HUMAN:PO5F1

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	POU5F1 ( synonyms: OCT3, OCT4, OTF3 )
Protein Name(s)	POU domain, class 5, transcription factor 1 Octamer-binding protein 3 Oct-3 Octamer-binding protein 4 Oct-4 Octamer-binding transcription factor 3 OTF-3
External Links
UniProt Identifier	PO5F1_HUMAN
UniProt Accessions	Q01860, A6NCS1, A6NLL8, P31359, Q15167, Q15168, Q16422, Q5STF3, Q5STF4,
EMBL	Z11898, Z11899, AB088113, AB202105, AB103619, BA000025, AL662833, AL662833, AL662844, AL773544, AL773544, BX088580, BX088580, CR759815, CR759815, CR388229, CR388229, CR847794, CR847794, CH471081, CH471081, BC117435, BC117437, Z21963, Z21964, S81255,
PIR	S25561, S32652,
RefSeq	NP_002692.2,
IntAct	Q01860,
Ensembl	ENST00000259915, ENST00000383524, ENST00000429603, ENST00000433063, ENST00000434616, ENST00000437747, ENST00000454714,
Pfam	PF00046, PF00157,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0005829	cytosol		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0005634	nucleus		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0005667	transcription factor complex		IDA: Inferred from Direct Assay		C	Source: BHF-UCL
	GO:0035198	miRNA binding		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0010843	promoter binding		IDA: Inferred from Direct Assay		F	Source: BHF-UCL
	GO:0043565	sequence-specific DNA binding		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0003700	sequence-specific DNA binding transcription...		IDA: Inferred from Direct Assay		F	Source: HGNC
	GO:0008134	transcription factor binding		IPI: Inferred from Physical Interaction		F	Source: BHF-UCL
	GO:0030528	transcription regulator activity		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0043130	ubiquitin binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0009653	anatomical structure morphogenesis		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0003130	BMP signaling pathway involved in heart ind...		IMP: Inferred from Mutant Phenotype		P	Source: BHF-UCL
	GO:0060912	cardiac cell fate specification		IDA: Inferred from Direct Assay		P	Source: BHF-UCL
	GO:0060795	cell fate commitment involved in formation ...		IMP: Inferred from Mutant Phenotype		P	Source: BHF-UCL
	GO:0060965	negative regulation of gene silencing by miRNA		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0035413	positive regulation of catenin protein nucl...		IDA: Inferred from Direct Assay		P	Source: BHF-UCL
	GO:0010552	positive regulation of gene-specific transc...		IDA: Inferred from Direct Assay		P	Source: BHF-UCL
	GO:0060391	positive regulation of SMAD protein nuclear...		IDA: Inferred from Direct Assay		P	Source: BHF-UCL
	GO:0090081	regulation of heart induction by regulation...		IMP: Inferred from Mutant Phenotype		P	Source: BHF-UCL
	GO:0090308	regulation of methylation-dependent chromat...		IDA: Inferred from Direct Assay		P	Source: BHF-UCL
	GO:0006355	regulation of transcription, DNA-dependent		IDA: Inferred from Direct Assay		P	Source: HGNC
	GO:0009611	response to wounding		IEP: Inferred from Expression Pattern		P	Source: UniProtKB
	GO:0035019	somatic stem cell maintenance		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0035019	somatic stem cell maintenance		IMP: Inferred from Mutant Phenotype		P	Source: BHF-UCL
	GO:0006350	transcription		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P20263	F
	GO:0001714	endodermal cell fate specification	PMID:20713518^[1]	IDA: Inferred from Direct Assay		P
	GO:0001824	blastocyst development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P20263	P
	GO:0003130	BMP signaling pathway involved in heart induction	PMID:19736317^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010982	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012287	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0371	F
	GO:0003677	DNA binding	PMID:16153702^[3]	IDA: Inferred from Direct Assay		F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000327	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001356	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:16153702^[3]	IDA: Inferred from Direct Assay		F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:8088794^[4]	TAS: Traceable Author Statement		F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:9814708^[5]	TAS: Traceable Author Statement		F
	GO:0005515	protein binding	PMID:11891324^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UJU5	F
	GO:0005515	protein binding	PMID:15523054^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q86UT5	F
	GO:0005515	protein binding	PMID:18191611^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P14618	F
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017970	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:16153702^[3]	IC: Inferred by Curator	GO:0003677	C
	GO:0005634	nucleus	PMID:18000303^[9]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:18191611^[8]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:19274063^[10]	IDA: Inferred from Direct Assay		C
	GO:0005654	nucleoplasm	PMID:20458727^[11]	IDA: Inferred from Direct Assay		C
	GO:0005667	transcription factor complex	PMID:19736317^[2]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:18281244^[12]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:20458727^[11]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	PMID:18000303^[9]	IDA: Inferred from Direct Assay		C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006351	transcription, DNA-dependent	PMID:16153702^[3]	IDA: Inferred from Direct Assay		P
	GO:0006351	transcription, DNA-dependent	PMID:8088794^[4]	TAS: Traceable Author Statement		P
	GO:0006351	transcription, DNA-dependent	PMID:9814708^[5]	TAS: Traceable Author Statement		P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000327	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001356	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012287	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017970	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:16153702^[3]	IDA: Inferred from Direct Assay		P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:8088794^[4]	TAS: Traceable Author Statement		P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:9814708^[5]	TAS: Traceable Author Statement		P
	GO:0006366	transcription from RNA polymerase II promoter	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P20263	P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0008134	transcription factor binding	PMID:19736317^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9H6I2	F
	GO:0009611	response to wounding	PMID:17982423^[13]	IEP: Inferred from Expression Pattern		P
	GO:0009653	anatomical structure morphogenesis	PMID:9814708^[5]	TAS: Traceable Author Statement		P
	GO:0009786	regulation of asymmetric cell division	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P20263	P
	GO:0010468	regulation of gene expression	PMID:18388306^[14]	IMP: Inferred from Mutant Phenotype		P
	GO:0031625	ubiquitin protein ligase binding	PMID:19274063^[10]	IPI: Inferred from Physical Interaction	UniProtKB:O00308	F
	GO:0035019	somatic stem cell maintenance	PMID:18388306^[14]	IMP: Inferred from Mutant Phenotype		P
	GO:0035019	somatic stem cell maintenance	PMID:19409607^[15]	IDA: Inferred from Direct Assay		P
	GO:0035019	somatic stem cell maintenance	PMID:19736317^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0035198	miRNA binding	PMID:18710938^[16]	IDA: Inferred from Direct Assay		F
	GO:0035198	miRNA binding	PMID:19409607^[15]	IDA: Inferred from Direct Assay		F
	GO:0035413	positive regulation of catenin import into nucleus	PMID:19736317^[2]	IDA: Inferred from Direct Assay		P
	GO:0042789	mRNA transcription from RNA polymerase II promoter	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P20263	P
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001356	F
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017970	F
	GO:0043565	sequence-specific DNA binding	PMID:20713518^[1]	IDA: Inferred from Direct Assay		F
	GO:0044212	transcription regulatory region DNA binding	PMID:19736317^[2]	IDA: Inferred from Direct Assay		F
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:19736317^[2]	IDA: Inferred from Direct Assay		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:20713518^[1]	IDA: Inferred from Direct Assay		P
	GO:0060391	positive regulation of SMAD protein import into nucleus	PMID:19736317^[2]	IDA: Inferred from Direct Assay		P
	GO:0060795	cell fate commitment involved in formation of primary germ layers	PMID:19736317^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0060913	cardiac cell fate determination	PMID:19736317^[2]	IDA: Inferred from Direct Assay		P
	GO:0060965	negative regulation of gene silencing by miRNA	PMID:19409607^[15]	IMP: Inferred from Mutant Phenotype		P
	GO:0090081	regulation of heart induction by regulation of canonical Wnt receptor signaling pathway	PMID:19736317^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0090308	regulation of methylation-dependent chromatin silencing	PMID:19736317^[2]	IDA: Inferred from Direct Assay		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Zhang Y et al. (2010) Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms. Genes Dev 24: 1746-57 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 Stefanovic S et al. (2009) Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate. J Cell Biol 186: 665-73 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Boyer LA et al. (2005) Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122: 947-56 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Crouau-Roy B et al. (1994) Localization of the OTF3 gene within the human MHC class I region by physical and meiotic mapping. Genomics 21: 241-3 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Nichols J et al. (1998) Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95: 379-91 PubMed GONUTS page
↑ Guo Y et al. (2002) The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression. Proc Natl Acad Sci U S A 99: 3663-7 PubMed GONUTS page
↑ Kato Y et al. (2005) PDZK1 directly regulates the function of organic cation/carnitine transporter OCTN2. Mol Pharmacol 67: 734-43 PubMed GONUTS page
↑ ^8.0 ^8.1 Lee J et al. (2008) Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription. Int J Biochem Cell Biol 40: 1043-54 PubMed GONUTS page
↑ ^9.0 ^9.1 Zhao M et al. (2007) Evidence for the presence of stem cell-like progenitor cells in human adult pancreas. J Endocrinol 195: 407-14 PubMed GONUTS page
↑ ^10.0 ^10.1 Xu H et al. (2009) WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells. Cell Res 19: 561-73 PubMed GONUTS page
↑ ^11.0 ^11.1 Trubiani O et al. (2010) Expression profile of the embryonic markers nanog, OCT-4, SSEA-1, SSEA-4, and frizzled-9 receptor in human periodontal ligament mesenchymal stem cells. J Cell Physiol 225: 123-31 PubMed GONUTS page
↑ Kristensen DM et al. (2008) Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. Hum Reprod 23: 775-82 PubMed GONUTS page
↑ McGowan SL et al. (2007) Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas. Mol Vis 13: 1984-2000 PubMed GONUTS page
↑ ^14.0 ^14.1 Fong H et al. (2008) Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells. Stem Cells 26: 1931-8 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Xu N et al. (2009) MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell 137: 647-58 PubMed GONUTS page
↑ Card DA et al. (2008) Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. Mol Cell Biol 28: 6426-38 PubMed GONUTS page

[PMID:20713518-0] 1.0 ^1.1 ^1.2 Zhang Y et al. (2010) Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms. Genes Dev 24: 1746-57 PubMed GONUTS page

[PMID:19736317-1] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 Stefanovic S et al. (2009) Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate. J Cell Biol 186: 665-73 PubMed GONUTS page

[PMID:16153702-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Boyer LA et al. (2005) Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122: 947-56 PubMed GONUTS page

[PMID:8088794-3] 4.0 ^4.1 ^4.2 Crouau-Roy B et al. (1994) Localization of the OTF3 gene within the human MHC class I region by physical and meiotic mapping. Genomics 21: 241-3 PubMed GONUTS page

[PMID:9814708-4] 5.0 ^5.1 ^5.2 ^5.3 Nichols J et al. (1998) Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95: 379-91 PubMed GONUTS page

[PMID:11891324-5] Guo Y et al. (2002) The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression. Proc Natl Acad Sci U S A 99: 3663-7 PubMed GONUTS page

[PMID:15523054-6] Kato Y et al. (2005) PDZK1 directly regulates the function of organic cation/carnitine transporter OCTN2. Mol Pharmacol 67: 734-43 PubMed GONUTS page

[PMID:18191611-7] 8.0 ^8.1 Lee J et al. (2008) Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription. Int J Biochem Cell Biol 40: 1043-54 PubMed GONUTS page

[PMID:18000303-8] 9.0 ^9.1 Zhao M et al. (2007) Evidence for the presence of stem cell-like progenitor cells in human adult pancreas. J Endocrinol 195: 407-14 PubMed GONUTS page

[PMID:19274063-9] 10.0 ^10.1 Xu H et al. (2009) WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells. Cell Res 19: 561-73 PubMed GONUTS page

[PMID:20458727-10] 11.0 ^11.1 Trubiani O et al. (2010) Expression profile of the embryonic markers nanog, OCT-4, SSEA-1, SSEA-4, and frizzled-9 receptor in human periodontal ligament mesenchymal stem cells. J Cell Physiol 225: 123-31 PubMed GONUTS page

[PMID:18281244-11] Kristensen DM et al. (2008) Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. Hum Reprod 23: 775-82 PubMed GONUTS page

[PMID:17982423-12] McGowan SL et al. (2007) Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas. Mol Vis 13: 1984-2000 PubMed GONUTS page

[PMID:18388306-13] 14.0 ^14.1 Fong H et al. (2008) Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells. Stem Cells 26: 1931-8 PubMed GONUTS page

[PMID:19409607-14] 15.0 ^15.1 ^15.2 Xu N et al. (2009) MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell 137: 647-58 PubMed GONUTS page

[PMID:18710938-15] Card DA et al. (2008) Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. Mol Cell Biol 28: 6426-38 PubMed GONUTS page

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HUMAN:PO5F1

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