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HUMAN:PVRL2

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Contents

Species (Taxon ID) Homo sapiens (Human). (taxon:9606)
Gene Name(s) PVRL2 ( synonyms: HVEB, PRR2 )
Protein Name(s)
  • Poliovirus receptor-related protein 2
  • Herpes virus entry mediator B
  • Herpesvirus entry mediator B
  • HveB
  • Nectin-2
External Links
UniProt Identifier PVRL2_HUMAN
UniProt Accessions Q92692, O75455, Q6IBI6, Q96J29,
EMBL X80038, AF058448, CR456818, CH471126, BC003091, AF044968, AF044962, AF044963, AF044964, AF044966, AF044967, AF050154,
PIR I68093,
RefSeq NP_001036189.1, NP_002847.1,
PDB 3R0N,
IntAct Q92692,
Ensembl ENST00000252483,
Pfam PF08205, PF07686,

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0009986

cell surface

IDA: Inferred from Direct Assay

C

Source: BHF-UCL

GO:0016021

integral to membrane

IDA: Inferred from Direct Assay

C

Source: BHF-UCL

GO:0005915

zonula adherens

ISS: Inferred from Sequence or Structural Similarity

C

Source: BHF-UCL

GO:0050839

cell adhesion molecule binding

IPI: Inferred from Physical Interaction

F

Source: BHF-UCL

GO:0015026

coreceptor activity

TAS: Traceable Author Statement

F

Source: ProtInc

GO:0042803

protein homodimerization activity

IPI: Inferred from Physical Interaction

F

Source: BHF-UCL

GO:0051856

adhesion to symbiont

IDA: Inferred from Direct Assay

P

Source: BHF-UCL

GO:0007156

homophilic cell adhesion

IDA: Inferred from Direct Assay

P

Source: BHF-UCL

GO:0002891

positive regulation of immunoglobulin media...

IMP: Inferred from Mutant Phenotype

P

Source: BHF-UCL

GO:0033005

positive regulation of mast cell activation

IMP: Inferred from Mutant Phenotype

P

Source: BHF-UCL

GO:0002860

positive regulation of natural killer cell ...

IMP: Inferred from Mutant Phenotype

P

Source: BHF-UCL

GO:0007286

spermatid development

ISS: Inferred from Sequence or Structural Similarity

P

Source: BHF-UCL

GO:0042271

susceptibility to natural killer cell media...

IMP: Inferred from Mutant Phenotype

P

Source: BHF-UCL

GO:0060370

susceptibility to T cell mediated cytotoxicity

IDA: Inferred from Direct Assay

P

Source: BHF-UCL

GO:0019064

viral envelope fusion with host membrane

IDA: Inferred from Direct Assay

P

Source: BHF-UCL

GO:0046814

virion attachment, binding of host cell sur...

IDA: Inferred from Direct Assay

P

Source: BHF-UCL

GO:0001675

acrosome assembly

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000074898

P

GO:0002860

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

PMID:12913096[1]

IMP: Inferred from Mutant Phenotype

P

GO:0002891

positive regulation of immunoglobulin mediated immune response

PMID:16831868[2]

IMP: Inferred from Mutant Phenotype

P

GO:0004872

receptor activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0675

F

GO:0005515

protein binding

PMID:19011627[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q495A1

F

GO:0005886

plasma membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

GO:0005886

plasma membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000074898

C

GO:0005886

plasma membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0039

C

GO:0005886

plasma membrane

PMID:9657005[4]

TAS: Traceable Author Statement

C

GO:0005886

plasma membrane

Reactome:REACT_11094

TAS: Traceable Author Statement

C

GO:0005886

plasma membrane

Reactome:REACT_11097

TAS: Traceable Author Statement

C

GO:0005886

plasma membrane

Reactome:REACT_19169

TAS: Traceable Author Statement

C

GO:0005886

plasma membrane

Reactome:REACT_19176

TAS: Traceable Author Statement

C

GO:0005886

plasma membrane

Reactome:REACT_19214

TAS: Traceable Author Statement

C

GO:0005886

plasma membrane

Reactome:REACT_19364

TAS: Traceable Author Statement

C

GO:0005911

cell-cell junction

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000074898

C

GO:0005911

cell-cell junction

PMID:9845526[5]

IDA: Inferred from Direct Assay

C

GO:0005915

zonula adherens

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000074898

C

GO:0005915

zonula adherens

PMID:10225955[6]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P32507

C

GO:0007010

cytoskeleton organization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000074898

P

GO:0007155

cell adhesion

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0130

P

GO:0007156

homophilic cell adhesion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000074898

P

GO:0007156

homophilic cell adhesion

PMID:9845526[5]

IDA: Inferred from Direct Assay

P

GO:0007286

spermatid development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000074898

P

GO:0007286

spermatid development

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P32507

P

GO:0007289

spermatid nucleus differentiation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000074898

P

GO:0009566

fertilization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000074898

P

GO:0009986

cell surface

PMID:16831868[2]

IDA: Inferred from Direct Assay

C

GO:0015026

coreceptor activity

PMID:9657005[4]

TAS: Traceable Author Statement

F

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

GO:0016021

integral to membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

GO:0016021

integral to membrane

PMID:12913096[1]

IDA: Inferred from Direct Assay

C

GO:0019064

viral envelope fusion with host membrane

PMID:12915581[7]

IDA: Inferred from Direct Assay

P

GO:0030382

sperm mitochondrion organization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000074898

P

GO:0032990

cell part morphogenesis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000074898

P

GO:0033005

positive regulation of mast cell activation

PMID:16831868[2]

IMP: Inferred from Mutant Phenotype

P

GO:0034329

cell junction assembly

Reactome:REACT_20676

TAS: Traceable Author Statement

P

GO:0034332

adherens junction organization

Reactome:REACT_19195

TAS: Traceable Author Statement

P

GO:0042271

susceptibility to natural killer cell mediated cytotoxicity

PMID:12913096[1]

IMP: Inferred from Mutant Phenotype

P

GO:0042803

protein homodimerization activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000074898

F

GO:0042803

protein homodimerization activity

PMID:9845526[5]

IPI: Inferred from Physical Interaction

UniProtKB:Q92692-1

F

GO:0042803

protein homodimerization activity

PMID:9845526[5]

IPI: Inferred from Physical Interaction

UniProtKB:Q92692-2

F

GO:0043064

flagellum organization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000074898

P

GO:0044419

interspecies interaction between organisms

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0945

P

GO:0045216

cell-cell junction organization

Reactome:REACT_19331

TAS: Traceable Author Statement

P

GO:0045954

positive regulation of natural killer cell mediated cytotoxicity

PMID:16304049[8]

IMP: Inferred from Mutant Phenotype

P

GO:0046814

virion attachment, binding of host cell surface coreceptor

PMID:12915581[7]

IDA: Inferred from Direct Assay

P

GO:0050776

regulation of immune response

Reactome:REACT_11152

TAS: Traceable Author Statement

P

GO:0050839

cell adhesion molecule binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000074898

F

GO:0050839

cell adhesion molecule binding

PMID:12913096[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q15762

F

GO:0050839

cell adhesion molecule binding

PMID:9845526[5]

IPI: Inferred from Physical Interaction

UniProtKB:Q92692

F

GO:0051654

establishment of mitochondrion localization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000074898

P

GO:0051856

adhesion to symbiont

PMID:12915581[7]

IDA: Inferred from Direct Assay

P

GO:0060370

susceptibility to T cell mediated cytotoxicity

PMID:15039383[9]

IDA: Inferred from Direct Assay

P


edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Bottino C et al. (2003) Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. J Exp Med 198: 557-67 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Bachelet I et al. (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem 281: 27190-6 PubMed GONUTS page
  3. ↑ Yu X et al. (2009) The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat Immunol 10: 48-57 PubMed GONUTS page
  4. ↑ 4.0 4.1 Warner MS et al. (1998) A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus. Virology 246: 179-89 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Lopez M et al. (1998) The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule. Blood 92: 4602-11 PubMed GONUTS page
  6. ↑ Takahashi K et al. (1999) Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein. J Cell Biol 145: 539-49 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Zago A & Spear PG (2003) Differences in the N termini of herpes simplex virus type 1 and 2 gDs that influence functional interactions with the human entry receptor Nectin-2 and an entry receptor expressed in Chinese hamster ovary cells. J Virol 77: 9695-9 PubMed GONUTS page
  8. ↑ Pende D et al. (2006) Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction. Blood 107: 2030-6 PubMed GONUTS page
  9. ↑ Tahara-Hanaoka S et al. (2004) Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112). Int Immunol 16: 533-8 PubMed GONUTS page
Retrieved from "http://gowiki.tamu.edu/wiki/index.php/HUMAN:PVRL2"
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