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HUMAN:SMAD9

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SMAD9 (synonyms: MADH6, MADH9)
Protein Name(s) Mothers against decapentaplegic homolog 9

MAD homolog 9 Mothers against DPP homolog 9 Madh6 SMAD family member 9 SMAD 9 Smad9

External Links
UniProt O15198
EMBL D83760
D83761
AL138706
AL138706
CH471075
CH471075
BC011559
BC104760
BC104762
BC143240
CCDS CCDS45032.1
CCDS9360.1
RefSeq NP_001120689.1
NP_005896.1
UniGene Hs.123119
ProteinModelPortal O15198
SMR O15198
BioGrid 110268
IntAct O15198
MINT MINT-1179670
STRING 9606.ENSP00000369154
PhosphoSite O15198
BioMuta SMAD9
MaxQB O15198
PaxDb O15198
PRIDE O15198
DNASU 4093
Ensembl ENST00000379826
ENST00000399275
GeneID 4093
KEGG hsa:4093
UCSC uc001uvw.3
uc001uvx.3
CTD 4093
GeneCards GC13M037418
HGNC HGNC:6774
HPA CAB009119
HPA031162
MIM 603295
615342
neXtProt NX_O15198
Orphanet 275777
PharmGKB PA30531
eggNOG NOG330956
GeneTree ENSGT00760000119091
HOGENOM HOG000286018
HOVERGEN HBG053353
InParanoid O15198
KO K16791
OMA FQQPPCP
OrthoDB EOG7W1540
PhylomeDB O15198
TreeFam TF314923
Reactome REACT_12034
ChiTaRS SMAD9
GeneWiki Mothers_against_decapentaplegic_homolog_9
GenomeRNAi 4093
NextBio 16050
PRO PR:O15198
Proteomes UP000005640
Bgee O15198
CleanEx HS_SMAD9
ExpressionAtlas O15198
Genevisible O15198
GO GO:0005737
GO:0005829
GO:0005622
GO:0005654
GO:0005634
GO:0005667
GO:0003677
GO:0046872
GO:0003700
GO:0030618
GO:0030509
GO:0060348
GO:0051216
GO:0071407
GO:0030902
GO:0035556
GO:0030901
GO:0006468
GO:0006351
GO:0007179
GO:0001657
Gene3D 2.60.200.10
3.90.520.10
InterPro IPR013790
IPR003619
IPR013019
IPR017855
IPR001132
IPR008984
PANTHER PTHR13703
Pfam PF03165
PF03166
SMART SM00523
SM00524
SUPFAM SSF49879
SSF56366
PROSITE PS51075
PS51076

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR001132
InterPro:IPR003619
InterPro:IPR013019
InterPro:IPR013790

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9JIW5

C

part_of:(UBERON:0002107)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9JIW5

C

part_of:(UBERON:0002107)

Seeded From UniProt

complete

involved_in

GO:0060395

SMAD protein signal transduction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9JIW5

P

Seeded From UniProt

complete

involved_in

GO:0030509

BMP signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9JIW5

P

occurs_in:(UBERON:0002107)

Seeded From UniProt

complete

involved_in

GO:0071773

cellular response to BMP stimulus

PMID:14687659[2]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0071141

SMAD protein complex

PMID:14687659[2]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0060395

SMAD protein signal transduction

PMID:14687659[2]

ECO:0000303

author statement without traceable support used in manual assertion

P

part_of:(GO:0071773)

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:P97454

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013019

F

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013019

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001132
InterPro:IPR003619
InterPro:IPR013019
InterPro:IPR013790

P

Seeded From UniProt

complete

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013019
InterPro:IPR036578

P

Seeded From UniProt

complete

involved_in

GO:1901522

positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

PMID:14687659[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

part_of:(GO:0071773)

Seeded From UniProt

complete

part_of

GO:0005622

intracellular

PMID:9256479[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0030618

transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity

PMID:19018011[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0030509

BMP signaling pathway

PMID:19018011[4]
Reactome:R-HSA-201451

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:19018011[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-202626
Reactome:R-HSA-201648
Reactome:R-HSA-201476
Reactome:R-HSA-201472
Reactome:R-HSA-201453
Reactome:R-HSA-201445
Reactome:R-HSA-201422

ECO:0000304

author statement supported by traceable reference used in manual assertion







C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-201472
Reactome:R-HSA-201425
Reactome:R-HSA-201423

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Nohe, A et al. (2004) Signal transduction of bone morphogenetic protein receptors. Cell. Signal. 16 291-9 PubMed GONUTS page
  3. Topper, JN et al. (1997) Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Proc. Natl. Acad. Sci. U.S.A. 94 9314-9 PubMed GONUTS page
  4. 4.0 4.1 4.2 Hoover, LL & Kubalak, SW (2008) Holding their own: the noncanonical roles of Smad proteins. Sci Signal 1 pe48 PubMed GONUTS page