HUMAN:RILP

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	RILP
Protein Name(s)	Rab-interacting lysosomal protein
External Links
UniProt Identifier	RILP_HUMAN
UniProt Accessions	Q96NA2, B2RBQ8, Q71RE6, Q9BSL3, Q9BYS3,
EMBL	AJ404317, AK055755, AK314767, AF370391, AJ278711, BC004961, BC031621,
RefSeq	NP_113618.2,
PDB	1YHN,
IntAct	Q96NA2,
Ensembl	ENST00000301336,
Pfam	PF09744, PF11461,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0031902	late endosome membrane		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0005765	lysosomal membrane		NAS: Non-traceable Author Statement		C	Source: UniProtKB
	GO:0030670	phagocytic vesicle membrane		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0017137	Rab GTPase binding		TAS: Traceable Author Statement		F	Source: UniProtKB
	GO:0015031	protein transport		NAS: Non-traceable Author Statement		P	Source: UniProtKB
	GO:0017137	Rab GTPase binding	PubMed ID:18272684	IPI: Inferred from Physical Interaction	UniProtKB:P18067	F	Figure. 4 : Using the two-hybrid assays ;the wild type of Rab7 and the CMT2B-associated Rab7 mutants were interacting strongly with RILP .Also Rab7 Q67L (which is an active mutated Rab7 protein impaired in GTP hydrolysis not GTP binding ) showed a strong interaction with RILP compared to the interaction of the dominant-negative mutant Rab7 T22N which was extremely weak .	complete
	GO:0005770	late endosome	PubMed ID:18272684	IDA: Inferred from Direct Assay		C	(Figure. 6M–X): When co-expressed with RILP,the Rab7 wild type, Rab7 Q67L and the CMT2B-associated Rab7 mutant proteins were present on the clustered endosomal structures. Which indicates that Rab7 not only interacts with RILP but it also colocalizes with RILP.	complete
	GO:0005739	mitochondrion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000037238	C
	GO:0005764	lysosome	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0458	C
	GO:0005764	lysosome	PMID:18272684^[1]	IDA: Inferred from Direct Assay		C
	GO:0005765	lysosomal membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0157	C
	GO:0005765	lysosomal membrane	PMID:11179213^[2]	NAS: Non-traceable Author Statement		C
	GO:0005768	endosome	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0967	C
	GO:0005770	late endosome	PMID:11179213^[2]	NAS: Non-traceable Author Statement		C
	GO:0005770	late endosome	PMID:18272684^[1]	IDA: Inferred from Direct Assay		C
	GO:0006810	transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P
	GO:0008333	endosome to lysosome transport	PMID:18272684^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0012505	endomembrane system	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0147	C
	GO:0015031	protein transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0653	P
	GO:0015031	protein transport	PMID:11179213^[2]	NAS: Non-traceable Author Statement		P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0017137	Rab GTPase binding	PMID:11179213^[2]	TAS: Traceable Author Statement		F
	GO:0017137	Rab GTPase binding	PMID:18272684^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P51149	F
	GO:0030670	phagocytic vesicle membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0205	C
	GO:0031410	cytoplasmic vesicle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0968	C
	GO:0031902	late endosome membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0151	C
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Spinosa MR et al. (2008) Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease. J Neurosci 28: 1640-8 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Cantalupo G et al. (2001) Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes. EMBO J 20: 683-93 PubMed GONUTS page

[PMID:18272684-0] 1.0 ^1.1 ^1.2 ^1.3 Spinosa MR et al. (2008) Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease. J Neurosci 28: 1640-8 PubMed GONUTS page

[PMID:11179213-1] 2.0 ^2.1 ^2.2 ^2.3 Cantalupo G et al. (2001) Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes. EMBO J 20: 683-93 PubMed GONUTS page

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HUMAN:RILP

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