HUMAN:SELS

From GONUTS

Jump to: navigation, search

Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	SELS ( synonyms: VIMP )
Protein Name(s)	Selenoprotein S SelS VCP-interacting membrane protein
External Links
UniProt Identifier	SELS_HUMAN
UniProt Accessions	Q9BQE4, Q3B771, Q9P0I6,
EMBL	AY324824, AF157317, AF328864, BC005840, BC107774,
RefSeq	NP_060915.2, NP_982298.1,
PDB	2Q2F,
IntAct	Q9BQE4,
Ensembl	ENST00000398226,
Pfam	PF06936,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0030968	endoplasmic reticulum unfolded protein response	PMID:15215856^[1]	IDA: Inferred from Direct Assay		P
	GO:0030970	retrograde protein transport, ER to cytosol	PMID:15215856^[1]	IDA: Inferred from Direct Assay		P
	GO:0005515	protein binding	PMID:15215856^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q9BUN8	F
	GO:0051775	response to redox state	PMID:15063746^[2]	IDA: Inferred from Direct Assay		P
	GO:0050728	negative regulation of inflammatory response	PMID:16574427^[3]	IC: Inferred by Curator	GO:0032720	P
	GO:0034362	low-density lipoprotein particle	PMID:17374524^[4]	IDA: Inferred from Direct Assay		C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0034361	very-low-density lipoprotein particle	PMID:17374524^[4]	IDA: Inferred from Direct Assay		C
	GO:0005783	endoplasmic reticulum	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0256	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9BCZ4	P
	GO:0008430	selenium binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009703	F
	GO:0006886	intracellular protein transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009703	P
	GO:0045184	establishment of protein localization	PMID:15215856^[1]	TAS: Traceable Author Statement		P
	GO:0030176	integral to endoplasmic reticulum membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009703	C
	GO:0009749	response to glucose stimulus	PMID:15063746^[2]	IEP: Inferred from Expression Pattern		P
	GO:0006983	ER overload response	PMID:17210132^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0005515	protein binding	PMID:15215856^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q01853	F
	GO:0006954	inflammatory response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000099301	P
	GO:0006916	anti-apoptosis	PMID:17210132^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0030433	ER-associated protein catabolic process	PMID:15215856^[1]	IDA: Inferred from Direct Assay		P
	GO:0004872	receptor activity	PMID:15215856^[1]	NAS: Non-traceable Author Statement		F
	GO:0006983	ER overload response	PMID:16574427^[3]	IDA: Inferred from Direct Assay		P
	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000099301	P
	GO:0019899	enzyme binding	PMID:15215856^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P55072	F
	GO:0016209	antioxidant activity	PMID:15063746^[2]	IDA: Inferred from Direct Assay		F
	GO:0045454	cell redox homeostasis	PMID:15063746^[2]	IDA: Inferred from Direct Assay		P
	GO:0030176	integral to endoplasmic reticulum membrane	PMID:15215856^[1]	IDA: Inferred from Direct Assay		C
	GO:0005783	endoplasmic reticulum	PMID:18029348^[6]	IDA: Inferred from Direct Assay		C
	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0097	C
	GO:0032715	negative regulation of interleukin-6 production	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9BCZ4	P
	GO:0032715	negative regulation of interleukin-6 production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000099301	P
	GO:0002865	negative regulation of acute inflammatory response to antigenic stimulus	PMID:18675776^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:0004872	receptor activity	PMID:15215856^[1]	NAS: Non-traceable Author Statement		F
	GO:0005515	protein binding	PMID:15215856^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q01853	F
	GO:0005515	protein binding	PMID:15215856^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q9BUN8	F
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005783	endoplasmic reticulum	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0256	C
	GO:0005783	endoplasmic reticulum	PMID:18029348^[6]	IDA: Inferred from Direct Assay		C
	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0097	C
	GO:0005792	microsome	PMID:12663463^[8]	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	PMID:12663463^[8]	TAS: Traceable Author Statement		C
	GO:0006111	regulation of gluconeogenesis	PMID:12663463^[8]	TAS: Traceable Author Statement		P
	GO:0006886	intracellular protein transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009703	P
	GO:0006916	anti-apoptosis	PMID:17210132^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0006983	ER overload response	PMID:16574427^[3]	IDA: Inferred from Direct Assay		P
	GO:0006983	ER overload response	PMID:17210132^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0008430	selenium binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009703	F
	GO:0009749	response to glucose stimulus	PMID:12031974^[9]	IEP: Inferred from Expression Pattern		P
	GO:0009749	response to glucose stimulus	PMID:15063746^[2]	IEP: Inferred from Expression Pattern		P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016209	antioxidant activity	PMID:15063746^[2]	IDA: Inferred from Direct Assay		F
	GO:0019899	enzyme binding	PMID:15215856^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P55072	F
	GO:0030176	integral to endoplasmic reticulum membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009703	C
	GO:0030176	integral to endoplasmic reticulum membrane	PMID:15215856^[1]	IDA: Inferred from Direct Assay		C
	GO:0030433	ER-associated protein catabolic process	PMID:15215856^[1]	IDA: Inferred from Direct Assay		P
	GO:0030968	endoplasmic reticulum unfolded protein response	PMID:15215856^[1]	IDA: Inferred from Direct Assay		P
	GO:0030970	retrograde protein transport, ER to cytosol	PMID:15215856^[1]	IDA: Inferred from Direct Assay		P
	GO:0032715	negative regulation of interleukin-6 production	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9BCZ4	P
	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9BCZ4	P
	GO:0032869	cellular response to insulin stimulus	PMID:12663463^[8]	TAS: Traceable Author Statement		P
	GO:0034361	very-low-density lipoprotein particle	PMID:17374524^[4]	IDA: Inferred from Direct Assay		C
	GO:0034362	low-density lipoprotein particle	PMID:17374524^[4]	IDA: Inferred from Direct Assay		C
	GO:0034599	cellular response to oxidative stress	PMID:18675776^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:0045184	establishment of protein localization	PMID:15215856^[1]	TAS: Traceable Author Statement		P
	GO:0045454	cell redox homeostasis	PMID:15063746^[2]	IDA: Inferred from Direct Assay		P
	GO:0045719	negative regulation of glycogen biosynthetic process	PMID:12663463^[8]	TAS: Traceable Author Statement		P
	GO:0046325	negative regulation of glucose import	PMID:12663463^[8]	TAS: Traceable Author Statement		P
	GO:0050728	negative regulation of inflammatory response	PMID:16574427^[3]	IC: Inferred by Curator	GO:0032720	P
	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process	PMID:18675776^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:0051775	response to redox state	PMID:15063746^[2]	IDA: Inferred from Direct Assay		P
	GO:0071222	cellular response to lipopolysaccharide	PMID:18675776^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:0080164	regulation of nitric oxide metabolic process	PMID:18675776^[7]	IMP: Inferred from Mutant Phenotype		P
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 Ye Y et al. (2004) A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature 429: 841-7 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Gao Y et al. (2004) Regulation of the selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein. FEBS Lett 563: 185-90 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Gao Y et al. (2006) Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells. Cytokine 33: 246-51 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Gao Y et al. (2007) Secretion of the glucose-regulated selenoprotein SEPS1 from hepatoma cells. Biochem Biophys Res Commun 356: 636-41 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Kim KH et al. (2007) SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis. Biochem Biophys Res Commun 354: 127-32 PubMed GONUTS page
↑ ^6.0 ^6.1 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Zeng J et al. (2008) Role of SelS in lipopolysaccharide-induced inflammatory response in hepatoma HepG2 cells. Arch Biochem Biophys 478: 1-6 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Gao Y et al. (2003) Elevation in Tanis expression alters glucose metabolism and insulin sensitivity in H4IIE cells. Diabetes 52: 929-34 PubMed GONUTS page
↑ Walder K et al. (2002) Tanis: a link between type 2 diabetes and inflammation? Diabetes 51: 1859-66 PubMed GONUTS page

[PMID:15215856-0] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 Ye Y et al. (2004) A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature 429: 841-7 PubMed GONUTS page

[PMID:15063746-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Gao Y et al. (2004) Regulation of the selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein. FEBS Lett 563: 185-90 PubMed GONUTS page

[PMID:16574427-2] 3.0 ^3.1 ^3.2 ^3.3 Gao Y et al. (2006) Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells. Cytokine 33: 246-51 PubMed GONUTS page

[PMID:17374524-3] 4.0 ^4.1 ^4.2 ^4.3 Gao Y et al. (2007) Secretion of the glucose-regulated selenoprotein SEPS1 from hepatoma cells. Biochem Biophys Res Commun 356: 636-41 PubMed GONUTS page

[PMID:17210132-4] 5.0 ^5.1 ^5.2 ^5.3 Kim KH et al. (2007) SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis. Biochem Biophys Res Commun 354: 127-32 PubMed GONUTS page

[PMID:18029348-5] 6.0 ^6.1 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page

[PMID:18675776-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Zeng J et al. (2008) Role of SelS in lipopolysaccharide-induced inflammatory response in hepatoma HepG2 cells. Arch Biochem Biophys 478: 1-6 PubMed GONUTS page

[PMID:12663463-7] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Gao Y et al. (2003) Elevation in Tanis expression alters glucose metabolism and insulin sensitivity in H4IIE cells. Diabetes 52: 929-34 PubMed GONUTS page

[PMID:12031974-8] Walder K et al. (2002) Tanis: a link between type 2 diabetes and inflammation? Diabetes 51: 1859-66 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

HUMAN:SELS

Contents

Annotations

Notes

References

a

c

e

e cont.

i

l

m

n

n cont.

p

r

s

v

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox