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HUMAN:SOX11
Contents |
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | SOX11 | |
| Protein Name(s) | Transcription factor SOX-11 | |
| External Links | ||
| UniProt | P35716 | |
| EMBL | U23752 AB028641 AC108025 X73038 | |
| IPI | IPI00020435 | |
| PIR | G01758 S34118 | |
| RefSeq | NP_003099.1 | |
| UniGene | Hs.432638 | |
| ProteinModelPortal | P35716 | |
| SMR | P35716 | |
| STRING | P35716 | |
| PhosphoSite | P35716 | |
| DMDM | 1351142 | |
| PRIDE | P35716 | |
| Ensembl | ENST00000322002 | |
| GeneID | 6664 | |
| KEGG | hsa:6664 | |
| UCSC | uc002qyj.1 | |
| CTD | 6664 | |
| GeneCards | GC02P005783 | |
| H-InvDB | HIX0029774 | |
| HGNC | HGNC:11191 | |
| HPA | CAB009378 HPA000536 | |
| MIM | 600898 | |
| neXtProt | NX_P35716 | |
| PharmGKB | PA36028 | |
| eggNOG | prNOG13586 | |
| HOGENOM | HBG715977 | |
| HOVERGEN | HBG005040 | |
| InParanoid | P35716 | |
| OMA | REAMDTE | |
| OrthoDB | EOG4QVCCX | |
| PhylomeDB | P35716 | |
| NextBio | 25981 | |
| ArrayExpress | P35716 | |
| Bgee | P35716 | |
| CleanEx | HS_SOX11 | |
| Genevestigator | P35716 | |
| GermOnline | ENSG00000176887 | |
| GO | GO:0005737 GO:0005634 GO:0001158 GO:0001077 GO:0001105 GO:0008135 GO:0003211 GO:0061386 GO:0061303 GO:0048557 GO:0048704 GO:0061029 GO:0014009 GO:0060022 GO:0002089 GO:0060174 GO:0060425 GO:0060548 GO:0060253 GO:0050672 GO:0000122 GO:2000678 GO:0014032 GO:0001841 GO:0060563 GO:0003357 GO:0003151 GO:0030513 GO:0035332 GO:0046887 GO:2001111 GO:0050769 GO:0045666 GO:0045778 GO:0045669 GO:2000648 GO:0017015 GO:0072404 GO:0060023 GO:0061053 GO:0021510 GO:0048485 GO:0060412 | |
| InterPro | IPR000910 IPR009071 IPR017386 | |
| Gene3D | G3DSA:1.10.30.10 | |
| KO | K09268 | |
| Pfam | PF00505 | |
| PIRSF | PIRSF038098 | |
| SMART | SM00398 | |
| SUPFAM | SSF47095 | |
| PROSITE | PS50118 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
F |
Seeded From UniProt |
|||
| GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
ISS: Inferred from Sequence or Structural Similarity |
F |
Seeded From UniProt |
||||
| GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
ISS: Inferred from Sequence or Structural Similarity |
F |
Seeded From UniProt |
||||
| GO:0000979 |
RNA polymerase II core promoter sequence-specific DNA binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0001071 |
nucleic acid binding transcription factor activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
F |
Seeded From UniProt |
|||
| GO:0001071 |
nucleic acid binding transcription factor activity |
ISS: Inferred from Sequence or Structural Similarity |
F |
Seeded From UniProt |
||||
| GO:0001077 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
F |
Seeded From UniProt |
|||
| GO:0001077 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
ISS: Inferred from Sequence or Structural Similarity |
F |
Seeded From UniProt |
||||
| GO:0001105 |
RNA polymerase II transcription coactivator activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
F |
Seeded From UniProt |
|||
| GO:0001105 |
RNA polymerase II transcription coactivator activity |
ISS: Inferred from Sequence or Structural Similarity |
F |
Seeded From UniProt |
||||
| GO:0001158 |
enhancer sequence-specific DNA binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
F |
Seeded From UniProt |
|||
| GO:0001158 |
enhancer sequence-specific DNA binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0001501 |
skeletal system development |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0001501 |
skeletal system development |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0001822 |
kidney development |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000040127 |
P |
Seeded From UniProt |
|||
| GO:0001841 |
neural tube formation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0001841 |
neural tube formation |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0002089 |
lens morphogenesis in camera-type eye |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0002089 |
lens morphogenesis in camera-type eye |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0003151 |
outflow tract morphogenesis |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0003151 |
outflow tract morphogenesis |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0003211 |
cardiac ventricle formation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0003211 |
cardiac ventricle formation |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0003357 |
noradrenergic neuron differentiation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0003357 |
noradrenergic neuron differentiation |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000040127 |
F |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0006351 |
transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006351 |
transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000040127 |
P |
Seeded From UniProt |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006412 |
translation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0007275 |
multicellular organismal development |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007399 |
nervous system development |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0008135 |
translation factor activity, nucleic acid binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0008283 |
cell proliferation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000040127 |
P |
Seeded From UniProt |
|||
| GO:0008284 |
positive regulation of cell proliferation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0008284 |
positive regulation of cell proliferation |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0010628 |
positive regulation of gene expression |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0010628 |
positive regulation of gene expression |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0010629 |
negative regulation of gene expression |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0010629 |
negative regulation of gene expression |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0014003 |
oligodendrocyte development |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000040127 |
P |
Seeded From UniProt |
|||
| GO:0014009 |
glial cell proliferation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0014009 |
glial cell proliferation |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0014032 |
neural crest cell development |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0014032 |
neural crest cell development |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0017015 |
regulation of transforming growth factor beta receptor signaling pathway |
IEP: Inferred from Expression Pattern |
|
P |
Seeded From UniProt |
|||
| GO:0021510 |
spinal cord development |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0021510 |
spinal cord development |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0021782 |
glial cell development |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0021782 |
glial cell development |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0030154 |
cell differentiation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0030182 |
neuron differentiation |
IEP: Inferred from Expression Pattern |
|
P |
Seeded From UniProt |
|||
| GO:0030513 |
positive regulation of BMP signaling pathway |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0030513 |
positive regulation of BMP signaling pathway |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0035332 |
positive regulation of hippo signaling cascade |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0035332 |
positive regulation of hippo signaling cascade |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0045666 |
positive regulation of neuron differentiation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0045666 |
positive regulation of neuron differentiation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0045669 |
positive regulation of osteoblast differentiation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0045778 |
positive regulation of ossification |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0045778 |
positive regulation of ossification |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000040127 |
P |
Seeded From UniProt |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0046887 |
positive regulation of hormone secretion |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0046887 |
positive regulation of hormone secretion |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0048485 |
sympathetic nervous system development |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0048485 |
sympathetic nervous system development |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0048557 |
embryonic digestive tract morphogenesis |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0048557 |
embryonic digestive tract morphogenesis |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0048704 |
embryonic skeletal system morphogenesis |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0048704 |
embryonic skeletal system morphogenesis |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0050672 |
negative regulation of lymphocyte proliferation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0050769 |
positive regulation of neurogenesis |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0050769 |
positive regulation of neurogenesis |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0060022 |
hard palate development |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0060022 |
hard palate development |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0060023 |
soft palate development |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0060023 |
soft palate development |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0060174 |
limb bud formation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0060174 |
limb bud formation |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0060253 |
negative regulation of glial cell proliferation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0060253 |
negative regulation of glial cell proliferation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0060412 |
ventricular septum morphogenesis |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0060412 |
ventricular septum morphogenesis |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0060425 |
lung morphogenesis |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0060425 |
lung morphogenesis |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0060548 |
negative regulation of cell death |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0060548 |
negative regulation of cell death |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0060563 |
neuroepithelial cell differentiation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0060563 |
neuroepithelial cell differentiation |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0061029 |
eyelid development in camera-type eye |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0061029 |
eyelid development in camera-type eye |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0061053 |
somite development |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0061053 |
somite development |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0061303 |
cornea development in camera-type eye |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0061303 |
cornea development in camera-type eye |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0061386 |
closure of optic fissure |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000078070 |
P |
Seeded From UniProt |
|||
| GO:0061386 |
closure of optic fissure |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0072404 |
signal transduction involved in G1/S transition checkpoint |
IEP: Inferred from Expression Pattern |
|
P |
Seeded From UniProt |
|||
| GO:2000648 |
positive regulation of stem cell proliferation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:2000678 |
negative regulation of transcription regulatory region DNA binding |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:2001111 |
positive regulation of lens epithelial cell proliferation |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
| |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Hide T et al. (2009) Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation. Cancer Res 69: 7953-9 PubMed GONUTS page
- ↑ 2.0 2.1 Wang X et al. (2010) Gene expression profiling and chromatin immunoprecipitation identify DBN1, SETMAR and HIG2 as direct targets of SOX11 in mantle cell lymphoma. PLoS One 5: e14085 PubMed GONUTS page
- ↑ 3.0 3.1 Ek S et al. (2008) Nuclear expression of the non B-cell lineage Sox11 transcription factor identifies mantle cell lymphoma. Blood 111: 800-5 PubMed GONUTS page
- ↑ 4.0 4.1 Tchénio T et al. (2000) Members of the SRY family regulate the human LINE retrotransposons. Nucleic Acids Res 28: 411-5 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Gustavsson E et al. (2010) SOX11 expression correlates to promoter methylation and regulates tumor growth in hematopoietic malignancies. Mol Cancer 9: 187 PubMed GONUTS page
- ↑ Azuma T et al. (1999) Human SOX11, an upregulated gene during the neural differentiation, has a long 3' untranslated region. DNA Res 6: 357-60 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Larson BL et al. (2010) Sox11 is expressed in early progenitor human multipotent stromal cells and decreases with extensive expansion of the cells. Tissue Eng Part A 16: 3385-94 PubMed GONUTS page