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HUMAN:P2RX7
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | P2RX7 | |
| Protein Name(s) | P2X purinoceptor 7
P2X7 ATP receptor P2Z receptor Purinergic receptor | |
| External Links | ||
| EMBL | Y09561 Y12851 Y12852 Y12853 Y12854 Y12855 Z98941 BC011913 | |
| IPI | IPI00293328 | |
| UniGene | Hs.729169 | |
| ProteinModelPortal | Q99572 | |
| SMR | Q99572 | |
| IntAct | Q99572 | |
| MINT | MINT-3972963 | |
| STRING | Q99572 | |
| TCDB | 1.A.7.1.3 | |
| PhosphoSite | Q99572 | |
| PRIDE | Q99572 | |
| Ensembl | ENST00000261826 | |
| GeneCards | GC12P118580 | |
| HGNC | HGNC:8537 | |
| HPA | HPA034967 HPA034968 | |
| MIM | 602566 | |
| neXtProt | NX_Q99572 | |
| eggNOG | prNOG13847 | |
| GeneTree | ENSGT00390000016028 | |
| HOGENOM | HBG713324 | |
| HOVERGEN | HBG053086 | |
| InParanoid | Q99572 | |
| OMA | QKTCEVS | |
| OrthoDB | EOG4DJJWD | |
| Reactome | REACT_6900 | |
| NextBio | 19358 | |
| ArrayExpress | Q99572 | |
| Bgee | Q99572 | |
| CleanEx | HS_P2RX7 | |
| Genevestigator | Q99572 | |
| GermOnline | ENSG00000089041 | |
| GO | GO:0032059 GO:0005737 GO:0005887 GO:0005524 GO:0004931 GO:0001530 GO:0042803 GO:0001614 GO:0005102 GO:0002218 GO:0032060 GO:0045087 GO:0051899 GO:0045779 GO:0043409 GO:0046931 GO:0030501 GO:0010524 GO:0045919 GO:0051495 GO:0050718 GO:0042981 GO:0051709 GO:0002028 GO:0033198 GO:0019233 | |
| InterPro | IPR003050 IPR001429 | |
| PANTHER | PTHR10125 | |
| Pfam | PF00864 | |
| PRINTS | PR01314 PR01307 | |
| TIGRFAMs | TIGR00863 | |
| PROSITE | PS01212 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001530 |
lipopolysaccharide binding |
ISS: Inferred from Sequence or Structural Similarity |
F |
Seeded From UniProt |
||||
| GO:0001614 |
purinergic nucleotide receptor activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0002028 |
regulation of sodium ion transport |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0002218 |
activation of innate immune response |
Reactome:REACT_75913 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0004872 |
receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004872 |
receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004872 |
receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004931 |
extracellular ATP-gated cation channel activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005102 |
receptor binding |
ISS: Inferred from Sequence or Structural Similarity |
F |
Seeded From UniProt |
||||
| GO:0005216 |
ion channel activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005216 |
ion channel activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005216 |
ion channel activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IC: Inferred by Curator |
GO:0001614 |
F |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0005886 |
plasma membrane |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0005886 |
plasma membrane |
Reactome:REACT_75791 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_75889 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_75933 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005887 |
integral to plasma membrane |
IC: Inferred by Curator |
GO:0001614 |
C |
Seeded From UniProt |
|||
| GO:0006810 |
transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006811 |
ion transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006811 |
ion transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006811 |
ion transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007166 |
cell surface receptor linked signaling pathway |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0010524 |
positive regulation of calcium ion transport into cytosol |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0162 |
C |
Seeded From UniProt |
|||
| GO:0016020 |
membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0019233 |
sensory perception of pain |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0030501 |
positive regulation of bone mineralization |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0032059 |
bleb |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0032060 |
bleb assembly |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0033198 |
response to ATP |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0035590 |
purinergic nucleotide receptor signaling pathway |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0042803 |
protein homodimerization activity |
NAS: Non-traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0042981 |
regulation of apoptosis |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0043409 |
negative regulation of MAPKKK cascade |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0045087 |
innate immune response |
Reactome:REACT_6802 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0045779 |
negative regulation of bone resorption |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0045919 |
positive regulation of cytolysis |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0046931 |
pore complex assembly |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0050718 |
positive regulation of interleukin-1 beta secretion |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0050718 |
positive regulation of interleukin-1 beta secretion |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0051495 |
positive regulation of cytoskeleton organization |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0051709 |
regulation of killing of cells of other organism |
NAS: Non-traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0051899 |
membrane depolarization |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Rassendren F et al. (1997) The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA. J Biol Chem 272: 5482-6 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Guo C et al. (2007) Evidence for functional P2X4/P2X7 heteromeric receptors. Mol Pharmacol 72: 1447-56 PubMed GONUTS page
- ↑ Dubyak GR (2007) Go it alone no more--P2X7 joins the society of heteromeric ATP-gated receptor channels. Mol Pharmacol 72: 1402-5 PubMed GONUTS page
- ↑ Pelegrin P & Surprenant A (2006) Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J 25: 5071-82 PubMed GONUTS page
- ↑ Warren AY et al. (2008) Interleukin-1 beta secretion from cord blood mononuclear cells in vitro involves P2X 7 receptor activation. Reprod Sci 15: 189-94 PubMed GONUTS page
