HUMAN:PCM1

From GONUTS

Jump to: navigation, search

Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	PCM1
Protein Name(s)	Pericentriolar material 1 protein PCM-1 hPCM-1
External Links
UniProt Identifier	PCM1_HUMAN
UniProt Accessions	Q15154, Q58F13, Q6P1K7, Q8NB85, Q9BWC1, Q9H4A2,
EMBL	L27841, AC087273, AC087625, BC000453, BC027477, BC065022, AK091406, AJ297349,
PIR	A54103,
RefSeq	NP_006188.3,
IntAct	Q15154,
Ensembl	ENST00000325083,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005813	centrosome	PMID:17139249^[1]	IDA: Inferred from Direct Assay		C	Fig.8A	complete
	GO:0000086	G2/M transition of mitotic cell cycle	Reactome:REACT_2203	TAS: Traceable Author Statement		P
	GO:0000242	pericentriolar material	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9R0L6	C
	GO:0000242	pericentriolar material	PMID:8120099^[2]	TAS: Traceable Author Statement		C
	GO:0000278	mitotic cell cycle	Reactome:REACT_152	TAS: Traceable Author Statement		P
	GO:0005515	protein binding	PMID:14520415^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q8TAM2	F
	GO:0005515	protein binding	PMID:15107855^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q96RK4	F
	GO:0005515	protein binding	PMID:15107855^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q96RK4	F
	GO:0005515	protein binding	PMID:16189514^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9P209	F
	GO:0005515	protein binding	PMID:17574030^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q96RK4	F
	GO:0005515	protein binding	PMID:18000879^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q8NFJ9	F
	GO:0005515	protein binding	PMID:18000879^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q96RK4	F
	GO:0005515	protein binding	PMID:18000879^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q96RK4	F
	GO:0005515	protein binding	PMID:18000879^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9BXC9	F
	GO:0005515	protein binding	PMID:18772192^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q6A078	F
	GO:0005515	protein binding	PMID:20551181^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q96NB1	F
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9R0L6	C
	GO:0005737	cytoplasm	PMID:18029348^[10]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:8120099^[2]	TAS: Traceable Author Statement		C
	GO:0005813	centrosome	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9R0L6	C
	GO:0005813	centrosome	PMID:18029348^[10]	IDA: Inferred from Direct Assay		C
	GO:0005813	centrosome	PMID:21399614^[11]	IDA: Inferred from Direct Assay		C
	GO:0005813	centrosome	PMID:8120099^[2]	TAS: Traceable Author Statement		C
	GO:0005815	microtubule organizing center	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0048	C
	GO:0005829	cytosol	Reactome:REACT_15313	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_15386	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_15401	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_15440	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_15467	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_15470	TAS: Traceable Author Statement		C
	GO:0005856	cytoskeleton	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0206	C
	GO:0005856	cytoskeleton	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0090	C
	GO:0022027	interkinetic nuclear migration	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9R0L6	P
	GO:0030030	cell projection organization	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0970	P
	GO:0031965	nuclear membrane	PMID:18029348^[10]	IDA: Inferred from Direct Assay		C
	GO:0034451	centriolar satellite	PMID:15616553^[12]	IDA: Inferred from Direct Assay		C
	GO:0034451	centriolar satellite	PMID:17574030^[6]	IDA: Inferred from Direct Assay		C
	GO:0034453	microtubule anchoring	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9R0L6	P
	GO:0042384	cilium assembly	PMID:15616553^[12]	IMP: Inferred from Mutant Phenotype		P
	GO:0042384	cilium assembly	PMID:17574030^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0042802	identical protein binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9PVV4	F
	GO:0050768	negative regulation of neurogenesis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9R0L6	P
	GO:0051297	centrosome organization	PMID:17574030^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0071539	protein localization to centrosome	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9R0L6	P
NOT	GO:0031513	nonmotile primary cilium	PMID:17574030^[6]	IDA: Inferred from Direct Assay		C
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Fumoto K et al. (2006) GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome. EMBO J 25: 5670-82 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Balczon R et al. (1994) PCM-1, A 228-kD centrosome autoantigen with a distinct cell cycle distribution. J Cell Biol 124: 783-93 PubMed GONUTS page
↑ Ansley SJ et al. (2003) Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome. Nature 425: 628-33 PubMed GONUTS page
↑ ^4.0 ^4.1 Kim JC et al. (2004) The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression. Nat Genet 36: 462-70 PubMed GONUTS page
↑ Rual JF et al. (2005) Towards a proteome-scale map of the human protein-protein interaction network. Nature 437: 1173-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Nachury MV et al. (2007) A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell 129: 1201-13 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Oeffner F et al. (2008) Novel interaction partners of Bardet-Biedl syndrome proteins. Cell Motil Cytoskeleton 65: 143-55 PubMed GONUTS page
↑ Kim J et al. (2008) CEP290 interacts with the centriolar satellite component PCM-1 and is required for Rab8 localization to the primary cilium. Hum Mol Genet 17: 3796-805 PubMed GONUTS page
↑ Sedjaï F et al. (2010) Control of ciliogenesis by FOR20, a novel centrosome and pericentriolar satellite protein. J Cell Sci 123: 2391-401 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
↑ Jakobsen L et al. (2011) Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J 30: 1520-35 PubMed GONUTS page
↑ ^12.0 ^12.1 Martin J et al. (2004) The sequence and analysis of duplication-rich human chromosome 16. Nature 432: 988-94 PubMed GONUTS page

[PMID:17139249-0] Fumoto K et al. (2006) GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome. EMBO J 25: 5670-82 PubMed GONUTS page

[PMID:8120099-1] 2.0 ^2.1 ^2.2 Balczon R et al. (1994) PCM-1, A 228-kD centrosome autoantigen with a distinct cell cycle distribution. J Cell Biol 124: 783-93 PubMed GONUTS page

[PMID:14520415-2] Ansley SJ et al. (2003) Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome. Nature 425: 628-33 PubMed GONUTS page

[PMID:15107855-3] 4.0 ^4.1 Kim JC et al. (2004) The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression. Nat Genet 36: 462-70 PubMed GONUTS page

[PMID:16189514-4] Rual JF et al. (2005) Towards a proteome-scale map of the human protein-protein interaction network. Nature 437: 1173-8 PubMed GONUTS page

[PMID:17574030-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Nachury MV et al. (2007) A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell 129: 1201-13 PubMed GONUTS page

[PMID:18000879-6] 7.0 ^7.1 ^7.2 ^7.3 Oeffner F et al. (2008) Novel interaction partners of Bardet-Biedl syndrome proteins. Cell Motil Cytoskeleton 65: 143-55 PubMed GONUTS page

[PMID:18772192-7] Kim J et al. (2008) CEP290 interacts with the centriolar satellite component PCM-1 and is required for Rab8 localization to the primary cilium. Hum Mol Genet 17: 3796-805 PubMed GONUTS page

[PMID:20551181-8] Sedjaï F et al. (2010) Control of ciliogenesis by FOR20, a novel centrosome and pericentriolar satellite protein. J Cell Sci 123: 2391-401 PubMed GONUTS page

[PMID:18029348-9] 10.0 ^10.1 ^10.2 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page

[PMID:21399614-10] Jakobsen L et al. (2011) Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J 30: 1520-35 PubMed GONUTS page

[PMID:15616553-11] 12.0 ^12.1 Martin J et al. (2004) The sequence and analysis of duplication-rich human chromosome 16. Nature 432: 988-94 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

HUMAN:PCM1

Contents

Annotations

Notes

References

c

e

e cont.

g

h

i

m

m cont.

n

p

s

v

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox