HUMAN:P73

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	TP73 ( synonyms: P73 )
Protein Name(s)	Tumor protein p73 p53-like transcription factor p53-related protein
External Links
UniProt Identifier	P73_HUMAN
UniProt Accessions	O15350, B7Z9C1, O15351, Q17RN8, Q5TBV5, Q5TBV6, Q8NHW9, Q8TDY5, Q8TDY6, Q9NTK8,
EMBL	Y11416, Y11416, Y11416, AF079094, AF079082, AF079083, AF079084, AF079085, AF079086, AF079087, AF079088, AF079089, AF079090, AF079091, AF079092, AF079093, AF077628, AF077616, AF077617, AF077618, AF077619, AF077620, AF077621, AF077624, AF077625, AF077626, AF077627, AY040827, AY040828, AY040829, AB055065, AB055066, AK304784, AL136528, AL136528, AL136528, AL136528, AL136528, CH471130, BC117251, BC117253,
RefSeq	NP_001119712.1, NP_001119713.1, NP_001119714.1, NP_001191113.1, NP_001191114.1, NP_001191115.1, NP_001191117.1, NP_001191118.1, NP_001191119.1, NP_001191120.1, NP_005418.1,
PDB	1COK, 1DXS, 2KBY, 2WQI, 2WQJ, 2WTT, 2XWC,
IntAct	O15350,
Ensembl	ENST00000378295,
Pfam	PF00870, PF07710, PF07647,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447_AN0	P
	GO:0000785	chromatin	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447_AN0	C
	GO:0001836	release of cytochrome c from mitochondria	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0002039	p53 binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	F
	GO:0002039	p53 binding	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447_AN0	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002117	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012346	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003677	DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	F
	GO:0003682	chromatin binding	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447_AN0	F
	GO:0003684	damaged DNA binding	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447_AN0	F
	GO:0003690	double-stranded DNA binding	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447_AN0	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002117	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008967	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012346	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:10802655^[1]	TAS: Traceable Author Statement		F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:15678106^[2]	IDA: Inferred from Direct Assay		F
	GO:0005515	protein binding	PMID:10469568^[3]	IPI: Inferred from Physical Interaction	UniProtKB:O15151	F
	GO:0005515	protein binding	PMID:10469568^[3]	IPI: Inferred from Physical Interaction	UniProtKB:O15350	F
	GO:0005515	protein binding	PMID:11275986^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P03126	F
	GO:0005515	protein binding	PMID:11275986^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P03126	F
	GO:0005515	protein binding	PMID:11706030^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9ESJ1	F
	GO:0005515	protein binding	PMID:11748232^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P09429	F
	GO:0005515	protein binding	PMID:11748232^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P09429	F
	GO:0005515	protein binding	PMID:14729977^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q13625	F
	GO:0005515	protein binding	PMID:14729977^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q96KQ4	F
	GO:0005515	protein binding	PMID:18280240^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P46937	F
	GO:0005515	protein binding	PMID:19581926^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P0C2W1	F
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002117	C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012346	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005667	transcription factor complex	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447_AN0	C
	GO:0005829	cytosol	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447_AN0	C
	GO:0006298	mismatch repair	PMID:10391249^[10]	TAS: Traceable Author Statement		P
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006351	transcription, DNA-dependent	PMID:10802655^[1]	TAS: Traceable Author Statement		P
	GO:0006351	transcription, DNA-dependent	PMID:15678106^[2]	IDA: Inferred from Direct Assay		P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002117	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012346	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006915	apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002117	P
	GO:0006915	apoptosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0053	P
	GO:0006915	apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0006954	inflammatory response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0006974	response to DNA damage stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447_AN0	P
	GO:0007049	cell cycle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0131	P
	GO:0007050	cell cycle arrest	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0008134	transcription factor binding	PMID:11748232^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P09429	F
	GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis	PMID:10391251^[11]	TAS: Traceable Author Statement		P
	GO:0009791	post-embryonic development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0010165	response to X-ray	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447_AN0	P
	GO:0010332	response to gamma radiation	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447_AN0	P
	GO:0010552	positive regulation of gene-specific transcription from RNA polymerase II promoter	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447_AN0	P
	GO:0010843	promoter binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011615	F
	GO:0010843	promoter binding	PMID:16343436^[12]	IDA: Inferred from Direct Assay		F
	GO:0016563	transcription activator activity	PMID:16343436^[12]	IDA: Inferred from Direct Assay		F
	GO:0016564	transcription repressor activity	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447_AN0	F
	GO:0021766	hippocampus development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0030900	forebrain development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0031571	mitotic cell cycle G1/S transition DNA damage checkpoint	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447_AN0	P
	GO:0033326	cerebrospinal fluid secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0034644	cellular response to UV	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447_AN0	P
	GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447_AN0	P
	GO:0043066	negative regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0043193	positive regulation of gene-specific transcription	PMID:16343436^[12]	IDA: Inferred from Direct Assay		P
	GO:0043508	negative regulation of JUN kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0043508	negative regulation of JUN kinase activity	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447_AN31	P
	GO:0043523	regulation of neuron apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0043524	negative regulation of neuron apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0043524	negative regulation of neuron apoptosis	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447_AN31	P
	GO:0045793	positive regulation of cell size	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0045893	positive regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:15678106^[2]	IDA: Inferred from Direct Assay		P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0048546	digestive tract morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0048666	neuron development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0051262	protein tetramerization	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010991	P
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	GO_REF:0000033		PANTHER:PTHR11447_AN0	P
	GO:0000187	activation of MAPK activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052265	P
	GO:0000785	chromatin	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052265	C
	GO:0000785	chromatin	GO_REF:0000033		PANTHER:PTHR11447_AN0	C
	GO:0001822	kidney development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052265	P
	GO:0001836	release of cytochrome c from mitochondria	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0002039	p53 binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	F
	GO:0002039	p53 binding	GO_REF:0000033		PANTHER:PTHR11447_AN0	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002117	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012346	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0006915	apoptosis	PMID:14634023^[13]	IDA: Inferred from Direct Assay		P	Figure 6 - Bar graph showing measured levels of cell death where p73 is shown to induces apoptosis (cell death) through PUMA Transactivation.	complete
	GO:0003677	DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	F
	GO:0003682	chromatin binding	GO_REF:0000033		PANTHER:PTHR11447_AN0	F
	GO:0003684	damaged DNA binding	GO_REF:0000033		PANTHER:PTHR11447_AN0	F
	GO:0003690	double-stranded DNA binding	GO_REF:0000033		PANTHER:PTHR11447_AN0	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002117	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008967	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012346	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:10802655^[1]	TAS: Traceable Author Statement		F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:15678106^[2]	IDA: Inferred from Direct Assay		F
	GO:0005515	protein binding	PMID:10469568^[3]	IPI: Inferred from Physical Interaction	UniProtKB:O15151	F
	GO:0005515	protein binding	PMID:10469568^[3]	IPI: Inferred from Physical Interaction	UniProtKB:O15350	F
	GO:0005515	protein binding	PMID:11275986^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P03126	F
	GO:0005515	protein binding	PMID:11275986^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P03126	F
	GO:0005515	protein binding	PMID:11706030^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9ESJ1	F
	GO:0005515	protein binding	PMID:11748232^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P09429	F
	GO:0005515	protein binding	PMID:11748232^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P09429	F
	GO:0005515	protein binding	PMID:14729977^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q13625	F
	GO:0005515	protein binding	PMID:14729977^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q96KQ4	F
	GO:0005515	protein binding	PMID:18280240^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P46937	F
	GO:0005515	protein binding	PMID:19581926^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P0C2W1	F
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002117	C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012346	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005667	transcription factor complex	GO_REF:0000033		PANTHER:PTHR11447_AN0	C
	GO:0005829	cytosol	GO_REF:0000033		PANTHER:PTHR11447_AN0	C
	GO:0006298	mismatch repair	PMID:10391249^[10]	TAS: Traceable Author Statement		P
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006351	transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0006351	transcription, DNA-dependent	PMID:10802655^[1]	TAS: Traceable Author Statement		P
	GO:0006351	transcription, DNA-dependent	PMID:15678106^[2]	IDA: Inferred from Direct Assay		P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002117	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008967	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012346	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:10802655^[1]	TAS: Traceable Author Statement		P
	GO:0006915	apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002117	P
	GO:0006915	apoptosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0053	P
	GO:0006915	apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0006954	inflammatory response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0006974	response to DNA damage stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO_REF:0000033		PANTHER:PTHR11447_AN0	P
	GO:0007049	cell cycle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0131	P
	GO:0007050	cell cycle arrest	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0008134	transcription factor binding	PMID:11748232^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P09429	F
	GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis	PMID:10391251^[11]	TAS: Traceable Author Statement		P
	GO:0009791	post-embryonic development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0010165	response to X-ray	GO_REF:0000033		PANTHER:PTHR11447_AN0	P
	GO:0010243	response to organic nitrogen	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052265	P
	GO:0010332	response to gamma radiation	GO_REF:0000033		PANTHER:PTHR11447_AN0	P
	GO:0021766	hippocampus development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0030900	forebrain development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0031571	mitotic cell cycle G1/S transition DNA damage checkpoint	GO_REF:0000033		PANTHER:PTHR11447_AN0	P
	GO:0033326	cerebrospinal fluid secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0034644	cellular response to UV	GO_REF:0000033		PANTHER:PTHR11447_AN0	P
	GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	GO_REF:0000033		PANTHER:PTHR11447_AN0	P
	GO:0043065	positive regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052265	P
	GO:0043066	negative regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0043508	negative regulation of JUN kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0043508	negative regulation of JUN kinase activity	GO_REF:0000033		PANTHER:PTHR11447_AN31	P
	GO:0043523	regulation of neuron apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0043524	negative regulation of neuron apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0043524	negative regulation of neuron apoptosis	GO_REF:0000033		PANTHER:PTHR11447_AN31	P
	GO:0043565	sequence-specific DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052265	F
	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011615	F
	GO:0044212	transcription regulatory region DNA binding	PMID:16343436^[12]	IDA: Inferred from Direct Assay		F
	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052265	P
	GO:0045793	positive regulation of cell size	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0045893	positive regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:15678106^[2]	IDA: Inferred from Direct Assay		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:16343436^[12]	IDA: Inferred from Direct Assay		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052265	P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0048546	digestive tract morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0048666	neuron development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000101269	P
	GO:0048714	positive regulation of oligodendrocyte differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052265	P
	GO:0051262	protein tetramerization	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010991	P
	GO:0006281	DNA repair	PMID:21891782^[14]	IDA: Inferred from Direct Assay		P	Figure 1A, 1B, & 1C. p73 concentrations rise after BA damage.	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Marin MC et al. (2000) A common polymorphism acts as an intragenic modifier of mutant p53 behaviour. Nat Genet 25: 47-54 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Rossi M et al. (2005) The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J 24: 836-48 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Ongkeko WM et al. (1999) MDM2 and MDMX bind and stabilize the p53-related protein p73. Curr Biol 9: 829-32 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Park JS et al. (2001) Functional inactivation of p73, a homolog of p53 tumor suppressor protein, by human papillomavirus E6 proteins. Int J Cancer 91: 822-7 PubMed GONUTS page
↑ ^5.0 ^5.1 Tsuji K et al. (2002) Differential effect of ik3-1/cables on p53- and p73-induced cell death. J Biol Chem 277: 2951-7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Stros M et al. (2002) HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter. J Biol Chem 277: 7157-64 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Bergamaschi D et al. (2004) ASPP1 and ASPP2: common activators of p53 family members. Mol Cell Biol 24: 1341-50 PubMed GONUTS page
↑ ^8.0 ^8.1 Levy D et al. (2008) Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. Mol Cell 29: 350-61 PubMed GONUTS page
↑ ^9.0 ^9.1 Peschiaroli A et al. (2009) The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73. Oncogene 28: 3157-66 PubMed GONUTS page
↑ ^10.0 ^10.1 Gong JG et al. (1999) The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 399: 806-9 PubMed GONUTS page
↑ ^11.0 ^11.1 Yuan ZM et al. (1999) p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature 399: 814-7 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Osada M et al. (2006) A novel response element confers p63- and p73-specific activation of the WNT4 promoter. Biochem Biophys Res Commun 339: 1120-8 PubMed GONUTS page
↑ Melino G et al. (2004) p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J Biol Chem 279: 8076-83 PubMed GONUTS page
↑ Zaika E et al. (2011) p73 protein regulates DNA damage repair. FASEB J 25: 4406-14 PubMed GONUTS page

[PMID:10802655-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Marin MC et al. (2000) A common polymorphism acts as an intragenic modifier of mutant p53 behaviour. Nat Genet 25: 47-54 PubMed GONUTS page

[PMID:15678106-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Rossi M et al. (2005) The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J 24: 836-48 PubMed GONUTS page

[PMID:10469568-2] 3.0 ^3.1 ^3.2 ^3.3 Ongkeko WM et al. (1999) MDM2 and MDMX bind and stabilize the p53-related protein p73. Curr Biol 9: 829-32 PubMed GONUTS page

[PMID:11275986-3] 4.0 ^4.1 ^4.2 ^4.3 Park JS et al. (2001) Functional inactivation of p73, a homolog of p53 tumor suppressor protein, by human papillomavirus E6 proteins. Int J Cancer 91: 822-7 PubMed GONUTS page

[PMID:11706030-4] 5.0 ^5.1 Tsuji K et al. (2002) Differential effect of ik3-1/cables on p53- and p73-induced cell death. J Biol Chem 277: 2951-7 PubMed GONUTS page

[PMID:11748232-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Stros M et al. (2002) HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter. J Biol Chem 277: 7157-64 PubMed GONUTS page

[PMID:14729977-6] 7.0 ^7.1 ^7.2 ^7.3 Bergamaschi D et al. (2004) ASPP1 and ASPP2: common activators of p53 family members. Mol Cell Biol 24: 1341-50 PubMed GONUTS page

[PMID:18280240-7] 8.0 ^8.1 Levy D et al. (2008) Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. Mol Cell 29: 350-61 PubMed GONUTS page

[PMID:19581926-8] 9.0 ^9.1 Peschiaroli A et al. (2009) The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73. Oncogene 28: 3157-66 PubMed GONUTS page

[PMID:10391249-9] 10.0 ^10.1 Gong JG et al. (1999) The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 399: 806-9 PubMed GONUTS page

[PMID:10391251-10] 11.0 ^11.1 Yuan ZM et al. (1999) p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature 399: 814-7 PubMed GONUTS page

[PMID:16343436-11] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Osada M et al. (2006) A novel response element confers p63- and p73-specific activation of the WNT4 promoter. Biochem Biophys Res Commun 339: 1120-8 PubMed GONUTS page

[PMID:14634023-12] Melino G et al. (2004) p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J Biol Chem 279: 8076-83 PubMed GONUTS page

[PMID:21891782-13] Zaika E et al. (2011) p73 protein regulates DNA damage repair. FASEB J 25: 4406-14 PubMed GONUTS page

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HUMAN:P73

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