HUMAN:PTN1

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Species (Taxon ID)	Homo sapiens (Human). ([1])
Gene Name(s)	PTPN1 (synonyms: PTP1B)
Protein Name(s)	Tyrosine-protein phosphatase non-receptor type 1 Protein-tyrosine phosphatase 1B PTP-1B
External Links
EMBL	M31724 M33689 M33684 M33688 M33687 M33686 M33685 BT006752 AL133230 AL034429 AL034429 AL133230 BC015660 BC018164
IPI	IPI00297261
PIR	A35992
RefSeq	NP_002818.1
UniGene	Hs.417549
PDB	1A5Y 1AAX 1BZC 1BZH 1BZJ 1C83 1C84 1C85 1C86 1C87 1C88 1ECV 1EEN 1EEO 1G1F 1G1G 1G1H 1G7F 1G7G 1GFY 1I57 1JF7 1KAK 1KAV 1L8G 1LQF 1NL9 1NNY 1NO6 1NWE 1NWL 1NZ7 1OEM 1OEO 1OES 1OET 1OEU 1OEV 1ONY 1ONZ 1PA1 1PH0 1PTT 1PTU 1PTV 1PTY 1PXH 1PYN 1Q1M 1Q6J 1Q6M 1Q6N 1Q6P 1Q6S 1Q6T 1QXK 1SUG 1T48 1T49 1T4J 1WAX 1XBO 2AZR 2B07 2B4S 2BGD 2BGE 2CM2 2CM3 2CM7 2CM8 2CMA 2CMB 2CMC 2CNE 2CNF 2CNG 2CNH 2CNI 2F6F 2F6T 2F6V 2F6W 2F6Y 2F6Z 2F70 2F71 2FJM 2FJN 2H4G 2H4K 2HB1 2HNP 2HNQ 2NT7 2NTA 2QBP 2QBQ 2QBR 2QBS 2VEU 2VEV 2VEW 2VEX 2VEY 2ZMM 2ZN7 3A5J 3A5K 3CWE 3D9C 3EAX 3EB1 3EU0 3I7Z 3I80 3ZV2
PDBsum	1A5Y 1AAX 1BZC 1BZH 1BZJ 1C83 1C84 1C85 1C86 1C87 1C88 1ECV 1EEN 1EEO 1G1F 1G1G 1G1H 1G7F 1G7G 1GFY 1I57 1JF7 1KAK 1KAV 1L8G 1LQF 1NL9 1NNY 1NO6 1NWE 1NWL 1NZ7 1OEM 1OEO 1OES 1OET 1OEU 1OEV 1ONY 1ONZ 1PA1 1PH0 1PTT 1PTU 1PTV 1PTY 1PXH 1PYN 1Q1M 1Q6J 1Q6M 1Q6N 1Q6P 1Q6S 1Q6T 1QXK 1SUG 1T48 1T49 1T4J 1WAX 1XBO 2AZR 2B07 2B4S 2BGD 2BGE 2CM2 2CM3 2CM7 2CM8 2CMA 2CMB 2CMC 2CNE 2CNF 2CNG 2CNH 2CNI 2F6F 2F6T 2F6V 2F6W 2F6Y 2F6Z 2F70 2F71 2FJM 2FJN 2H4G 2H4K 2HB1 2HNP 2HNQ 2NT7 2NTA 2QBP 2QBQ 2QBR 2QBS 2VEU 2VEV 2VEW 2VEX 2VEY 2ZMM 2ZN7 3A5J 3A5K 3CWE 3D9C 3EAX 3EB1 3EU0 3I7Z 3I80 3ZV2
ProteinModelPortal	P18031
SMR	P18031
DIP	DIP-38014N
IntAct	P18031
MINT	MINT-441655
STRING	P18031
PhosphoSite	P18031
OGP	P18031
PeptideAtlas	P18031
PRIDE	P18031
Ensembl	ENST00000371621
GeneID	5770
KEGG	hsa:5770
UCSC	uc002xvl.1
CTD	5770
GeneCards	GC20P045875
H-InvDB	HIX0015910 HIX0027718
HGNC	HGNC:9642
HPA	CAB009329 CAB015217 HPA012542
MIM	176885
neXtProt	NX_P18031
eggNOG	prNOG14339
GeneTree	ENSGT00600000084160
HOGENOM	HBG444576
HOVERGEN	HBG008321
InParanoid	P18031
OMA	AYLCYRV
OrthoDB	EOG418BND
PhylomeDB	P18031
BRENDA	3.1.3.48
Pathway_Interaction_DB	nfat_tfpathway igf1_pathway insulin_pathway pdgfrbpathway ptp1bpathway
Reactome	REACT_13552 REACT_604 REACT_6900
DrugBank	DB00720 DB01133
NextBio	22442
PMAP-CutDB	P18031
ArrayExpress	P18031
Bgee	P18031
CleanEx	HS_PTPN1
Genevestigator	P18031
GermOnline	ENSG00000196396
GO	GO:0005829 GO:0005769 GO:0005789 GO:0046875 GO:0004725 GO:0008270 GO:0031532 GO:0007596 GO:0060333 GO:0046627 GO:0030100 GO:0060334 GO:0060338 GO:0060337
InterPro	IPR000387 IPR016130 IPR012265 IPR000242
PANTHER	PTHR19134:SF57
Pfam	PF00102
PIRSF	PIRSF000926
PRINTS	PR00700
SMART	SM00194
PROSITE	PS00383 PS50056 PS50055

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0904	F	Seeded From UniProt
	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000242	F	Seeded From UniProt
	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012265	F	Seeded From UniProt
	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016130	F	Seeded From UniProt
	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:3.1.3.48	F	Seeded From UniProt
	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000014309	F	Seeded From UniProt
	GO:0004725	protein tyrosine phosphatase activity	PMID:18074158^[1]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0005158	insulin receptor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000014309	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:11106648^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P15116	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:12907755^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P10912	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:17159996^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P63166	F	Seeded From UniProt
	GO:0005626	insoluble fraction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000014309	C	Seeded From UniProt
	GO:0005769	early endosome	PMID:21135139^[5]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005783	endoplasmic reticulum	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0256	C	Seeded From UniProt
	GO:0005783	endoplasmic reticulum	PMID:18029348^[6]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0097	C	Seeded From UniProt
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000014309	C	Seeded From UniProt
	GO:0005829	cytosol	Reactome:REACT_15464	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005829	cytosol	Reactome:REACT_25329	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0006470	protein dephosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000242	P	Seeded From UniProt
	GO:0006470	protein dephosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012265	P	Seeded From UniProt
	GO:0006470	protein dephosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029053	P	Seeded From UniProt
	GO:0006470	protein dephosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000014309	P	Seeded From UniProt
	GO:0007596	blood coagulation	Reactome:REACT_604	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0008270	zinc ion binding	PMID:18074158^[1]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0008286	insulin receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029053	P	Seeded From UniProt
	GO:0009966	regulation of signal transduction	PMID:21135139^[5]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded From UniProt
	GO:0016311	dephosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000387	P	Seeded From UniProt
	GO:0016311	dephosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016130	P	Seeded From UniProt
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F	Seeded From UniProt
	GO:0016791	phosphatase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000387	F	Seeded From UniProt
	GO:0016791	phosphatase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016130	F	Seeded From UniProt
	GO:0019221	cytokine-mediated signaling pathway	Reactome:REACT_25229	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0030100	regulation of endocytosis	PMID:21135139^[5]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0031410	cytoplasmic vesicle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000014309	C	Seeded From UniProt
	GO:0031532	actin cytoskeleton reorganization	PMID:21135139^[5]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000014309	P	Seeded From UniProt
	GO:0035335	peptidyl-tyrosine dephosphorylation	PMID:21135139^[5]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0046626	regulation of insulin receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000014309	P	Seeded From UniProt
	GO:0046627	negative regulation of insulin receptor signaling pathway	PMID:11742412^[7]	NAS: Non-traceable Author Statement		P	Seeded From UniProt
	GO:0046875	ephrin receptor binding	PMID:21135139^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P29320	F	Seeded From UniProt
	GO:0060333	interferon-gamma-mediated signaling pathway	Reactome:REACT_25078	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0060334	regulation of interferon-gamma-mediated signaling pathway	Reactome:REACT_24980	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0060337	type I interferon-mediated signaling pathway	Reactome:REACT_25162	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0060338	regulation of type I interferon-mediated signaling pathway	Reactome:REACT_25216	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0005886	plasma membrane	PMID:21135139^[5]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0033157	regulation of intracellular protein transport	PMID:22045810^[8]	IMP: Inferred from Mutant Phenotype		P	Figs. 2AB, 3ABC, 4BC, 5B, and 6B	complete
	GO:2000646	positive regulation of receptor catabolic process	PMID:22045810^[8]	IMP: Inferred from Mutant Phenotype		P	Fig. 1BC, 4A, S4	complete
	GO:0006470	protein dephosphorylation	PMID:22045810^[8]	IMP: Inferred from Mutant Phenotype		P	Fig. 1A and Fig. 7A	complete
	GO:0043407	negative regulation of MAP kinase activity	PMID:22045810^[8]	IMP: Inferred from Mutant Phenotype		P	Fig. 1A and Fig. 4D	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Krezel A & Maret W (2008) Thionein/metallothionein control Zn(II) availability and the activity of enzymes. J Biol Inorg Chem 13: 401-9 PubMed GONUTS page
↑ Rhee J et al. (2001) Essential tyrosine residues for interaction of the non-receptor protein-tyrosine phosphatase PTP1B with N-cadherin. J Biol Chem 276: 6640-4 PubMed GONUTS page
↑ Pasquali C et al. (2003) Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor. Mol Endocrinol 17: 2228-39 PubMed GONUTS page
↑ Dadke S et al. (2007) Regulation of protein tyrosine phosphatase 1B by sumoylation. Nat Cell Biol 9: 80-5 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Nievergall E et al. (2010) PTP1B regulates Eph receptor function and trafficking. J Cell Biol 191: 1189-203 PubMed GONUTS page
↑ Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
↑ Saltiel AR & Kahn CR (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414: 799-806 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Sangwan V et al. (2011) Protein-tyrosine phosphatase 1B modulates early endosome fusion and trafficking of Met and epidermal growth factor receptors. J Biol Chem 286: 45000-13 PubMed GONUTS page

[PMID:18074158-0] 1.0 ^1.1 Krezel A & Maret W (2008) Thionein/metallothionein control Zn(II) availability and the activity of enzymes. J Biol Inorg Chem 13: 401-9 PubMed GONUTS page

[PMID:11106648-1] Rhee J et al. (2001) Essential tyrosine residues for interaction of the non-receptor protein-tyrosine phosphatase PTP1B with N-cadherin. J Biol Chem 276: 6640-4 PubMed GONUTS page

[PMID:12907755-2] Pasquali C et al. (2003) Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor. Mol Endocrinol 17: 2228-39 PubMed GONUTS page

[PMID:17159996-3] Dadke S et al. (2007) Regulation of protein tyrosine phosphatase 1B by sumoylation. Nat Cell Biol 9: 80-5 PubMed GONUTS page

[PMID:21135139-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Nievergall E et al. (2010) PTP1B regulates Eph receptor function and trafficking. J Cell Biol 191: 1189-203 PubMed GONUTS page

[PMID:18029348-5] Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page

[PMID:11742412-6] Saltiel AR & Kahn CR (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414: 799-806 PubMed GONUTS page

[PMID:22045810-7] 8.0 ^8.1 ^8.2 ^8.3 Sangwan V et al. (2011) Protein-tyrosine phosphatase 1B modulates early endosome fusion and trafficking of Met and epidermal growth factor receptors. J Biol Chem 286: 45000-13 PubMed GONUTS page

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HUMAN:PTN1

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