HUMAN:PAK2

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	PAK2
Protein Name(s)	Serine/threonine-protein kinase PAK 2 Gamma-PAK PAK65 S6/H4 kinase p21-activated kinase 2 PAK-2 p58 PAK-2p27 p27 PAK-2p34 p34 C-t-PAK2
External Links
UniProt Identifier	PAK2_HUMAN
UniProt Accessions	Q13177, Q13154, Q6ISC3,
EMBL	U24153, BC069613, U25975,
PIR	S58682,
RefSeq	NP_002568.2,
PDB	3PCS,
IntAct	Q13177,
Ensembl	ENST00000327134,
Pfam	PF00786, PF00069,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005829	cytosol		EXP: Inferred from Experiment		C	Source: Reactome
	GO:0016020	membrane		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0005634	nucleus		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0048471	perinuclear region of cytoplasm		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0005524	ATP binding		IEA: Inferred from Electronic Annotation		F	Source: UniProtKB-KW
	GO:0042802	identical protein binding		IPI: Inferred from Physical Interaction		F	Source: IntAct
	GO:0004674	protein serine/threonine kinase activity		IDA: Inferred from Direct Assay		F	Source: MGI
	GO:0006915	apoptosis		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0044419	interspecies interaction between organisms		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0006469	negative regulation of protein kinase activity		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0046777	protein amino acid autophosphorylation		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0040008	regulation of growth		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0007165	signal transduction		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0019901	protein kinase binding	PMID 11121037	IPI: Inferred from Physical Interaction	UniProtKB:P00519	F	Figure 1	complete
	GO:0030296	protein tyrosine kinase activator activity	PMID 11121037	IDA: Inferred from Direct Assay		F	Figure 2 b and c	complete
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0003824	catalytic activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0021	F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0004672	protein kinase activity	PMID:10748018^[1]	TAS: Traceable Author Statement		F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0723	F
	GO:0004674	protein serine/threonine kinase activity	PMID:11121037^[2]	IDA: Inferred from Direct Assay		F
	GO:0004674	protein serine/threonine kinase activity	PMID:11805089^[3]	IDA: Inferred from Direct Assay		F
	GO:0005515	protein binding	PMID:10607567^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P03406	F
	GO:0005515	protein binding	PMID:16837009^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P04049	F
	GO:0005515	protein binding	PMID:16837009^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P53667	F
	GO:0005515	protein binding	PMID:17353931^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P25205	F
	GO:0005515	protein binding	PMID:17353931^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P35580	F
	GO:0005515	protein binding	PMID:17353931^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q14161	F
	GO:0005515	protein binding	PMID:17353931^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y2X7	F
	GO:0005515	protein binding	PMID:18716323^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q14160	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005829	cytosol	Reactome:REACT_19197	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_19221	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_19246	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_19269	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_20657	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_11221	TAS: Traceable Author Statement		C
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	P
	GO:0006468	protein phosphorylation	PMID:11805089^[3]	IDA: Inferred from Direct Assay		P
	GO:0006468	protein phosphorylation	PMID:7744004^[8]	TAS: Traceable Author Statement		P
	GO:0006469	negative regulation of protein kinase activity	PMID:10748018^[1]	TAS: Traceable Author Statement		P
	GO:0006915	apoptosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0053	P
	GO:0006915	apoptosis	Reactome:REACT_578	TAS: Traceable Author Statement		P
	GO:0006921	cellular component disassembly involved in apoptosis	Reactome:REACT_995	TAS: Traceable Author Statement		P
	GO:0007165	signal transduction	PMID:7744004^[8]	TAS: Traceable Author Statement		P
	GO:0007411	axon guidance	Reactome:REACT_18266	TAS: Traceable Author Statement		P
	GO:0008152	metabolic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0021	P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C
	GO:0016032	viral reproduction	Reactome:REACT_6185	TAS: Traceable Author Statement		P
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F
	GO:0018105	peptidyl-serine phosphorylation	PMID:11121037^[2]	IDA: Inferred from Direct Assay		P
	GO:0019901	protein kinase binding	PMID:11121037^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P00519	F
	GO:0030296	protein tyrosine kinase activator activity	PMID:11121037^[2]	IDA: Inferred from Direct Assay		F
	GO:0031295	T cell costimulation	Reactome:REACT_19183	TAS: Traceable Author Statement		P
	GO:0031295	T cell costimulation	Reactome:REACT_19344	TAS: Traceable Author Statement		P
	GO:0040008	regulation of growth	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0341	P
	GO:0042802	identical protein binding	PMID:16837009^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q13177	F
	GO:0042981	regulation of apoptosis	Reactome:REACT_13648	TAS: Traceable Author Statement		P
	GO:0044419	interspecies interaction between organisms	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0945	P
	GO:0046777	protein autophosphorylation	PMID:11805089^[3]	IDA: Inferred from Direct Assay		P
	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0198	C
	GO:0050690	regulation of defense response to virus by virus	Reactome:REACT_11068	TAS: Traceable Author Statement		P
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:11121037^[2]	IDA: Inferred from Direct Assay		P
	GO:0050852	T cell receptor signaling pathway	Reactome:REACT_12526	TAS: Traceable Author Statement		P
	GO:0061098	positive regulation of protein tyrosine kinase activity	PMID:11121037^[2]	IDA: Inferred from Direct Assay		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Goeckeler ZM et al. (2000) Phosphorylation of myosin light chain kinase by p21-activated kinase PAK2. J Biol Chem 275: 18366-74 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Roig J et al. (2000) Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK. Proc Natl Acad Sci U S A 97: 14346-51 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Lee KK & Yonehara S (2002) Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST). J Biol Chem 277: 12351-8 PubMed GONUTS page
↑ Renkema GH et al. (1999) Identification of the Nef-associated kinase as p21-activated kinase 2. Curr Biol 9: 1407-10 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Pirruccello M et al. (2006) A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. J Mol Biol 361: 312-26 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Ewing RM et al. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol 3: 89 PubMed GONUTS page
↑ Nola S et al. (2008) Scrib regulates PAK activity during the cell migration process. Hum Mol Genet 17: 3552-65 PubMed GONUTS page
↑ ^8.0 ^8.1 Martin GA et al. (1995) A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. EMBO J 14: 1970-8 PubMed GONUTS page

[PMID:10748018-0] 1.0 ^1.1 Goeckeler ZM et al. (2000) Phosphorylation of myosin light chain kinase by p21-activated kinase PAK2. J Biol Chem 275: 18366-74 PubMed GONUTS page

[PMID:11121037-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Roig J et al. (2000) Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK. Proc Natl Acad Sci U S A 97: 14346-51 PubMed GONUTS page

[PMID:11805089-2] 3.0 ^3.1 ^3.2 Lee KK & Yonehara S (2002) Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST). J Biol Chem 277: 12351-8 PubMed GONUTS page

[PMID:10607567-3] Renkema GH et al. (1999) Identification of the Nef-associated kinase as p21-activated kinase 2. Curr Biol 9: 1407-10 PubMed GONUTS page

[PMID:16837009-4] 5.0 ^5.1 ^5.2 Pirruccello M et al. (2006) A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. J Mol Biol 361: 312-26 PubMed GONUTS page

[PMID:17353931-5] 6.0 ^6.1 ^6.2 ^6.3 Ewing RM et al. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol 3: 89 PubMed GONUTS page

[PMID:18716323-6] Nola S et al. (2008) Scrib regulates PAK activity during the cell migration process. Hum Mol Genet 17: 3552-65 PubMed GONUTS page

[PMID:7744004-7] 8.0 ^8.1 Martin GA et al. (1995) A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. EMBO J 14: 1970-8 PubMed GONUTS page

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HUMAN:PAK2

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