et al. (2006) Physical and functional interactions between Daxx and STAT3. Oncogene 25: 2131-6 PubMed GONUTS page

[PMID:16531398-7] Lu B et al. (2006) Tid1 isoforms are mitochondrial DnaJ-like chaperones with unique carboxyl termini that determine cytosolic fate. J Biol Chem 281: 13150-8 PubMed GONUTS page

[PMID:17923090-8] Tang X et al. (2007) Acetylation-dependent signal transduction for type I interferon receptor. Cell 131: 93-105 PubMed GONUTS page

[PMID:18234692-9] 10.0 ^10.1 ^10.2 ^10.3 Muromoto R et al. (2008) BART is essential for nuclear retention of STAT3. Int Immunol 20: 395-403 PubMed GONUTS page

[PMID:18503751-10] Ohbayashi N et al. (2008) An RNA biding protein, Y14 interacts with and modulates STAT3 activation. Biochem Biophys Res Commun 372: 475-9 PubMed GONUTS page

[PMID:19345327-11] Lee H et al. (2009) Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. Cancer Cell 15: 283-93 PubMed GONUTS page

[PMID:20871632-12] 13.0 ^13.1 Nitta RT et al. (2011) The role of the c-Jun N-terminal kinase 2-α-isoform in non-small cell lung carcinoma tumorigenesis. Oncogene 30: 234-44 PubMed GONUTS page

[PMID:20929579-13] Mathews LA et al. (2010) Epigenetic regulation of CpG promoter methylation in invasive prostate cancer cells. Mol Cancer 9: 267 PubMed GONUTS page

[PMID:9989503-14] Zhu M et al. (1999) Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling. Cell 96: 121-30 PubMed GONUTS page

[PMID:12444102-15] Scoles DR et al. (2002) Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling. Hum Mol Genet 11: 3179-89 PubMed GONUTS page

[PMID:18029348-16] 17.0 ^17.1 ^17.2 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page

[PMID:15664994-17] 18.0 ^18.1 ^18.2 ^18.3 Numata A et al. (2005) Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway. J Biol Chem 280: 12621-9 PubMed GONUTS page

[PMID:9670957-18] 19.0 ^19.1 Mellado M et al. (1998) The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor. J Immunol 161: 805-13 PubMed GONUTS page

[PMID:10205054-19] 20.0 ^20.1 Nakashima K et al. (1999) Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. Science 284: 479-82 PubMed GONUTS page

[PMID:12552091-20] 21.0 ^21.1 ^21.2 ^21.3 Leung KC et al. (2003) Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2. Proc Natl Acad Sci U S A 100: 1016-21 PubMed GONUTS page

[PMID:10925297-21] Ryu H et al. (2000) Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin. J Immunol 165: 2116-23 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

HUMAN:STAT3

Contents

Annotations

Notes

References

a

c

d

e

g

h

h cont.

i

j

l

m

n

p

p cont.

r

s

t

v

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox