HUMAN:NOTC1

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	NOTCH1 ( synonyms: TAN1 )
Protein Name(s)	Neurogenic locus notch homolog protein 1 Notch 1 hN1 Translocation-associated notch protein TAN-1 Notch 1 extracellular truncation Notch 1 intracellular domain NICD
External Links
UniProt Identifier	NOTC1_HUMAN
UniProt Accessions	P46531, Q59ED8, Q5SXM3,
EMBL	AF308602, AL592301, AL354671, AL354671, AL592301, M73980, AB209873,
PIR	A40043,
RefSeq	NP_060087.3,
PDB	1PB5, 1TOZ, 1YYH, 2F8X, 2F8Y, 2HE0, 2VJ3, 3ETO, 3I08, 3L95, 3NBN,
IntAct	P46531,
Ensembl	ENST00000277541,
Pfam	PF00023, PF00008, PF07645, PF06816, PF07684, PF00066,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0001669	acrosomal vesicle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	C
	GO:0001701	in utero embryonic development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0001708	cell fate specification	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0001837	epithelial to mesenchymal transition	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0001889	liver development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0002040	sprouting angiogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0002052	positive regulation of neuroblast proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0003160	endocardium morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0003180	aortic valve morphogenesis	PMID:16025100^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0003264	regulation of cardioblast proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0003682	chromatin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	F
	GO:0004872	receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR022362	F
	GO:0004872	receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0675	F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001881	F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018097	F
	GO:0005515	protein binding	PMID:10713164^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q06330	F
	GO:0005515	protein binding	PMID:10713164^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q13573	F
	GO:0005515	protein binding	PMID:10713164^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q13573	F
	GO:0005515	protein binding	PMID:10713164^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y618	F
	GO:0005515	protein binding	PMID:11101851^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q92585	F
	GO:0005515	protein binding	PMID:11390662^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q92585	F
	GO:0005515	protein binding	PMID:16530044^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q92585	F
	GO:0005576	extracellular region	Reactome:REACT_410	TAS: Traceable Author Statement		C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:10713164^[2]	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_14814	TAS: Traceable Author Statement		C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	C
	GO:0005788	endoplasmic reticulum lumen	Reactome:REACT_1833	TAS: Traceable Author Statement		C
	GO:0005794	Golgi apparatus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	C
	GO:0005796	Golgi lumen	Reactome:REACT_1127	TAS: Traceable Author Statement		C
	GO:0005796	Golgi lumen	Reactome:REACT_1833	TAS: Traceable Author Statement		C
	GO:0005796	Golgi lumen	Reactome:REACT_2005	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_1784	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	Reactome:REACT_1576	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_1784	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_2005	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_410	TAS: Traceable Author Statement		C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR022362	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:10713164^[2]	TAS: Traceable Author Statement		P
	GO:0006357	regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0006955	immune response	PMID:1831692^[6]	NAS: Non-traceable Author Statement		P
	GO:0007219	Notch signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011656	P
	GO:0007219	Notch signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR022362	P
	GO:0007219	Notch signaling pathway	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0914	P
	GO:0007219	Notch signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0007219	Notch signaling pathway	PMID:10713164^[2]	TAS: Traceable Author Statement		P
	GO:0007219	Notch signaling pathway	Reactome:REACT_299	TAS: Traceable Author Statement		P
	GO:0007220	Notch receptor processing	Reactome:REACT_2001	TAS: Traceable Author Statement		P
	GO:0007220	Notch receptor processing	Reactome:REACT_691	TAS: Traceable Author Statement		P
	GO:0007221	positive regulation of transcription of Notch receptor target	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0007275	multicellular organismal development	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011656	P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0007283	spermatogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0007368	determination of left/right symmetry	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0007386	compartment pattern formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0007409	axonogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0007440	foregut morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0007492	endoderm development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0007507	heart development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0008284	positive regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0008544	epidermis development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0009790	embryo development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0010001	glial cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0010467	gene expression	Reactome:REACT_71	TAS: Traceable Author Statement		P
	GO:0010468	regulation of gene expression	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0010812	negative regulation of cell-substrate adhesion	PMID:16501043^[7]	IDA: Inferred from Direct Assay		P
	GO:0014807	regulation of somitogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000800	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008297	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010660	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011656	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016021	integral to membrane	GO_REF:0000029	NAS: Non-traceable Author Statement		C
	GO:0016563	transcription activator activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	F
	GO:0021515	cell differentiation in spinal cord	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0021915	neural tube development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0030154	cell differentiation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000800	P
	GO:0030154	cell differentiation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010660	P
	GO:0030154	cell differentiation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011656	P
	GO:0030154	cell differentiation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0221	P
	GO:0030154	cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0030182	neuron differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0030216	keratinocyte differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0030324	lung development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0030326	embryonic limb morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0030514	negative regulation of BMP signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0030514	negative regulation of BMP signaling pathway	PMID:19695258^[8]	TAS: Traceable Author Statement		P
	GO:0030900	forebrain development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0031069	hair follicle morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0031100	organ regeneration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0031490	chromatin DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	F
	GO:0031960	response to corticosteroid stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0032496	response to lipopolysaccharide	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0032582	negative regulation of gene-specific transcription	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0032582	negative regulation of gene-specific transcription	PMID:19695258^[8]	TAS: Traceable Author Statement		P
	GO:0035116	embryonic hindlimb morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0042127	regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0042246	tissue regeneration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0042640	anagen	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0043065	positive regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0043066	negative regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0043565	sequence-specific DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	F
	GO:0045165	cell fate commitment	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0045596	negative regulation of cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0045603	positive regulation of endothelial cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0045618	positive regulation of keratinocyte differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0045662	negative regulation of myoblast differentiation	PMID:10713164^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0045668	negative regulation of osteoblast differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0045668	negative regulation of osteoblast differentiation	PMID:19695258^[8]	TAS: Traceable Author Statement		P
	GO:0045687	positive regulation of glial cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0045893	positive regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0046533	negative regulation of photoreceptor cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0048103	somatic stem cell division	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0048663	neuron fate commitment	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0048708	astrocyte differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0048709	oligodendrocyte differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0048754	branching morphogenesis of a tube	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0050678	regulation of epithelial cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0050767	regulation of neurogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0050793	regulation of developmental process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008297	P
	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0060548	negative regulation of cell death	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0060740	prostate gland epithelium morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0060768	regulation of epithelial cell proliferation involved in prostate gland development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0001669	acrosomal vesicle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	C
	GO:0001701	in utero embryonic development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0001708	cell fate specification	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0001837	epithelial to mesenchymal transition	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0001889	liver development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0002040	sprouting angiogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0002052	positive regulation of neuroblast proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0003180	aortic valve morphogenesis	PMID:16025100^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0003264	regulation of cardioblast proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0003682	chromatin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	F
	GO:0004872	receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR022362	F
	GO:0004872	receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0675	F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001881	F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018097	F
	GO:0005515	protein binding	PMID:10713164^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q06330	F
	GO:0005515	protein binding	PMID:10713164^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q13573	F
	GO:0005515	protein binding	PMID:10713164^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q13573	F
	GO:0005515	protein binding	PMID:10713164^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y618	F
	GO:0005515	protein binding	PMID:11101851^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q92585	F
	GO:0005515	protein binding	PMID:11390662^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q92585	F
	GO:0005515	protein binding	PMID:16530044^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q92585	F
	GO:0005576	extracellular region	Reactome:REACT_410	TAS: Traceable Author Statement		C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:10713164^[2]	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_14814	TAS: Traceable Author Statement		C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	C
	GO:0005788	endoplasmic reticulum lumen	Reactome:REACT_1833	TAS: Traceable Author Statement		C
	GO:0005794	Golgi apparatus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	C
	GO:0005796	Golgi lumen	Reactome:REACT_1127	TAS: Traceable Author Statement		C
	GO:0005796	Golgi lumen	Reactome:REACT_1833	TAS: Traceable Author Statement		C
	GO:0005796	Golgi lumen	Reactome:REACT_2005	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_1784	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	Reactome:REACT_1576	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_1784	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_2005	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_410	TAS: Traceable Author Statement		C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006351	transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0006351	transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR022362	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:10713164^[2]	TAS: Traceable Author Statement		P
	GO:0006357	regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0006955	immune response	PMID:1831692^[6]	NAS: Non-traceable Author Statement		P
	GO:0007219	Notch signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011656	P
	GO:0007219	Notch signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR022362	P
	GO:0007219	Notch signaling pathway	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0914	P
	GO:0007219	Notch signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0007219	Notch signaling pathway	PMID:10713164^[2]	TAS: Traceable Author Statement		P
	GO:0007219	Notch signaling pathway	Reactome:REACT_299	TAS: Traceable Author Statement		P
	GO:0007220	Notch receptor processing	Reactome:REACT_2001	TAS: Traceable Author Statement		P
	GO:0007220	Notch receptor processing	Reactome:REACT_691	TAS: Traceable Author Statement		P
	GO:0007221	positive regulation of transcription of Notch receptor target	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0007221	positive regulation of transcription of Notch receptor target	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0007275	multicellular organismal development	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011656	P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0007283	spermatogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0007368	determination of left/right symmetry	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0007386	compartment pattern formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0007409	axonogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0007440	foregut morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0007492	endoderm development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0007507	heart development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0007507	heart development	PMID:21457232^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0008284	positive regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0009790	embryo development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0010001	glial cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0010467	gene expression	Reactome:REACT_71	TAS: Traceable Author Statement		P
	GO:0010468	regulation of gene expression	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0010718	positive regulation of epithelial to mesenchymal transition	PMID:17984306^[10]	IMP: Inferred from Mutant Phenotype		P
	GO:0010812	negative regulation of cell-substrate adhesion	PMID:16501043^[7]	IDA: Inferred from Direct Assay		P
	GO:0014807	regulation of somitogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000800	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008297	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010660	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011656	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016021	integral to membrane	GO_REF:0000029	NAS: Non-traceable Author Statement		C
	GO:0021515	cell differentiation in spinal cord	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0021915	neural tube development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0030154	cell differentiation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000800	P
	GO:0030154	cell differentiation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010660	P
	GO:0030154	cell differentiation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011656	P
	GO:0030154	cell differentiation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0221	P
	GO:0030154	cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0030182	neuron differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0030216	keratinocyte differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0030324	lung development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0030326	embryonic limb morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0030514	negative regulation of BMP signaling pathway	PMID:19695258^[8]	TAS: Traceable Author Statement		P
	GO:0030900	forebrain development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0031069	hair follicle morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0031100	organ regeneration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0031490	chromatin DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	F
	GO:0031960	response to corticosteroid stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0032496	response to lipopolysaccharide	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0035116	embryonic hindlimb morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0042127	regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0042246	tissue regeneration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0042640	anagen	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0043065	positive regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0043066	negative regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0043565	sequence-specific DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	F
	GO:0045165	cell fate commitment	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0045596	negative regulation of cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0045603	positive regulation of endothelial cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0045618	positive regulation of keratinocyte differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0045662	negative regulation of myoblast differentiation	PMID:10713164^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0045668	negative regulation of osteoblast differentiation	PMID:19695258^[8]	TAS: Traceable Author Statement		P
	GO:0045687	positive regulation of glial cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:19695258^[8]	TAS: Traceable Author Statement		P
	GO:0045893	positive regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0045955	negative regulation of calcium ion-dependent exocytosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0046533	negative regulation of photoreceptor cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0048103	somatic stem cell division	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0048663	neuron fate commitment	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0048708	astrocyte differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0048709	oligodendrocyte differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000026212	P
	GO:0048754	branching morphogenesis of a tube	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0050678	regulation of epithelial cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0050767	regulation of neurogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0050793	regulation of developmental process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008297	P
	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0060548	negative regulation of cell death	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0060740	prostate gland epithelium morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
	GO:0060768	regulation of epithelial cell proliferation involved in prostate gland development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028288	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Garg V et al. (2005) Mutations in NOTCH1 cause aortic valve disease. Nature 437: 270-4 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 Zhou S et al. (2000) SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. Mol Cell Biol 20: 2400-10 PubMed GONUTS page
↑ ^3.0 ^3.1 Wu L et al. (2000) MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet 26: 484-9 PubMed GONUTS page
↑ ^4.0 ^4.1 Kitagawa M et al. (2001) A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters. Mol Cell Biol 21: 4337-46 PubMed GONUTS page
↑ ^5.0 ^5.1 Nam Y et al. (2006) Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell 124: 973-83 PubMed GONUTS page
↑ ^6.0 ^6.1 Ellisen LW et al. (1991) TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66: 649-61 PubMed GONUTS page
↑ ^7.0 ^7.1 Ayyanan A et al. (2006) Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism. Proc Natl Acad Sci U S A 103: 3799-804 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Nigam V & Srivastava D (2009) Notch1 represses osteogenic pathways in aortic valve cells. J Mol Cell Cardiol 47: 828-34 PubMed GONUTS page
↑ Iascone M et al. (2012) Identification of de novo mutations and rare variants in hypoplastic left heart syndrome. Clin Genet 81: 542-54 PubMed GONUTS page
↑ Leong KG et al. (2007) Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. J Exp Med 204: 2935-48 PubMed GONUTS page

[PMID:16025100-0] 1.0 ^1.1 Garg V et al. (2005) Mutations in NOTCH1 cause aortic valve disease. Nature 437: 270-4 PubMed GONUTS page

[PMID:10713164-1] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 Zhou S et al. (2000) SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. Mol Cell Biol 20: 2400-10 PubMed GONUTS page

[PMID:11101851-2] 3.0 ^3.1 Wu L et al. (2000) MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet 26: 484-9 PubMed GONUTS page

[PMID:11390662-3] 4.0 ^4.1 Kitagawa M et al. (2001) A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters. Mol Cell Biol 21: 4337-46 PubMed GONUTS page

[PMID:16530044-4] 5.0 ^5.1 Nam Y et al. (2006) Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell 124: 973-83 PubMed GONUTS page

[PMID:1831692-5] 6.0 ^6.1 Ellisen LW et al. (1991) TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66: 649-61 PubMed GONUTS page

[PMID:16501043-6] 7.0 ^7.1 Ayyanan A et al. (2006) Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism. Proc Natl Acad Sci U S A 103: 3799-804 PubMed GONUTS page

[PMID:19695258-7] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Nigam V & Srivastava D (2009) Notch1 represses osteogenic pathways in aortic valve cells. J Mol Cell Cardiol 47: 828-34 PubMed GONUTS page

[PMID:21457232-8] Iascone M et al. (2012) Identification of de novo mutations and rare variants in hypoplastic left heart syndrome. Clin Genet 81: 542-54 PubMed GONUTS page

[PMID:17984306-9] Leong KG et al. (2007) Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. J Exp Med 204: 2935-48 PubMed GONUTS page

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HUMAN:NOTC1

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