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HUMAN:RFA1
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | RPA1 (synonyms: REPA1, RPA70) | |
| Protein Name(s) | Replication protein A 70 kDa DNA-binding subunit
RP-A p70 Replication factor A protein 1 RF-A protein 1 Single-stranded DNA-binding protein | |
| External Links | ||
| EMBL | M63488 AK289704 AB209732 AY599563 CH471108 BC018126 | |
| IPI | IPI00020127 | |
| PIR | A40457 | |
| RefSeq | NP_002936.1 | |
| UniGene | Hs.461925 | |
| PDB | 1EWI 1FGU 1JMC 1L1O 2B29 2B3G | |
| PDBsum | 1EWI 1FGU 1JMC 1L1O 2B29 2B3G | |
| ProteinModelPortal | P27694 | |
| SMR | P27694 | |
| DisProt | DP00061 | |
| DIP | DIP-24189N | |
| IntAct | P27694 | |
| MINT | MINT-91488 | |
| STRING | P27694 | |
| PhosphoSite | P27694 | |
| PeptideAtlas | P27694 | |
| PRIDE | P27694 | |
| Ensembl | ENST00000254719 | |
| GeneID | 6117 | |
| KEGG | hsa:6117 | |
| UCSC | uc002fto.2 | |
| CTD | 6117 | |
| GeneCards | GC17P001680 | |
| H-InvDB | HIX0017624 | |
| HGNC | HGNC:10289 | |
| HPA | CAB004563 HPA006914 | |
| MIM | 179835 | |
| neXtProt | NX_P27694 | |
| PharmGKB | PA34651 | |
| eggNOG | prNOG17565 | |
| GeneTree | ENSGT00390000012403 | |
| HOGENOM | HBG618684 | |
| HOVERGEN | HBG010502 | |
| InParanoid | P27694 | |
| OMA | NIYLMDM | |
| OrthoDB | EOG4V9TQ8 | |
| PhylomeDB | P27694 | |
| Reactome | REACT_152 REACT_1538 REACT_216 REACT_22172 REACT_27271 REACT_383 | |
| NextBio | 23755 | |
| ArrayExpress | P27694 | |
| Bgee | P27694 | |
| CleanEx | HS_RPA1 | |
| Genevestigator | P27694 | |
| GermOnline | ENSG00000132383 | |
| GO | GO:0015629 GO:0005737 GO:0005662 GO:0016605 GO:0046872 GO:0005515 GO:0003697 GO:0000075 GO:0000730 GO:0006271 GO:0000082 GO:0000216 GO:0000718 GO:0006297 GO:0000084 GO:0000722 GO:0032201 GO:0006283 | |
| InterPro | IPR012340 IPR016027 IPR004365 IPR013955 IPR007199 IPR004591 | |
| Gene3D | G3DSA:2.40.50.140 | |
| Pfam | PF04057 PF08646 PF01336 | |
| SUPFAM | SSF50249 | |
| TIGRFAMs | TIGR00617 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000075 |
cell cycle checkpoint |
Reactome:REACT_1538 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0000082 |
G1/S transition of mitotic cell cycle |
Reactome:REACT_1783 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0000084 |
S phase of mitotic cell cycle |
Reactome:REACT_899 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0000216 |
M/G1 transition of mitotic cell cycle |
Reactome:REACT_1725 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0000278 |
mitotic cell cycle |
Reactome:REACT_152 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0000718 |
nucleotide-excision repair, DNA damage removal |
Reactome:REACT_311 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0000722 |
telomere maintenance via recombination |
Reactome:REACT_7999 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0000722 |
telomere maintenance via recombination |
Reactome:REACT_8027 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0000723 |
telomere maintenance |
Reactome:REACT_7970 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0000724 |
double-strand break repair via homologous recombination |
Reactome:REACT_1874 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0000730 |
DNA recombinase assembly |
Reactome:REACT_2141 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0003676 |
nucleic acid binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003697 |
single-stranded DNA binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004229 |
F |
Seeded From UniProt |
|||
| GO:0003697 |
single-stranded DNA binding |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_1033 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_1106 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_1124 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_1196 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_1278 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_1311 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_1316 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_1465 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_1492 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_2026 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_2149 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_2163 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_315 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_353 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_465 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_6729 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_677 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_6798 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_6936 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_6939 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_789 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_7949 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_7955 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_8015 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005662 |
DNA replication factor A complex |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004229 |
C |
Seeded From UniProt |
|||
| GO:0005662 |
DNA replication factor A complex |
IPI: Inferred from Physical Interaction |
C |
Seeded From UniProt |
||||
| GO:0005662 |
DNA replication factor A complex |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0006260 |
DNA replication |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006260 |
DNA replication |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006260 |
DNA replication |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006260 |
DNA replication |
Reactome:REACT_6769 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0006261 |
DNA-dependent DNA replication |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0006271 |
DNA strand elongation involved in DNA replication |
Reactome:REACT_932 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0006281 |
DNA repair |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006281 |
DNA repair |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0006281 |
DNA repair |
Reactome:REACT_216 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0006283 |
transcription-coupled nucleotide-excision repair |
Reactome:REACT_1628 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0006289 |
nucleotide-excision repair |
Reactome:REACT_1826 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0006297 |
nucleotide-excision repair, DNA gap filling |
Reactome:REACT_1998 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0006302 |
double-strand break repair |
Reactome:REACT_2054 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0006310 |
DNA recombination |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006310 |
DNA recombination |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0006974 |
response to DNA damage stimulus |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0015629 |
actin cytoskeleton |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0016605 |
PML body |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0032201 |
telomere maintenance via semi-conservative replication |
Reactome:REACT_7961 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0046872 |
metal ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005730 |
nucleolus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0031576 |
G2/M transition checkpoint |
IMP: Inferred from Mutant Phenotype |
P |
P.19099, Table 1, Figures 1,2 |
complete | |||
| GO:0006281 |
DNA repair |
IMP: Inferred from Mutant Phenotype |
P |
Figure 6 |
complete | |||
| GO:0003697 |
single-stranded DNA binding |
IMP: Inferred from Mutant Phenotype |
F |
Figure 3. Table 4 |
complete | |||
| GO:0006260 |
DNA replication |
IMP: Inferred from Mutant Phenotype |
P |
Figure 4. |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Gomes XV & Wold MS (1996) Functional domains of the 70-kilodalton subunit of human replication protein A. Biochemistry 35: 10558-68 PubMed GONUTS page
- ↑ Brosh RM Jr et al. (1999) Functional and physical interaction between WRN helicase and human replication protein A. J Biol Chem 274: 18341-50 PubMed GONUTS page
- ↑ Brosh RM Jr et al. (2000) Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity. J Biol Chem 275: 23500-8 PubMed GONUTS page
- ↑ 4.0 4.1 Dornreiter I et al. (1992) Interaction of DNA polymerase alpha-primase with cellular replication protein A and SV40 T antigen. EMBO J 11: 769-76 PubMed GONUTS page
- ↑ Wu X et al. (2005) Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells. Oncogene 24: 4728-35 PubMed GONUTS page
- ↑ 6.0 6.1 Doherty KM et al. (2005) Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases. J Biol Chem 280: 29494-505 PubMed GONUTS page
- ↑ Du Y et al. (2009) Streamline proteomic approach for characterizing protein-protein interaction network in a RAD52 protein complex. J Proteome Res 8: 2211-7 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
- ↑ 9.0 9.1 Park J et al. (2005) Sumoylation of the novel protein hRIP{beta} is involved in replication protein A deposition in PML nuclear bodies. Mol Cell Biol 25: 8202-14 PubMed GONUTS page
- ↑ 10.0 10.1 Haring SJ et al. (2008) Cellular functions of human RPA1. Multiple roles of domains in replication, repair, and checkpoints. J Biol Chem 283: 19095-111 PubMed GONUTS page
