HUMAN:SCYL2

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	SCYL2 ( synonyms: CVAK104, KIAA1360 )
Protein Name(s)	SCY1-like protein 2 Coated vesicle-associated kinase of 104 kDa
External Links
UniProt Identifier	SCYL2_HUMAN
UniProt Accessions	Q6P3W7, A8KAB5, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7,
EMBL	AK001597, AK024274, AK027551, AK292980, CH471054, BC012387, BC063798, AB037781,
RefSeq	NP_060458.3,
IntAct	Q6P3W7,
Ensembl	ENST00000360820,
Pfam	PF00069,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0030136	clathrin-coated vesicle		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0010008	endosome membrane		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0005794	Golgi apparatus		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0048471	perinuclear region of cytoplasm		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0005524	ATP binding		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0004672	protein kinase activity		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0005515	protein binding	19643732	IPI: Inferred from Physical Interaction	UniProtKB:O14640	F	Fig 1C. Immunoprecipitation analysis: positive signal in anti-CVAK104 precipitates, but not with control rabbit IgG.	complete
	GO:0006468	protein phosphorylation		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0002092	positive regulation of receptor internalization	19643732	IDA: Inferred from Direct Assay		P	Fig 2B. When cotransfected with CVAK104, dotlike pattern of Fzd5-GFP is seen throughout in the cell; in control it is localised at edge.	complete
	GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	19643732	IDA: Inferred from Direct Assay		P	Fig 6. Results implicate CVAK104 in negative regulation of Wnt signalling pathway, e.g. knockdown of CVAK104 resulted in increase in activated beta-catenin.	complete
	GO:0005102	receptor binding	19643732	IPI: Inferred from Physical Interaction	UniProtKB:Q13467	F	Fig 4A. Only Fzd5-GFP co-precipitated with FLAG-CVAK104.	complete
	GO:0002092	positive regulation of receptor internalization	PMID:19643732^[1]	IDA: Inferred from Direct Assay		P
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0005102	receptor binding	PMID:19643732^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q13467	F
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011989	F
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016024	F
	GO:0005515	protein binding	PMID:19643732^[1]	IPI: Inferred from Physical Interaction	UniProtKB:O14640	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005768	endosome	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0967	C
	GO:0005794	Golgi apparatus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0333	C
	GO:0005794	Golgi apparatus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0132	C
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	P
	GO:0008333	endosome to lysosome transport	PMID:19643732^[1]	IDA: Inferred from Direct Assay		P
	GO:0010008	endosome membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0100	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F
	GO:0030136	clathrin-coated vesicle	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0070	C
	GO:0031410	cytoplasmic vesicle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0968	C
	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0198	C
	GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	PMID:19643732^[1]	IDA: Inferred from Direct Assay		P
	GO:2000370	positive regulation of clathrin-mediated endocytosis	PMID:19643732^[1]	IDA: Inferred from Direct Assay		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Terabayashi T et al. (2009) A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5). J Biol Chem 284: 26716-24 PubMed GONUTS page

[PMID:19643732-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Terabayashi T et al. (2009) A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5). J Biol Chem 284: 26716-24 PubMed GONUTS page

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HUMAN:SCYL2

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