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HUMAN:RASN
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | NRAS (synonyms: HRAS1) | |
| Protein Name(s) | GTPase NRas
Transforming protein N-Ras | |
| External Links | ||
| EMBL | X02751 X00642 X00643 X00644 X00645 L00043 L00040 L00041 L00042 AF493919 AY428630 BC005219 M25898 X53291 X53292 K03211 M10055 X05565 X07440 | |
| IPI | IPI00000005 | |
| PIR | A90839 I38149 | |
| RefSeq | NP_002515.1 | |
| UniGene | Hs.486502 | |
| PDB | 3CON | |
| PDBsum | 3CON | |
| ProteinModelPortal | P01111 | |
| SMR | P01111 | |
| DIP | DIP-1058N | |
| IntAct | P01111 | |
| MINT | MINT-131535 | |
| STRING | P01111 | |
| PhosphoSite | P01111 | |
| OGP | P01111 | |
| PeptideAtlas | P01111 | |
| PRIDE | P01111 | |
| Ensembl | ENST00000369535 | |
| GeneID | 4893 | |
| KEGG | hsa:4893 | |
| UCSC | uc009wgu.1 | |
| CTD | 4893 | |
| GeneCards | GC01M113105 | |
| HGNC | HGNC:7989 | |
| HPA | CAB010157 | |
| MIM | 164790 607785 613224 | |
| neXtProt | NX_P01111 | |
| Orphanet | 3261 648 | |
| PharmGKB | PA31768 | |
| HOGENOM | HBG745225 | |
| HOVERGEN | HBG009351 | |
| InParanoid | P01111 | |
| OMA | DIGTYRE | |
| OrthoDB | EOG4BRWMX | |
| PhylomeDB | P01111 | |
| Pathway_Interaction_DB | pi3kcipathway cd8tcrdownstreampathway ephbfwdpathway il2_1pathway trkrpathway er_nongenomic_pathway tcrraspathway tcrpathway cd8tcrpathway pi3kplctrkpathway mapktrkpathway | |
| Reactome | REACT_11061 REACT_16888 REACT_18266 REACT_498 REACT_604 REACT_6900 REACT_9417 | |
| NextBio | 18835 | |
| ArrayExpress | P01111 | |
| Bgee | P01111 | |
| CleanEx | HS_NRAS | |
| Genevestigator | P01111 | |
| GermOnline | ENSG00000009307 | |
| GO | GO:0000139 GO:0005886 GO:0005525 GO:0003924 GO:0000186 GO:0007411 GO:0007596 GO:0007173 GO:0008286 GO:0050900 GO:0048011 GO:0007265 | |
| InterPro | IPR005225 IPR001806 IPR020849 | |
| PANTHER | PTHR24070 | |
| Pfam | PF00071 | |
| PRINTS | PR00449 | |
| SMART | SM00173 | |
| TIGRFAMs | TIGR00231 | |
| PROSITE | PS51421 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000139 |
Golgi membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0134 |
C |
Seeded From UniProt |
|||
| GO:0000165 |
MAPKKK cascade |
Reactome:REACT_634 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0000166 |
nucleotide binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0000186 |
activation of MAPKK activity |
Reactome:REACT_12005 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0000186 |
activation of MAPKK activity |
Reactome:REACT_962 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0003924 |
GTPase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003924 |
GTPase activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000029445 |
F |
Seeded From UniProt |
|||
| GO:0005525 |
GTP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005525 |
GTP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005525 |
GTP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005525 |
GTP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005624 |
membrane fraction |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000029445 |
C |
Seeded From UniProt |
|||
| GO:0005794 |
Golgi apparatus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000036381 |
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0039 |
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
Reactome:REACT_12001 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_12041 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_12386 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_12402 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_12516 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_16923 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_18366 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_2010 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_359 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_525 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_996 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0006184 |
GTP catabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007165 |
signal transduction |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007173 |
epidermal growth factor receptor signaling pathway |
Reactome:REACT_9417 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0007264 |
small GTPase mediated signal transduction |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007264 |
small GTPase mediated signal transduction |
Reactome:REACT_12077 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0007265 |
Ras protein signal transduction |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000029445 |
P |
Seeded From UniProt |
|||
| GO:0007265 |
Ras protein signal transduction |
Reactome:REACT_12033 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0007411 |
axon guidance |
Reactome:REACT_18266 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0007596 |
blood coagulation |
Reactome:REACT_604 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0008284 |
positive regulation of cell proliferation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000029445 |
P |
Seeded From UniProt |
|||
| GO:0008286 |
insulin receptor signaling pathway |
Reactome:REACT_498 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0008321 |
Ral guanyl-nucleotide exchange factor activity |
Reactome:REACT_12041 |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
||
| GO:0008542 |
visual learning |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000029445 |
P |
Seeded From UniProt |
|||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0030036 |
actin cytoskeleton organization |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000029445 |
P |
Seeded From UniProt |
|||
| GO:0032228 |
regulation of synaptic transmission, GABAergic |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000029445 |
P |
Seeded From UniProt |
|||
| GO:0035022 |
positive regulation of Rac protein signal transduction |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000029445 |
P |
Seeded From UniProt |
|||
| GO:0048011 |
nerve growth factor receptor signaling pathway |
Reactome:REACT_11061 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0048169 |
regulation of long-term neuronal synaptic plasticity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000029445 |
P |
Seeded From UniProt |
|||
| GO:0050900 |
leukocyte migration |
Reactome:REACT_12051 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0051146 |
striated muscle cell differentiation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000029445 |
P |
Seeded From UniProt |
|||
| GO:0005794 |
Golgi apparatus |
IDA: Inferred from Direct Assay |
C |
Overexpression of PAQR10/PAQR11 also markedly increased Golgi localization of NRas and KRas4A (Figure2B and 2C), (summarized in Figure 2E). |
complete | |||
| GO:0072600 |
establishment of protein localization in Golgi |
IMP: Inferred from Mutant Phenotype |
P |
Figure 2B |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Jin T et al. (2012) PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus. Cell Res 22: 661-76 PubMed GONUTS page