GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
HUMAN:PK3CD
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | PIK3CD | |
| Protein Name(s) | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform
PI3-kinase subunit delta PI3K-delta PI3Kdelta PtdIns-3-kinase subunit delta Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta PtdIns-3-kinase subunit p110-delta p110delta | |
| External Links | ||
| EMBL | Y10055 U86453 DQ263594 AL691449 BC132919 BC132921 | |
| IPI | IPI00298410 | |
| RefSeq | NP_005017.3 | |
| UniGene | Hs.518451 | |
| ProteinModelPortal | O00329 | |
| SMR | O00329 | |
| IntAct | O00329 | |
| MINT | MINT-7242357 | |
| STRING | O00329 | |
| PhosphoSite | O00329 | |
| PRIDE | O00329 | |
| Ensembl | ENST00000377346 | |
| GeneID | 5293 | |
| KEGG | hsa:5293 | |
| UCSC | uc001aqb.2 | |
| CTD | 5293 | |
| GeneCards | GC01P008867 | |
| H-InvDB | HIX0028728 | |
| HGNC | HGNC:8977 | |
| HPA | CAB015420 | |
| MIM | 602839 | |
| neXtProt | NX_O00329 | |
| eggNOG | prNOG11835 | |
| HOVERGEN | HBG052721 | |
| OrthoDB | EOG4XKV67 | |
| PhylomeDB | O00329 | |
| BioCyc | MetaCyc:ENSG00000171608-MONOMER | |
| BRENDA | 2.7.1.137 | |
| Pathway_Interaction_DB | pi3kcipathway trail_pathway | |
| Reactome | REACT_6900 | |
| NextBio | 20454 | |
| ArrayExpress | O00329 | |
| Bgee | O00329 | |
| CleanEx | HS_PIK3CD | |
| Genevestigator | O00329 | |
| GermOnline | ENSG00000171608 | |
| GO | GO:0005942 GO:0005886 GO:0016303 GO:0005524 GO:0046934 GO:0030154 GO:0048015 GO:0006468 | |
| InterPro | IPR016024 IPR008973 IPR011009 IPR000403 IPR018936 IPR002420 IPR003113 IPR000341 IPR015433 IPR001263 | |
| Gene3D | G3DSA:1.10.1070.11 G3DSA:1.25.40.70 | |
| KO | K00922 | |
| PANTHER | PTHR10048 | |
| Pfam | PF00454 PF00792 PF02192 PF00794 PF00613 | |
| SMART | SM00142 SM00143 SM00144 SM00145 SM00146 | |
| SUPFAM | SSF48371 SSF49562 SSF56112 | |
| PROSITE | PS00915 PS00916 PS50290 PS51544 PS51547 PS51546 PS51545 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0001782 |
B cell homeostasis |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000101315 |
P |
Seeded From UniProt |
|||
| GO:0005488 |
binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005886 |
plasma membrane |
Reactome:REACT_23799 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_23861 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_23869 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_24024 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005942 |
phosphatidylinositol 3-kinase complex |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005942 |
phosphatidylinositol 3-kinase complex |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005942 |
phosphatidylinositol 3-kinase complex |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005942 |
phosphatidylinositol 3-kinase complex |
NAS: Non-traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0005942 |
phosphatidylinositol 3-kinase complex |
NAS: Non-traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0006468 |
protein phosphorylation |
NAS: Non-traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0006935 |
chemotaxis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006954 |
inflammatory response |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007165 |
signal transduction |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007165 |
signal transduction |
NAS: Non-traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0007166 |
cell surface receptor linked signaling pathway |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000101315 |
P |
Seeded From UniProt |
|||
| GO:0016301 |
kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016303 |
1-phosphatidylinositol-3-kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016303 |
1-phosphatidylinositol-3-kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016303 |
1-phosphatidylinositol-3-kinase activity |
NAS: Non-traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0016310 |
phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0016740 |
transferase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016773 |
phosphotransferase activity, alcohol group as acceptor |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016773 |
phosphotransferase activity, alcohol group as acceptor |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0030154 |
cell differentiation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0042113 |
B cell activation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000101315 |
P |
Seeded From UniProt |
|||
| GO:0045087 |
innate immune response |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0046854 |
phosphatidylinositol phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0046854 |
phosphatidylinositol phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0046934 |
phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0046934 |
phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0048015 |
phosphatidylinositol-mediated signaling |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0048015 |
phosphatidylinositol-mediated signaling |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0030335 |
positive regulation of cell migration |
IMP: Inferred from Mutant Phenotype |
P |
Fig. 3AD, Fig. 5A, and Supplemental Fig. 4A |
complete | |||
| GO:0010628 |
positive regulation of gene expression |
IMP: Inferred from Mutant Phenotype |
P |
Fig. 3C |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Vanhaesebroeck B et al. (1997) P110delta, a novel phosphoinositide 3-kinase in leukocytes. Proc Natl Acad Sci U S A 94: 4330-5 PubMed GONUTS page
- ↑ 2.0 2.1 Chantry D et al. (1997) p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J Biol Chem 272: 19236-41 PubMed GONUTS page
- ↑ 3.0 3.1 Luk SK et al. (2012) The catalytic phosphoinositol 3-kinase isoform p110δ is required for glioma cell migration and invasion. Eur J Cancer 48: 149-57 PubMed GONUTS page
