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HUMAN:RAB7A
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | RAB7A (synonyms: RAB7) | |
| Protein Name(s) | Ras-related protein Rab-7a | |
| External Links | ||
| EMBL | X93499 U44104 AF050175 AF498942 AK000826 AK290721 BC008721 CH471052 | |
| IPI | IPI00016342 | |
| PIR | JC5268 | |
| RefSeq | NP_004628.4 | |
| UniGene | Hs.15738 Hs.728150 | |
| PDB | 1T91 1YHN 3LAW | |
| PDBsum | 1T91 1YHN 3LAW | |
| ProteinModelPortal | P51149 | |
| SMR | P51149 | |
| DIP | DIP-39879N | |
| IntAct | P51149 | |
| MINT | MINT-4999676 | |
| STRING | P51149 | |
| PhosphoSite | P51149 | |
| PeptideAtlas | P51149 | |
| PRIDE | P51149 | |
| Ensembl | ENST00000265062 ENST00000430113 | |
| GeneID | 7879 | |
| KEGG | hsa:7879 | |
| UCSC | uc003eks.1 | |
| CTD | 7879 | |
| GeneCards | GC03P125832 | |
| H-InvDB | HIX0003657 | |
| HGNC | HGNC:9788 | |
| HPA | HPA006964 | |
| MIM | 600882 602298 | |
| neXtProt | NX_P51149 | |
| Orphanet | 99936 | |
| PharmGKB | PA162400619 | |
| eggNOG | prNOG16295 | |
| GeneTree | ENSGT00600000084038 | |
| HOGENOM | HBG745225 | |
| HOVERGEN | HBG009351 | |
| InParanoid | P51149 | |
| OMA | SPRDPEH | |
| OrthoDB | EOG4QFWF4 | |
| PhylomeDB | P51149 | |
| Pathway_Interaction_DB | il12_2pathway | |
| NextBio | 30336 | |
| ArrayExpress | P51149 | |
| Bgee | P51149 | |
| CleanEx | HS_RAB7A | |
| Genevestigator | P51149 | |
| GermOnline | ENSG00000075785 | |
| GO | GO:0005794 GO:0005770 GO:0005764 GO:0042470 GO:0045335 GO:0019003 GO:0005525 GO:0003924 GO:0005515 GO:0006897 GO:0008333 GO:0007174 GO:0015031 GO:0007264 | |
| InterPro | IPR005225 IPR001806 IPR003579 | |
| KO | K07897 | |
| Pfam | PF00071 | |
| PRINTS | PR00449 | |
| SMART | SM00175 | |
| TIGRFAMs | TIGR00231 | |
| PROSITE | PS51419 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003924 |
GTPase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0003924 |
GTPase activity |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005525 |
GTP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005525 |
GTP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005525 |
GTP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005525 |
GTP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005525 |
GTP binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005764 |
lysosome |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005764 |
lysosome |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0158 |
C |
Seeded From UniProt |
|||
| GO:0005764 |
lysosome |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005768 |
endosome |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005770 |
late endosome |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000109230 |
C |
Seeded From UniProt |
|||
| GO:0005770 |
late endosome |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0152 |
C |
Seeded From UniProt |
|||
| GO:0005770 |
late endosome |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005770 |
late endosome |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0005794 |
Golgi apparatus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000109230 |
C |
Seeded From UniProt |
|||
| GO:0005794 |
Golgi apparatus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0006184 |
GTP catabolic process |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0006184 |
GTP catabolic process |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0006810 |
transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006897 |
endocytosis |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0007174 |
epidermal growth factor catabolic process |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0007264 |
small GTPase mediated signal transduction |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007264 |
small GTPase mediated signal transduction |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0008333 |
endosome to lysosome transport |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0015031 |
protein transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0015031 |
protein transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0019003 |
GDP binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0031410 |
cytoplasmic vesicle |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0042470 |
melanosome |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0161 |
C |
Seeded From UniProt |
|||
| GO:0043231 |
intracellular membrane-bounded organelle |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0045335 |
phagocytic vesicle |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0206 |
C |
Seeded From UniProt |
|||
| GO:0005764 |
lysosome |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005770 |
late endosome |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0045732 |
positive regulation of protein catabolic process |
IMP: Inferred from Mutant Phenotype |
P |
Fig. 6A, and Fig. 7A |
complete | |||
| GO:0019068 |
virion assembly |
IMP: Inferred from Mutant Phenotype |
P |
Fig. 3 |
complete | |||
| GO:0009405 |
pathogenesis |
IMP: Inferred from Mutant Phenotype |
P |
Fig. 2C |
complete | |||
| GO:0019076 |
release of virus from host |
IMP: Inferred from Mutant Phenotype |
P |
Fig. 2AB and Fig. 5 |
complete | |||
| GO:0048524 |
positive regulation of viral reproduction |
IMP: Inferred from Mutant Phenotype |
P |
Fig. 1A, 1B |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Spinosa MR et al. (2008) Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease. J Neurosci 28: 1640-8 PubMed GONUTS page
- ↑ 2.0 2.1 Vitelli R et al. (1996) Molecular cloning and expression analysis of the human Rab7 GTP-ase complementary deoxyribonucleic acid. Biochem Biophys Res Commun 229: 887-90 PubMed GONUTS page
- ↑ Burger A et al. (2006) Novel RING E3 ubiquitin ligases in breast cancer. Neoplasia 8: 689-95 PubMed GONUTS page
- ↑ Pankiv S et al. (2010) FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport. J Cell Biol 188: 253-69 PubMed GONUTS page
- ↑ 5.0 5.1 Seaman MN (2004) Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer. J Cell Biol 165: 111-22 PubMed GONUTS page
- ↑ 6.0 6.1 Chavrier P et al. (1990) Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments. Cell 62: 317-29 PubMed GONUTS page
- ↑ 7.0 7.1 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 Caillet M et al. (2011) Rab7A is required for efficient production of infectious HIV-1. PLoS Pathog 7: e1002347 PubMed GONUTS page
