GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
HUMAN:REL
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | REL | |
| Protein Name(s) | Proto-oncogene c-Rel | |
| External Links | ||
| EMBL | X75042 DQ314888 M11595 | |
| IPI | IPI00029773 | |
| PIR | A60646 | |
| RefSeq | NP_002899.1 | |
| UniGene | Hs.631886 | |
| ProteinModelPortal | Q04864 | |
| SMR | Q04864 | |
| DIP | DIP-301N | |
| IntAct | Q04864 | |
| MINT | MINT-1137552 | |
| STRING | Q04864 | |
| PhosphoSite | Q04864 | |
| PRIDE | Q04864 | |
| Ensembl | ENST00000295025 | |
| GeneID | 5966 | |
| KEGG | hsa:5966 | |
| UCSC | uc002sam.1 | |
| CTD | 5966 | |
| GeneCards | GC02P060851 | |
| H-InvDB | HIX0029962 | |
| HGNC | HGNC:9954 | |
| HPA | CAB004404 | |
| MIM | 164910 | |
| neXtProt | NX_Q04864 | |
| PharmGKB | PA34321 | |
| eggNOG | prNOG18542 | |
| GeneTree | ENSGT00500000044765 | |
| HOGENOM | HBG282218 | |
| HOVERGEN | HBG017916 | |
| InParanoid | Q04864 | |
| OMA | CADNSMI | |
| OrthoDB | EOG4NVZK2 | |
| PhylomeDB | Q04864 | |
| Pathway_Interaction_DB | nfkappabatypicalpathway ar_tf_pathway | |
| NextBio | 23226 | |
| ArrayExpress | Q04864 | |
| Bgee | Q04864 | |
| CleanEx | HS_REL | |
| Genevestigator | Q04864 | |
| GermOnline | ENSG00000162924 | |
| GO | GO:0005634 GO:0003677 GO:0005515 GO:0003700 GO:0043123 | |
| InterPro | IPR013783 IPR014756 IPR002909 IPR000451 IPR008967 IPR011539 | |
| Gene3D | G3DSA:2.60.40.10 G3DSA:2.60.40.340 | |
| KO | K09254 | |
| Pfam | PF00554 | |
| PRINTS | PR00057 | |
| SMART | SM00429 | |
| SUPFAM | SSF81296 SSF49417 | |
| PROSITE | PS01204 PS50254 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001816 |
cytokine production |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000099928 |
P |
Seeded From UniProt |
|||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000099928 |
F |
Seeded From UniProt |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
NAS: Non-traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
Seeded From UniProt |
|||
| GO:0006351 |
transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006351 |
transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000099928 |
P |
Seeded From UniProt |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
NAS: Non-traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB cascade |
IEP: Inferred from Expression Pattern |
|
P |
Seeded From UniProt |
|||
| GO:0045084 |
positive regulation of interleukin-12 biosynthetic process |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000099928 |
P |
Seeded From UniProt |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000099928 |
P |
Seeded From UniProt |
|||
| GO:0032688 |
negative regulation of interferon-beta production |
IDA: Inferred from Direct Assay |
P |
Fig. 4 |
complete | |||
| GO:0005634 |
nucleus |
IMP: Inferred from Mutant Phenotype |
C |
Fig. 3D |
complete | |||
| GO:0010629 |
negative regulation of gene expression |
IDA: Inferred from Direct Assay |
P |
Fig. 4C |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Mathew S et al. (1993) Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization. Oncogene 8: 191-3 PubMed GONUTS page
- ↑ Burstein E et al. (2005) COMMD proteins, a novel family of structural and functional homologs of MURR1. J Biol Chem 280: 22222-32 PubMed GONUTS page
- ↑ Matsuda A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22: 3307-18 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Siednienko J et al. (2011) Nuclear factor κB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1. J Biol Chem 286: 44750-63 PubMed GONUTS page
cdn |
n cont.p |
p cont.rst |
