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HUMAN:SMAD2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SMAD2 (synonyms: MADH2, MADR2)
Protein Name(s) Mothers against decapentaplegic homolog 2

MAD homolog 2 Mothers against DPP homolog 2 JV18-1 Mad-related protein 2 hMAD-2 SMAD family member 2 SMAD 2 Smad2 hSMAD2

External Links
UniProt Q15796
EMBL U59911
U68018
U65019
AF027964
U78733
U78727
U78728
U78729
U78730
U78731
U78732
BC014840
BC025699
CCDS CCDS11934.1
PIR S71797
RefSeq NP_001003652.1
NP_005892.1
XP_005258316.1
XP_006722514.1
XP_011524285.1
UniGene Hs.12253
Hs.705764
Hs.741342
PDB 1DEV
1KHX
1U7V
2LB3
PDBsum 1DEV
1KHX
1U7V
2LB3
ProteinModelPortal Q15796
SMR Q15796
BioGrid 110262
DIP DIP-29716N
IntAct Q15796
MINT MINT-5006109
STRING 9606.ENSP00000262160
ChEMBL CHEMBL2396512
PhosphoSite Q15796
BioMuta SMAD2
DMDM 13633914
MaxQB Q15796
PaxDb Q15796
PRIDE Q15796
DNASU 4087
Ensembl ENST00000262160
ENST00000356825
ENST00000402690
ENST00000586040
GeneID 4087
KEGG hsa:4087
UCSC uc002lcy.4
uc010xdc.3
CTD 4087
GeneCards GC18M045357
HGNC HGNC:6768
HPA CAB025507
MIM 601366
neXtProt NX_Q15796
PharmGKB PA134959722
eggNOG NOG320700
GeneTree ENSGT00760000119091
HOGENOM HOG000286018
HOVERGEN HBG053353
InParanoid Q15796
KO K04500
OMA NYPDQTR
OrthoDB EOG7W1540
PhylomeDB Q15796
TreeFam TF314923
Reactome REACT_111057
REACT_120727
REACT_120734
REACT_120850
REACT_121111
REACT_150238
REACT_169103
REACT_169107
REACT_169165
REACT_169263
REACT_263856
SignaLink Q15796
ChiTaRS SMAD2
EvolutionaryTrace Q15796
GeneWiki Mothers_against_decapentaplegic_homolog_2
GenomeRNAi 4087
NextBio 16020
PRO PR:Q15796
Proteomes UP000005640
Bgee Q15796
CleanEx HS_SMAD2
ExpressionAtlas Q15796
Genevisible Q15796
GO GO:0032444
GO:0005737
GO:0005829
GO:0000790
GO:0005654
GO:0005634
GO:0071141
GO:0071144
GO:0005667
GO:0033613
GO:0003682
GO:0070410
GO:0003690
GO:0035326
GO:0070411
GO:0046872
GO:0019902
GO:0070412
GO:0000978
GO:0001077
GO:0003700
GO:0046332
GO:0008134
GO:0005160
GO:0030618
GO:0034713
GO:0031625
GO:0032924
GO:0009952
GO:0045165
GO:0007182
GO:0048701
GO:0048617
GO:0001706
GO:0007369
GO:0010467
GO:0001701
GO:0030073
GO:0035556
GO:0030324
GO:0001707
GO:0000122
GO:0045892
GO:0030512
GO:0038092
GO:0035265
GO:0060021
GO:0031016
GO:0048340
GO:0060039
GO:0030513
GO:0010718
GO:1900224
GO:0045944
GO:0045893
GO:0009791
GO:0031053
GO:0051098
GO:0017015
GO:0070723
GO:0009749
GO:0007183
GO:0060395
GO:0035019
GO:0006367
GO:0006351
GO:0007179
GO:0001657
GO:0007352
Gene3D 2.60.200.10
3.90.520.10
InterPro IPR013790
IPR003619
IPR013019
IPR017855
IPR001132
IPR008984
PANTHER PTHR13703
Pfam PF03165
PF03166
SMART SM00523
SM00524
SUPFAM SSF49879
SSF56366
PROSITE PS51075
PS51076

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0032444

activin responsive factor complex

IDA: Inferred from Direct Assay

C

Source: UniProtKB

Missing: reference

GO:0005829

cytosol

EXP: Inferred from Experiment

C

Source: Reactome

Missing: reference

GO:0003690

double-stranded DNA binding

ISS: Inferred from Sequence or Structural Similarity

F

Source: UniProtKB

Missing: with/from, reference

GO:0042301

phosphate binding

IPI: Inferred from Physical Interaction

F

Source: UniProtKB

Missing: with/from, reference

GO:0010843

promoter binding

IDA: Inferred from Direct Assay

F

Source: UniProtKB

Missing: reference

GO:0046332

SMAD binding

IPI: Inferred from Physical Interaction

F

Source: UniProtKB

Missing: with/from, reference

GO:0016563

transcription activator activity

ISS: Inferred from Sequence or Structural Similarity

F

Source: UniProtKB

Missing: with/from, reference

GO:0003700

transcription factor activity

IEA

F

Source: InterPro

Missing: with/from, reference

GO:0008134

transcription factor binding

IPI: Inferred from Physical Interaction

F

Source: UniProtKB

Missing: with/from, reference

GO:0030618

transforming growth factor beta receptor, p...

IDA: Inferred from Direct Assay

F

Source: UniProtKB

Missing: reference

GO:0034713

type I transforming growth factor beta rece...

IPI: Inferred from Physical Interaction

F

Source: UniProtKB

Missing: with/from, reference

GO:0043130

ubiquitin binding

IPI: Inferred from Physical Interaction

F

Source: UniProtKB

Missing: with/from, reference

GO:0031625

ubiquitin protein ligase binding

IPI: Inferred from Physical Interaction

F

Source: UniProtKB

Missing: with/from, reference

GO:0009952

anterior/posterior pattern formation

ISS: Inferred from Sequence or Structural Similarity

P

Source: UniProtKB

Missing: with/from, reference

GO:0045165

cell fate commitment

ISS: Inferred from Sequence or Structural Similarity

P

Source: UniProtKB

Missing: with/from, reference

GO:0007242

intracellular signaling cascade

ISS: Inferred from Sequence or Structural Similarity

P

Source: UniProtKB

Missing: with/from, reference

GO:0001707

mesoderm formation

ISS: Inferred from Sequence or Structural Similarity

P

Source: UniProtKB

Missing: with/from, reference

GO:0045892

negative regulation of transcription, DNA-d...

IMP: Inferred from Mutant Phenotype

P

Source: UniProtKB

Missing: reference

GO:0048340

paraxial mesoderm morphogenesis

ISS: Inferred from Sequence or Structural Similarity

P

Source: UniProtKB

Missing: with/from, reference

GO:0045944

positive regulation of transcription from R...

ISS: Inferred from Sequence or Structural Similarity

P

Source: UniProtKB

Missing: with/from, reference

GO:0031053

primary microRNA processing

TAS: Traceable Author Statement

P

Source: UniProtKB

Missing: reference

GO:0051098

regulation of binding

ISS: Inferred from Sequence or Structural Similarity

P

Source: UniProtKB

Missing: with/from, reference

GO:0017015

regulation of transforming growth factor be...

IMP: Inferred from Mutant Phenotype

P

Source: UniProtKB

Missing: reference

GO:0007183

SMAD protein complex assembly

IDA: Inferred from Direct Assay

P

Source: UniProtKB

Missing: reference

GO:0007352

zygotic determination of dorsal/ventral axis

IMP: Inferred from Mutant Phenotype

P

Source: UniProtKB

Missing: reference

GO:0001657

ureteric bud development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0001701

in utero embryonic development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0001707

mesoderm formation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0001707

mesoderm formation

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

P

complete

GO:0003682

chromatin binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

F

complete

GO:0003690

double-stranded DNA binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

F

complete

GO:0003690

double-stranded DNA binding

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

F

complete

GO:0003700

sequence-specific DNA binding transcription factor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013019

F

complete

GO:0003700

sequence-specific DNA binding transcription factor activity

PMID:9389648[1]

IDA: Inferred from Direct Assay

F

complete

GO:0005160

transforming growth factor beta receptor binding

PMID:9311995[2]

IPI: Inferred from Physical Interaction

UniProtKB:P36897

F

complete

GO:0005515

protein binding

PMID:12764135[3]

IPI: Inferred from Physical Interaction

UniProtKB:P12757-1

F

complete

GO:0005515

protein binding

PMID:15107821[4]

IPI: Inferred from Physical Interaction

UniProtKB:P12755

F

complete

GO:0005515

protein binding

PMID:15647271[5]

IPI: Inferred from Physical Interaction

UniProtKB:Q9Y2U8

F

complete

GO:0005515

protein binding

PMID:16200078[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q2VWA4

F

complete

GO:0005515

protein binding

PMID:17099224[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q93062

F

complete

GO:0005515

protein binding

PMID:17292623[8]

IPI: Inferred from Physical Interaction

UniProtKB:P84550

F

complete

GO:0005515

protein binding

PMID:18568018[9]

IPI: Inferred from Physical Interaction

UniProtKB:Q9GZV5

F

complete

GO:0005515

protein binding

PMID:18729074[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q13485

F

complete

GO:0005515

protein binding

PMID:18729074[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q9BZ29

F

complete

GO:0005515

protein binding

PMID:19049980[11]

IPI: Inferred from Physical Interaction

UniProtKB:Q9HAZ2

F

complete

GO:0005515

protein binding

PMID:19122240[12]

IPI: Inferred from Physical Interaction

UniProtKB:Q13526

F

complete

GO:0005515

protein binding

PMID:19135894[13]

IPI: Inferred from Physical Interaction

UniProtKB:Q9UPN9

F

complete

GO:0005515

protein binding

PMID:19345189[14]

IPI: Inferred from Physical Interaction

UniProtKB:Q9H3D4

F

complete

GO:0005515

protein binding

PMID:20195357[15]

IPI: Inferred from Physical Interaction

UniProtKB:P61586

F

complete

GO:0005515

protein binding

PMID:9389648[1]

IPI: Inferred from Physical Interaction

UniProtKB:O75593

F

complete

GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001132

C

complete

GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003619

C

complete

GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013019

C

complete

GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013790

C

complete

GO:0005622

intracellular

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

C

complete

GO:0005634

nucleus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

complete

GO:0005634

nucleus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

C

complete

GO:0005634

nucleus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000048329

C

complete

GO:0005634

nucleus

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0191

C

complete

GO:0005634

nucleus

PMID:12411310[16]

IDA: Inferred from Direct Assay

C

complete

GO:0005634

nucleus

PMID:8980228[17]

IDA: Inferred from Direct Assay

C

complete

GO:0005634

nucleus

PMID:9311995[2]

IDA: Inferred from Direct Assay

C

complete

GO:0005634

nucleus

PMID:9389648[1]

IDA: Inferred from Direct Assay

C

complete

GO:0005654

nucleoplasm

Reactome:REACT_6726

TAS: Traceable Author Statement

C

complete

GO:0005654

nucleoplasm

Reactome:REACT_6857

TAS: Traceable Author Statement

C

complete

GO:0005654

nucleoplasm

Reactome:REACT_6887

TAS: Traceable Author Statement

C

complete

GO:0005667

transcription factor complex

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013019

C

complete

GO:0005667

transcription factor complex

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

C

complete

GO:0005667

transcription factor complex

PMID:17438144[18]

IDA: Inferred from Direct Assay

C

complete

GO:0005737

cytoplasm

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

complete

GO:0005737

cytoplasm

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

C

complete

GO:0005737

cytoplasm

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000048329

C

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

complete

GO:0005737

cytoplasm

PMID:12411310[16]

IDA: Inferred from Direct Assay

C

complete

GO:0005737

cytoplasm

PMID:9311995[2]

IDA: Inferred from Direct Assay

C

complete

GO:0005737

cytoplasm

PMID:9389648[1]

IDA: Inferred from Direct Assay

C

complete

GO:0005829

cytosol

Reactome:REACT_6726

TAS: Traceable Author Statement

C

complete

GO:0005829

cytosol

Reactome:REACT_6744

TAS: Traceable Author Statement

C

complete

GO:0005829

cytosol

Reactome:REACT_6760

TAS: Traceable Author Statement

C

complete

GO:0005829

cytosol

Reactome:REACT_6786

TAS: Traceable Author Statement

C

complete

GO:0005829

cytosol

Reactome:REACT_6879

TAS: Traceable Author Statement

C

complete

GO:0005829

cytosol

Reactome:REACT_6923

TAS: Traceable Author Statement

C

complete

GO:0006351

transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

complete

GO:0006351

transcription, DNA-dependent

PMID:17438144[18]

IDA: Inferred from Direct Assay

P

complete

GO:0006351

transcription, DNA-dependent

PMID:9389648[1]

IDA: Inferred from Direct Assay

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001132

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003619

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013019

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013790

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0805

P

complete

GO:0006468

protein phosphorylation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0007179

transforming growth factor beta receptor signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013019

P

complete

GO:0007179

transforming growth factor beta receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:8752209[19]

IDA: Inferred from Direct Assay

P

complete

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:8980228[17]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:9389648[1]

IDA: Inferred from Direct Assay

P

complete

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:9732876[20]

IDA: Inferred from Direct Assay

P

complete

GO:0007179

transforming growth factor beta receptor signaling pathway

Reactome:REACT_6844

TAS: Traceable Author Statement

P

complete

GO:0007182

common-partner SMAD protein phosphorylation

PMID:16806156[21]

IDA: Inferred from Direct Assay

P

complete

GO:0007183

SMAD protein complex assembly

PMID:9111321[22]

IDA: Inferred from Direct Assay

P

complete

GO:0007352

zygotic specification of dorsal/ventral axis

PMID:9436979[23]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0007369

gastrulation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0007369

gastrulation

PMID:19018011[24]

TAS: Traceable Author Statement

P

complete

GO:0007389

pattern specification process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0007492

endoderm development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0007507

heart development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0008134

transcription factor binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

F

complete

GO:0008134

transcription factor binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000048329

F

complete

GO:0008134

transcription factor binding

PMID:9702198[25]

IPI: Inferred from Physical Interaction

UniProtKB:O75593

F

complete

GO:0008285

negative regulation of cell proliferation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000048329

P

complete

GO:0009749

response to glucose stimulus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0009791

post-embryonic development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0009880

embryonic pattern specification

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0009952

anterior/posterior pattern formation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0009952

anterior/posterior pattern formation

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

P

complete

GO:0010718

positive regulation of epithelial to mesenchymal transition

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0010718

positive regulation of epithelial to mesenchymal transition

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

P

complete

GO:0017015

regulation of transforming growth factor beta receptor signaling pathway

PMID:14555988[26]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0030073

insulin secretion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0030324

lung development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0030618

transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity

PMID:9256479[27]

IDA: Inferred from Direct Assay

F

complete

GO:0030618

transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity

PMID:9389648[1]

IDA: Inferred from Direct Assay

F

complete

GO:0031016

pancreas development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0031053

primary miRNA processing

PMID:19018011[24]

TAS: Traceable Author Statement

P

complete

GO:0031625

ubiquitin protein ligase binding

PMID:19122240[12]

IPI: Inferred from Physical Interaction

UniProtKB:Q9HAU4

F

complete

GO:0032444

activin responsive factor complex

PMID:9389648[1]

IDA: Inferred from Direct Assay

C

complete

GO:0033613

activating transcription factor binding

PMID:11160896[28]

IPI: Inferred from Physical Interaction

UniProtKB:Q02078

F

complete

GO:0034713

type I transforming growth factor beta receptor binding

PMID:8980228[17]

IPI: Inferred from Physical Interaction

UniProtKB:P36897

F

complete

GO:0035265

organ growth

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0035556

intracellular signal transduction

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0035556

intracellular signal transduction

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

P

complete

GO:0043234

protein complex

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000048329

C

complete

GO:0045165

cell fate commitment

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0045165

cell fate commitment

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

P

complete

GO:0045892

negative regulation of transcription, DNA-dependent

PMID:14555988[26]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0045893

positive regulation of transcription, DNA-dependent

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0045893

positive regulation of transcription, DNA-dependent

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

P

complete

GO:0045893

positive regulation of transcription, DNA-dependent

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

P

complete

GO:0045893

positive regulation of transcription, DNA-dependent

PMID:14555988[26]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0045893

positive regulation of transcription, DNA-dependent

PMID:9311995[2]

IDA: Inferred from Direct Assay

P

complete

GO:0045893

positive regulation of transcription, DNA-dependent

PMID:9389648[1]

IDA: Inferred from Direct Assay

P

complete

GO:0045893

positive regulation of transcription, DNA-dependent

PMID:9732876[20]

IDA: Inferred from Direct Assay

P

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

P

complete

GO:0046332

SMAD binding

PMID:11160896[28]

IPI: Inferred from Physical Interaction

UniProtKB:Q06413

F

complete

GO:0048340

paraxial mesoderm morphogenesis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0048340

paraxial mesoderm morphogenesis

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

P

complete

GO:0048589

developmental growth

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0048617

embryonic foregut morphogenesis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0048701

embryonic cranial skeleton morphogenesis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0051098

regulation of binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0051098

regulation of binding

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

P

complete

GO:0060021

palate development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0060021

palate development

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

P

complete

GO:0060039

pericardium development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

complete

GO:0070410

co-SMAD binding

PMID:9111321[22]

IPI: Inferred from Physical Interaction

UniProtKB:Q13485

F

complete

GO:0070410

co-SMAD binding

PMID:9311995[2]

IPI: Inferred from Physical Interaction

UniProtKB:Q13485

F

complete

GO:0070411

I-SMAD binding

PMID:9256479[27]

IPI: Inferred from Physical Interaction

UniProtKB:O43541

F

complete

GO:0070412

R-SMAD binding

PMID:9311995[2]

IPI: Inferred from Physical Interaction

UniProtKB:P84022

F

complete

GO:0070723

response to cholesterol

PMID:17878231[29]

IDA: Inferred from Direct Assay

P

complete

contributes_to

GO:0003677

DNA binding

PMID:9389648[1]

IDA: Inferred from Direct Assay

F

complete

contributes_to

GO:0003700

sequence-specific DNA binding transcription factor activity

PMID:17438144[18]

IDA: Inferred from Direct Assay

F

complete

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

Reactome:REACT_121111

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0000790

nuclear chromatin

PMID:21828274[30]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0000978

RNA polymerase II core promoter proximal region sequence-specific DNA binding

PMID:9389648[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0001077

transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding

PMID:9389648[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0001657

ureteric bud development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0001701

in utero embryonic development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0001706

endoderm formation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0001707

mesoderm formation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0001707

mesoderm formation

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

P

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0003682

chromatin binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

F

Seeded From UniProt

complete

GO:0003690

double-stranded DNA binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

F

Seeded From UniProt

complete

GO:0003690

double-stranded DNA binding

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013019

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

PMID:9389648[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005160

transforming growth factor beta receptor binding

PMID:9311995[2]

IPI: Inferred from Physical Interaction

UniProtKB:P36897

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11278756[31]

IPI: Inferred from Physical Interaction

UniProtKB:Q13573

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11387212[32]

IPI: Inferred from Physical Interaction

UniProtKB:P98082

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12764135[3]

IPI: Inferred from Physical Interaction

UniProtKB:P12757-1

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15107821[4]

IPI: Inferred from Physical Interaction

UniProtKB:P12755

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15231748[33]

IPI: Inferred from Physical Interaction

UniProtKB:O95405

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15231748[33]

IPI: Inferred from Physical Interaction

UniProtKB:Q12955

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15231748[33]

IPI: Inferred from Physical Interaction

UniProtKB:Q13485

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15231748[33]

IPI: Inferred from Physical Interaction

UniProtKB:Q9HAU4

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15350224[34]

IPI: Inferred from Physical Interaction

UniProtKB:Q13485

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15647271[5]

IPI: Inferred from Physical Interaction

UniProtKB:Q9Y2U8

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:16200078[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q2VWA4

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:16751101[35]

IPI: Inferred from Physical Interaction

UniProtKB:P35813

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:17099224[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q93062

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:17292623[8]

IPI: Inferred from Physical Interaction

UniProtKB:P84550

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18511908[36]

IPI: Inferred from Physical Interaction

UniProtKB:O95405

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18511908[36]

IPI: Inferred from Physical Interaction

UniProtKB:Q13485

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18568018[9]

IPI: Inferred from Physical Interaction

UniProtKB:Q9GZV5

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18729074[10]

IPI: Inferred from Physical Interaction

UniProtKB:O00308

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18729074[10]

IPI: Inferred from Physical Interaction

UniProtKB:P84022

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18729074[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q13485

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18729074[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q13573

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18729074[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q9BZ29

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18729074[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q9HAU4

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18832382[37]

IPI: Inferred from Physical Interaction

UniProtKB:P52926

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18923419[38]

IPI: Inferred from Physical Interaction

UniProtKB:Q8TAK6

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19049980[11]

IPI: Inferred from Physical Interaction

UniProtKB:Q9HAZ2

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19122240[12]

IPI: Inferred from Physical Interaction

UniProtKB:Q13526

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19135894[13]

IPI: Inferred from Physical Interaction

UniProtKB:Q13485

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19135894[13]

IPI: Inferred from Physical Interaction

UniProtKB:Q9UPN9

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19135894[13]

IPI: Inferred from Physical Interaction

UniProtKB:Q9UPN9

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19289081[39]

IPI: Inferred from Physical Interaction

UniProtKB:Q9H6Z4

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19345189[14]

IPI: Inferred from Physical Interaction

UniProtKB:P04637

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19345189[14]

IPI: Inferred from Physical Interaction

UniProtKB:Q9H3D4

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20061380[40]

IPI: Inferred from Physical Interaction

UniProtKB:Q9NYA4

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20129061[41]

IPI: Inferred from Physical Interaction

UniProtKB:Q969W9

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20195357[15]

IPI: Inferred from Physical Interaction

UniProtKB:P05060

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20195357[15]

IPI: Inferred from Physical Interaction

UniProtKB:P07197

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20195357[15]

IPI: Inferred from Physical Interaction

UniProtKB:P61586

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20195357[15]

IPI: Inferred from Physical Interaction

UniProtKB:Q12955

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20195357[15]

IPI: Inferred from Physical Interaction

UniProtKB:Q96KR1

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20603019[42]

IPI: Inferred from Physical Interaction

UniProtKB:Q9UPN9

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:21258410[43]

IPI: Inferred from Physical Interaction

UniProtKB:O00308

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:21297662[44]

IPI: Inferred from Physical Interaction

UniProtKB:Q13485

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:21532621[45]

IPI: Inferred from Physical Interaction

UniProtKB:Q13485

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:21599657[46]

IPI: Inferred from Physical Interaction

UniProtKB:Q9UK33

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:21741598[47]

IPI: Inferred from Physical Interaction

UniProtKB:Q9H3D4

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:21947082[48]

IPI: Inferred from Physical Interaction

UniProtKB:Q9Y4E8

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:21960005[49]

IPI: Inferred from Physical Interaction

UniProtKB:Q9H6Z4

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:21988832[50]

IPI: Inferred from Physical Interaction

UniProtKB:P84022

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:21988832[50]

IPI: Inferred from Physical Interaction

UniProtKB:Q13485

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:22045334[51]

IPI: Inferred from Physical Interaction

UniProtKB:Q9HAU4

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:22442258[52]

IPI: Inferred from Physical Interaction

UniProtKB:Q13485

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:24627487[53]

IPI: Inferred from Physical Interaction

UniProtKB:O15165

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:25241761[54]

IPI: Inferred from Physical Interaction

UniProtKB:P04637

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:25670079[55]

IPI: Inferred from Physical Interaction

UniProtKB:P04637

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:9389648[1]

IPI: Inferred from Physical Interaction

UniProtKB:O75593

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:9389648[1]

IPI: Inferred from Physical Interaction

UniProtKB:P70056

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:9389648[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q13485

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:9865696[56]

IPI: Inferred from Physical Interaction

UniProtKB:O95405

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:9892009[57]

IPI: Inferred from Physical Interaction

UniProtKB:P36896

F

Seeded From UniProt

complete

GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001132
InterPro:IPR003619
InterPro:IPR013019
InterPro:IPR013790

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:12411310[16]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:16751101[35]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:21599657[46]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:8980228[17]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:9311995[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:9389648[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_111132

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_111216

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_120772

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_120778

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_120826

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_120838

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_120868

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_120873

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_120960

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_120994

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_121012

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_121015

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_121097

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_121142

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_121162

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_121212

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_121269

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_121278

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_121336

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_121342

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_121362

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_121396

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_264082

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_264509

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_6726

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_6857

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

Reactome:REACT_6887

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005667

transcription factor complex

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013019

C

Seeded From UniProt

complete

GO:0005667

transcription factor complex

PMID:17438144[18]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:12411310[16]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:9311995[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:9389648[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_120812

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_120826

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_120908

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_120991

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_121015

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_121119

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_121239

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_121290

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_121368

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_150345

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_169111

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_169188

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_169196

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_169220

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_169270

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_169375

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_169400

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_169422

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_6726

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_6744

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_6760

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_6786

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_6879

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_6923

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0006351

transcription, DNA-templated

Reactome:REACT_121061

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001132
InterPro:IPR003619
InterPro:IPR013019
InterPro:IPR013790

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0006367

transcription initiation from RNA polymerase II promoter

Reactome:REACT_12627

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0007179

transforming growth factor beta receptor signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013019

P

Seeded From UniProt

complete

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:8752209[19]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:8980228[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:9389648[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:9732876[20]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007179

transforming growth factor beta receptor signaling pathway

Reactome:REACT_120850

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007179

transforming growth factor beta receptor signaling pathway

Reactome:REACT_6844

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007182

common-partner SMAD protein phosphorylation

PMID:16806156[21]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007183

SMAD protein complex assembly

PMID:9111321[22]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007352

zygotic specification of dorsal/ventral axis

PMID:9436979[23]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007369

gastrulation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0007369

gastrulation

PMID:19018011[24]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007389

pattern specification process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0007492

endoderm development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0007507

heart development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0008134

transcription factor binding

PMID:9702198[25]

IPI: Inferred from Physical Interaction

UniProtKB:O75593

F

Seeded From UniProt

complete

GO:0009749

response to glucose

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0009791

post-embryonic development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0009880

embryonic pattern specification

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0009952

anterior/posterior pattern specification

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0009952

anterior/posterior pattern specification

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

P

Seeded From UniProt

complete

GO:0010467

gene expression

Reactome:REACT_71

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0010628

positive regulation of gene expression

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0010629

negative regulation of gene expression

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0010718

positive regulation of epithelial to mesenchymal transition

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0010718

positive regulation of epithelial to mesenchymal transition

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

P

Seeded From UniProt

complete

GO:0017015

regulation of transforming growth factor beta receptor signaling pathway

PMID:14555988[26]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0019902

phosphatase binding

PMID:16751101[35]

IPI: Inferred from Physical Interaction

UniProtKB:P35813

F

Seeded From UniProt

complete

GO:0030073

insulin secretion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0030324

lung development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

Reactome:REACT_120727

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0030513

positive regulation of BMP signaling pathway

PMID:19366699[58]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030618

transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity

PMID:9256479[27]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0030618

transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity

PMID:9389648[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0031016

pancreas development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0031053

primary miRNA processing

PMID:19018011[24]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0031625

ubiquitin protein ligase binding

PMID:19122240[12]

IPI: Inferred from Physical Interaction

UniProtKB:Q9HAU4

F

Seeded From UniProt

complete

GO:0032444

activin responsive factor complex

PMID:9389648[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0032924

activin receptor signaling pathway

PMID:15150278[59]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0033613

activating transcription factor binding

PMID:11160896[28]

IPI: Inferred from Physical Interaction

UniProtKB:Q02078

F

Seeded From UniProt

complete

GO:0034713

type I transforming growth factor beta receptor binding

PMID:8980228[17]

IPI: Inferred from Physical Interaction

UniProtKB:P36897

F

Seeded From UniProt

complete

GO:0035019

somatic stem cell maintenance

Reactome:REACT_263856

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0035265

organ growth

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0035326

enhancer binding

PMID:21828274[30]

IC: Inferred by Curator

GO:0000790

F

Seeded From UniProt

complete

GO:0035556

intracellular signal transduction

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0035556

intracellular signal transduction

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

P

Seeded From UniProt

complete

GO:0038092

nodal signaling pathway

PMID:15150278[59]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042803

protein homodimerization activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

F

Seeded From UniProt

complete

GO:0045165

cell fate commitment

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0045165

cell fate commitment

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

P

Seeded From UniProt

complete

GO:0045892

negative regulation of transcription, DNA-templated

PMID:14555988[26]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

P

Seeded From UniProt

complete

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

P

Seeded From UniProt

complete

GO:0045893

positive regulation of transcription, DNA-templated

PMID:14555988[26]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045893

positive regulation of transcription, DNA-templated

PMID:9311995[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0045893

positive regulation of transcription, DNA-templated

PMID:9389648[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0045893

positive regulation of transcription, DNA-templated

PMID:9732876[20]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

P

Seeded From UniProt

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:9389648[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

Reactome:REACT_120734

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0046332

SMAD binding

PMID:11160896[28]

IPI: Inferred from Physical Interaction

UniProtKB:Q06413

F

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

GO:0046982

protein heterodimerization activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

F

Seeded From UniProt

complete

GO:0048340

paraxial mesoderm morphogenesis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0048340

paraxial mesoderm morphogenesis

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

P

Seeded From UniProt

complete

GO:0048589

developmental growth

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0048617

embryonic foregut morphogenesis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0048701

embryonic cranial skeleton morphogenesis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0051098

regulation of binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0051098

regulation of binding

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

P

Seeded From UniProt

complete

GO:0060021

palate development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0060021

palate development

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62432

P

Seeded From UniProt

complete

GO:0060039

pericardium development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0060395

SMAD protein signal transduction

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000130115

P

Seeded From UniProt

complete

GO:0070410

co-SMAD binding

PMID:9111321[22]

IPI: Inferred from Physical Interaction

UniProtKB:Q13485

F

Seeded From UniProt

complete

GO:0070410

co-SMAD binding

PMID:9311995[2]

IPI: Inferred from Physical Interaction

UniProtKB:Q13485

F

Seeded From UniProt

complete

GO:0070411

I-SMAD binding

PMID:9256479[27]

IPI: Inferred from Physical Interaction

UniProtKB:O43541

F

Seeded From UniProt

complete

GO:0070412

R-SMAD binding

PMID:9311995[2]

IPI: Inferred from Physical Interaction

UniProtKB:P84022

F

Seeded From UniProt

complete

GO:0070723

response to cholesterol

PMID:17878231[29]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0071141

SMAD protein complex

PMID:18832382[37]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0071144

SMAD2-SMAD3 protein complex

PMID:21828274[30]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:1900224

positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry

PMID:17239842[60]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

contributes_to

GO:0003677

DNA binding

PMID:9389648[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

contributes_to

GO:0003700

transcription factor activity, sequence-specific DNA binding

PMID:17438144[18]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

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