HUMAN:OPRM

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	OPRM1 ( synonyms: MOR1 )
Protein Name(s)	Mu-type opioid receptor M-OR-1 MOR-1 Mu opiate receptor Mu opioid receptor MOP hMOP
External Links
UniProt Identifier	OPRM_HUMAN
UniProt Accessions	P35372, B2R9S7, B8Q1L7, Q12930, Q4VWM1, Q4VWM2, Q4VWM3, Q4VWM4, Q4VWM6, Q4VWX6, Q5TDA1, Q6UQ80, Q7Z2D8, Q8IWW3, Q8IWW4, Q9UCZ4, Q9UN57,
EMBL	L25119, U12569, L29301, AY036622, AY036623, AY225404, AY309001, AY309005, AY309006, AY309007, AY309008, AY309009, EU340241, AY364230, AK313901, AY521028, AY587764, AL132774, AL136444, CH471051, BC074927, AY292290, AY292291, AF153500,
PIR	I56553, S65693,
RefSeq	NP_000905.3, NP_001008503.2, NP_001008504.2, NP_001008505.2, NP_001138751.1, NP_001138754.1, NP_001138755.1, NP_001138756.1, NP_001138757.1, NP_001138758.1, NP_001138759.1,
IntAct	P35372,
Ensembl	ENST00000330432, ENST00000434900,
Pfam	PF00001,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005783	endoplasmic reticulum		TAS: Traceable Author Statement		C	Source: ProtInc
	GO:0005794	Golgi apparatus		TAS: Traceable Author Statement		C	Source: ProtInc
	GO:0005887	integral to plasma membrane		TAS: Traceable Author Statement		C	Source: ProtInc
	GO:0004988	mu-opioid receptor activity		TAS: Traceable Author Statement		F	Source: ProtInc
	GO:0005515	protein binding		IPI: Inferred from Physical Interaction		F	Source: IntAct
	GO:0008285	negative regulation of cell proliferation		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0007600	sensory perception		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0050331	thiamin diphosphate kinase activity	PMID:21049048^[1]	EXP: Inferred from Experiment		F	Table 8 shows ThTp levels related to this protein. Also Figure 1 describes the kinase activity.	complete
	GO:0006757	ADP phosphorylation	PMID:21049048^[1]	EXP: Inferred from Experiment		P	Table 8 shows AThDP levels related to this protein. Also Figure 1 illustrates how AThDP and ATP are created by ADP phosphorylation.	complete
	GO:0019899	enzyme binding	PMID:21049048^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q9BU02	F	Figure 2 and 3 both show ThTpase activity with the protein	complete
	GO:0004871	signal transducer activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0807	F
	GO:0004872	receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0675	F
	GO:0004930	G-protein coupled receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0297	F
	GO:0004985	opioid receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001418	F
	GO:0004988	mu-opioid receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000105	F
	GO:0004988	mu-opioid receptor activity	PMID:9689128^[2]	TAS: Traceable Author Statement		F
	GO:0005515	protein binding	PMID:15086532^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q5JY77	F
	GO:0005783	endoplasmic reticulum	PMID:9242668^[4]	TAS: Traceable Author Statement		C
	GO:0005794	Golgi apparatus	PMID:9242668^[4]	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	PMID:9242668^[4]	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_14795	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_15298	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_15336	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_15388	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_15473	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_15491	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_15538	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_15549	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_22239	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_22289	TAS: Traceable Author Statement		C
	GO:0005887	integral to plasma membrane	PMID:7905839^[5]	TAS: Traceable Author Statement		C
	GO:0007165	signal transduction	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0807	P
	GO:0007186	G-protein coupled receptor protein signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000105	P
	GO:0007186	G-protein coupled receptor protein signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000276	P
	GO:0007186	G-protein coupled receptor protein signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001418	P
	GO:0007186	G-protein coupled receptor protein signaling pathway	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0297	P
	GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	PMID:7905839^[5]	TAS: Traceable Author Statement		P
	GO:0007600	sensory perception	PMID:9689128^[2]	TAS: Traceable Author Statement		P
	GO:0007610	behavior	PMID:9689128^[2]	TAS: Traceable Author Statement		P
	GO:0008285	negative regulation of cell proliferation	PMID:2159143^[6]	TAS: Traceable Author Statement		P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000105	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000276	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001418	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0038003	opioid receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001418	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Gangolf M et al. (2010) Thiamine status in humans and content of phosphorylated thiamine derivatives in biopsies and cultured cells. PLoS One 5: e13616 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Bond C et al. (1998) Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Proc Natl Acad Sci U S A 95: 9608-13 PubMed GONUTS page
↑ Simonin F et al. (2004) Identification of a novel family of G protein-coupled receptor associated sorting proteins. J Neurochem 89: 766-75 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Massotte D et al. (1997) Characterization of delta, kappa, and mu human opioid receptors overexpressed in baculovirus-infected insect cells. J Biol Chem 272: 19987-92 PubMed GONUTS page
↑ ^5.0 ^5.1 Wang JB et al. (1994) Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment. FEBS Lett 338: 217-22 PubMed GONUTS page
↑ Maneckjee R & Minna JD (1990) Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines. Proc Natl Acad Sci U S A 87: 3294-8 PubMed GONUTS page

[PMID:21049048-0] 1.0 ^1.1 ^1.2 Gangolf M et al. (2010) Thiamine status in humans and content of phosphorylated thiamine derivatives in biopsies and cultured cells. PLoS One 5: e13616 PubMed GONUTS page

[PMID:9689128-1] 2.0 ^2.1 ^2.2 Bond C et al. (1998) Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Proc Natl Acad Sci U S A 95: 9608-13 PubMed GONUTS page

[PMID:15086532-2] Simonin F et al. (2004) Identification of a novel family of G protein-coupled receptor associated sorting proteins. J Neurochem 89: 766-75 PubMed GONUTS page

[PMID:9242668-3] 4.0 ^4.1 ^4.2 Massotte D et al. (1997) Characterization of delta, kappa, and mu human opioid receptors overexpressed in baculovirus-infected insect cells. J Biol Chem 272: 19987-92 PubMed GONUTS page

[PMID:7905839-4] 5.0 ^5.1 Wang JB et al. (1994) Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment. FEBS Lett 338: 217-22 PubMed GONUTS page

[PMID:2159143-5] Maneckjee R & Minna JD (1990) Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines. Proc Natl Acad Sci U S A 87: 3294-8 PubMed GONUTS page

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HUMAN:OPRM

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