HUMAN:SOX9

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Species (Taxon ID)	Homo sapiens (Human). ([1])
Gene Name(s)	SOX9
Protein Name(s)	Transcription factor SOX-9
External Links
EMBL	Z46629 S74506 S74504 S74505 BT006875 CH471099 BC007951 BC056420
IPI	IPI00009713
PIR	A55204
RefSeq	NP_000337.1
UniGene	Hs.647409
PDB	1S9M 1SX9
PDBsum	1S9M 1SX9
ProteinModelPortal	P48436
SMR	P48436
STRING	P48436
PhosphoSite	P48436
PRIDE	P48436
Ensembl	ENST00000245479
GeneID	6662
KEGG	hsa:6662
UCSC	uc002jiw.1
CTD	6662
GeneCards	GC17P065510
H-InvDB	HIX0014127
HGNC	HGNC:11204
HPA	CAB022456 HPA001758
MIM	114290 278850 608160
neXtProt	NX_P48436
Orphanet	140
PharmGKB	PA36041
eggNOG	prNOG04276
GeneTree	ENSGT00600000084111
HOGENOM	HBG447471
HOVERGEN	HBG002061
InParanoid	P48436
OMA	GAGHVWM
OrthoDB	EOG4TXBRZ
PhylomeDB	P48436
NextBio	25973
ArrayExpress	P48436
Bgee	P48436
CleanEx	HS_SOX9
Genevestigator	P48436
GermOnline	ENSG00000125398
GO	GO:0016585 GO:0003682 GO:0001046 GO:0001158 GO:0034236 GO:0004672 GO:0001077 GO:0003705 GO:0019933 GO:0001502 GO:0001708 GO:0071364 GO:0071504 GO:0071347 GO:0071260 GO:0071300 GO:0071560 GO:0003413 GO:0003415 GO:0006338 GO:0090103 GO:0003203 GO:0007173 GO:0060517 GO:0001837 GO:0070371 GO:0001942 GO:0060729 GO:0019100 GO:0072289 GO:0043066 GO:0090090 GO:0032331 GO:0050680 GO:0002683 GO:0045662 GO:0046533 GO:0045892 GO:0006334 GO:0030916 GO:0090190 GO:0061036 GO:0032332 GO:0030858 GO:0010634 GO:0050679 GO:2000020 GO:0002053 GO:2000741 GO:0014068 GO:0001934 GO:0006461 GO:0010564 GO:0060784 GO:0072034 GO:0060221 GO:0035019 GO:0007283
InterPro	IPR000910 IPR009071 IPR022151
Gene3D	G3DSA:1.10.30.10
KO	K09270
Pfam	PF00505 PF12444
SMART	SM00398
SUPFAM	SSF47095
PROSITE	PS50118

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0001046	core promoter sequence-specific DNA binding	PMID:20530484^[1]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	PMID:20484372^[2]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	PMID:20530484^[1]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	PMID:21367821^[3]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0001158	enhancer sequence-specific DNA binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	F	Seeded From UniProt
	GO:0001501	skeletal system development	PMID:8640233^[4]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0001502	cartilage condensation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0001502	cartilage condensation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0001708	cell fate specification	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0001708	cell fate specification	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0001837	epithelial to mesenchymal transition	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0001837	epithelial to mesenchymal transition	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0001894	tissue homeostasis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0001942	hair follicle development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0001942	hair follicle development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0002063	chondrocyte development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0002683	negative regulation of immune system process	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0003170	heart valve development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0003179	heart valve morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0003179	heart valve morphogenesis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0003188	heart valve formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0003203	endocardial cushion morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0003203	endocardial cushion morphogenesis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0003413	chondrocyte differentiation involved in endochondral bone morphogenesis	PMID:20676705^[5]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0003415	chondrocyte hypertrophy	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000910	F	Seeded From UniProt
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F	Seeded From UniProt
	GO:0003677	DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	F	Seeded From UniProt
	GO:0003682	chromatin binding	PMID:20484372^[2]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	F	Seeded From UniProt
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:10805756^[6]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:8640233^[4]	IMP: Inferred from Mutant Phenotype		F	Seeded From UniProt
	GO:0003705	sequence-specific distal enhancer binding RNA polymerase II transcription factor activity	PMID:20484372^[2]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0003705	sequence-specific distal enhancer binding RNA polymerase II transcription factor activity	PMID:21412441^[7]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0004672	protein kinase activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:20530484^[1]	IPI: Inferred from Physical Interaction	UniProtKB:O75030	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:20530484^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P32243	F	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C	Seeded From UniProt
	GO:0005634	nucleus	PMID:10805756^[6]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005634	nucleus	PMID:12420222^[8]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005634	nucleus	PMID:18029348^[9]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005634	nucleus	PMID:18512230^[10]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005634	nucleus	PMID:8640233^[4]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0006334	nucleosome assembly	PMID:20484372^[2]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0006338	chromatin remodeling	PMID:20484372^[2]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P	Seeded From UniProt
	GO:0006351	transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P	Seeded From UniProt
	GO:0006461	protein complex assembly	PMID:20530484^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0007165	signal transduction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0007165	signal transduction	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:21512138^[11]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0007283	spermatogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0007283	spermatogenesis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0007507	heart development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0008013	beta-catenin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	F	Seeded From UniProt
	GO:0008284	positive regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0008284	positive regulation of cell proliferation	PMID:20651055^[12]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0008285	negative regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0008584	male gonad development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0008584	male gonad development	PMID:17848411^[13]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0008584	male gonad development	PMID:8640233^[4]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0010564	regulation of cell cycle process	PMID:12420222^[8]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0010628	positive regulation of gene expression	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0010634	positive regulation of epithelial cell migration	PMID:21512138^[11]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0014032	neural crest cell development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0014068	positive regulation of phosphatidylinositol 3-kinase cascade	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0016585	chromatin remodeling complex	PMID:20484372^[2]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0019100	male germ-line sex determination	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0019100	male germ-line sex determination	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0019933	cAMP-mediated signaling	PMID:10805756^[6]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0030154	cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0030155	regulation of cell adhesion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0030198	extracellular matrix organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0030279	negative regulation of ossification	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0030502	negative regulation of bone mineralization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0030850	prostate gland development	PMID:20103652^[14]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0030858	positive regulation of epithelial cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0030858	positive regulation of epithelial cell differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0030916	otic vesicle formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0030916	otic vesicle formation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0031018	endocrine pancreas development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0032331	negative regulation of chondrocyte differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0032331	negative regulation of chondrocyte differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0032332	positive regulation of chondrocyte differentiation	PMID:20676705^[5]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0032332	positive regulation of chondrocyte differentiation	PMID:21401405^[15]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0034236	protein kinase A catalytic subunit binding	PMID:10805756^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P05132	F	Seeded From UniProt
	GO:0035019	somatic stem cell maintenance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0035019	somatic stem cell maintenance	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0035326	enhancer binding	PMID:10805756^[6]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0035622	intrahepatic bile duct development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0042127	regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0042127	regulation of cell proliferation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0042981	regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0042981	regulation of apoptosis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0043066	negative regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0043066	negative regulation of apoptosis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0043066	negative regulation of apoptosis	PMID:21367821^[3]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0043234	protein complex	PMID:20530484^[1]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0043565	sequence-specific DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	F	Seeded From UniProt
	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	F	Seeded From UniProt
	GO:0045165	cell fate commitment	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0045595	regulation of cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0045662	negative regulation of myoblast differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0045662	negative regulation of myoblast differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0045892	negative regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:20651055^[12]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:10805756^[6]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:20651055^[12]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:20530484^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:8640233^[4]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0046533	negative regulation of photoreceptor cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0046533	negative regulation of photoreceptor cell differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0048709	oligodendrocyte differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0050679	positive regulation of epithelial cell proliferation	PMID:20103652^[14]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0051216	cartilage development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0051216	cartilage development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0060008	Sertoli cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0060008	Sertoli cell differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0060009	Sertoli cell development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0060018	astrocyte fate commitment	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0060041	retina development in camera-type eye	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0060041	retina development in camera-type eye	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0060221	retinal rod cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0060221	retinal rod cell differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0060350	endochondral bone morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0060512	prostate gland morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0060517	epithelial cell proliferation involved in prostatic bud elongation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0060517	epithelial cell proliferation involved in prostatic bud elongation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0060729	intestinal epithelial structure maintenance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0060729	intestinal epithelial structure maintenance	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0060784	regulation of cell proliferation involved in tissue homeostasis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0060784	regulation of cell proliferation involved in tissue homeostasis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0061036	positive regulation of cartilage development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0061036	positive regulation of cartilage development	PMID:21401405^[15]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0061138	morphogenesis of a branching epithelium	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0061138	morphogenesis of a branching epithelium	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0070168	negative regulation of biomineral tissue development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0070371	ERK1 and ERK2 cascade	PMID:21512138^[11]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0071260	cellular response to mechanical stimulus	PMID:21512138^[11]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0071300	cellular response to retinoic acid	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0071300	cellular response to retinoic acid	PMID:12420222^[8]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0071347	cellular response to interleukin-1	PMID:20079164^[16]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0071364	cellular response to epidermal growth factor stimulus	PMID:21512138^[11]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0071504	cellular response to heparin	PMID:21512138^[11]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0071560	cellular response to transforming growth factor beta stimulus	PMID:21401405^[15]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0072034	renal vesicle induction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0072034	renal vesicle induction	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0072197	ureter morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0072289	metanephric nephron tubule formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0072289	metanephric nephron tubule formation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0090103	cochlea morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0090103	cochlea morphogenesis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0090184	positive regulation of kidney development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0090184	positive regulation of kidney development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04887	P	Seeded From UniProt
	GO:2000020	positive regulation of male gonad development	PMID:21412441^[7]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:2000138	positive regulation of cell proliferation involved in heart morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000579	P	Seeded From UniProt
	GO:2000741	positive regulation of mesenchymal stem cell differentiation	PMID:21401405^[15]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0005730	nucleolus	PMID:18029348^[9]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0007530	sex determination	PMID:8447323^[17]	IMP: Inferred from Mutant Phenotype		P	Figures 5 and 6. Presentation of the SRY's conserved motif of 80 amino acids, including the mutations in the patient. DNA sequences of two subcloned SRY PCR molecules.	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Masuda T & Esumi N (2010) SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium. J Biol Chem 285: 26933-44 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Coustry F et al. (2010) The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template. Nucleic Acids Res 38: 6018-28 PubMed GONUTS page
↑ ^3.0 ^3.1 Ikegami D et al. (2011) Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development 138: 1507-19 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Südbeck P et al. (1996) Sex reversal by loss of the C-terminal transactivation domain of human SOX9. Nat Genet 13: 230-2 PubMed GONUTS page
↑ ^5.0 ^5.1 Kim Y et al. (2011) Generation of transgenic mice for conditional overexpression of Sox9. J Bone Miner Metab 29: 123-9 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Huang W et al. (2000) Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer. Mol Cell Biol 20: 4149-58 PubMed GONUTS page
↑ ^7.0 ^7.1 Knower KC et al. (2011) Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations. PLoS One 6: e17751 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Afonja O et al. (2002) RAR agonists stimulate SOX9 gene expression in breast cancer cell lines: evidence for a role in retinoid-mediated growth inhibition. Oncogene 21: 7850-60 PubMed GONUTS page
↑ ^9.0 ^9.1 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
↑ Hoff S et al. (2008) Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody. J Comp Neurol 509: 356-71 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Ling S et al. (2011) An EGFR-ERK-SOX9 signaling cascade links urothelial development and regeneration to cancer. Cancer Res 71: 3812-21 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Jiang SS et al. (2010) Upregulation of SOX9 in lung adenocarcinoma and its involvement in the regulation of cell growth and tumorigenicity. Clin Cancer Res 16: 4363-73 PubMed GONUTS page
↑ O'Shaughnessy PJ et al. (2007) Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester. J Clin Endocrinol Metab 92: 4792-801 PubMed GONUTS page
↑ ^14.0 ^14.1 Thomsen MK et al. (2010) SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation. Cancer Res 70: 979-87 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Kim HJ & Im GI (2011) Electroporation-mediated transfer of SOX trio genes (SOX-5, SOX-6, and SOX-9) to enhance the chondrogenesis of mesenchymal stem cells. Stem Cells Dev 20: 2103-14 PubMed GONUTS page
↑ Yu ZG et al. (2009) Interleukin-1 inhibits Sox9 and collagen type II expression via nuclear factor-kappaB in the cultured human intervertebral disc cells. Chin Med J (Engl) 122: 2483-8 PubMed GONUTS page
↑ Braun A et al. (1993) True hermaphroditism in a 46,XY individual, caused by a postzygotic somatic point mutation in the male gonadal sex-determining locus (SRY): molecular genetics and histological findings in a sporadic case. Am J Hum Genet 52: 578-85 PubMed GONUTS page

[PMID:20530484-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Masuda T & Esumi N (2010) SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium. J Biol Chem 285: 26933-44 PubMed GONUTS page

[PMID:20484372-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Coustry F et al. (2010) The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template. Nucleic Acids Res 38: 6018-28 PubMed GONUTS page

[PMID:21367821-2] 3.0 ^3.1 Ikegami D et al. (2011) Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development 138: 1507-19 PubMed GONUTS page

[PMID:8640233-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Südbeck P et al. (1996) Sex reversal by loss of the C-terminal transactivation domain of human SOX9. Nat Genet 13: 230-2 PubMed GONUTS page

[PMID:20676705-4] 5.0 ^5.1 Kim Y et al. (2011) Generation of transgenic mice for conditional overexpression of Sox9. J Bone Miner Metab 29: 123-9 PubMed GONUTS page

[PMID:10805756-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Huang W et al. (2000) Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer. Mol Cell Biol 20: 4149-58 PubMed GONUTS page

[PMID:21412441-6] 7.0 ^7.1 Knower KC et al. (2011) Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations. PLoS One 6: e17751 PubMed GONUTS page

[PMID:12420222-7] 8.0 ^8.1 ^8.2 Afonja O et al. (2002) RAR agonists stimulate SOX9 gene expression in breast cancer cell lines: evidence for a role in retinoid-mediated growth inhibition. Oncogene 21: 7850-60 PubMed GONUTS page

[PMID:18029348-8] 9.0 ^9.1 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page

[PMID:18512230-9] Hoff S et al. (2008) Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody. J Comp Neurol 509: 356-71 PubMed GONUTS page

[PMID:21512138-10] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Ling S et al. (2011) An EGFR-ERK-SOX9 signaling cascade links urothelial development and regeneration to cancer. Cancer Res 71: 3812-21 PubMed GONUTS page

[PMID:20651055-11] 12.0 ^12.1 ^12.2 Jiang SS et al. (2010) Upregulation of SOX9 in lung adenocarcinoma and its involvement in the regulation of cell growth and tumorigenicity. Clin Cancer Res 16: 4363-73 PubMed GONUTS page

[PMID:17848411-12] O'Shaughnessy PJ et al. (2007) Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester. J Clin Endocrinol Metab 92: 4792-801 PubMed GONUTS page

[PMID:20103652-13] 14.0 ^14.1 Thomsen MK et al. (2010) SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation. Cancer Res 70: 979-87 PubMed GONUTS page

[PMID:21401405-14] 15.0 ^15.1 ^15.2 ^15.3 Kim HJ & Im GI (2011) Electroporation-mediated transfer of SOX trio genes (SOX-5, SOX-6, and SOX-9) to enhance the chondrogenesis of mesenchymal stem cells. Stem Cells Dev 20: 2103-14 PubMed GONUTS page

[PMID:20079164-15] Yu ZG et al. (2009) Interleukin-1 inhibits Sox9 and collagen type II expression via nuclear factor-kappaB in the cultured human intervertebral disc cells. Chin Med J (Engl) 122: 2483-8 PubMed GONUTS page

[PMID:8447323-16] Braun A et al. (1993) True hermaphroditism in a 46,XY individual, caused by a postzygotic somatic point mutation in the male gonadal sex-determining locus (SRY): molecular genetics and histological findings in a sporadic case. Am J Hum Genet 52: 578-85 PubMed GONUTS page

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HUMAN:SOX9

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