HUMAN:PIGEH

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	PION
Protein Name(s)	Protein pigeon homolog Gamma-secretase-activating protein GSAP
External Links
UniProt Identifier	PIGEH_HUMAN
UniProt Accessions	A4D1B5, A4D1B6, Q3MJC0, Q8ND73, Q9UMH3, Q9Y4L9,
EMBL	AC004921, AC073635, CH236949, CH236949, CH471091, BC101499, AL834358, AL079277, AL079297,
RefSeq	NP_059135.2,
Ensembl	ENST00000257626,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0034205	beta-amyloid formation	PMID:20811458^[1]	IMP: Inferred from Mutant Phenotype		P	Figure 2 - transfection of cells with GSAP siRNA reduced the concentration of amyloid beta. Additionally, recombinant GSAP stimulated amyloid beta production in E. Coli.	complete
	GO:0001540	beta-amyloid binding	PMID:20811458^[1]	IDA: Inferred from Direct Assay		F
	GO:0005794	Golgi apparatus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0333	C
	GO:0005794	Golgi apparatus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0132	C
	GO:0005802	trans-Golgi network	PMID:20811458^[1]	IDA: Inferred from Direct Assay		C
	GO:0030162	regulation of proteolysis	PMID:20811458^[1]	IDA: Inferred from Direct Assay		P
	GO:0034205	beta-amyloid formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043679	P
	GO:0034205	beta-amyloid formation	PMID:20811458^[1]	IDA: Inferred from Direct Assay		P
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↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 He G et al. (2010) Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease. Nature 467: 95-8 PubMed GONUTS page